Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2018 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2018 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Serum microRNA expression profiling in patients with multiple system atrophy

  • Authors:
    • Kodai Kume
    • Hisakazu Iwama
    • Kazushi Deguchi
    • Kazuyo Ikeda
    • Tadayuki Takata
    • Yohei Kokudo
    • Masaki Kamada
    • Keiko Fujikawa
    • Kayo Hirose
    • Hisashi Masugata
    • Tetsuo Touge
    • Tsutomu Masaki
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Kagawa University Hospital, Kita‑gun, Kagawa 761‑0793, Japan, Life Science Research Center, Faculty of Medicine, Kagawa University, Kita‑gun, Kagawa 761‑0793, Japan, Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita‑gun, Kagawa 761‑0793, Japan, Department of Intractable Neurological Research, Faculty of Medicine, Kagawa University, Kita‑gun, Kagawa 761‑0793, Japan, Department of Integrated Medicine, Faculty of Medicine, Kagawa University, Kita‑gun, Kagawa 761‑0793, Japan, Department of Health Sciences, Faculty of Medicine, Kagawa University, Kita‑gun, Kagawa 761‑0793, Japan
    Copyright: © Kume et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 852-860
    |
    Published online on: November 7, 2017
       https://doi.org/10.3892/mmr.2017.7995
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Multiple system atrophy (MSA) is a sporadic neurodegenerative disease that is pathologically characterized by α‑synuclein positive glial cytoplasmic inclusions in oligodendrocytes. The clinical diagnosis of MSA is often challenging as there are no established biomarkers and diagnoses are now based on clinical findings alone. At present, the etiology and pathogenesis of MSA are unclear. It has been reported that dysregulation of microRNA (miRNA/miR) serves an important role in neurodegenerative disorders including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. The miRNA profile of patients with MSA remains to be established. The present study investigated the serum miRNA expression level of 10 patients with MSA, using microarray chips including 668 miRNAs. It was identified that 50 miRNAs were significantly upregulated and 17 miRNAs were significantly downregulated in the serum of the patients with MSA. The most upregulated miRNA was miR‑16, which may induce the accumulation of α‑synuclein. The target genes of some miRNAs upregulated in MSA (including miR‑17, 20a, 24, 25, 30d and 451) were associated with autophagy‑associated molecules. The present study concluded that the expression pattern of miRNAs may be a clinical biomarker for MSA and targeting these miRNAs may provide a novel treatment for MSA.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Stefanova N, Bücke P, Duerr S and Wenning GK: Multiple system atrophy: An update. Lancet Neurol. 8:1172–1178. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Joutsa J, Gardberg M, Röyttä M and Kaasinen V: Diagnostic accuracy of parkinsonism syndromes by general neurologists. Parkinsonism Relat Disord. 20:840–844. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Jellinger KA: Neuropathology of multiple system atrophy: New thoughts about pathogenesis. Mov Disord. 29:1720–1741. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Stefanova N, Kaufmann WA, Humpel C, Poewe W and Wenning GK: Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: Implications for multiple system atrophy. Acta Neuropathol. 124:51–65. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Salta E and De Strooper B: Non-coding RNAs with essential roles in neurodegenerative disorders. Lancet Neurol. 11:189–200. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Cloutier F, Marrero A, O'Connell C and Morin P Jr: MicroRNAs as potential circulating biomarkers for amyotrophic lateral sclerosis. J Mol Neurosci. 56:102–112. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Pellecchia MT, Pivonello R, Longo K, Manfredi M, Tessitore A, Amboni M, Pivonello C, Rocco M, Cozzolino A, Colao A and Barone P: Multiple system atrophy is associated with changes in peripheral insulin-like growth factor system. Mov Disord. 25:2621–2626. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Numao A, Suzuki K, Miyamoto M, Miyamoto T and Hirata K: Clinical correlates of serum insulin-like growth factor-1 in patients with Parkinson's disease, multiple system atrophy and progressive supranuclear palsy. Parkinsonism Relat Disord. 20:212–216. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Jia CY, Li HH, Zhu XC, Dong YW, Fu D, Zhao QL, Wu W and Wu XZ: MiR-223 suppresses cell proliferation by targeting IGF-1R. PLoS One. 6:e270082011. View Article : Google Scholar : PubMed/NCBI

