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Article

MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin

Retraction in: /10.3892/mmr.2022.12764
  • Authors:
    • Zhiwei Liao
    • Yue Li
    • Yuanhang Zhou
    • Qi Huang
    • Jian Dong
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Renhe Hospital, Shanghai 200431, P.R. China
  • Pages: 602-611
    |
    Published online on: October 26, 2017
       https://doi.org/10.3892/mmr.2017.7908
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Abstract

Gastric cancer is the fifth most frequent malignancy and the fourth most common cause of cancer‑associated mortality worldwide. MicroRNAs (miRNAs) are a group of small RNAs that regulate several cellular processes. In particular, a large number of miRNAs are involved in gastric cancer formation and progression. Thus, miRNAs may be considered as effective diagnostic biomarkers and therapeutic methods for gastric cancer. The aim of the current study was to detect miRNA (miR)‑197 expression in gastric cancer and to investigate its biological role and associated mechanism in gastric cancer. In the present study, miR‑197 expression was demonstrated to be considerably downregulated in gastric cancer tissues and cell lines. Its low expression level was associated with tumour size, invasive depth, tumour‑node‑metastasis staging and lymph node metastasis. High expression of miR‑197 inhibited tumour cell proliferation and invasion in vitro. Subsequently, metadherin (MTDH) was identified as a direct target gene of miR‑197 in gastric cancer, and this was confirmed by bioinformatics analysis, Dual‑luciferase reporter assay, reverse transcription quantitative polymerase chain reaction and western blot analysis. MTDH expression was upregulated in gastric cancer and was inversely correlated with miR‑197 expression levels. In addition, MTDH overexpression prevented the proliferation and inhibited invasion induced by miR‑197 overexpression. In addition, miR‑197 was demonstrated to regulate the phosphatase and tensin homolog (PTEN)/AKT signalling pathway in gastric cancer. The results of the present study suggested that miR‑197 serves a tumour‑suppressing role in human gastric carcinogenesis and progression by regulating the MTDH/PTEN/AKT signalling pathway. The miR‑197/MTDH axis may provide a novel effective therapeutic target for patients with gastric cancer.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Shen L, Shan YS, Hu HM, Price TJ, Sirohi B, Yeh KH, Yang YH, Sano T, Yang HK, Zhang X, et al: Management of gastric cancer in Asia: Resource-stratified guidelines. Lancet Oncol. 14:e535–e547. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Ferro A, Peleteiro B, Malvezzi M, Bosetti C, Bertuccio P, Levi F, Negri E, La Vecchia C and Lunet N: Worldwide trends in gastric cancer mortality (1980–2011), with predictions to 2015, and incidence by subtype. Eur J Cancer. 50:1330–1344. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Kato M and Asaka M: Recent knowledge of the relationship between Helicobacter pylori and gastric cancer and recent progress of gastroendoscopic diagnosis and treatment for gastric cancer. Jpn J Clin Oncol. 40:828–837. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Li L, Ying XJ, Sun TT, Yi K, Tian HL, Sun R, Tian JH and Yang KH: Overview of methodological quality of systematic reviews about gastric cancer risk and protective factors. Asian Pac J Cancer Prev. 13:2069–2079. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Resende C, Thiel A, Machado JC and Ristimäki A: Gastric cancer: Basic aspects. Helicobacter. 16 Suppl 1:S38–S44. 2011. View Article : Google Scholar

7 

Thrumurthy SG, Chaudry MA, Chau I and Allum W: Does surgery have a role in managing incurable gastric cancer? Nat Rev Clin Oncol. 12:676–682. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Ying SY, Chang DC and Lin SL: The microRNA (miRNA): Overview of the RNA genes that modulate gene function. Mol Biotechnol. 38:257–268. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15–20. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Guan A, Wang H, Li X, Xie H, Wang R, Zhu Y and Li R: MiR-330-3p inhibits gastric cancer progression through targeting MSI1. Am J Transl Res. 8:4802–4811. 2016.PubMed/NCBI

12 

Wu SG, Huang YJ, Bao B, Wu LM, Dong J, Liu XH, Li ZH, Wang XY, Wang L, Chen BJ and Chen W: miR-508-5p acts as an anti-oncogene by targeting MESDC1 in hepatocellular carcinoma. Neoplasma. 64:40–47. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Yu H, Duan P, Zhu H and Rao D: miR-613 inhibits bladder cancer proliferation and migration through targeting SphK1. Am J Transl Res. 9:1213–1221. 2017.PubMed/NCBI

14 

Xu J, Jiang N, Shi H, Zhao S, Yao S and Shen H: (Corrigendum) miR-28-5p promotes the development and progression of ovarian cancer through inhibition of N4BP1. Int J Oncol. 50:22362017. View Article : Google Scholar : PubMed/NCBI

15 

Hu Y, Tang Z, Jiang B, Chen J and Fu Z: miR-198 functions as a tumor suppressor in breast cancer by targeting CUB domain-containing protein 1. Oncol Lett. 13:1753–1760. 2017.PubMed/NCBI

