Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2018 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2018 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Identification of biomarkers for childhood obesity based on expressional correlation and functional similarity

  • Authors:
    • Zheng‑Lun Zhu
    • Qiu‑Meng Yang
    • Chen Li
    • Jun Chen
    • Min Xiang
    • Ming‑Min Chen
    • Min Yan
    • Zheng‑Gang Zhu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 109-116
    |
    Published online on: October 27, 2017
       https://doi.org/10.3892/mmr.2017.7913
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the current study was to identify potential biomarkers of childhood obesity, and investigate molecular mechanisms and candidate agents in order to improve therapeutic strategies for childhood obesity. The GSE9624 gene expression profile was downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) in omental adipose tissues were analyzed with limma package by comparing samples from obese and normal control children. Two‑way hierarchical clustering was applied using the pheatmap package. The co‑expression (CE) analysis was performed using online CoExpress software. Subsequent to functional classification via the GOSim package, the gene network enriched by DEGs was visualized using the Cytoscape package. The codon usage bias of the DEGs was then examined using the CAI program from the European Molecular Biology Open Software Suite. In total, 583 DEGs (273 upregulated genes and 310 downregulated genes) were observed in the omental adipose tissues between samples from obese and normal control children. Hierarchical clustering identified a significant difference between samples from obese and normal control children. Subsequent to CE analysis, 130 DEGs, which were classified into 4 clusters, were selected. The following 3 upregulated and 2 downregulated genes were identified to be significant: Upregulated genes, microtubule‑associated protein tau (MAPT), destrin (actin depolymerizing factor) (DSTN) and spectrin, β, non‑erythrocytic 1 (SPTBN1); downregulated genes, Rho/Rac guanine nucleotide exchange factor 2 (ARHGEF2) and spindle and kinetochore associated complex subunit 1 (SKA1). The top 3 amino acids were identified to be glycine, leucine and serine with a high bias. The DEGs MAPT, DSTN, SPTBN1, ARHGEF2 and SKA1 are suggested to be candidate biomarkers for childhood obesity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Etelson D, Brand DA, Patrick PA and Shirali A: Childhood obesity: Do parents recognize this health risk? Obes Res. 11:1362–1368. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Dietz WH: Health consequences of obesity in youth: Childhood predictors of adult disease. Pediatrics. 101:518–525. 1998.PubMed/NCBI

3 

Dehghan M, Akhtar-Danesh N and Merchant AT: Childhood obesity, prevalence and prevention. Nutr J. 4:242005. View Article : Google Scholar : PubMed/NCBI

4 

Daniels SR: The consequences of childhood overweight and obesity. Future Child. 16:47–67. 2006. View Article : Google Scholar : PubMed/NCBI

5 

French SA, Story M and Perry CL: Self-esteem and obesity in children and adolescents: A literature review. Obes Res. 3:479–490. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Han JC, Lawlor DA and Kimm SY: Childhood obesity. Lancet. 375:1737–1748. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Govaerts C, Srinivasan S, Shapiro A, Zhang S, Picard F, Clement K, Lubrano-Berthelier C and Vaisse C: Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function. Peptides. 26:1909–1919. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Tao YX and Segaloff DL: Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity. Endocrinology. 144:4544–4551. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Yeo GS, Farooqi IS, Aminian S, Halsall DJ, Stanhope RG and O'Rahilly S: A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Gene. 20:111–112. 1998. View Article : Google Scholar