11 

Zhu S, Peng W, Li X, Weng J, Zhang X, Guo J, Huang D, Rong Q and Chen S: miR-1827 inhibits osteogenic differentiation by targeting IGF1 in MSMSCs. Sci Rep. 7:461362017. View Article : Google Scholar : PubMed/NCBI

12 

Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, Dürr A, Fowler CJ, et al: Second consensus statement on the diagnosis of multiple system atrophy. Neurology. 71:670–676. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Vallelunga A, Ragusa M, Di Mauro S, Iannitti T, Pilleri M, Biundo R, Weis L, Di Pietro C, De Iuliis A, Nicoletti A, et al: Identification of circulating microRNAs for the differential diagnosis of Parkinson's disease and multiple system atrophy. Front Cell Neurosci. 8:1562014. View Article : Google Scholar : PubMed/NCBI

15 

Lee ST, Chu K, Jung KH, Ban JJ, Im WS, Jo HY, Park JH, Lim JY, Shin JW, Moon J, et al: Altered expression of miR-202 in cerebellum of multiple-system atrophy. Mol Neurobiol. 51:180–186. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Ubhi K, Rockenstein E, Kragh C, Inglis C, Spencer B, Michael S, Mante M, Adame A, Galasko D and Masliah E: Widespread microRNA dysregulation in multiple system atrophy-disease-related alteration in miR-96. Eur J Neurosci. 39:1026–1041. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Schafferer S, Khurana R, Refolo V, Venezia S, Sturm E, Piatti P, Hechenberger C, Hackl H, Kessler R, Willi M, et al: Changes in the miRNA-mRNA regulatory network precede motor symptoms in a mouse model of multiple system atrophy: Clinical implications. PLoS One. 11:e01507052016. View Article : Google Scholar : PubMed/NCBI

18 

Huang E, Liu R and Chu Y: miRNA-15a/16: As tumor suppressors and more. Future Oncol. 11:2351–2363. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Zhang Z and Cheng Y: miR-16-1 promotes the aberrant α-synuclein accumulation in Parkinson disease via targeting heat shock protein 70. ScientificWorldJournal. 2014:9383482014.PubMed/NCBI