16 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Esquela-Kerscher A and Slack FJ: Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Chen P, Zhao H, Huang J, Yan X, Zhang Y and Gao Y: MicroRNA-17-5p promotes gastric cancer proliferation, migration and invasion by directly targeting early growth response 2. Am J Cancer Res. 6:2010–2020. 2016.PubMed/NCBI

19 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Babashah S and Soleimani M: The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis. Eur J Cancer. 47:1127–1137. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Chen CZ: MicroRNAs as oncogenes and tumor suppressors. N Engl J Med. 353:1768–1771. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Zheng G, Wang H, Zhang X, Yang Y, Wang L, Du L, Li W, Li J, Qu A, Liu Y and Wang C: Identification and validation of reference genes for qPCR detection of serum microRNAs in colorectal adenocarcinoma patients. PLoS One. 8:e830252013. View Article : Google Scholar : PubMed/NCBI

23 

Xin J, Zhang XK, Xin DY, Li XF, Sun DK, Ma YY and Tian LQ: FUS1 acts as a tumor-suppressor gene by upregulating miR-197 in human glioblastoma. Oncol Rep. 34:868–876. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Yang Y, Li F, Saha MN, Abdi J, Qiu L and Chang H: miR-137 and miR-197 induce apoptosis and suppress tumorigenicity by targeting MCL-1 in multiple myeloma. Clin Cancer Res. 21:2399–2411. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCt Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Dong L, Qin S, Li Y, Zhao L, Dong S, Wang Y, Zhang C and Han S: High expression of astrocyte elevated gene-1 is associated with clinical staging, metastasis, and unfavorable prognosis in gastric carcinoma. Tumour Biol. 36:2169–2178. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Jian-bo X, Hui W, Yu-long H, Chang-hua Z, Long-juan Z, Shi-rong C and Wen-hua Z: Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Med Oncol. 28:455–462. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Du C, Yi X, Liu W, Han T, Liu Z, Ding Z, Zheng Z, Piao Y, Yuan J, Han Y, et al: MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NFκB-dependent pathway. BMC Cancer. 14:8692014. View Article : Google Scholar : PubMed/NCBI

29 

Xu C, Kong X, Wang H, Zhang N, Kong X, Ding X, Li X and Yang Q: MTDH mediates estrogen-independent growth and tamoxifen resistance by down-regulating PTEN in MCF-7 breast cancer cells. Cell Physiol Biochem. 33:1557–1567. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Kloosterman WP and Plasterk RH: The diverse functions of microRNAs in animal development and disease. Dev Cell. 11:441–450. 2006. View Article : Google Scholar : PubMed/NCBI

31 

He L and Hannon GJ: MicroRNAs: Small RNAs with a big role in gene regulation. Nat Rev Genet. 5:522–531. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Shrestha S, Hsu SD, Huang WY, Huang HY, Chen W, Weng SL and Huang HD: A systematic review of microRNA expression profiling studies in human gastric cancer. Cancer Med. 3:878–888. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Wang TY, Liu SG, Zhao BS, Qi B, Qin XG and Yao WJ: Implications of microRNA-197 downregulated expression in esophageal cancer with poor prognosis. Genet Mol Res. 13:5574–5581. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Dai W, Wang C, Wang F, Wang Y, Shen M, Chen K, Cheng P, Zhang Y, Yang J, Zhu R, et al: Anti-miR-197 inhibits migration in HCC cells by targeting KAI 1/CD82. Biochem Biophys Res Commun. 446:541–548. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Mavridis K, Gueugnon F, Petit-Courty A, Courty Y, Barascu A, Guyetant S and Scorilas A: The oncomiR miR-197 is a novel prognostic indicator for non-small cell lung cancer patients. Br J Cancer. 112:1527–1535. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Shaker O, Maher M, Nassar Y, Morcos G and Gad Z: Role of microRNAs −29b-2, −155, −197 and −205 as diagnostic biomarkers in serum of breast cancer females. Gene. 560:77–82. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Hu J, Liu G, Zhao Z, Jia W and Xia H: MicroRNA-197 mediates the overgrowth and anti-apoptotic effects by downregulating insulin-like growth factor-binding protein-3 during nephroblastoma tumorigenesis. Fetal Pediatr Pathol. 35:287–298. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Hamada S, Satoh K, Miura S, Hirota M, Kanno A, Masamune A, Kikuta K, Kume K, Unno J, Egawa S, et al: miR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin. J Cell Physiol. 228:1255–1263. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Tian LQ, Liu EQ, Zhu XD, Wang XG, Li J and Xu GM: MicroRNA-197 inhibits cell proliferation by targeting GAB2 in glioblastoma. Mol Med Rep. 13:4279–4288. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Sun Z, Zhou N, Han Q, Zhao L, Bai C, Chen Y, Zhou J and Zhao RC: MicroRNA-197 influences 5-fluorouracil resistance via thymidylate synthase in colorectal cancer. Clin Transl Oncol. 17:876–883. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Wang H, Su X, Yang M, Chen T, Hou J, Li N and Cao X: Reciprocal control of miR-197 and IL-6/STAT3 pathway reveals miR-197 as potential therapeutic target for hepatocellular carcinoma. Oncoimmunology. 4:e10314402015. View Article : Google Scholar : PubMed/NCBI

