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Article

microRNA‑211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1

  • Authors:
    • Guangyuan Chen
    • Ping Huang
    • Jiabin Xie
    • Rihong Li
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology, Songgang People's Hospital, Shenzhen, Guangdong 518105, P.R. China
  • Pages: 1275-1282
    |
    Published online on: November 7, 2017
       https://doi.org/10.3892/mmr.2017.8006
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Abstract

Of gynecological cancers, cervical cancer has the second highest incidence globally and is a major cause of cancer‑associated mortality in women. An increasing number of studies have reported that microRNAs (miRNAs) have important roles in cervical cancer carcinogenesis and progression through regulation of various critical protein‑coding genes. The aim of the present study was to investigate the expression and biological roles of miRNA‑211 (miR‑211) in cervical cancer and its underlying molecular mechanism. The results of reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) demonstrated that the expression levels of miR‑211 in cervical cancer tissues and cell lines were significantly lower compared with adjacent normal tissues and the normal human cervix epithelial cell line, respectively. Furthermore, upregulation of miR‑211 by transfection with miR‑211 mimics inhibited cell proliferation, migration and invasion of cervical cancer, as determined by MTT, Transwell and Matrigel assays, respectively. Bioinformatics analysis and luciferase reporter assay results indicated that zinc finger E‑box binding homeobox 1 (ZEB1) may be a direct target gene of miR‑211. In addition, RT‑qPCR and western blot analysis results demonstrated that miR‑211 overexpression markedly reduced ZEB1 expression at mRNA and protein levels in cervical cancer. Furthermore, the effects of ZEB1 downregulation on the proliferation, migration and invasion of cervical cancer cells were similar to those induced by miR‑211 overexpression. These results indicate that miR‑211 may act as a tumor suppressor in cervical cancer by directly targeting ZEB1. Therefore, miR‑211/ZEB1‑based targeted therapy may represent a potential novel treatment for patients with cervical cancer.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Chen J, Yao D, Li Y, Chen H, He C, Ding N, Lu Y, Ou T, Zhao S, Li L and Long F: Serum microRNA expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma. Int J Mol Med. 32:557–567. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Nagamitsu Y, Nishi H, Sasaki T, Takaesu Y, Terauchi F and Isaka K: Profiling analysis of circulating microRNA expression in cervical cancer. Mol Clin Oncol. 5:189–194. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Schiffman MH and Castle P: Epidemiologic studies of a necessary causal risk factor: Human papillomavirus infection and cervical neoplasia. J Natl Cancer Inst. 95:E22003. View Article : Google Scholar : PubMed/NCBI

6 

Dueñas-Gonzalez A, Cetina L, Mariscal I and de la Garza J: Modern management of locally advanced cervical carcinoma. Cancer Treat Rev. 29:389–399. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Roque DR, Wysham WZ and Soper JT: The surgical management of cervical cancer: An overview and literature review. Obstet Gynecol Surv. 69:426–441. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Wang N, Wei H, Yin D, Lu Y, Zhang Y, Zhang Q, Ma X and Zhang S: MicroRNA-195 inhibits proliferation of cervical cancer cells by targeting cyclin D1a. Tumour Biol. 37:4711–4720. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Rhoades MW, Reinhart BJ, Lim LP, Burge CB, Bartel B and Bartel DP: Prediction of plant microRNA targets. Cell. 110:513–520. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Lu Y, Zhou Y, Qu W, Deng M and Zhang C: A Lasso regression model for the construction of microRNA-target regulatory networks. Bioinformatics. 27:2406–2413. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Siomi H and Siomi MC: Posttranscriptional regulation of microRNA biogenesis in animals. Mol Cell. 38:323–332. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Gardiner AS, Twiss JL and Perrone-Bizzozero NI: Competing interactions of RNA-binding proteins, MicroRNAs, and their targets control neuronal development and function. Biomolecules. 5:2903–2918. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Zhang Y, Guan DH, Bi RX, Xie J, Yang CH and Jiang YH: Prognostic value of microRNAs in gastric cancer: A meta-analysis. Oncotarget. 8:55489–55510. 2017.PubMed/NCBI

