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Article Open Access

NG25, an inhibitor of transforming growth factor‑β‑activated kinase 1, ameliorates neuronal apoptosis in neonatal hypoxic‑ischemic rats

Retraction in: /10.3892/mmr.2024.13423
  • Authors:
    • Hua Wang
    • Zhong Chen
    • Yu Li
    • Qiaoyun Ji
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Ophthalmology, Fourth Affiliated Hospital of Sichuan University, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1710-1716
    |
    Published online on: November 10, 2017
       https://doi.org/10.3892/mmr.2017.8024
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Abstract

Transforming growth factor (TGF)‑β‑activated kinase 1 (TAK1) was found to be activated by TGF‑β and acts as a central regulator of cell death in various types of disease. However, the expression and function of TAK1 in the neonatal brain following hypoxia‑ischemia (HI) remains unclear. In the present study, western blotting and immunofluorescence were employed to determine the expression and distribution of TAK1 in the brain cortex of a perinatal HI rat model. In addition, the specific inhibitor of TAK1, NG25 was administered via intracerebroventricular injection, prior to insult of the neonatal rat brains, for neuroprotection. Western blotting and double immunofluorescence indicated that an increased expression level of phosphorylated‑TAK1 was observed, and was localized with neurons and astrocytes, compared with the sham group. Further study demonstrated that injection of NG25 prior to insult significantly inhibited TAK1/c‑Jun N‑terminal kinases activity and dramatically ameliorated acute hypoxic‑ischemic cerebral injury by inhibiting cell apoptosis in perinatal rats. Thus, NG25 ameliorates neuronal apoptosis in neonatal HI rats by inhibiting TAK1 expression and cell apoptosis. In addition, NG25 may serve as a promising novel neuroprotective inhibitor for perinatal cerebral injury.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Chen Z, Li Y and Ji Q: NG25, an inhibitor of transforming growth factor‑β‑activated kinase 1, ameliorates neuronal apoptosis in neonatal hypoxic‑ischemic rats Retraction in /10.3892/mmr.2024.13423. Mol Med Rep 17: 1710-1716, 2018.
APA
Wang, H., Chen, Z., Li, Y., & Ji, Q. (2018). NG25, an inhibitor of transforming growth factor‑β‑activated kinase 1, ameliorates neuronal apoptosis in neonatal hypoxic‑ischemic rats Retraction in /10.3892/mmr.2024.13423. Molecular Medicine Reports, 17, 1710-1716. https://doi.org/10.3892/mmr.2017.8024
MLA
Wang, H., Chen, Z., Li, Y., Ji, Q."NG25, an inhibitor of transforming growth factor‑β‑activated kinase 1, ameliorates neuronal apoptosis in neonatal hypoxic‑ischemic rats Retraction in /10.3892/mmr.2024.13423". Molecular Medicine Reports 17.1 (2018): 1710-1716.
Chicago
Wang, H., Chen, Z., Li, Y., Ji, Q."NG25, an inhibitor of transforming growth factor‑β‑activated kinase 1, ameliorates neuronal apoptosis in neonatal hypoxic‑ischemic rats Retraction in /10.3892/mmr.2024.13423". Molecular Medicine Reports 17, no. 1 (2018): 1710-1716. https://doi.org/10.3892/mmr.2017.8024
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Chen Z, Li Y and Ji Q: NG25, an inhibitor of transforming growth factor‑β‑activated kinase 1, ameliorates neuronal apoptosis in neonatal hypoxic‑ischemic rats Retraction in /10.3892/mmr.2024.13423. Mol Med Rep 17: 1710-1716, 2018.
APA
Wang, H., Chen, Z., Li, Y., & Ji, Q. (2018). NG25, an inhibitor of transforming growth factor‑β‑activated kinase 1, ameliorates neuronal apoptosis in neonatal hypoxic‑ischemic rats Retraction in /10.3892/mmr.2024.13423. Molecular Medicine Reports, 17, 1710-1716. https://doi.org/10.3892/mmr.2017.8024
MLA
Wang, H., Chen, Z., Li, Y., Ji, Q."NG25, an inhibitor of transforming growth factor‑β‑activated kinase 1, ameliorates neuronal apoptosis in neonatal hypoxic‑ischemic rats Retraction in /10.3892/mmr.2024.13423". Molecular Medicine Reports 17.1 (2018): 1710-1716.
Chicago
Wang, H., Chen, Z., Li, Y., Ji, Q."NG25, an inhibitor of transforming growth factor‑β‑activated kinase 1, ameliorates neuronal apoptosis in neonatal hypoxic‑ischemic rats Retraction in /10.3892/mmr.2024.13423". Molecular Medicine Reports 17, no. 1 (2018): 1710-1716. https://doi.org/10.3892/mmr.2017.8024
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