42 

Wan L and Kang Y: Pleiotropic roles of AEG-1/MTDH/LYRIC in breast cancer. Adv Cancer Res. 120:113–134. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Gnosa S, Shen YM, Wang CJ, Zhang H, Stratmann J, Arbman G and Sun XF: Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines. J Transl Med. 10:1092012. View Article : Google Scholar : PubMed/NCBI

44 

Li J, Zhang N, Song LB, Liao WT, Jiang LL, Gong LY, Wu J, Yuan J, Zhang HZ, Zeng MS and Li M: Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res. 14:3319–3326. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Yu JQ, Zhou Q, Zhu H, Zheng FY and Chen ZW: Overexpression of astrocyte elevated gene-1 (AEG-1) in cervical cancer and its correlation with angiogenesis. Asian Pac J Cancer Prev. 16:2277–2281. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Yang G, Zhang L, Lin S, Li L, Liu M, Chen H, Cao M, Liu D, Huang YR and Bo J: AEG-1 is associated with tumor progression in nonmuscle-invasive bladder cancer. Med Oncol. 31:9862014. View Article : Google Scholar : PubMed/NCBI

47 

Hu G, Wei Y and Kang Y: The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res. 15:5615–5620. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Emdad L, Lee SG, Su ZZ, Jeon HY, Boukerche H, Sarkar D and Fisher PB: Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc Natl Acad Sci USA. 106:21300–21305. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Zhang CF, Xia YH, Zheng QF, Li ZJ, Guo XH, Zhou HC, Zhang LL, Dong LP, Han Y, Liu ZE, et al: Effect of silencing AEG-1 with small interfering RNA on the proliferation and cell cycle of gastric carcinoma SGC-7901 cells. Zhonghua Zhong Liu Za Zhi. 35:22–27. 2013.(Article In Chinese). PubMed/NCBI

50 

Tang Y, Liu X, Su B, Zhang Z, Zeng X, Lei Y, Shan J, Wu Y, Tang H and Su Q: MicroRNA-22 acts as a metastasis suppressor by targeting metadherin in gastric cancer. Mol Med Rep. 11:454–460. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Shen X, Si Y, Yang Z, Wang Q, Yuan J and Zhang X: MicroRNA-542-3p suppresses cell growth of gastric cancer cells via targeting oncogene astrocyte-elevated gene-1. Med Oncol. 32:3612015. View Article : Google Scholar : PubMed/NCBI

52 

Li S, Guo X, Ma X, Tang C, Ke Z and Huang W: Expression of astrocyte elevated gene-1 closely correlates with the angiogenesis of gastric cancer. Oncol Lett. 7:1447–1454. 2014.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liao Z, Li Y, Zhou Y, Huang Q and Dong J: MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin Retraction in /10.3892/mmr.2022.12764. Mol Med Rep 17: 602-611, 2018.
APA
Liao, Z., Li, Y., Zhou, Y., Huang, Q., & Dong, J. (2018). MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin Retraction in /10.3892/mmr.2022.12764. Molecular Medicine Reports, 17, 602-611. https://doi.org/10.3892/mmr.2017.7908
MLA
Liao, Z., Li, Y., Zhou, Y., Huang, Q., Dong, J."MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin Retraction in /10.3892/mmr.2022.12764". Molecular Medicine Reports 17.1 (2018): 602-611.
Chicago
Liao, Z., Li, Y., Zhou, Y., Huang, Q., Dong, J."MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin Retraction in /10.3892/mmr.2022.12764". Molecular Medicine Reports 17, no. 1 (2018): 602-611. https://doi.org/10.3892/mmr.2017.7908
Copy and paste a formatted citation
x
Spandidos Publications style
Liao Z, Li Y, Zhou Y, Huang Q and Dong J: MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin Retraction in /10.3892/mmr.2022.12764. Mol Med Rep 17: 602-611, 2018.
APA
Liao, Z., Li, Y., Zhou, Y., Huang, Q., & Dong, J. (2018). MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin Retraction in /10.3892/mmr.2022.12764. Molecular Medicine Reports, 17, 602-611. https://doi.org/10.3892/mmr.2017.7908
MLA
Liao, Z., Li, Y., Zhou, Y., Huang, Q., Dong, J."MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin Retraction in /10.3892/mmr.2022.12764". Molecular Medicine Reports 17.1 (2018): 602-611.
Chicago
Liao, Z., Li, Y., Zhou, Y., Huang, Q., Dong, J."MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin Retraction in /10.3892/mmr.2022.12764". Molecular Medicine Reports 17, no. 1 (2018): 602-611. https://doi.org/10.3892/mmr.2017.7908
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