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Article

Preconditioning with carbon monoxide inhalation promotes retinal ganglion cell survival against optic nerve crush via inhibition of the apoptotic pathway

  • Authors:
    • Ruobing Wang
    • Zeli Chen
    • Jiangchun Wu
    • Fangzhou Xia
    • Qinglei Sun
    • Aijun Sun
    • Lin Liu
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China, Department of Ophthalmology, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, P.R. China, Department of Anatomy, Second Military Medical University, Shanghai 200433, P.R. China
  • Pages: 1297-1304
    |
    Published online on: November 6, 2017
       https://doi.org/10.3892/mmr.2017.7990
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Abstract

Optic neurodegeneration, in addition to central nervous trauma, initiates impairments to neurons resulting in retinal ganglion cell (RGC) damage. Carbon monoxide (CO) has been observed to elicit neuroprotection in various experimental models. The present study investigated the potential retinal neuroprotection of preconditioning with CO inhalation in a rat model of optic nerve crush (ONC). Adult male Sprague‑Dawley rats were preconditioned with inhaled CO (250 ppm) or air for 1 h prior to ONC. Animals were euthanized at 1 or 2 weeks following surgery. RGC densities were quantified by hematoxylin and eosin (H&E) staining and FluoroGold labeling. Visual function was measured via flash visual evoked potentials (FVEP). Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining, and caspase‑9 and caspase‑3 activity in the retinas, were assessed at 2 weeks post‑ONC. The RGC density of CO + crush rats was significantly increased compared with that of the corresponding crush‑only rats at 2 weeks (survival rate, 66.2 vs. 48.2% as demonstrated by H&E staining, P<0.01; and 67.6 vs. 37.6% as demonstrated by FluoroGold labeling, P<0.05). FVEP measures indicated a significantly better‑preserved latency and amplitude of the P1 wave in the CO + crush rats compared with the crush‑only rats. The TUNEL assays demonstrated fewer apoptotic cells in the CO + crush group compared with the crush‑only group, accompanied by the suppression of caspase‑9 and caspase‑3 activity. The results of the present study suggested that inhaled CO preconditioning may be neuroprotective against ONC insult via inhibition of neuronal apoptosis.
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1 

Sharma TP, McDowell CM, Liu Y, Wagner AH, Thole D, Faga BP, Wordinger RJ, Braun TA and Clark AF: Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice. Mol Neurodegener. 9:142014. View Article : Google Scholar : PubMed/NCBI

2 

Schwartz M: Optic nerve crush: Protection and regeneration. Brain Res Bull. 62:467–471. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Stutzki H, Leibig C, Andreadaki A, Fischer D and Zeck G: Inflammatory stimulation preserves physiological properties of retinal ganglion cells after optic nerve injury. Front Cell Neurosci. 8:382014. View Article : Google Scholar : PubMed/NCBI

4 

Schmitt HM, Pelzel HR, Schlamp CL and Nickells RW: Histone deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury. Mol Neurodegener. 9:392014. View Article : Google Scholar : PubMed/NCBI

5 

Wang R and Xu J, Xie J, Kang Z, Sun X, Chen N, Liu L and Xu J: Hyperbaric oxygen preconditioning promotes survival of retinal ganglion cells in a rat model of optic nerve crush. J Neurotrauma. 27:763–770. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Levkovitch-Verbin H, Harris-Cerruti C, Groner Y, Wheeler LA, Schwartz M and Yoles E: RGC death in mice after optic nerve crush injury: Oxidative stress and neuroprotection. Invest Ophthalmol Vis Sci. 41:4169–4174. 2000.PubMed/NCBI

7 

Bien A, Seidenbecher CI, Böckers TM, Sabel BA and Kreutz MR: Apoptotic versus necrotic characteristics of retinal ganglion cell death after partial optic nerve injury. J Neurotrauma. 16:153–163. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Sun JC, Xu T, Zuo Q, Wang RB, Qi AQ, Cao WL, Sun AJ, Sun XJ and Xu J: Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush. PLoS One. 9:e992992014. View Article : Google Scholar : PubMed/NCBI

