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Article

Amelioration of lung ischemia‑reperfusion injury by JNK and p38 small interfering RNAs in rat pulmonary microvascular endothelial cells in an ischemia‑reperfusion injury lung transplantation model

  • Authors:
    • Juan Wang
    • Jing Tan
    • Yanhong Liu
    • Linlin Song
    • Di Li
    • Xiaoguang Cui
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The Heilongjiang Province Key Laboratory of Research on Anesthesiology and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China
  • Pages: 1228-1234
    |
    Published online on: November 6, 2017
       https://doi.org/10.3892/mmr.2017.7985
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Abstract

The inhibition of mitogen‑activated protein kinases (MAPKs), including c‑Jun NH2‑terminal protein kinase (JNK), p38 MAPK (p38) and extracellular signal‑regulated protein kinase 1/2 (ERK1/2), have an important effect on lung ischemia‑reperfusion injury (IRI) during lung transplantation (LT). However, the way in which combined MAPK inhibition exerts optimal protective effects on lung IRI remains to be elucidated. Therefore, the present study evaluated the therapeutic efficacy of the inhibition of MAPKs in rat pulmonary microvascular endothelial cells (PMVECs) in an IRI model of LT. The rat PMVECs were transfected with small interfering RNAs (siRNAs) against JNK, p38 or ERK1/2. Cotransfection was performed with siRNAs against JNK and p38 in the J+p group, JNK and ERK1/2 in the J+E group, p38 and ERK1/2 in the p+E group, or all three in the J+p+E group. Non‑targeting (NT) siRNA was used as a control. The PMVECs were then treated to induce IRI, and the levels of inflammation, apoptosis and oxidative stress were detected. Differences between compared groups were determined using Tukey's honest significant difference test. In all groups, silencing of the MAPKs was shown to attenuate inflammation, apoptosis and oxidative stress to differing extents, compared with the NT group. The J+p and J+p+E groups showed lower levels of interleukin (IL)‑1β, IL‑6 and malondialdehyde, a lower percentage of early‑apoptotic cells, and higher superoxide dismutase (SOD) activity, compared with the other groups. No significant differences were observed in the inflammatory response, SOD activity or early apoptosis between the J+p and J+p+E groups. These findings suggested that the dual inhibition of JNK and p38 led to maximal amelioration of lung IRI in the PMVECs of the IRI model of LT, which occurred through anti‑inflammatory, anti‑oxidative and anti‑apoptotic mechanisms.
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View References

1 

What is lung transplantation? Am J Respir Crit Care Med. 192:P7–P8. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Chen F and Date H: Update on ischemia-reperfusion injury in lung transplantation. Curr Opin Organ Transplant. 20:515–520. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Hu R, Chen ZF, Yan J, Li QF, Huang Y, Xu H, Zhang XP and Jiang H: Endoplasmic reticulum stress of neutrophils is required for ischemia/reperfusion-induced acute lung injury. J Immunol. 195:4802–4809. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Cargnello M and Roux PP: Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev. 75:50–83. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Kim EK and Choi EJ: Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta. 1802:396–405. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Yue TL, Wang C, Gu JL, Ma XL, Kumar S, Lee JC, Feuerstein GZ, Thomas H, Maleeff B and Ohlstein EH: Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart. Circ Res. 86:692–699. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Li J, Wang F, Xia Y, Dai W, Chen K, Li S, Liu T, Zheng Y, Wang J, Lu W, et al: Astaxanthin pretreatment attenuates hepatic ischemia reperfusion-induced apoptosis and autophagy via the ROS/MAPK pathway in mice. Mar Drugs. 13:3368–3387. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Sakiyama S, Hamilton J, Han B, Jiao Y, Shen-Tu G, de Perrot M, Keshavjee S and Liu M: Activation of mitogen-activated protein kinases during human lung transplantation. J Heart Lung Transplant. 24:2079–2085. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Lv X, Tan J, Liu D, Wu P and Cui X: Intratracheal administration of p38α short-hairpin RNA plasmid ameliorates lung ischemia-reperfusion injury in rats. J Heart Lung Transplant. 31:655–662. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Tan J, Liu D, Lv X, Wang L, Zhao C, Che Y, Xie Q and Cui X: MAPK mediates inflammatory response and cell death in rat pulmonary microvascular endothelial cells in an ischemia-reperfusion model of lung transplantation. J Heart Lung Transplant. 32:823–831. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Wang N, Zhang D, Sun G, Zhang H, You Q, Shao M and Yue Y: Lipopolysaccharide-induced caveolin-1 phosphorylation-dependent increase in transcellular permeability precedes the increase in paracellular permeability. Drug Des Devel Ther. 9:4965–4977. 2015.PubMed/NCBI

