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Article

Reduced triglyceride accumulation due to overactivation of farnesoid X receptor signaling contributes to impaired liver regeneration following 50% hepatectomy in extra‑cholestatic liver tissue

  • Authors:
    • Wen‑Jun Jia
    • Shi‑Quan Sun
    • Luo‑Shun Huang
    • Qiao‑Li Tang
    • Yu‑Dong Qiu
    • Liang Mao
  • View Affiliations / Copyright

    Affiliations: Department of Hepatopancreatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China, Ministry of Education Key Laboratory of Model Animal for Disease Study, School of Medicine and Model Animal Research Center, Nanjing University, Nanjing, Jiangsu 210093, P.R. China
    Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1545-1554
    |
    Published online on: November 10, 2017
       https://doi.org/10.3892/mmr.2017.8025
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Abstract

The aim of the present study was to investigate the role of triglyceride metabolism in the effect of obstructive cholestasis on liver regeneration following 50% partial hepatectomy (PH). Obstructive cholestatic rat models were achieved via ligation of the common bile duct (BDL). Following comparisons between hepatic pathological alterations with patients with perihilar cholangiocarcinoma, rats in the 7 day post‑BDL group were selected as the BDL model for subsequent experiments. Liver weight restoration, proliferating cell nuclear antigen labeling index, cytokine and growth factor expression levels, and hepatic triglyceride content were evaluated to analyze liver regeneration post‑PH within BDL and control group rats. The results of the present study revealed that obstructive cholestasis impaired liver mass restoration, which occurred via inhibition of early stage hepatocyte proliferation. In addition, reduced triglyceride content and inhibited expression of fatty acid β‑oxidation‑associated genes, peroxisome proliferator activated receptor α and carnitine palmitoyltransferase, were associated with an insufficient energy supply within the BDL group post‑PH. Notably, the expression levels of fatty acid synthesis‑associated genes, including sterol‑regulatory element‑binding protein‑1c, acetyl‑coA carboxylase 1 and fatty acid synthase were also reduced within the BDL group, which accounted for the reduced triglyceride content and fatty acid utilization. Further investigation revealed that overactivated farnesoid X receptor (FXR) signaling may inhibit fatty acid synthesis within BDL group rats. Collectively, the role of triglycerides in liver regeneration following PH in extra‑cholestatic livers was identified in the present study. Additionally, the results indicated that overactivated FXR signaling‑induced triglyceride reduction is associated with insufficient energy supply and therefore contributes to the extent of impairment of liver regeneration following PH within extra‑cholestatic livers.
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Copy and paste a formatted citation
Spandidos Publications style
Jia WJ, Sun SQ, Huang LS, Tang QL, Qiu YD and Mao L: Reduced triglyceride accumulation due to overactivation of farnesoid X receptor signaling contributes to impaired liver regeneration following 50% hepatectomy in extra‑cholestatic liver tissue. Mol Med Rep 17: 1545-1554, 2018.
APA
Jia, W., Sun, S., Huang, L., Tang, Q., Qiu, Y., & Mao, L. (2018). Reduced triglyceride accumulation due to overactivation of farnesoid X receptor signaling contributes to impaired liver regeneration following 50% hepatectomy in extra‑cholestatic liver tissue. Molecular Medicine Reports, 17, 1545-1554. https://doi.org/10.3892/mmr.2017.8025
MLA
Jia, W., Sun, S., Huang, L., Tang, Q., Qiu, Y., Mao, L."Reduced triglyceride accumulation due to overactivation of farnesoid X receptor signaling contributes to impaired liver regeneration following 50% hepatectomy in extra‑cholestatic liver tissue". Molecular Medicine Reports 17.1 (2018): 1545-1554.
Chicago
Jia, W., Sun, S., Huang, L., Tang, Q., Qiu, Y., Mao, L."Reduced triglyceride accumulation due to overactivation of farnesoid X receptor signaling contributes to impaired liver regeneration following 50% hepatectomy in extra‑cholestatic liver tissue". Molecular Medicine Reports 17, no. 1 (2018): 1545-1554. https://doi.org/10.3892/mmr.2017.8025
Copy and paste a formatted citation
x
Spandidos Publications style
Jia WJ, Sun SQ, Huang LS, Tang QL, Qiu YD and Mao L: Reduced triglyceride accumulation due to overactivation of farnesoid X receptor signaling contributes to impaired liver regeneration following 50% hepatectomy in extra‑cholestatic liver tissue. Mol Med Rep 17: 1545-1554, 2018.
APA
Jia, W., Sun, S., Huang, L., Tang, Q., Qiu, Y., & Mao, L. (2018). Reduced triglyceride accumulation due to overactivation of farnesoid X receptor signaling contributes to impaired liver regeneration following 50% hepatectomy in extra‑cholestatic liver tissue. Molecular Medicine Reports, 17, 1545-1554. https://doi.org/10.3892/mmr.2017.8025
MLA
Jia, W., Sun, S., Huang, L., Tang, Q., Qiu, Y., Mao, L."Reduced triglyceride accumulation due to overactivation of farnesoid X receptor signaling contributes to impaired liver regeneration following 50% hepatectomy in extra‑cholestatic liver tissue". Molecular Medicine Reports 17.1 (2018): 1545-1554.
Chicago
Jia, W., Sun, S., Huang, L., Tang, Q., Qiu, Y., Mao, L."Reduced triglyceride accumulation due to overactivation of farnesoid X receptor signaling contributes to impaired liver regeneration following 50% hepatectomy in extra‑cholestatic liver tissue". Molecular Medicine Reports 17, no. 1 (2018): 1545-1554. https://doi.org/10.3892/mmr.2017.8025
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