10 

Del Giudice Miraglia E, Cirillo G, Nigro V, Santoro N, D'urso L, Raimondo P, Cozzolino D, Scafato D and Perrone L: Low frequency of melanocortin-4 receptor (MC4R) mutations in a Mediterranean population with early-onset obesity. Int J Obes Relat Metab Disord. 26:647–651. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Challis BG, Pritchard LE, Creemers JW, Delplanque J, Keogh JM, Luan J, Wareham NJ, Yeo GS, Bhattacharyya S, Froguel P, et al: A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. Hum Mol Genet. 11:1997–2004. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Santoro N, Perrone L, Cirillo G, Raimondo P, Amato A, Coppola F, Santarpia M, D'Aniello A and Del Giudice Miraglia E: Weight loss in obese children carrying the proopiomelanocortin R236G variant. J Endocrinol Invest. 29:226–230. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Hung CN, Poon WT, Lee CY, Law CY and Chan AY: A case of early-onset obesity, hypocortisolism, and skin pigmentation problem due to a novel homozygous mutation in the proopiomelanocortin (POMC) gene in an Indian boy. J Pediatr Endocrinol Metab. 25:175–179. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Wardle J, Carnell S, Haworth CM, Farooqi IS, O'Rahilly S and Plomin R: Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab. 93:3640–3643. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, et al: Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc Natl Acad Sci USA. 110:2557–2562. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Liu WM, Mei R, Di X, Ryder TB, Hubbell E, Dee S, Webster TA, Harrington CA, Ho MH, Baid J, et al: Analysis of high density expression microarrays with signed-rank call algorithms. Bioinformatics. 18:1593–1599. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Smyth GK and Speed T: Normalization of cDNA microarray data. Methods. 31:265–273. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Smyth GK: Limma: Linear models for microarray dataBioinformatics and Computational Biology Solutions Using R and Bioconductor. Gentleman R, Carey VJ, Huber W, Irizarry RA and Dudoit S: Springer; New York: pp. 397–420. 2005, View Article : Google Scholar

19 

Team RC: R: A Language and Environment for Statistical ComputingR Foundation for Statistical Computing. Vienna: 2012

20 

Deza MM and Deza E: Encyclopedia of Distances. 1st edition. Springer-Verlag; Berlin: 2009, View Article : Google Scholar

21 

Obayashi T, Kinoshita K, Nakai K, Shibaoka M, Hayashi S, Saeki M, Shibata D, Saito K and Ohta H: ATTED-II: A database of co-expressed genes and cis elements for identifying co-regulated gene groups in Arabidopsis. Nucleic Acids Res. 35:(Database Issue). D863–D869. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Fröhlich H, Speer N, Poustka A and Beissbarth T: GOSim-an R-package for computation of information theoretic GO similarities between terms and gene products. BMC Bioinformatics. 8:1662007. View Article : Google Scholar : PubMed/NCBI

23 

Smoot ME, Ono K, Ruscheinski J, Wang PL and Ideker T: Cytoscape 2.8: New features for data integration and network visualization. Bioinformatics. 27:431–432. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Liu Q, Dou S, Ji Z and Xue Q: Synonymous codon usage and gene function are strongly related in Oryza sativa. Bio Systems. 80:123–131. 2005. View Article : Google Scholar : PubMed/NCBI

25 

McInerney JO: GCUA: General codon usage analysis. Bioinformatics. 14:372–373. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Rice P, Longden I and Bleasby A: EMBOSS: The European molecular biology open software suite. Trends Genet. 16:276–277. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Ebbeling CB, Pawlak DB and Ludwig DS: Childhood obesity: Public-health crisis, common sense cure. Lancet. 360:473–482. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Welburn JP, Grishchuk EL, Backer CB, Wilson-Kubalek EM, Yates JR III and Cheeseman IM: The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. Dev Cell. 16:374–385. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Welburn JP, Grishchuk EL, Backer CB, Wilson-Kubalek EM, Yates JR III and Cheeseman IM: The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. Dev Cell. 16:374–385. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Schmidt JC, Arthanari H, Boeszoermenyi A, Dashkevich NM, Wilson-Kubalek EM, Monnier N, Markus M, Oberer M, Milligan RA, Bathe M, et al: The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments. Dev Cell. 23:968–980. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Bochukova EG, Huang N, Keogh J, Henning E, Purmann C, Blaszczyk K, Saeed S, Hamilton-Shield J, Clayton-Smith J, O'Rahilly S, et al: Large, rare chromosomal deletions associated with severe early-onset obesity. Nature. 463:666–670. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Farooqi IS: Genetic and hereditary aspects of childhood obesity. Best Pract Res Clin Endocrinol Metab. 19:359–374. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Walters RG, Jacquemont S, Valsesia A, de Smith AJ, Martinet D, Andersson J, Falchi M, Chen F, Andrieux J, Lobbens S, et al: A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature. 463:671–675. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Bachmann-Gagescu R, Mefford HC, Cowan C, Glew GM, Hing AV, Wallace S, Bader PI, Hamati A, Reitnauer PJ, Smith R, et al: Recurrent 200-kb deletions of 16p11. 2 that include the SH2B1 gene are associated with developmental delay and obesity. Genet Med. 12:641–647. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Siesser PF, Motolese M, Walker MP, Goldfarb D, Gewain K, Yan F, Kulikauskas RM, Chien AJ, Wordeman L and Major MB: FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility. Sci Signal. 5:ra642012. View Article : Google Scholar : PubMed/NCBI