9 

Mansour-Robaey S, Clarke DB, Wang YC, Bray GM and Aguayo AJ: Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc Natl Acad Sci USA. 91:1632–1636. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Weaver LK: Carbon monoxide poisoning. Crit Care Clin. 15:297–317. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Otterbein LE, Bach FH, Alam J, Soares M, Lu Tao H, Wysk M, Davis RJ, Flavell RA and Choi AM: Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med. 6:422–428. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Song R, Mahidhara RS, Liu F, Ning W, Otterbein LE and Choi AM: Carbon monoxide inhibits human airway smooth muscle cell proliferation via mitogen-activated protein kinase pathway. Am J Respir Cell Mol Biol. 27:603–610. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Brouard S, Otterbein LE, Anrather J, Tobiasch E, Bach FH, Choi AM and Soares MP: Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. J Exp Med. 192:1015–1026. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Wang B, Cao W, Biswal S and Doré S: Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia. Stroke. 42:2605–2610. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Biermann J, Lagrèze WA, Dimitriu C, Stoykow C and Goebel U: Preconditioning with inhalative carbon monoxide protects rat retinal ganglion cells from ischemia/reperfusion injury. Invest Ophthalmol Vis Sci. 51:3784–3791. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Chen Z, Wang R, Wu J, Xia F, Sun Q, Xu J and Liu L: Low-dose carbon monoxide inhalation protects neuronal cells from apoptosis after optic nerve crush. Biochem Biophys Res Commun. 469:809–815. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Yang S, He H, Zhu Y, Wan X, Zhou LF, Wang J, Wang WF, Liu L and Li B: Chemical and material communication between the optic nerves in rats. Clin Exp Ophthalmol. 43:742–748. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Liu L, Sun Q, Wang R, Chen Z, Wu J, Xia F and Fan XQ: Methane attenuates retinal ischemia/reperfusion injury via anti-oxidative and anti-apoptotic pathways. Brain Res. 1646:327–333. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Vigneswara V, Berry M, Logan A and Ahmed Z: Pigment epithelium-derived factor is retinal ganglion cell neuroprotective and axogenic after optic nerve crush injury. Invest Ophthalmol Vis Sci. 54:2624–2633. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Mead B, Thompson A, Scheven BA, Logan A, Berry M and Leadbeater W: Comparative evaluation of methods for estimating retinal ganglion cell loss in retinal sections and wholemounts. PLoS One. 9:e1106122014. View Article : Google Scholar : PubMed/NCBI

21 

Carter DA, Bray GM and Aguayo AJ: Regenerated retinal ganglion cell axons can form well-differentiated synapses in the superior colliculus of adult hamsters. J Neurosci. 9:4042–4050. 1989.PubMed/NCBI

22 

Osterhout JA, El-Danaf RN, Nguyen PL and Huberman AD: Birthdate and outgrowth timing predict cellular mechanisms of axon target matching in the developing visual pathway. Cell Rep. 8:1006–1017. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Mawrin C, Pap T, Pallas M, Dietzmann K, Behrens-Baumann W and Vorwerk CK: Changes of retinal glutamate transporter GLT-1 mRNA levels following optic nerve damage. Mol Vis. 9:10–13. 2003.PubMed/NCBI

24 

Barañano DE and Snyder SH: Neural roles for heme oxygenase: Contrasts to nitric oxide synthase. Proc Natl Acad Sci USA. 98:10996–11002. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Hettiarachchi N, Dallas M, Al-Owais M, Griffiths H, Hooper N, Scragg J, Boyle J and Peers C: Heme oxygenase-1 protects against Alzheimer's amyloid-β(1–42)-induced toxicity via carbon monoxide production. Cell Death Dis. 5:e15692014. View Article : Google Scholar : PubMed/NCBI

26 

Wang X, Qin W, Qiu X, Cao J, Liu D and Sun B: A novel role of exogenous carbon monoxide on protecting cardiac function and improving survival against sepsis via mitochondrial energetic metabolism pathway. Int J Biol Sci. 10:777–788. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Nikolic I, Saksida T, Mangano K, Vujicic M, Stojanovic I, Nicoletti F and Stosic-Grujicic S: Pharmacological application of carbon monoxide ameliorates islet-directed autoimmunity in mice via anti-inflammatory and anti-apoptotic effects. Diabetologia. 57:980–990. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Brouard S, Berberat PO, Tobiasch E, Seldon MP, Bach FH and Soares MP: Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis. J Biol Chem. 277:17950–17961. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Gavrieli Y, Sherman Y and Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 119:493–501. 1992. View Article : Google Scholar : PubMed/NCBI

30 

Hirata H, Takahashi A, Kobayashi S, Yonehara S, Sawai H, Okazaki T, Yamamoto K and Sasada M: Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. J Exp Med. 187:587–600. 1998. View Article : Google Scholar : PubMed/NCBI