20 

Kawamoto Y, Akiguchi I, Shirakashi Y, Honjo Y, Tomimoto H, Takahashi R and Budka H: Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy. Brain Res. 1136:219–227. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Pan B, Chen Y, Song H, Xu Y, Wang R and Chen L: Mir-24-3p downregulation contributes to VP16-DDP resistance in small-cell lung cancer by targeting ATG4A. Oncotarget. 6:317–331. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Comincini S, Allavena G, Palumbo S, Morini M, Durando F, Angeletti F, Pirtoli L and Miracco C: microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells. Cancer Biol Ther. 14:574–586. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Sun KT, Chen MY, Tu MG, Wang IK, Chang SS and Li CY: MicroRNA-20a regulates autophagy related protein-ATG16L1 in hypoxia-induced osteoclast differentiation. Bone. 73:145–153. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Wu H, Wang F, Hu S, Yin C, Li X, Zhao S, Wang J and Yan X: MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts. Cell Signal. 24:2179–2186. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Wang Z, Wang N, Liu P, Chen Q, Situ H, Xie T, Zhang J, Peng C, Lin Y and Chen J: MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin. Oncotarget. 5:7013–7026. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Yang X, Zhong X, Tanyi JL, Shen J, Xu C, Gao P, Zheng TM, DeMichele A and Zhang L: mir-30d regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells. Biochem Biophys Res Commun. 431:617–622. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Zhang Y, Yang WQ, Zhu H, Qian YY, Zhou L, Ren YJ, Ren XC, Zhang L, Liu XP, Liu CG, et al: Regulation of autophagy by miR-30d impacts sensitivity of anaplastic thyroid carcinoma to cisplatin. Biochem Pharmacol. 87:562–570. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Song L, Su M, Wang S, Zou Y, Wang X, Wang Y, Cui H, Zhao P, Hui R and Wang J: MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1. J Cell Mol Med. 18:2266–2274. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Tanji K, Odagiri S, Maruyama A, Mori F, Kakita A, Takahashi H and Wakabayashi K: Alteration of autophagosomal proteins in the brain of multiple system atrophy. Neurobiol Dis. 49:190–198. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Haneklaus M, Gerlic M, O'Neill LA and Masters SL: miR-223: Infection, inflammation and cancer. J Intern Med. 274:215–226. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Boyerinas B, Park SM, Hau A, Murmann AE and Peter ME: The role of let-7 in cell differentiation and cancer. Endocr Relat Cancer. 17:F19–F36. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Lehmann SM, Krüger C, Park B, Derkow K, Rosenberger K, Baumgart J, Trimbuch T, Eom G, Hinz M, Kaul D, et al: An unconventional role for miRNA: Let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci. 15:827–835. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kume K, Iwama H, Deguchi K, Ikeda K, Takata T, Kokudo Y, Kamada M, Fujikawa K, Hirose K, Masugata H, Masugata H, et al: Serum microRNA expression profiling in patients with multiple system atrophy. Mol Med Rep 17: 852-860, 2018.
APA
Kume, K., Iwama, H., Deguchi, K., Ikeda, K., Takata, T., Kokudo, Y. ... Masaki, T. (2018). Serum microRNA expression profiling in patients with multiple system atrophy. Molecular Medicine Reports, 17, 852-860. https://doi.org/10.3892/mmr.2017.7995
MLA
Kume, K., Iwama, H., Deguchi, K., Ikeda, K., Takata, T., Kokudo, Y., Kamada, M., Fujikawa, K., Hirose, K., Masugata, H., Touge, T., Masaki, T."Serum microRNA expression profiling in patients with multiple system atrophy". Molecular Medicine Reports 17.1 (2018): 852-860.
Chicago
Kume, K., Iwama, H., Deguchi, K., Ikeda, K., Takata, T., Kokudo, Y., Kamada, M., Fujikawa, K., Hirose, K., Masugata, H., Touge, T., Masaki, T."Serum microRNA expression profiling in patients with multiple system atrophy". Molecular Medicine Reports 17, no. 1 (2018): 852-860. https://doi.org/10.3892/mmr.2017.7995
Copy and paste a formatted citation
x
Spandidos Publications style
Kume K, Iwama H, Deguchi K, Ikeda K, Takata T, Kokudo Y, Kamada M, Fujikawa K, Hirose K, Masugata H, Masugata H, et al: Serum microRNA expression profiling in patients with multiple system atrophy. Mol Med Rep 17: 852-860, 2018.
APA
Kume, K., Iwama, H., Deguchi, K., Ikeda, K., Takata, T., Kokudo, Y. ... Masaki, T. (2018). Serum microRNA expression profiling in patients with multiple system atrophy. Molecular Medicine Reports, 17, 852-860. https://doi.org/10.3892/mmr.2017.7995
MLA
Kume, K., Iwama, H., Deguchi, K., Ikeda, K., Takata, T., Kokudo, Y., Kamada, M., Fujikawa, K., Hirose, K., Masugata, H., Touge, T., Masaki, T."Serum microRNA expression profiling in patients with multiple system atrophy". Molecular Medicine Reports 17.1 (2018): 852-860.
Chicago
Kume, K., Iwama, H., Deguchi, K., Ikeda, K., Takata, T., Kokudo, Y., Kamada, M., Fujikawa, K., Hirose, K., Masugata, H., Touge, T., Masaki, T."Serum microRNA expression profiling in patients with multiple system atrophy". Molecular Medicine Reports 17, no. 1 (2018): 852-860. https://doi.org/10.3892/mmr.2017.7995
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team