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Molecular Medicine Reports
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Article

Long noncoding RNA‑ATB promotes cell proliferation, migration and invasion in gastric cancer

  • Authors:
    • Ying Chen
    • Guoqing Wei
    • Hongwei Xia
    • Qiulin Tang
    • Feng Bi
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Laboratory of Signal Transduction and Molecular Targeted Therapy, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 1940-1946
    |
    Published online on: November 15, 2017
       https://doi.org/10.3892/mmr.2017.8077
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Abstract

Long noncoding RNA (lncRNA)‑activated by transforming growth factor (TGF)-β (lncRNA-ATB) was recognized as an unfavorable prognostic factor in various cancers; however, its regulatory role in gastric cancer (GC) remains elusive. The present study aimed to measure lncRNA‑ATB expression in GC and to explore its involvement in GC progression. lncRNA‑ATB expression levels were measured in 40 pairs of GC tissues and their normal adjacent tissues, as well as in 5 GC cell lines and a normal gastric mucosal cell line by reverse transcription-quantitative polymerase chain reaction. Knockdown experiments were performed to explore the effect of lncRNA‑ATB on the cell proliferation, invasion and migration. The results demonstrated that lncRNA‑ATB expression levels in GC tissues and GC cell lines were significantly higher than in the adjacent normal tissues and normal gastric mucosal cells. Further analysis of the correlation between the clinicopathological features and lncRNA‑ATB expression indicated that higher expression of lncRNA‑ATB was correlated with increased invasion depth, more distant metastasis and advanced tumor‑node‑metastasis stage. In addition, downregulated lncRNA‑ATB expression suppressed cellular proliferation, invasion and migration of GC cells. In conclusion, these data suggested that lncRNA‑ATB may serve as a clinical outcome predictor and potential therapeutic target in GC.
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Copy and paste a formatted citation
Spandidos Publications style
Chen Y, Wei G, Xia H, Tang Q and Bi F: Long noncoding RNA‑ATB promotes cell proliferation, migration and invasion in gastric cancer. Mol Med Rep 17: 1940-1946, 2018.
APA
Chen, Y., Wei, G., Xia, H., Tang, Q., & Bi, F. (2018). Long noncoding RNA‑ATB promotes cell proliferation, migration and invasion in gastric cancer. Molecular Medicine Reports, 17, 1940-1946. https://doi.org/10.3892/mmr.2017.8077
MLA
Chen, Y., Wei, G., Xia, H., Tang, Q., Bi, F."Long noncoding RNA‑ATB promotes cell proliferation, migration and invasion in gastric cancer". Molecular Medicine Reports 17.1 (2018): 1940-1946.
Chicago
Chen, Y., Wei, G., Xia, H., Tang, Q., Bi, F."Long noncoding RNA‑ATB promotes cell proliferation, migration and invasion in gastric cancer". Molecular Medicine Reports 17, no. 1 (2018): 1940-1946. https://doi.org/10.3892/mmr.2017.8077
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Wei G, Xia H, Tang Q and Bi F: Long noncoding RNA‑ATB promotes cell proliferation, migration and invasion in gastric cancer. Mol Med Rep 17: 1940-1946, 2018.
APA
Chen, Y., Wei, G., Xia, H., Tang, Q., & Bi, F. (2018). Long noncoding RNA‑ATB promotes cell proliferation, migration and invasion in gastric cancer. Molecular Medicine Reports, 17, 1940-1946. https://doi.org/10.3892/mmr.2017.8077
MLA
Chen, Y., Wei, G., Xia, H., Tang, Q., Bi, F."Long noncoding RNA‑ATB promotes cell proliferation, migration and invasion in gastric cancer". Molecular Medicine Reports 17.1 (2018): 1940-1946.
Chicago
Chen, Y., Wei, G., Xia, H., Tang, Q., Bi, F."Long noncoding RNA‑ATB promotes cell proliferation, migration and invasion in gastric cancer". Molecular Medicine Reports 17, no. 1 (2018): 1940-1946. https://doi.org/10.3892/mmr.2017.8077
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