14 

Drusco A and Croce CM: MicroRNAs and cancer: A long story for short RNAs. Adv Cancer Res. 135:1–24. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Long MJ, Wu FX, Li P, Liu M, Li X and Tang H: MicroRNA-10a targets CHL1 and promotes cell growth, migration and invasion in human cervical cancer cells. Cancer Lett. 324:186–196. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Zou D, Zhou Q, Wang D, Guan L, Yuan L and Li S: The downregulation of MicroRNA-10b and its role in cervical cancer. Oncol Res. 24:99–108. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Zhang T, Zou P, Wang T, Xiang J, Cheng J, Chen D and Zhou J: Down-regulation of miR-320 associated with cancer progression and cell apoptosis via targeting Mcl-1 in cervical cancer. Tumour Biol. 37:8931–8940. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Ling S, Ruiqin M, Guohong Z, Bing S and Yanshan C: Decreased microRNA-206 and its function in cervical cancer. Eur J Gynaecol Oncol. 36:716–721. 2015.PubMed/NCBI

19 

Chang KW, Liu CJ, Chu TH, Cheng HW, Hung PS, Hu WY and Lin SC: Association between high miR-211 microRNA expression and the poor prognosis of oral carcinoma. J Dent Res. 87:1063–1068. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Cai K, Shen F, Cui JH, Yu Y and Pan HQ: Expression of miR-221 in colon cancer correlates with prognosis. Int J Clin Exp Med. 8:2794–2798. 2015.PubMed/NCBI

21 

Cai C, Ashktorab H, Pang X, Zhao Y, Sha W, Liu Y and Gu X: MicroRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5. PLoS One. 7:e297502012. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15–20. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Sakurai E, Maesawa C, Shibazaki M, Yasuhira S, Oikawa H, Sato M, Tsunoda K, Ishikawa Y, Watanabe A, Takahashi K, et al: Downregulation of microRNA-211 is involved in expression of preferentially expressed antigen of melanoma in melanoma cells. Int J Oncol. 39:665–672. 2011.PubMed/NCBI

25 

Chu TH, Yang CC, Liu CJ, Lui MT, Lin SC and Chang KW: miR-211 promotes the progression of head and neck carcinomas by targeting TGFbetaRII. Cancer Lett. 337:115–124. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Jiang G, Cui Y, Yu X, Wu Z, Ding G and Cao L: miR-211 suppresses hepatocellular carcinoma by downregulating SATB2. Oncotarget. 6:9457–9466. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Xia B, Yang S, Liu T and Lou G: miR-211 suppresses epithelial ovarian cancer proliferation and cell-cycle progression by targeting Cyclin D1 and CDK6. Mol Cancer. 14:572015. View Article : Google Scholar : PubMed/NCBI

28 

Ma Y, Zheng X, Zhou J, Zhang Y and Chen K: ZEB1 promotes the progression and metastasis of cervical squamous cell carcinoma via the promotion of epithelial-mesenchymal transition. Int J Clin Exp Pathol. 8:11258–11267. 2015.PubMed/NCBI

29 

Chen Z, Li S, Huang K, Zhang Q, Wang J, Li X, Hu T, Wang S, Yang R, Jia Y, et al: The nuclear protein expression levels of SNAI1 and ZEB1 are involved in the progression and lymph node metastasis of cervical cancer via the epithelial-mesenchymal transition pathway. Hum Pathol. 44:2097–2105. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Ran J, Lin DL, Wu RF, Chen QH, Huang HP, Qiu NX and Quan S: ZEB1 promotes epithelial-mesenchymal transition in cervical cancer metastasis. Fertil Steril. 103(1606–14): e1–2. 2015.PubMed/NCBI

31 

Feenstra M, Veltkamp M, van Kuik J, Wiertsema S, Slootweg P, van den Tweel J, de Weger R and Tilanus M: HLA class I expression and chromosomal deletions at 6p and 15q in head and neck squamous cell carcinomas. Tissue Antigens. 54:235–245. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Natrajan R, Louhelainen J, Williams S, Laye J and Knowles MA: High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder. Cancer Res. 63:7657–7662. 2003.PubMed/NCBI

