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Article

LncRNA PlncRNA‑1 regulates proliferation and differentiation of hair follicle stem cells through TGF‑β1‑mediated Wnt/β‑catenin signal pathway

  • Authors:
    • Yuan Si
    • Jingzhu Bai
    • Jiang Wu
    • Qun Li
    • You Mo
    • Ruihua Fang
    • Wei Lai
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, The Third Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510180, P.R. China, Department of Dermatology, Guangzhou First People's Hospital, Guangzhou, Guangdong 510630, P.R. China
  • Pages: 1191-1197
    |
    Published online on: November 3, 2017
       https://doi.org/10.3892/mmr.2017.7944
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Abstract

The present study demonstrated that hair follicle stem cells (HFSc) have multidirectional differentiation potential and participate in skin wound healing processes. Long non‑coding RNAs (lncRNAs) are defined as non‑protein coding transcripts longer than 200 nucleotides, which are important in the proliferation and differentiation of cells. The purpose of the present study was to investigate the role of PlncRNA‑1 in the proliferation and differentiation of HFSc. Results revealed that PlncRNA‑1, transforming growth factor (TGF)‑β1, Wnt and β‑catenin expression levels were significantly downregulated in HFSc. PlncRNA‑1 transfection promoted proliferation and differentiation of HFSc. TGF‑β1, Wnt and β‑catenin expression levels were upregulated in HFSc following transfection of PlncRNA‑1. Results demonstrated that TGF‑β1 inhibitor LY2109761 blocked proliferation and differentiation of HFSc promoted by PlncRNA‑1 transfection. In addition, TGF‑β1 inhibitor LY2109761 led to decreased Wnt and β‑catenin expression levels in HFSc. Furthermore, PlncRNA‑1 transfection stimulated the cell cycle of HFSc, whereas TGF‑β1 inhibitor LY2109761 inhibited the cell cycle of HFSc and decreased the acceleration of the cell cycle induced by PlncRNA‑1 transfection. In conclusion, these findings suggest that PlncRNA‑1 may promote proliferation and differentiation of HFSc through upregulation of TGF‑β1‑mediated Wnt/β‑catenin signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Si Y, Bai J, Wu J, Li Q, Mo Y, Fang R and Lai W: LncRNA PlncRNA‑1 regulates proliferation and differentiation of hair follicle stem cells through TGF‑β1‑mediated Wnt/β‑catenin signal pathway. Mol Med Rep 17: 1191-1197, 2018.
APA
Si, Y., Bai, J., Wu, J., Li, Q., Mo, Y., Fang, R., & Lai, W. (2018). LncRNA PlncRNA‑1 regulates proliferation and differentiation of hair follicle stem cells through TGF‑β1‑mediated Wnt/β‑catenin signal pathway. Molecular Medicine Reports, 17, 1191-1197. https://doi.org/10.3892/mmr.2017.7944
MLA
Si, Y., Bai, J., Wu, J., Li, Q., Mo, Y., Fang, R., Lai, W."LncRNA PlncRNA‑1 regulates proliferation and differentiation of hair follicle stem cells through TGF‑β1‑mediated Wnt/β‑catenin signal pathway". Molecular Medicine Reports 17.1 (2018): 1191-1197.
Chicago
Si, Y., Bai, J., Wu, J., Li, Q., Mo, Y., Fang, R., Lai, W."LncRNA PlncRNA‑1 regulates proliferation and differentiation of hair follicle stem cells through TGF‑β1‑mediated Wnt/β‑catenin signal pathway". Molecular Medicine Reports 17, no. 1 (2018): 1191-1197. https://doi.org/10.3892/mmr.2017.7944
Copy and paste a formatted citation
x
Spandidos Publications style
Si Y, Bai J, Wu J, Li Q, Mo Y, Fang R and Lai W: LncRNA PlncRNA‑1 regulates proliferation and differentiation of hair follicle stem cells through TGF‑β1‑mediated Wnt/β‑catenin signal pathway. Mol Med Rep 17: 1191-1197, 2018.
APA
Si, Y., Bai, J., Wu, J., Li, Q., Mo, Y., Fang, R., & Lai, W. (2018). LncRNA PlncRNA‑1 regulates proliferation and differentiation of hair follicle stem cells through TGF‑β1‑mediated Wnt/β‑catenin signal pathway. Molecular Medicine Reports, 17, 1191-1197. https://doi.org/10.3892/mmr.2017.7944
MLA
Si, Y., Bai, J., Wu, J., Li, Q., Mo, Y., Fang, R., Lai, W."LncRNA PlncRNA‑1 regulates proliferation and differentiation of hair follicle stem cells through TGF‑β1‑mediated Wnt/β‑catenin signal pathway". Molecular Medicine Reports 17.1 (2018): 1191-1197.
Chicago
Si, Y., Bai, J., Wu, J., Li, Q., Mo, Y., Fang, R., Lai, W."LncRNA PlncRNA‑1 regulates proliferation and differentiation of hair follicle stem cells through TGF‑β1‑mediated Wnt/β‑catenin signal pathway". Molecular Medicine Reports 17, no. 1 (2018): 1191-1197. https://doi.org/10.3892/mmr.2017.7944
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