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Article

DJ‑1 alleviates high glucose‑induced endothelial cells injury via PI3K/Akt‑eNOS signaling pathway

  • Authors:
    • Hongan Tian
    • Shunzhen Li
    • Kaihu Yu
  • View Affiliations / Copyright

    Affiliations: Radiology Department, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China
  • Pages: 1205-1211
    |
    Published online on: November 6, 2017
       https://doi.org/10.3892/mmr.2017.7975
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Abstract

Hyperglycemia mediated endothelial cells (ECs) injury is closely associated with diabetic vascular complications. It was revealed that DJ‑1 possesses cellular protective effects by suppressing oxidative stress. The present study aimed to investigate the beneficial effects of DJ‑1 on high glucose (HG)‑induced human umbilical vein endothelial cell (HUVEC) injury and to elucidate its underlying mechanisms. HUVECs were incubated under 5.5 mM (control group) or 25 mM D‑glucose (HG group) and then transfected with recombinant adenoviral vectors to overexpression of DJ‑1. Cell proliferation and apoptosis were measured using the EdU incorporation assay and flow cytometry with Annexin V-FITC/propidium iodide double staining, respectively. Apoptotic‑related proteins were determined using western blot analysis. Reactive oxygen species (ROS) production, lactate dehydrogenase (LDH) and nitric oxide (NO) levels, the content of malondialdehyde (MDA), and the activities of superoxide dismutase (SOD) were measured. Results demonstrated that overexpression of DJ‑1 promoted cell proliferation and inhibited HUVECs apoptosis stimulated by HG. DJ‑1 also suppressed the HG‑induced reduction in the Bcl‑2/Bax ratio and HG activated ROS generation in HUVECs. Furthermore, HG significantly increased the levels of LDH and MDA, and reduced the level of SOD; however, these effects were reversed by Ad‑DJ‑1 transfection. Furthermore, the cellular protective effect of overexpression of DJ‑1 enhanced p‑Akt/Akt ratio, eNOS activation and NO production, and these trends were partially reversed by a phosphatidylinositol‑4,5‑bisphosphate 3‑kinase (PI3K) inhibitor (LY294002). Taken together, the present study highlighted the involvement of DJ‑1 in HG‑related EC injury and identified that DJ‑1 exerts a cellular protective effect in HUVECs exposed to HG induced oxidative stress via activation of the PI3K/Akt‑eNOS signaling pathway.
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1 

Wang L, Gao P, Zhang M, Huang Z, Zhang D, Deng Q, Li Y, Zhao Z, Qin X, Jin D, et al: Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA:. 317:2515–2523. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Ashcroft FM and Rorsman P: Diabetes mellitus and the β cell: The last ten years. Cell. 148:1160–1171. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U and Shaw JE: Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 103:137–149. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Oelze M, Schuhmacher S and Daiber A: Organic nitrates and nitrate resistance in diabetes: The role of vascular dysfunction and oxidative stress with emphasis on antioxidant properties of pentaerithrityl tetranitrate. Exp Diabetes Res. 2010:2131762010. View Article : Google Scholar : PubMed/NCBI

