Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2018 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2018 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Cardioprotective effects of anisodamine against myocardial ischemia/reperfusion injury through the inhibition of oxidative stress, inflammation and apoptosis

  • Authors:
    • Bao‑Ju Yao
    • Xiao‑Qing He
    • Yu‑Hui Lin
    • Wen‑Jun Dai
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First People's Hospital of Huainan, Huainan, Anhui 232007, P.R. China, Department of Cardiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China
  • Pages: 1253-1260
    |
    Published online on: November 8, 2017
       https://doi.org/10.3892/mmr.2017.8009
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the cardioprotective effects of anisodamine against myocardial ischemia/reperfusion (I/R) injury and the molecular mechanisms involved. The present results demonstrated that anisodamine attenuated myocardial infarct sizes, decreased the levels of creatine kinase and lactate dehydrogenase, whereas it increased the left ventricular (LV) systolic pressure, the LV end‑diastolic pressure, and the LV pressure maximum rising and falling rates in a myocardial I/R rat model. In addition, anisodamine was revealed to suppress oxidative stress, inflammatory factor production and myocardial cell apoptosis, as demonstrated by the downregulation of caspase‑3 and apoptosis regulator BAX protein expression. The production of reactive oxygen species was decreased and the protein expression of inducible nitric oxide synthase (iNOS) was downregulated, whereas the expression of endothelial NOS was enhanced. In addition, the activity of nicotinamide‑adenine dinucleotide phosphate oxidase (Nox) was suppressed and the expression of Nox4 was downregulated in rats with myocardial I/R injury. In conclusion, the results of the present study suggested that anisodamine exerted a cardioprotective effect against myocardial I/R injury in rats, through the inhibition of oxidative stress, the suppression of inflammatory processes and the inhibition of myocardial cell apoptosis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Woodcock A, Bakerly ND, New JP, Gibson JM, Wu W, Vestbo J and Leather D: The salford lung study protocol: A pragmatic, randomised phase III real-world effectiveness trial in asthma. BMC Pulm Med. 15:1602015. View Article : Google Scholar : PubMed/NCBI

2 

Gafarov VV, Panov DO, Gromova EA, Gagulin IV and Gafarova AV: Workplace stress and its impact on the 16-year risk of myocardial infarction and stroke in an open female population aged 25–64 years in Russia/Siberia (WHO MONICA-psychosocial program). Ter Arkh. 87:71–76. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Horspool MJ, Julious SA, Boote J, Bradburn MJ, Cooper CL, Davis S, Elphick H, Norman P, Smithson WH and VanStaa T: Preventing and lessening exacerbations of asthma in school-age children associated with a new term (PLEASANT): Study protocol for a cluster randomised control trial. Trials. 14:2972013. View Article : Google Scholar : PubMed/NCBI

4 

Kim DE, Lee Y, Kim M, Lee S, Jon S and Lee SH: Bilirubin nanoparticles ameliorate allergic lung inflammation in a mouse model of asthma. Biomaterials. 140:37–44. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Chen YP, Zhang JH, Li CQ, Sun QX and Jiang XH: Obesity enhances Th2 inflammatory response via natural killer T cells in a murine model of allergic asthma. Int J Clin Exp Med. 8:15403–15412. 2015.PubMed/NCBI

