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INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program

  • Authors:
    • Francesca Pirini
    • Sebastian Rodriguez‑Torres
    • Bola Grace Ayandibu
    • María Orera‑Clemente
    • Alberto Gonzalez‑de la Vega
    • Fahcina Lawson
    • Roland J. Thorpe
    • David Sidransky
    • Rafael Guerrero‑Preston
  • View Affiliations / Copyright

    Affiliations: Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, I‑47014 Meldola, Italy, Department of Otolaryngology, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA, Genetic Laboratory, University General Hospital Gregorio Marañón, 28007 Madrid, Spain, Molecular Genetics and Clinical Genetics Department, CGC Genetics, 28016 Madrid, Spain, Johns Hopkins University Centre for Health Disparities Solutions, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Copyright: © Pirini et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1699-1709
    |
    Published online on: November 14, 2017
       https://doi.org/10.3892/mmr.2017.8039
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Abstract

Single nucleotide polymorphisms associated with lipid metabolism and energy balance are implicated in the weight loss response caused by nutritional interventions. Diet‑induced weight loss is also associated with differential global DNA methylation. DNA methylation has been proposed as a predictive biomarker for weight loss response. Personalized biomarkers for successful weight loss may inform clinical decisions when deciding between behavioral and surgical weight loss interventions. The aim of the present study was to investigate the association between global DNA methylation, genetic variants associated with energy balance and lipid metabolism, and weight loss following a non‑surgical weight loss regimen. The present study included 105 obese participants that were enrolled in a personalized weight loss program based on their allelic composition of the following five energy balance and lipid metabolism‑associated loci: Near insulin‑induced gene 2 (INSIG2); melanocortin 4 receptor; adrenoceptor β2; apolipoprotein A5; and G‑protein subunit β3. The present study investigated the association between a global DNA methylation index (GDMI), the allelic composition of the five energy balance and lipid metabolism‑associated loci, and weight loss during a 12 month program, after controlling for age, sex and body mass index (BMI). The results demonstrated a significant association between the GDMI and near INSIG2 locus, after adjusting for BMI and weight loss, and significant trends were observed when stratifying by gender. In conclusion, a combination of genetic and epigenetic biomarkers may be used to design personalized weight loss interventions, enabling adherence and ensuring improved outcomes for obesity treatment programs. Precision weight loss programs designed based on molecular information may enable the creation of personalized interventions for patients, that use genomic biomarkers for treatment design and for treatment adherence monitoring, thus improving response to treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Pirini F, Rodriguez‑Torres S, Ayandibu BG, Orera‑Clemente M, Gonzalez‑de la Vega A, Lawson F, Thorpe RJ, Sidransky D and Guerrero‑Preston R: INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program. Mol Med Rep 17: 1699-1709, 2018.
APA
Pirini, F., Rodriguez‑Torres, S., Ayandibu, B.G., Orera‑Clemente, M., Gonzalez‑de la Vega, A., Lawson, F. ... Guerrero‑Preston, R. (2018). INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program. Molecular Medicine Reports, 17, 1699-1709. https://doi.org/10.3892/mmr.2017.8039
MLA
Pirini, F., Rodriguez‑Torres, S., Ayandibu, B. G., Orera‑Clemente, M., Gonzalez‑de la Vega, A., Lawson, F., Thorpe, R. J., Sidransky, D., Guerrero‑Preston, R."INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program". Molecular Medicine Reports 17.1 (2018): 1699-1709.
Chicago
Pirini, F., Rodriguez‑Torres, S., Ayandibu, B. G., Orera‑Clemente, M., Gonzalez‑de la Vega, A., Lawson, F., Thorpe, R. J., Sidransky, D., Guerrero‑Preston, R."INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program". Molecular Medicine Reports 17, no. 1 (2018): 1699-1709. https://doi.org/10.3892/mmr.2017.8039
Copy and paste a formatted citation
x
Spandidos Publications style
Pirini F, Rodriguez‑Torres S, Ayandibu BG, Orera‑Clemente M, Gonzalez‑de la Vega A, Lawson F, Thorpe RJ, Sidransky D and Guerrero‑Preston R: INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program. Mol Med Rep 17: 1699-1709, 2018.
APA
Pirini, F., Rodriguez‑Torres, S., Ayandibu, B.G., Orera‑Clemente, M., Gonzalez‑de la Vega, A., Lawson, F. ... Guerrero‑Preston, R. (2018). INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program. Molecular Medicine Reports, 17, 1699-1709. https://doi.org/10.3892/mmr.2017.8039
MLA
Pirini, F., Rodriguez‑Torres, S., Ayandibu, B. G., Orera‑Clemente, M., Gonzalez‑de la Vega, A., Lawson, F., Thorpe, R. J., Sidransky, D., Guerrero‑Preston, R."INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program". Molecular Medicine Reports 17.1 (2018): 1699-1709.
Chicago
Pirini, F., Rodriguez‑Torres, S., Ayandibu, B. G., Orera‑Clemente, M., Gonzalez‑de la Vega, A., Lawson, F., Thorpe, R. J., Sidransky, D., Guerrero‑Preston, R."INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program". Molecular Medicine Reports 17, no. 1 (2018): 1699-1709. https://doi.org/10.3892/mmr.2017.8039
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