36 

Brajenovic M, Joberty G, Küster B, Bouwmeester T and Drewes G: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. J Biol Chem. 279:12804–12811. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Poroyko V and Birukova A: ARHGEF2 (rho/rac guanine nucleotide exchange factor (GEF) 2). Atlas Genet Cytogenet Oncol Haematol. 4:582007.

38 

Conde C and Cáceres A: Microtubule assembly, organization and dynamics in axons and dendrites. Nat Rev Neurosci. 10:319–332. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Kuznetsov SA, Rodionov VI, Gelfand VI and Rosenblat VA: Microtubule-associated protein MAP1 promotes microtubule assembly in vitro. FEBS Lett. 135:241–244. 1981. View Article : Google Scholar : PubMed/NCBI

40 

Emoto M, Langille SE and Czech MP: A role for kinesin in insulin-stimulated GLUT4 glucose transporter translocation in 3T3-L1 adipocytes. J Biol Chem. 276:10677–10682. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Patki V, Buxton J, Chawla A, Lifshitz L, Fogarty K, Carrington W, Tuft R and Corvera S: Insulin action on GLUT4 traffic visualized in single 3T3-l1 adipocytes by using ultra-fast microscopy. Mol Biol Cell. 12:129–141. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Kanzaki M and Pessin JE: Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling. J Biol Chem. 276:42436–42444. 2001. View Article : Google Scholar : PubMed/NCBI

43 

Hillen N, Mester G, Lemmel C, Weinzierl AO, Müller M, Wernet D, Hennenlotter J, Stenzl A, Rammensee HG and Stevanović S: Essential differences in ligand presentation and T cell epitope recognition among HLA molecules of the HLA-B44 supertype. Eur J Immunol. 38:2993–3003. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Guilherme R, Guimiot F, Tabet AC, Khung-Savatovsky S, Gauthier E, Nouchy M, Benzacken B, Verloes A, Oury JF, Delezoide AL and Aboura A: Abnormal muscle development of the diaphragm in a fetus with 2p14-p16 duplication. Am J Med Genet A. 149A:2892–2897. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Aksu S, Koczan D, Renne U, Thiesen HJ and Brockmann GA: Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse lines. J Appl Genet. 48:133–143. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Moriyama K, Yonezawa N, Sakai H, Yahara I and Nishida E: Mutational analysis of an actin-binding site of cofilin and characterization of chimeric proteins between cofilin and destrin. J Biol Chem. 267:7240–7244. 1992.PubMed/NCBI

47 

Yahara I, Aizawa H, Moriyama K, Iida K, Yonezawa N, Nishida E, Hatanaka H and Inagaki F: A role of cofilin/destrin in reorganization of actin cytoskeleton in response to stresses and cell stimuli. Cell Struct Funct. 21:421–424. 1996. View Article : Google Scholar : PubMed/NCBI