5 

Beckman JA, Creager MA and Libby P: Diabetes and atherosclerosis: Epidemiology, pathophysiology and management. JAMA. 287:2570–2581. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Advani A and Gilbert RE: The endothelium in diabetic nephropathy. Semin Nephrol. 32:199–207. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Dhar A, Dhar I, Desai KM and Wu L: Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose. Br J Pharmacol. 161:1843–1856. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, Iguchi-Ariga SM and Ariga H: DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun. 231:509–513. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Shi M, Bradner J, Hancock AM, Chung KA, Quinn JF, Peskind ER, Galasko D, Jankovic J, Zabetian CP, Kim HM, et al: Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression. Ann Neurol. 69:570–580. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Kitamura Y, Inden M, Kimoto Y, Takata K, Yanagisawa D, Hijioka M, Ashihara E, Tooyama I, Shimohama S and Ariga H: Effects of a DJ-1-binding compound on spatial learning and memory impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 55:67–72. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Kinumi T, Kimata J, Taira T, Ariga H and Niki E: Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 317:722–728. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Liu C, Chen Y, Kochevar IE and Jurkunas UV: Decreased DJ-1 leads to impaired Nrf2-regulated antioxidant defense and increased UV-A-induced apoptosis in corneal endothelial cells. Invest Ophthalmol Vis Sci. 55:5551–5560. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Lev N, Ickowicz D, Melamed E and Offen D: Oxidative insults induce DJ-1 upregulation and redistribution: Implications for neuroprotection. Neurotoxicology. 29:397–405. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Inden M, Taira T, Kitamura Y, Yanagida T, Tsuchiya D, Takata K, Yanagisawa D, Nishimura K, Taniguchi T, Kiso Y, et al: PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. Neurobiol Dis. 24:144–158. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Dongworth RK, Mukherjee UA, Hall AR, Astin R, Ong SB, Yao Z, Dyson A, Szabadkai G, Davidson SM, Yellon DM and Hausenloy DJ: DJ-1 protects against cell death following acute cardiac ischemia-reperfusion injury. Cell Death Dis. 5:e10822014. View Article : Google Scholar : PubMed/NCBI

16 

Kim DK, Kim HS, Kim AR, Kim JH, Kim B, Noh G, Kim HS, Beaven MA, Kim YM and Choi WS: DJ-1 regulates mast cell activation and IgE-mediated allergic responses. J Allergy Clin Immunol. 131:1653–1662. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Hwang S, Song S, Hong YK, Choi G, Suh YS, Han SY, Lee M, Park SH, Lee JH, Lee S, et al: Drosophila DJ-1 decreases neural sensitivity to stress by negatively regulating Daxx-like protein through dFOXO. PLoS Genet. 9:e10034122013. View Article : Google Scholar : PubMed/NCBI

18 

Han T, Liu M and Yang S: DJ-1 alleviates angiotensin II-induced endothelial progenitor cell damage by activating the PPARgamma/HO-1 pathway. J Cell Biochem. Jun 10–2017.(Epub ahead of print).

19 

Cai S, Khoo J and Channon KM: Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells. Cardiovasc Res. 65:823–831. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Fan W, Han D, Sun Z, Ma S, Gao L, Chen J, Li X, Li X, Fan M, Li C, et al: Endothelial deletion of mTORC1 protects against hindlimb ischemia in diabetic mice via activation of autophagy, attenuation of oxidative stress and alleviation of inflammation. Free Radic Biol Med. 108:725–740. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Tang ST, Wang F, Shao M, Wang Y and Zhu HQ: MicroRNA-126 suppresses inflammation in endothelial cells under hyperglycemic condition by targeting HMGB1. Vascul Pharmacol. 88:48–55. 2017. View Article : Google Scholar : PubMed/NCBI

