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Article Open Access

Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage

Corrigendum in: /10.3892/mmr.2025.13673
  • Authors:
    • Jun‑Hui Chen
    • Ting Wu
    • Li‑Kun Yang
    • Lei Chen
    • Jie Zhu
    • Pei‑Pei Li
    • Xu Hu
    • Yu‑Hai Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, l0lst Hospital of PLA, Wuxi, Jiangsu 214044, P.R. China, Department of Cardiology, l0lst Hospital of PLA, Wuxi, Jiangsu 214044, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1651-1659
    |
    Published online on: November 15, 2017
       https://doi.org/10.3892/mmr.2017.8074
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Abstract

The aim of the present study was to assess the therapeutic effects of atorvastatin on cerebral vessel autoregulation and to explore the underlying mechanisms in a rabbit model of subarachnoid hemorrhage (SAH). A total of 48 healthy male New Zealand rabbits (weight, 2‑2.5 kg) were randomly allocated into SAH, Sham or SAH + atorvastatin groups (n=16/group). The Sham group received 20 mg/kg/d saline solution, whereas 20 mg/kg/d atorvastatin was administered to rabbits in the SAH + atorvastatin group following SAH induction. Changes in diameter, perimeter and basilar artery (BA) area were assessed and expression levels of the vasoactive molecules endothelin‑1 (ET‑1), von Willebrand factor (vWF) and thrombomodulin (TM) were measured. Neuronal apoptosis was analyzed 72 h following SAH by terminal deoxynucleotidyl-transferase‑mediated dUTP nick‑end labeling (TUNEL) staining. The mortality rate in the SAH group was 18.75, 25% in the SAH + atorvastatin treated group and 0% in the Sham group (n=16/group). The neurological score in the SAH + atorvastatin group was 1.75±0.68, which was significantly higher compared with the Sham group (0.38±0.49; P<0.05). The BA area in the SAH + atorvastatin group (89.6±9.11) was significantly lower compared with the SAH group (115.4±11.0; P<0.01). The present study demonstrated that SAH induction resulted in a significant increase in the diameter, perimeter and cross‑sectional area of the BA in the SAH + atorvastatin group. Administration of atorvastatin may significantly downregulate the expression levels of ET‑1, vWF and TM (all P<0.01) vs. sham and SAH groups. TUNEL staining demonstrated that neuronal apoptosis was remarkably reduced in the hippocampus of SAH rabbits following treatment with atorvastatin (P<0.05). Atorvastatin treatment may alleviate cerebral vasospasm and mediate structural and functional remodeling of vascular endothelial cells, in addition to promoting anti‑apoptotic signaling. These results provided supporting evidence for the use of atorvastatin as an effective and well‑tolerated treatment for SAH in various clinical settings and may protect the autoregulation of cerebral vessels.
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Copy and paste a formatted citation
Spandidos Publications style
Chen JH, Wu T, Yang LK, Chen L, Zhu J, Li PP, Hu X and Wang YH: Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage Corrigendum in /10.3892/mmr.2025.13673. Mol Med Rep 17: 1651-1659, 2018.
APA
Chen, J., Wu, T., Yang, L., Chen, L., Zhu, J., Li, P. ... Wang, Y. (2018). Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage Corrigendum in /10.3892/mmr.2025.13673. Molecular Medicine Reports, 17, 1651-1659. https://doi.org/10.3892/mmr.2017.8074
MLA
Chen, J., Wu, T., Yang, L., Chen, L., Zhu, J., Li, P., Hu, X., Wang, Y."Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage Corrigendum in /10.3892/mmr.2025.13673". Molecular Medicine Reports 17.1 (2018): 1651-1659.
Chicago
Chen, J., Wu, T., Yang, L., Chen, L., Zhu, J., Li, P., Hu, X., Wang, Y."Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage Corrigendum in /10.3892/mmr.2025.13673". Molecular Medicine Reports 17, no. 1 (2018): 1651-1659. https://doi.org/10.3892/mmr.2017.8074
Copy and paste a formatted citation
x
Spandidos Publications style
Chen JH, Wu T, Yang LK, Chen L, Zhu J, Li PP, Hu X and Wang YH: Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage Corrigendum in /10.3892/mmr.2025.13673. Mol Med Rep 17: 1651-1659, 2018.
APA
Chen, J., Wu, T., Yang, L., Chen, L., Zhu, J., Li, P. ... Wang, Y. (2018). Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage Corrigendum in /10.3892/mmr.2025.13673. Molecular Medicine Reports, 17, 1651-1659. https://doi.org/10.3892/mmr.2017.8074
MLA
Chen, J., Wu, T., Yang, L., Chen, L., Zhu, J., Li, P., Hu, X., Wang, Y."Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage Corrigendum in /10.3892/mmr.2025.13673". Molecular Medicine Reports 17.1 (2018): 1651-1659.
Chicago
Chen, J., Wu, T., Yang, L., Chen, L., Zhu, J., Li, P., Hu, X., Wang, Y."Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage Corrigendum in /10.3892/mmr.2025.13673". Molecular Medicine Reports 17, no. 1 (2018): 1651-1659. https://doi.org/10.3892/mmr.2017.8074
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