6 

Zambalde ÉP, Teixeira MM, Favarin DC, de Oliveira JR, Magalhães ML, Cunha MM, Silva WC Junior, Okuma CH, Rodrigues V Junior, Levy BD and Rogerio AP: The anti-inflammatory and pro-resolution effects of aspirin-triggered RvD1 (AT-RvD1) on peripheral blood mononuclear cells from patients with severe asthma. Int Immunopharmacol. 35:142–148. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Cao L, Guo C, Chen J, Chen Z and Yan Z: Free vascularized fibular grafting improves vascularity compared with core decompression in femoral head osteonecrosis: A randomized clinical trial. Clin Orthop Relat Res. 475:2230–2240. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Celik O, Celik E, Turkcuoglu I, Yilmaz E, Ulas M, Simsek Y, Karaer A, Celik N, Aydin NE, Ozerol I and Unlu C: Surgical removal of endometrioma decreases the NF-kB1 (p50/105) and NF-kB p65 (Rel A) expression in the eutopic endometrium during the implantation window. Reprod Sci. 20:762–770. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Wang W, Yu JN and Tao XJ: Systemic lupus erythematosus complicated with femoral head ischemic necrosis treated by Chinese medicine therapy for activating blood and dredging collaterals method. Chin J Integr Med. 17:105–110. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Wei L, Zhang H, Li X, Yang C, Wang G, Zhang L, Cui M and Han L: Efficacy and safety evaluation of intravenous infusion of cervus and cucumis polypeptides for treatment of avascular necrosis of the femoral head: A randomized clinical trial. J Tradit Chin Med. 36:39–44. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Fan JB, Ruan JW, Liu W, Zhu LQ, Zhu XH, Yi H, Cui SY, Zhao JN and Cui ZM: miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone. Oncotarget. 7:70613–70622. 2016.PubMed/NCBI

12 

Jia J, Feng X, Xu W, Yang S, Zhang Q, Liu X, Feng Y and Dai Z: MiR-17-5p modulates osteoblastic differentiation and cell proliferation by targeting SMAD7 in non-traumatic osteonecrosis. Exp Mol Med. 46:e1072014. View Article : Google Scholar : PubMed/NCBI

13 

Yuan HF, Christina VR, Guo CA, Chu YW, Liu RH and Yan ZQ: Involvement of MicroRNA-210 demethylation in steroid-associated osteonecrosis of the femoral head. Sci Rep. 6:200462016. View Article : Google Scholar : PubMed/NCBI

14 

Song Y, Du Z, Ren M, Yang Q, Wang Q, Chen G, Zhao H, Li Z, Wang J and Zhang G: Association of gene variants of transcription factors PPARγ, RUNX2, Osterix genes and COL2A1, IGFBP3 genes with the development of osteonecrosis of the femoral head in Chinese population. Bone. 101:104–112. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Wan P, Su W, Zhang Y, Li Z, Deng C and Zhuo Y: Trimetazidine protects retinal ganglion cells from acute glaucoma via the Nrf2/Ho-1 pathway. Clin Sci (Lond). 131:2363–2375. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Wang XR, Shi GX, Yang JW, Yan CQ, Lin LT, Du SQ, Zhu W, He T, Zeng XH, Xu Q and Liu CZ: Acupuncture ameliorates cognitive impairment and hippocampus neuronal loss in experimental vascular dementia through Nrf2-mediated antioxidant response. Free Radic Biol Med. 89:1077–1084. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Milger K, Götschke J, Krause L, Nathan P, Alessandrini F, Tufman A, Fischer R, Bartel S, Theis FJ, Behr J, et al: Identification of a plasma miRNA biomarker signature for allergic asthma: A translational approach. Allergy. May 17–2017.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

18 

Zhou ZC, Gu SZ, Wu J and Liang QW: VEGF, eNOS, and ABCB1 genetic polymorphisms may increase the risk of osteonecrosis of the femoral head. Genet Mol Res. 14:13688–13698. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Jonsson BA, Kadar T, Havelin LI, Haugan K, Espehaug B, Indrekvam K, Furnes O and Hallan G: Oxinium modular femoral heads do not reduce polyethylene wear in cemented total hip arthroplasty at five years: A randomised trial of 120 hips using radiostereometric analysis. Bone Joint J. 97-B:1463–1469. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Yun SJ, Nam DH and Ryu JK: Femoral artery access using the US-determined inguinal ligament and femoral head as reliable landmarks: Prospective study of usefulness and safety. J Vasc Interv Radiol. 26:552–559. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Xu ZP, Wang H, Hou LN, et al: Modulatory effect of anisodamine on airway hyper-reactivity and eosinophilic inflammation in a murine model of allergic asthma. Int Immunopharmacol. 11:260–265. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Tingart M, Beckmann J, Opolka A, Matsuura M, Schaumburger J, Grifka J and Grässel S: Analysis of bone matrix composition and trabecular microarchitecture of the femoral metaphysis in patients with osteonecrosis of the femoral head. J Orthop Res. 27:1175–1181. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Kong X, Li X, Zhang C, Zhu L, Liu C, Qin Q, Liu C, Wang Q, Zhu J, Wu X, et al: Ethyl acetate fraction of Huogu formula inhibits adipogenic differentiation of bone marrow stromal cells via the BMP and Wnt signaling pathways. Int J Biol Sci. 13:480–491. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Lin D, Zuo S, Li L, Wang L and Lian K: Treatment of neglected femoral neck fractures using the modified dynamic hip screw with autogenous bone and bone morphogenetic protein-2 composite materials grafting. Indian J Orthop. 49:342–346. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Liu YH, Zhang J, Dai Z, et al: [Protection of anisodamine on the mitochondrial injury induced by oxidative stress in swine with cardiac arrest]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 25:290–293. 2013.PubMed/NCBI

