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Article

Fli‑1 promotes metastasis by regulating MMP2 signaling in hepatocellular carcinoma

  • Authors:
    • Huiling Wang
    • Yingliang Ou
    • Jinrui Ou
    • Zhixiang Jian
  • View Affiliations / Copyright

    Affiliations: Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China
  • Pages: 1986-1992
    |
    Published online on: November 14, 2017
       https://doi.org/10.3892/mmr.2017.8047
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Abstract

Friend leukemia virus integration 1 (Fli‑1) is a newly identified ETS protein, and has critical roles in many malignancies. However, the physiological characters and potential mechanisms of Fli‑1 in hepatocellular carcinoma (HCC) progression remains unclear. In the present study, Fli‑1 was highly expressed in HCC samples and tumor cell lines. knockdown of Fli‑1 with small interfering (si)RNAs significantly reduced the colony formation and metastasis capacity of HCC cell lines in vitro. Subsequent investigation identified that Fli‑1 functioned as an oncogene in HCC carcinogenesis and it exerted its promoting metastatic effect primarily by modulating the matrix metalloproteinase (MMP)2 signaling pathway. Collectively, these data provide a novel insight into the mechanism of Fli‑1/MMP2 signaling pathway in the pathogenesis of HCC, and Fli‑1 may serve as a novel therapeutic target for HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Ou Y, Ou J and Jian Z: Fli‑1 promotes metastasis by regulating MMP2 signaling in hepatocellular carcinoma. Mol Med Rep 17: 1986-1992, 2018.
APA
Wang, H., Ou, Y., Ou, J., & Jian, Z. (2018). Fli‑1 promotes metastasis by regulating MMP2 signaling in hepatocellular carcinoma. Molecular Medicine Reports, 17, 1986-1992. https://doi.org/10.3892/mmr.2017.8047
MLA
Wang, H., Ou, Y., Ou, J., Jian, Z."Fli‑1 promotes metastasis by regulating MMP2 signaling in hepatocellular carcinoma". Molecular Medicine Reports 17.1 (2018): 1986-1992.
Chicago
Wang, H., Ou, Y., Ou, J., Jian, Z."Fli‑1 promotes metastasis by regulating MMP2 signaling in hepatocellular carcinoma". Molecular Medicine Reports 17, no. 1 (2018): 1986-1992. https://doi.org/10.3892/mmr.2017.8047
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Ou Y, Ou J and Jian Z: Fli‑1 promotes metastasis by regulating MMP2 signaling in hepatocellular carcinoma. Mol Med Rep 17: 1986-1992, 2018.
APA
Wang, H., Ou, Y., Ou, J., & Jian, Z. (2018). Fli‑1 promotes metastasis by regulating MMP2 signaling in hepatocellular carcinoma. Molecular Medicine Reports, 17, 1986-1992. https://doi.org/10.3892/mmr.2017.8047
MLA
Wang, H., Ou, Y., Ou, J., Jian, Z."Fli‑1 promotes metastasis by regulating MMP2 signaling in hepatocellular carcinoma". Molecular Medicine Reports 17.1 (2018): 1986-1992.
Chicago
Wang, H., Ou, Y., Ou, J., Jian, Z."Fli‑1 promotes metastasis by regulating MMP2 signaling in hepatocellular carcinoma". Molecular Medicine Reports 17, no. 1 (2018): 1986-1992. https://doi.org/10.3892/mmr.2017.8047
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