22 

He TC, Zhou S, da Costa LT, Yu J, Kinzler KW and Vogelstein B: A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA. 95:2509–2514. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Gong L, Liu FQ, Wang J, Wang XP, Hou XG, Sun Y, Qin WD, Wei SJ, Zhang Y, Chen L and Zhang MX: Hyperglycemia induces apoptosis of pancreatic islet endothelial cells via reactive nitrogen species-mediated Jun N-terminal kinase activation. Biochim Biophys Acta. 1813:1211–1219. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Chen J, Saxena G, Mungrue IN, Lusis AJ and Shalev A: Thioredoxin-interacting protein: A critical link between glucose toxicity and beta-cell apoptosis. Diabetes. 57:938–944. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Zhong ZY and Tang Y: Upregulation of periostin prevents high glucose-induced mitochondrial apoptosis in human umbilical vein endothelial cells via activation of nrf2/ho-1 signaling. Cell Physiol Biochem. 39:71–80. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Zhao H, Ma T, Fan B, Yang L, Han C, Luo J and Kong L: Protective effect of trans-α-viniferin against high glucose-induced oxidative stress in human umbilical vein endothelial cells through the SIRT1 pathway. Free Radic Res. 50:68–83. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Won KJ, Jung SH, Jung SH, Lee KP, Lee HM, Lee DY, Park ES, Kim J and Kim B: DJ-1/park7 modulates vasorelaxation and blood pressure via epigenetic modification of endothelial nitric oxide synthase. Cardiovasc Res. 101:473–481. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, et al: Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science. 299:256–259. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Jain D, Jain R, Eberhard D, Eglinger J, Bugliani M, Piemonti L, Marchetti P and Lammert E: Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes. J Mol Cell Biol. 4:221–230. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Lin TK, Liou CW, Chen SD, Chuang YC, Tiao MM, Wang PW, Chen JB and Chuang JH: Mitochondrial dysfunction and biogenesis in the pathogenesis of Parkinson's disease. Chang Gung Med J. 32:589–599. 2009.PubMed/NCBI

31 

Wang H and Gao W: DJ-1 expression in cervical carcinoma and its effects on cell viability and apoptosis. Med Sci Monit. 22:2943–2949. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Ma J, Wu R, Zhang Q, Wu JB, Lou J, Zheng Z, Ding JQ and Yuan Z: DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis. Biochem J. 462:489–497. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Bhola PD and Letai A: Mitochondria-judges and executioners of cell death sentences. Mol Cell. 61:695–704. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Giaime E, Yamaguchi H, Gautier CA, Kitada T and Shen J: Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening. Plos One. 7:e405012012. View Article : Google Scholar : PubMed/NCBI

35 

Jo HS, Yeo EJ, Shin MJ, Choi YJ, Yeo HJ, Cho SB, Park JH, Lee CH, Eum WS and Choi SY: Tat-DJ-1 enhances cell survival by inhibition of oxidative stress, NF-κB and MAPK activation in HepG2 cells. Biotechnol Lett. 39:511–521. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Jo HS, Cha HJ, Kim SJ, Yeo HJ, Cho SB, Park JH, Lee CH, Yeo EJ, Choi YJ, Eum WS and Choi SY: Tat-DJ-1 inhibits oxidative stress-mediated RINm5F cell death through suppression of NF-κB and MAPK activation. Med Chem Res. 25:2589–2598. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Shen ZY, Sun Q, Xia ZY, Meng QT, Lei SQ, Zhao B, Tang LH, Xue R and Chen R: Overexpression of DJ-1 reduces oxidative stress and attenuates hypoxia/reoxygenation injury in NRK-52E cells exposed to high glucose. Int J Mol Med. 38:729–736. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Canet-Avilés RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA and Cookson MR: The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc Natl Acad Sci USA. 101:9103–9108. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Parsanejad M, Bourquard N, Qu D, Zhang Y, Huang E, Rousseaux MW, Aleyasin H, Irrcher I, Callaghan S, Vaillant DC, et al: DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress. Plos One. 9:e1066012014. View Article : Google Scholar : PubMed/NCBI

