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Article

High‑cholesterol diet results in elevated amyloid‑β and oxysterols in rats

  • Authors:
    • Quanri Liu
    • Yu An
    • Weiwei Ma
    • Lingli Feng
    • Chao Wang
    • Yanhui Lu
    • Rong Xiao
  • View Affiliations / Copyright

    Affiliations: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, P.R. China
  • Pages: 1235-1240
    |
    Published online on: November 7, 2017
       https://doi.org/10.3892/mmr.2017.8003
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Abstract

The aim of the present study was to investigate the effects of diet cholesterol on oxysterol levels and amyloid‑β (Aβ) production in the peripheral blood and the brains of Sprague‑Dawley (SD) rats. SD rats were randomly divided into five groups and fed 0.015, 0.05, 0.2, 0.5 and 1.6% cholesterol‑containing diets for 8 weeks. The effect of the different diets on the levels of cholesterol, oxysterols [including 27‑hydroxycholesterol (OHC), 24S‑OHC, 7α‑OHC and 7β‑OHC], and the Aβ1‑40 and Aβ1‑42 peptides were examined in the plasma and the brain of the rats. The results demonstrated that diet cholesterol increased the levels of plasma cholesterol in a dose‑dependent manner. The plasma levels of 27‑OHC, 7α‑OHC and 7β‑OHC significantly increased in the 0.5 and 1.6% cholesterol diet groups and the brain levels of 27‑OHC significantly increased in the 1.6% cholesterol diet group. Increased concentration of cholesterol in the diet had no significant influence on plasma and brain levels of 24S‑OHC in the rats. In addition, Aβ1‑40 and Aβ1‑42 levels in plasma and brain were significantly elevated following administration of 0.5 and 1.6% diet cholesterol. The present study revealed that high diet cholesterol contributed to increased level of oxysterols, especially 27‑OHC, in the peripheral blood and the brain, which may be the link between increased peripheral cholesterol and brain Aβ production.
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1 

van Vliet P: Cholesterol and late-life cognitive decline. J Alzheimers Dis. 30 Suppl 2:S147–S162. 2012.PubMed/NCBI

2 

Wood WG, Li L, Müller WE and Eckert GP: Cholesterol as a causative factor in Alzheimer's disease: A debatable hypothesis. J Neurochem. 129:559–572. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Anstey KJ, Lipnicki DM and Low LF: Cholesterol as a risk factor for dementia and cognitive decline: A systematic review of prospective studies with meta-analysis. Am J Geriatr Psychiatry. 16:343–354. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Purnell C, Gao S, Callahan CM and Hendrie HC: Cardiovascular risk factors and incident Alzheimer disease: A systematic review of the literature. Alzheimer Dis Assoc Disord. 23:1–10. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Yu X and Zheng J: Cholesterol promotes the interaction of Alzheimer β-amyloid monomer with lipid bilayer. J Mol Biol. 421:561–571. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Drolle E, Gaikwad RM and Leonenko Z: Nanoscale electrostatic domains in cholesterol-laden lipid membranes create a target for amyloid binding. Biophys J. 103:L27–L29. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Di Scala C, Chahinian H, Yahi N, Garmy N and Fantini J: Interaction of Alzheimer's β-amyloid peptides with cholesterol: Mechanistic insights into amyloid pore formation. Biochemistry. 53:4489–4502. 2014. View Article : Google Scholar : PubMed/NCBI

8 

McGuinness B, O'Hare J, Craig D, Bullock R, Malouf R and Passmore P: Statins for the treatment of dementia. Cochrane Database Syst Rev: CD007514. 2010. View Article : Google Scholar

9 

Daugvilaite V, Arfelt KN, Benned-Jensen T, Sailer AW and Rosenkilde MM: Oxysterol-EBI2 signaling in immune regulation and viral infection. Eur J Immunol. 44:1904–1912. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Olkkonen VM, Beaslas O and Nissilä E: Oxysterols and their cellular effectors. Biomolecules. 2:76–103. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Björkhem I, Cedazo-Minguez A, Leoni V and Meaney S: Oxysterols and neurodegenerative diseases. Mol Aspects Med. 30:171–179. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Prasanthi JR, Huls A, Thomasson S, Thompson A, Schommer E and Ghribi O: Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. Mol Neurodegener. 4:12009. View Article : Google Scholar : PubMed/NCBI