12 

Audia JP, Lindsey AS, Housley NA, Ochoa CR, Zhou C, Toba M, Oka M, Annamdevula NS, Fitzgerald MS, Frank DW and Alvarez DF: In the absence of effector proteins, the Pseudomonas aeruginosa type three secretion system needle tip complex contributes to lung injury and systemic inflammatory responses. PLoS One. 8:e817922013. View Article : Google Scholar : PubMed/NCBI

13 

Yuan Q, Jiang YW, Ma TT, Fang QH and Pan L: Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats. J Inflamm. 11:402014. View Article : Google Scholar

14 

McCourtie AS, Merry HE, Farivar AS, Goss CH and Mulligan MS: Alveolar macrophage secretory products augment the response of rat pulmonary artery endothelial cells to hypoxia and reoxygenation. Ann Thorac Surg. 85:1056–1060. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Casiraghi M, Tatreau JR, Abano JB, Blackwell JW, Watson L, Burridge K, Randell SH and Egan TM: In vitro modeling of nonhypoxic cold ischemia-reperfusion simulating lung transplantation. J Thorac Cardiovasc Surg. 138:760–767. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Yuan Q, Jiang YW and Fang QH: Improving effect of Sivelestat on lipopolysaccharide-induced lung injury in rats. APMIS. 122:810–817. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Parra-Bonilla G, Alvarez DF, Al-Mehdi AB, Alexeyev M and Stevens T: Critical role for lactate dehydrogenase A in aerobic glycolysis that sustains pulmonary microvascular endothelial cell proliferation. Am J Physiol Lung Cell Mol Physiol. 299:L513–L522. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Obiako B, Calchary W, Xu N, Kunstadt R, Richardson B, Nix J and Sayner SL: Bicarbonate disruption of the pulmonary endothelial barrier via activation of endogenous soluble adenylyl cyclase, isoform 10. Am J Physiol Lung Cell Mol Physiol. 305:L185–L192. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Dib H, Chafey P, Clary G, Federici C, Le Gall M, Dwyer J, Gavard J, Tamas N, Bussone G, Broussard C, et al: Proteomes of umbilical vein and microvascular endothelial cells reflect distinct biological properties and influence immune recognition. Proteomics. 12:2547–2555. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Carroll MC and Holers VM: Innate autoimmunity. Adv Immunol. 86:137–157. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Chen GY and Nuñez G: Sterile inflammation: Sensing and reacting to damage. Nat Rev Immunol. 10:826–837. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Weyker PD, Webb CA, Kiamanesh D and Flynn BC: Lung ischemia reperfusion injury: A bench-to-bedside review. Semin Cardiothorac Vasc Anesth. 17:28–43. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Ferrari RS and Andrade CF: Oxidative stress and lung ischemia-reperfusion injury. Oxid Med Cell Longev. 2015:5909872015. View Article : Google Scholar : PubMed/NCBI

24 

Aljuffali IA, Lin YK and Fang JY: Noninvasive approach for enhancing small interfering RNA delivery percutaneously. Expert Opin Drug Deliv. 13:265–280. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Kesharwani P, Gajbhiye V and Jain NK: A review of nanocarriers for the delivery of small interfering RNA. Biomaterials. 33:7138–7150. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Chopra P, Kanoje V, Semwal A and Ray A: Therapeutic potential of inhaled p38 mitogen-activated protein kinase inhibitors for inflammatory pulmonary diseases. Expert Opin Investig Drugs. 17:1411–1425. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Murayama T, Tanabe M, Matsuda S, Shimazu M, Kamei S, Wakabayashi G, Kawachi S, Matsumoto K, Yamazaki K, Matsumoto K, et al: JNK (c-Jun NH2 terminal kinase) and p38 during ischemia reperfusion injury in the small intestine. Transplantation. 81:1325–1330. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Zhang X, Bedard EL, Potter R, Zhong R, Alam J, Choi AM and Lee PJ: Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury. Am J Physiol Lung Cell Mol Physiol. 283:L815–L829. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Liou SF, Ke HJ, Hsu JH, Liang JC, Lin HH, Chen IJ and Yeh JL: San-Huang-Xie-Xin-Tang prevents rat hearts from ischemia/reperfusion-induced apoptosis through eNOS and MAPK pathways. Evid Based Complement Alternat Med. 2011:9150512011. View Article : Google Scholar : PubMed/NCBI