40 

Wang B, Qin H, Wang Y, Chen W, Luo J, Zhu X, Wen W and Lei W: Effect of DJ-1 overexpression on the proliferation, apoptosis, invasion and migration of laryngeal squamous cell carcinoma SNU-46 cells through PI3K/AKT/mTOR. Oncol Rep. 32:1108–1116. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Xie L, Wu Y, Fan Z, Liu Y and Zeng J: Astragalus polysaccharide protects human cardiac microvascular endothelial cells from hypoxia/reoxygenation injury: The role of PI3K/AKT, Bax/Bcl-2 and caspase-3. Mol Med Rep. 14:904–910. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Yan J, Tie G, Park B, Yan Y, Nowicki PT and Messina LM: Recovery from hind limb ischemia is less effective in type 2 than in type 1 diabetic mice: roles of endothelial nitric oxide synthase and endothelial progenitor cells. J Vasc Surg. 50:1412–1422. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Han F, Guo Y, Xu L, Hou N, Han F and Sun X: Induction of haemeoxygenase-1 directly improves endothelial function in isolated aortas from obese rats through the Ampk-Pi3k/Akt-Enos pathway. Cell Physiol Biochem. 36:1480–1490. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Wang XM, Song SS, Xiao H, Gao P, Li XJ and Si LY: Fibroblast growth factor 21 protects against high glucose induced cellular damage and dysfunction of endothelial nitric-oxide synthase in endothelial cells. Cell Physiol Biochem. 34:658–671. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Xing Y, Lai J, Liu X, Zhang N, Ming J, Liu H and Zhang X: Netrin-1 restores cell injury and impaired angiogenesis in vascular endothelial cells upon high glucose by PI3K/AKT-eNOS. J Mol Endocrinol. 58:167–177. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Ceriello A, Testa R and Genovese S: Clinical implications of oxidative stress and potential role of natural antioxidants in diabetic vascular complications. Nutr Metab Cardiovasc Dis. 26:285–292. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Bansal S, Chawla D, Siddarth M, Banerjee BD, Madhu SV and Tripathi AK: A study on serum advanced glycation end products and its association with oxidative stress and paraoxonase activity in type 2 diabetic patients with vascular complications. Clin Biochem. 46:109–114. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Pinna C, Morazzoni P and Sala A: Proanthocyanidins from Vitis vinifera inhibit oxidative stress-induced vascular impairment in pulmonary arteries from diabetic rats. Phytomedicine. 25:39–44. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tian H, Li S and Yu K: DJ‑1 alleviates high glucose‑induced endothelial cells injury via PI3K/Akt‑eNOS signaling pathway. Mol Med Rep 17: 1205-1211, 2018.
APA
Tian, H., Li, S., & Yu, K. (2018). DJ‑1 alleviates high glucose‑induced endothelial cells injury via PI3K/Akt‑eNOS signaling pathway. Molecular Medicine Reports, 17, 1205-1211. https://doi.org/10.3892/mmr.2017.7975
MLA
Tian, H., Li, S., Yu, K."DJ‑1 alleviates high glucose‑induced endothelial cells injury via PI3K/Akt‑eNOS signaling pathway". Molecular Medicine Reports 17.1 (2018): 1205-1211.
Chicago
Tian, H., Li, S., Yu, K."DJ‑1 alleviates high glucose‑induced endothelial cells injury via PI3K/Akt‑eNOS signaling pathway". Molecular Medicine Reports 17, no. 1 (2018): 1205-1211. https://doi.org/10.3892/mmr.2017.7975
Copy and paste a formatted citation
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Spandidos Publications style
Tian H, Li S and Yu K: DJ‑1 alleviates high glucose‑induced endothelial cells injury via PI3K/Akt‑eNOS signaling pathway. Mol Med Rep 17: 1205-1211, 2018.
APA
Tian, H., Li, S., & Yu, K. (2018). DJ‑1 alleviates high glucose‑induced endothelial cells injury via PI3K/Akt‑eNOS signaling pathway. Molecular Medicine Reports, 17, 1205-1211. https://doi.org/10.3892/mmr.2017.7975
MLA
Tian, H., Li, S., Yu, K."DJ‑1 alleviates high glucose‑induced endothelial cells injury via PI3K/Akt‑eNOS signaling pathway". Molecular Medicine Reports 17.1 (2018): 1205-1211.
Chicago
Tian, H., Li, S., Yu, K."DJ‑1 alleviates high glucose‑induced endothelial cells injury via PI3K/Akt‑eNOS signaling pathway". Molecular Medicine Reports 17, no. 1 (2018): 1205-1211. https://doi.org/10.3892/mmr.2017.7975
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