31 

Seki M, Soussou W, Manabe S and Lipton SA: Protection of retinal ganglion cells by caspase substrate-binding peptide IQACRG from N-methyl-D-aspartate receptor-mediated excitotoxicity. Invest Ophthalmol Vis Sci. 51:1198–1207. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Mahrouf-Yorgov M, Augeul L, Da Silva CC, Jourdan M, Rigolet M, Manin S, Ferrera R, Ovize M, Henry A, Guguin A, et al: Mesenchymal stem cells sense mitochondria released from damaged cells as danger signals to activate their rescue properties. Cell Death Differ. 24:1224–1238. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Abe T, Yazawa K, Fujino M, Imamura R, Hatayama N, Kakuta Y, Tsutahara K, Okumi M, Ichimaru N, Kaimori JY, et al: High-pressure carbon monoxide preserves rat kidney grafts from apoptosis and inflammation. Lab Invest. 97:468–477. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Fagone P, Mangano K, Mammana S, Cavalli E, Di Marco R, Barcellona ML, Salvatorelli L, Magro G and Nicoletti F: Carbon monoxide-releasing molecule-A1 (CORM-A1) improves clinical signs of experimental autoimmune uveoretinitis (EAU) in rats. Clin Immunol. 157:198–204. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Caumartin Y, Stephen J, Deng JP, Lian D, Lan Z, Liu W, Garcia B, Jevnikar AM, Wang H, Cepinskas G and Luke PP: Carbon monoxide-releasing molecules protect against ischemia-reperfusion injury during kidney transplantation. Kidney Int. 79:1080–1089. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Ferrándiz ML, Maicas N, Garcia-Arnandis I, Terencio MC, Motterlini R, Devesa I, Joosten LA, van den Berg WB and Alcaraz MJ: Treatment with a CO-releasing molecule (CORM-3) reduces joint inflammation and erosion in murine collagen-induced arthritis. Ann Rheum Dis. 67:1211–1217. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Sato K, Balla J, Otterbein L, Smith RN, Brouard S, Lin Y, Csizmadia E, Sevigny J, Robson SC, Vercellotti G, et al: Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants. J Immunol. 166:4185–4194. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Zevin S, Saunders S, Gourlay SG, Jacob P and Benowitz NL: Cardiovascular effects of carbon monoxide and cigarette smoking. J Am Coll Cardiol. 38:1633–1638. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Liu SH, Ma K, Xu XR and Xu B: A single dose of carbon monoxide intraperitoneal administration protects rat intestine from injury induced by lipopolysaccharide. Cell Stress Chaperones. 15:717–727. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang R, Chen Z, Wu J, Xia F, Sun Q, Sun A and Liu L: Preconditioning with carbon monoxide inhalation promotes retinal ganglion cell survival against optic nerve crush via inhibition of the apoptotic pathway. Mol Med Rep 17: 1297-1304, 2018.
APA
Wang, R., Chen, Z., Wu, J., Xia, F., Sun, Q., Sun, A., & Liu, L. (2018). Preconditioning with carbon monoxide inhalation promotes retinal ganglion cell survival against optic nerve crush via inhibition of the apoptotic pathway. Molecular Medicine Reports, 17, 1297-1304. https://doi.org/10.3892/mmr.2017.7990
MLA
Wang, R., Chen, Z., Wu, J., Xia, F., Sun, Q., Sun, A., Liu, L."Preconditioning with carbon monoxide inhalation promotes retinal ganglion cell survival against optic nerve crush via inhibition of the apoptotic pathway". Molecular Medicine Reports 17.1 (2018): 1297-1304.
Chicago
Wang, R., Chen, Z., Wu, J., Xia, F., Sun, Q., Sun, A., Liu, L."Preconditioning with carbon monoxide inhalation promotes retinal ganglion cell survival against optic nerve crush via inhibition of the apoptotic pathway". Molecular Medicine Reports 17, no. 1 (2018): 1297-1304. https://doi.org/10.3892/mmr.2017.7990
Copy and paste a formatted citation
x
Spandidos Publications style
Wang R, Chen Z, Wu J, Xia F, Sun Q, Sun A and Liu L: Preconditioning with carbon monoxide inhalation promotes retinal ganglion cell survival against optic nerve crush via inhibition of the apoptotic pathway. Mol Med Rep 17: 1297-1304, 2018.
APA
Wang, R., Chen, Z., Wu, J., Xia, F., Sun, Q., Sun, A., & Liu, L. (2018). Preconditioning with carbon monoxide inhalation promotes retinal ganglion cell survival against optic nerve crush via inhibition of the apoptotic pathway. Molecular Medicine Reports, 17, 1297-1304. https://doi.org/10.3892/mmr.2017.7990
MLA
Wang, R., Chen, Z., Wu, J., Xia, F., Sun, Q., Sun, A., Liu, L."Preconditioning with carbon monoxide inhalation promotes retinal ganglion cell survival against optic nerve crush via inhibition of the apoptotic pathway". Molecular Medicine Reports 17.1 (2018): 1297-1304.
Chicago
Wang, R., Chen, Z., Wu, J., Xia, F., Sun, Q., Sun, A., Liu, L."Preconditioning with carbon monoxide inhalation promotes retinal ganglion cell survival against optic nerve crush via inhibition of the apoptotic pathway". Molecular Medicine Reports 17, no. 1 (2018): 1297-1304. https://doi.org/10.3892/mmr.2017.7990
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