26 

Renkawitz T, Santori FS, Grifka J, Valverde C, Morlock MM and Learmonth ID: A new short uncemented, proximally fixed anatomic femoral implant with a prominent lateral flare: Design rationals and study design of an international clinical trial. BMC Musculoskelet Disord. 9:1472008. View Article : Google Scholar : PubMed/NCBI

27 

Ma XL, Liu ZP, Ma JX, Han C and Zang JC: Dynamic expression of Runx2, Osterix and AJ18 in the femoral head of steroid-induced osteonecrosis in rats. Orthop Surg. 2:278–284. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Li J, Wang Y, Li Y, Sun J and Zhao G: The effect of combined regulation of the expression of peroxisome proliferator-activated receptor-γ and calcitonin gene-related peptide on alcohol-induced adipogenic differentiation of bone marrow mesenchymal stem cells. Mol Cell Biochem. 392:39–48. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yao BJ, He XQ, Lin YH and Dai WJ: Cardioprotective effects of anisodamine against myocardial ischemia/reperfusion injury through the inhibition of oxidative stress, inflammation and apoptosis. Mol Med Rep 17: 1253-1260, 2018.
APA
Yao, B., He, X., Lin, Y., & Dai, W. (2018). Cardioprotective effects of anisodamine against myocardial ischemia/reperfusion injury through the inhibition of oxidative stress, inflammation and apoptosis. Molecular Medicine Reports, 17, 1253-1260. https://doi.org/10.3892/mmr.2017.8009
MLA
Yao, B., He, X., Lin, Y., Dai, W."Cardioprotective effects of anisodamine against myocardial ischemia/reperfusion injury through the inhibition of oxidative stress, inflammation and apoptosis". Molecular Medicine Reports 17.1 (2018): 1253-1260.
Chicago
Yao, B., He, X., Lin, Y., Dai, W."Cardioprotective effects of anisodamine against myocardial ischemia/reperfusion injury through the inhibition of oxidative stress, inflammation and apoptosis". Molecular Medicine Reports 17, no. 1 (2018): 1253-1260. https://doi.org/10.3892/mmr.2017.8009
Copy and paste a formatted citation
x
Spandidos Publications style
Yao BJ, He XQ, Lin YH and Dai WJ: Cardioprotective effects of anisodamine against myocardial ischemia/reperfusion injury through the inhibition of oxidative stress, inflammation and apoptosis. Mol Med Rep 17: 1253-1260, 2018.
APA
Yao, B., He, X., Lin, Y., & Dai, W. (2018). Cardioprotective effects of anisodamine against myocardial ischemia/reperfusion injury through the inhibition of oxidative stress, inflammation and apoptosis. Molecular Medicine Reports, 17, 1253-1260. https://doi.org/10.3892/mmr.2017.8009
MLA
Yao, B., He, X., Lin, Y., Dai, W."Cardioprotective effects of anisodamine against myocardial ischemia/reperfusion injury through the inhibition of oxidative stress, inflammation and apoptosis". Molecular Medicine Reports 17.1 (2018): 1253-1260.
Chicago
Yao, B., He, X., Lin, Y., Dai, W."Cardioprotective effects of anisodamine against myocardial ischemia/reperfusion injury through the inhibition of oxidative stress, inflammation and apoptosis". Molecular Medicine Reports 17, no. 1 (2018): 1253-1260. https://doi.org/10.3892/mmr.2017.8009
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team