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Article Open Access

Curcumin alleviates liver oxidative stress in type 1 diabetic rats

  • Authors:
    • Zhenglu Xie
    • Binbin Wu
    • Guozhi Shen
    • Xiaqing Li
    • Qianying Wu
  • View Affiliations / Copyright

    Affiliations: Department of Agriculture and Biotechnology, Jinshan College of Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 103-108
    |
    Published online on: October 26, 2017
       https://doi.org/10.3892/mmr.2017.7911
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Abstract

The aim of the present study was to determine the effects of curcumin on antioxidants using a rat model of type 1 diabetes. Seven‑week‑old male Sprague‑Dawley rats were injected with Streptozotocin (STZ) intraperitoneally to induce this model, and then treated with 1.0% curcumin (weight ratio) mixed in their diet for 21 days. The present study included three groups: Control group (NC), diabetic rat model group (DC) and a curcumin treated group (Diab‑Cur). The results demonstrated that curcumin treatment markedly decreased the blood glucose levels, plasma malondialdehyde concentration and plasma activity of glutathione peroxidase (GSH‑Px) and catalase (CAT); however, it increased the plasma superoxide dismutase (SOD) and insulin levels. Curcumin treatment increased the expression of the CAT, GSH‑Px, HO‑1 and norvegicus NAD(P)H quinone dehydrogenase 1, and decreased the SOD1 expression, which, led to a diminished oxidative stress status. In addition, curcumin treatment significantly increased the protein expression of Keap1 in the Diab‑Cur group when compared with the DC group, decreased cytosolic concentrations of Nrf2 while increasing nuclear accumulation of Nrf2. The results provide evidence that oxidative stress in the STZ‑induced diabetic rat model may be attenuated by curcumin via the activation of the Keap1‑Nrf2‑ARE signaling pathway, as evidenced by a decrease in the blood glucose concentration and an increase in the transcription of several antioxidant genes.
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Copy and paste a formatted citation
Spandidos Publications style
Xie Z, Wu B, Shen G, Li X and Wu Q: Curcumin alleviates liver oxidative stress in type 1 diabetic rats. Mol Med Rep 17: 103-108, 2018.
APA
Xie, Z., Wu, B., Shen, G., Li, X., & Wu, Q. (2018). Curcumin alleviates liver oxidative stress in type 1 diabetic rats. Molecular Medicine Reports, 17, 103-108. https://doi.org/10.3892/mmr.2017.7911
MLA
Xie, Z., Wu, B., Shen, G., Li, X., Wu, Q."Curcumin alleviates liver oxidative stress in type 1 diabetic rats". Molecular Medicine Reports 17.1 (2018): 103-108.
Chicago
Xie, Z., Wu, B., Shen, G., Li, X., Wu, Q."Curcumin alleviates liver oxidative stress in type 1 diabetic rats". Molecular Medicine Reports 17, no. 1 (2018): 103-108. https://doi.org/10.3892/mmr.2017.7911
Copy and paste a formatted citation
x
Spandidos Publications style
Xie Z, Wu B, Shen G, Li X and Wu Q: Curcumin alleviates liver oxidative stress in type 1 diabetic rats. Mol Med Rep 17: 103-108, 2018.
APA
Xie, Z., Wu, B., Shen, G., Li, X., & Wu, Q. (2018). Curcumin alleviates liver oxidative stress in type 1 diabetic rats. Molecular Medicine Reports, 17, 103-108. https://doi.org/10.3892/mmr.2017.7911
MLA
Xie, Z., Wu, B., Shen, G., Li, X., Wu, Q."Curcumin alleviates liver oxidative stress in type 1 diabetic rats". Molecular Medicine Reports 17.1 (2018): 103-108.
Chicago
Xie, Z., Wu, B., Shen, G., Li, X., Wu, Q."Curcumin alleviates liver oxidative stress in type 1 diabetic rats". Molecular Medicine Reports 17, no. 1 (2018): 103-108. https://doi.org/10.3892/mmr.2017.7911
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