48 

Agrawal PB, Greenleaf RS, Tomczak KK, Lehtokari VL, Wallgren-Pettersson C, Wallefeld W, Laing NG, Darras BT, Maciver SK, Dormitzer PR and Beggs AH: Nemaline Myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2. Am J Hum Genet. 80:162–167. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Verdoni AM, Aoyama N, Ikeda A and Ikeda S: Effect of destrin mutations on the gene expression profile in vivo. Physiol Genomics. 34:9–21. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Maciver SK and Hussey PJ: The ADF/cofilin family: Actin-remodeling proteins. Genome Biol. 3:30072002. View Article : Google Scholar

51 

Hawkins M, Pope B, Maciver SK and Weeds AG: Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments. Biochemistry. 32:9985–9993. 1993. View Article : Google Scholar : PubMed/NCBI

52 

Wiche G: Role of plectin in cytoskeleton organization and dynamics. J Cell Sci. 111:2477–2486. 1998.PubMed/NCBI

53 

Kawaguchi N, Sundberg C, Kveiborg M, Moghadaszadeh B, Asmar M, Dietrich N, Thodeti CK, Nielsen FC, Möller P, Mercurio AM, et al: ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function. J Cell Sci. 116:3893–3904. 2003. View Article : Google Scholar : PubMed/NCBI

54 

Bost F, Aouadi M, Caron L and Binétruy B: The role of MAPKs in adipocyte differentiation and obesity. Biochimie. 87:51–56. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu ZL, Yang QM, Li C, Chen J, Xiang M, Chen MM, Yan M and Zhu ZG: Identification of biomarkers for childhood obesity based on expressional correlation and functional similarity. Mol Med Rep 17: 109-116, 2018.
APA
Zhu, Z., Yang, Q., Li, C., Chen, J., Xiang, M., Chen, M. ... Zhu, Z. (2018). Identification of biomarkers for childhood obesity based on expressional correlation and functional similarity. Molecular Medicine Reports, 17, 109-116. https://doi.org/10.3892/mmr.2017.7913
MLA
Zhu, Z., Yang, Q., Li, C., Chen, J., Xiang, M., Chen, M., Yan, M., Zhu, Z."Identification of biomarkers for childhood obesity based on expressional correlation and functional similarity". Molecular Medicine Reports 17.1 (2018): 109-116.
Chicago
Zhu, Z., Yang, Q., Li, C., Chen, J., Xiang, M., Chen, M., Yan, M., Zhu, Z."Identification of biomarkers for childhood obesity based on expressional correlation and functional similarity". Molecular Medicine Reports 17, no. 1 (2018): 109-116. https://doi.org/10.3892/mmr.2017.7913
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu ZL, Yang QM, Li C, Chen J, Xiang M, Chen MM, Yan M and Zhu ZG: Identification of biomarkers for childhood obesity based on expressional correlation and functional similarity. Mol Med Rep 17: 109-116, 2018.
APA
Zhu, Z., Yang, Q., Li, C., Chen, J., Xiang, M., Chen, M. ... Zhu, Z. (2018). Identification of biomarkers for childhood obesity based on expressional correlation and functional similarity. Molecular Medicine Reports, 17, 109-116. https://doi.org/10.3892/mmr.2017.7913
MLA
Zhu, Z., Yang, Q., Li, C., Chen, J., Xiang, M., Chen, M., Yan, M., Zhu, Z."Identification of biomarkers for childhood obesity based on expressional correlation and functional similarity". Molecular Medicine Reports 17.1 (2018): 109-116.
Chicago
Zhu, Z., Yang, Q., Li, C., Chen, J., Xiang, M., Chen, M., Yan, M., Zhu, Z."Identification of biomarkers for childhood obesity based on expressional correlation and functional similarity". Molecular Medicine Reports 17, no. 1 (2018): 109-116. https://doi.org/10.3892/mmr.2017.7913
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team