30 

Arthur JS and Ley SC: Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol. 13:679–692. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Darling NJ and Cook SJ: The role of MAPK signalling pathways in the response to endoplasmic reticulum stress. Biochim Biophys Acta. 1843:2150–2163. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Engelbrecht AM, Niesler C, Page C and Lochner A: p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes. Basic Res Cardiol. 99:338–350. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Dhanasekaran DN and Reddy EP: JNK signaling in apoptosis. Oncogene. 27:6245–6251. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Garcia-Fernandez LF, Losada A, Alcaide V, Alvarez AM, Cuadrado A, González L, Nakayama K, Nakayama KI, Fernández-Sousa JM, Muñoz A, et al: Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta. Oncogene. 21:7533–7544. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Wei H, Li Z, Hu S, Chen X and Cong X: Apoptosis of mesenchymal stem cells induced by hydrogen peroxide concerns both endoplasmic reticulum stress and mitochondrial death pathway through regulation of caspases, p38 and JNK. J Cell Biochem. 111:967–978. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Sehgal V and Ram PT: Network motifs in JNK signaling. Genes Cancer. 4:409–413. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Ka SO, Hwang HP, Jang JH, Hyuk Bang I, Bae UJ, Yu HC, Cho BH and Park BH: The protein kinase 2 inhibitor tetrabromobenzotriazole protects against renal ischemia reperfusion injury. Sci Rep. 5:148162015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Tan J, Liu Y, Song L, Li D and Cui X: Amelioration of lung ischemia‑reperfusion injury by JNK and p38 small interfering RNAs in rat pulmonary microvascular endothelial cells in an ischemia‑reperfusion injury lung transplantation model. Mol Med Rep 17: 1228-1234, 2018.
APA
Wang, J., Tan, J., Liu, Y., Song, L., Li, D., & Cui, X. (2018). Amelioration of lung ischemia‑reperfusion injury by JNK and p38 small interfering RNAs in rat pulmonary microvascular endothelial cells in an ischemia‑reperfusion injury lung transplantation model. Molecular Medicine Reports, 17, 1228-1234. https://doi.org/10.3892/mmr.2017.7985
MLA
Wang, J., Tan, J., Liu, Y., Song, L., Li, D., Cui, X."Amelioration of lung ischemia‑reperfusion injury by JNK and p38 small interfering RNAs in rat pulmonary microvascular endothelial cells in an ischemia‑reperfusion injury lung transplantation model". Molecular Medicine Reports 17.1 (2018): 1228-1234.
Chicago
Wang, J., Tan, J., Liu, Y., Song, L., Li, D., Cui, X."Amelioration of lung ischemia‑reperfusion injury by JNK and p38 small interfering RNAs in rat pulmonary microvascular endothelial cells in an ischemia‑reperfusion injury lung transplantation model". Molecular Medicine Reports 17, no. 1 (2018): 1228-1234. https://doi.org/10.3892/mmr.2017.7985
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Tan J, Liu Y, Song L, Li D and Cui X: Amelioration of lung ischemia‑reperfusion injury by JNK and p38 small interfering RNAs in rat pulmonary microvascular endothelial cells in an ischemia‑reperfusion injury lung transplantation model. Mol Med Rep 17: 1228-1234, 2018.
APA
Wang, J., Tan, J., Liu, Y., Song, L., Li, D., & Cui, X. (2018). Amelioration of lung ischemia‑reperfusion injury by JNK and p38 small interfering RNAs in rat pulmonary microvascular endothelial cells in an ischemia‑reperfusion injury lung transplantation model. Molecular Medicine Reports, 17, 1228-1234. https://doi.org/10.3892/mmr.2017.7985
MLA
Wang, J., Tan, J., Liu, Y., Song, L., Li, D., Cui, X."Amelioration of lung ischemia‑reperfusion injury by JNK and p38 small interfering RNAs in rat pulmonary microvascular endothelial cells in an ischemia‑reperfusion injury lung transplantation model". Molecular Medicine Reports 17.1 (2018): 1228-1234.
Chicago
Wang, J., Tan, J., Liu, Y., Song, L., Li, D., Cui, X."Amelioration of lung ischemia‑reperfusion injury by JNK and p38 small interfering RNAs in rat pulmonary microvascular endothelial cells in an ischemia‑reperfusion injury lung transplantation model". Molecular Medicine Reports 17, no. 1 (2018): 1228-1234. https://doi.org/10.3892/mmr.2017.7985
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