Administration of chlorogenic acid alleviates spinal cord injury via TLR4/NF‑κB and p38 signaling pathway anti‑inflammatory activity

  • Authors:
    • Dayong Chen
    • Dan Pan
    • Shaolong Tang
    • Zhihong Tan
    • Yanan Zhang
    • Yunfeng Fu
    • Guohua Lü
    • Qinghua Huang
  • View Affiliations

  • Published online on: November 6, 2017     https://doi.org/10.3892/mmr.2017.7987
  • Pages: 1340-1346
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Abstract

Chlorogenic acid, as a secondary metabolite of plants, exhibits a variety of effects including free radical scavenging, antiseptic, anti‑inflammatory and anti‑viral, in addition to its ability to reduce blood glucose, protect the liver and act as an anti‑hyperlipidemic agent and cholagogue. The present study demonstrated that administration of chlorogenic acid alleviated spinal cord injury (SCI) via anti‑inflammatory activity mediated by nuclear factor (NF)‑κB and p38 signaling pathways. Wistar rats were used to structure a SCI model rat to explore the effects of administration of chlorogenic acid on SCI. The Basso, Beattie and Bresnahan test was executed for assessment of neuronal functional recovery and then spinal cord tissue wet/dry weight ratio was recorded. The present study demonstrated that chlorogenic acid increased SCI‑inhibition of BBB scores and decreased SCI‑induction of spinal cord wet/dry weight ratio in rats. In addition, chlorogenic acid suppressed SCI‑induced inflammatory activity, inducible nitric oxide synthase activity and cyclooxygenase‑2 protein expression in the SCI rat. Furthermore, chlorogenic acid suppressed Toll like receptor (TLR)‑4/myeloid differentiation primary response 88 (MyD88)/NF‑κB/IκB signaling pathways and downregulated p38 mitogen activated protein kinase protein expression in SCI rats. The findings suggest that administration of chlorogenic acid alleviates SCI via anti‑inflammatory activity mediated by TLR4/MyD88/NF‑κB and p38 signaling pathways.
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January-2018
Volume 17 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Chen D, Pan D, Tang S, Tan Z, Zhang Y, Fu Y, Lü G and Huang Q: Administration of chlorogenic acid alleviates spinal cord injury via TLR4/NF‑κB and p38 signaling pathway anti‑inflammatory activity. Mol Med Rep 17: 1340-1346, 2018.
APA
Chen, D., Pan, D., Tang, S., Tan, Z., Zhang, Y., Fu, Y. ... Huang, Q. (2018). Administration of chlorogenic acid alleviates spinal cord injury via TLR4/NF‑κB and p38 signaling pathway anti‑inflammatory activity. Molecular Medicine Reports, 17, 1340-1346. https://doi.org/10.3892/mmr.2017.7987
MLA
Chen, D., Pan, D., Tang, S., Tan, Z., Zhang, Y., Fu, Y., Lü, G., Huang, Q."Administration of chlorogenic acid alleviates spinal cord injury via TLR4/NF‑κB and p38 signaling pathway anti‑inflammatory activity". Molecular Medicine Reports 17.1 (2018): 1340-1346.
Chicago
Chen, D., Pan, D., Tang, S., Tan, Z., Zhang, Y., Fu, Y., Lü, G., Huang, Q."Administration of chlorogenic acid alleviates spinal cord injury via TLR4/NF‑κB and p38 signaling pathway anti‑inflammatory activity". Molecular Medicine Reports 17, no. 1 (2018): 1340-1346. https://doi.org/10.3892/mmr.2017.7987