13 

Zhang DD, Yu HL, Ma WW, Liu QR, Han J, Wang H and Xiao R: 27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain. Neuroscience. 300:163–173. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Burkard I, Rentsch KM and von Eckardstein A: Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry. J Lipid Res. 45:776–781. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Karu K, Hornshaw M, Woffendin G, Bodin K, Hamberg M, Alvelius G, Sjövall J, Turton J, Wang Y and Griffiths WJ: Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols. J Lipid Res. 48:976–987. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Zurkinden L, Solcà C, Vögeli IA, Vogt B, Ackermann D, Erickson SK, Frey FJ, Sviridov D and Escher G: Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE-knockout mice. FASEB J. 28:1198–1209. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Saito Y and Noguchi N: 7-Hydroxycholestrol as a possible biomarker of cellular lipid peroxidation: Difference between cellular and plasma lipid peroxidation. Biochem Biophys Res Commun. 446:741–744. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Shafaati M, Olin M, Båvner A, Pettersson H, Rozell B, Meaney S, Parini P and Björkhem I: Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. J Intern Med. 270:377–387. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Chen YL, Wang LM, Chen Y, Gao JY, Marshall C, Cai ZY, Hu G and Xiao M: Changes in astrocyte functional markers and β-amyloid metabolism-related proteins in the early stages of hypercholesterolemia. Neuroscience. 316:178–191. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Wirths O, Thelen K, Breyhan H, Luzón-Toro B, Hoffmann KH, Falkai P, Lütjohann D and Bayer TA: Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease. Exp Gerontol. 41:220–224. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Marwarha G and Ghribi O: Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap? Exp Gerontol. 68:13–18. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Q, An Y, Ma W, Feng L, Wang C, Lu Y and Xiao R: High‑cholesterol diet results in elevated amyloid‑β and oxysterols in rats. Mol Med Rep 17: 1235-1240, 2018.
APA
Liu, Q., An, Y., Ma, W., Feng, L., Wang, C., Lu, Y., & Xiao, R. (2018). High‑cholesterol diet results in elevated amyloid‑β and oxysterols in rats. Molecular Medicine Reports, 17, 1235-1240. https://doi.org/10.3892/mmr.2017.8003
MLA
Liu, Q., An, Y., Ma, W., Feng, L., Wang, C., Lu, Y., Xiao, R."High‑cholesterol diet results in elevated amyloid‑β and oxysterols in rats". Molecular Medicine Reports 17.1 (2018): 1235-1240.
Chicago
Liu, Q., An, Y., Ma, W., Feng, L., Wang, C., Lu, Y., Xiao, R."High‑cholesterol diet results in elevated amyloid‑β and oxysterols in rats". Molecular Medicine Reports 17, no. 1 (2018): 1235-1240. https://doi.org/10.3892/mmr.2017.8003
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Q, An Y, Ma W, Feng L, Wang C, Lu Y and Xiao R: High‑cholesterol diet results in elevated amyloid‑β and oxysterols in rats. Mol Med Rep 17: 1235-1240, 2018.
APA
Liu, Q., An, Y., Ma, W., Feng, L., Wang, C., Lu, Y., & Xiao, R. (2018). High‑cholesterol diet results in elevated amyloid‑β and oxysterols in rats. Molecular Medicine Reports, 17, 1235-1240. https://doi.org/10.3892/mmr.2017.8003
MLA
Liu, Q., An, Y., Ma, W., Feng, L., Wang, C., Lu, Y., Xiao, R."High‑cholesterol diet results in elevated amyloid‑β and oxysterols in rats". Molecular Medicine Reports 17.1 (2018): 1235-1240.
Chicago
Liu, Q., An, Y., Ma, W., Feng, L., Wang, C., Lu, Y., Xiao, R."High‑cholesterol diet results in elevated amyloid‑β and oxysterols in rats". Molecular Medicine Reports 17, no. 1 (2018): 1235-1240. https://doi.org/10.3892/mmr.2017.8003
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