33 

Lipton L and Tomlinson I: The genetics of FAP and FAP-like syndromes. Fam Cancer. 5:221–226. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Mazar J, DeYoung K, Khaitan D, Meister E, Almodovar A, Goydos J, Ray A and Perera RJ: The regulation of miRNA-211 expression and its role in melanoma cell invasiveness. PLoS One. 5:e137792010. View Article : Google Scholar : PubMed/NCBI

35 

Maftouh M, Avan A, Funel N, Frampton AE, Fiuji H, Pelliccioni S, Castellano L, Galla V, Peters GJ and Giovannetti E: miR-211 modulates gemcitabine activity through downregulation of ribonucleotide reductase and inhibits the invasive behavior of pancreatic cancer cells. Nucleosides Nucleotides Nucleic Acids. 33:384–393. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Song GQ and Zhao Y: MicroRNA-211, a direct negative regulator of CDC25B expression, inhibits triple-negative breast cancer cells' growth and migration. Tumour Biol. 36:5001–5009. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Ye L, Wang H and Liu B: miR-211 promotes non-small cell lung cancer proliferation by targeting SRCIN1. Tumour Biol. 37:1151–1157. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Wang CY, Hua L, Sun J, Yao KH, Chen JT, Zhang JJ and Hu JH: MiR-211 inhibits cell proliferation and invasion of gastric cancer by down-regulating SOX4. Int J Clin Exp Pathol. 8:14013–14020. 2015.PubMed/NCBI

39 

Yu Z, Ni L, Chen D, Zhang Q, Su Z, Wang Y, Yu W, Wu X, Ye J, Yang S, et al: Identification of miR-7 as an oncogene in renal cell carcinoma. J Mol Histol. 44:669–677. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Shen A, Zhang Y, Yang H, Xu R and Huang G: Overexpression of ZEB1 relates to metastasis and invasion in osteosarcoma. J Surg Oncol. 105:830–834. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Singh M, Spoelstra NS, Jean A, Howe E, Torkko KC, Clark HR, Darling DS, Shroyer KR, Horwitz KB, Broaddus RR and Richer JK: ZEB1 expression in type I vs type II endometrial cancers: A marker of aggressive disease. Mod Pathol. 21:912–923. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Graham TR, Zhau HE, Odero-Marah VA, Osunkoya AO, Kimbro KS, Tighiouart M, Liu T, Simons JW and O'Regan RM: Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer Res. 68:2479–2488. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Drake JM, Strohbehn G, Bair TB, Moreland JG and Henry MD: ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells. Mol Biol Cell. 20:2207–2217. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Hurt EM, Saykally JN, Anose BM, Kalli KR and Sanders MM: Expression of the ZEB1 (deltaEF1) transcription factor in human: Additional insights. Mol Cell Biochem. 318:89–99. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen G, Huang P, Xie J and Li R: microRNA‑211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1. Mol Med Rep 17: 1275-1282, 2018.
APA
Chen, G., Huang, P., Xie, J., & Li, R. (2018). microRNA‑211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1. Molecular Medicine Reports, 17, 1275-1282. https://doi.org/10.3892/mmr.2017.8006
MLA
Chen, G., Huang, P., Xie, J., Li, R."microRNA‑211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1". Molecular Medicine Reports 17.1 (2018): 1275-1282.
Chicago
Chen, G., Huang, P., Xie, J., Li, R."microRNA‑211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1". Molecular Medicine Reports 17, no. 1 (2018): 1275-1282. https://doi.org/10.3892/mmr.2017.8006
Copy and paste a formatted citation
x
Spandidos Publications style
Chen G, Huang P, Xie J and Li R: microRNA‑211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1. Mol Med Rep 17: 1275-1282, 2018.
APA
Chen, G., Huang, P., Xie, J., & Li, R. (2018). microRNA‑211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1. Molecular Medicine Reports, 17, 1275-1282. https://doi.org/10.3892/mmr.2017.8006
MLA
Chen, G., Huang, P., Xie, J., Li, R."microRNA‑211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1". Molecular Medicine Reports 17.1 (2018): 1275-1282.
Chicago
Chen, G., Huang, P., Xie, J., Li, R."microRNA‑211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1". Molecular Medicine Reports 17, no. 1 (2018): 1275-1282. https://doi.org/10.3892/mmr.2017.8006
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