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Article

Cytochrome c is important in apoptosis of labial glands in primary Sjogren's syndrome

  • Authors:
    • Yuanyuan Kang
    • Yan Sun
    • Ying Zhang
    • Zhe Wang
  • View Affiliations / Copyright

    Affiliations: Department of Emergency and Oral Medicine, The School of Stomatology, China Medical University and Liaoning Institute of Dental Research and Liaoning Province Key Laboratory of Oral Diseases and Liaoning Province Translational Medicine Research Center of Oral Diseases, Shenyang, Liaoning 110002, P.R. China, Department of Pathology, The Second Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110004, P.R. China
  • Pages: 1993-1997
    |
    Published online on: November 15, 2017
       https://doi.org/10.3892/mmr.2017.8083
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Abstract

The present study aimed to investigate the expression and effect of cytochrome c (Cytc) in patients with primary Sjogren's syndrome (pSS). In total, 35 newly diagnosed pSS patients and 35 healthy subjects were enrolled in the present study. The mRNA expression levels of Cytc were detected using reverse transcription‑polymerase chain reaction and RT‑quantitative PCR. The expression of the Cytc protein in labial salivary glands was detected by immunohistochemistry and was associated with the integral optical density (IOD) of clinical and laboratory variables. In addition, the content of Cytc in the cytoplasm and mitochondria were examined. The mRNA and protein expression levels of Cytc, and the content of Cytc in the cytoplasm of the pSS patients was increased significantly compared with the healthy controls (P<0.05). The content of Cytc in the mitochondria was significantly decreased compared with the healthy controls (P<0.05). The IOD of Cytc protein levels was positively correlated with immunoglobin G (r=0.8142, P<0.05) and erythrocyte sedimentation rate (r=0.7512, P<0.05). Cytc was upregulated in the pSS patients, indicating the potential role of Cytc in the pathogenesis and development of pSS. Further studies may facilitate the development of targeting this molecular pathway for the treatment of pSS.
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Copy and paste a formatted citation
Spandidos Publications style
Kang Y, Sun Y, Zhang Y and Wang Z: Cytochrome c is important in apoptosis of labial glands in primary Sjogren's syndrome. Mol Med Rep 17: 1993-1997, 2018.
APA
Kang, Y., Sun, Y., Zhang, Y., & Wang, Z. (2018). Cytochrome c is important in apoptosis of labial glands in primary Sjogren's syndrome. Molecular Medicine Reports, 17, 1993-1997. https://doi.org/10.3892/mmr.2017.8083
MLA
Kang, Y., Sun, Y., Zhang, Y., Wang, Z."Cytochrome c is important in apoptosis of labial glands in primary Sjogren's syndrome". Molecular Medicine Reports 17.1 (2018): 1993-1997.
Chicago
Kang, Y., Sun, Y., Zhang, Y., Wang, Z."Cytochrome c is important in apoptosis of labial glands in primary Sjogren's syndrome". Molecular Medicine Reports 17, no. 1 (2018): 1993-1997. https://doi.org/10.3892/mmr.2017.8083
Copy and paste a formatted citation
x
Spandidos Publications style
Kang Y, Sun Y, Zhang Y and Wang Z: Cytochrome c is important in apoptosis of labial glands in primary Sjogren's syndrome. Mol Med Rep 17: 1993-1997, 2018.
APA
Kang, Y., Sun, Y., Zhang, Y., & Wang, Z. (2018). Cytochrome c is important in apoptosis of labial glands in primary Sjogren's syndrome. Molecular Medicine Reports, 17, 1993-1997. https://doi.org/10.3892/mmr.2017.8083
MLA
Kang, Y., Sun, Y., Zhang, Y., Wang, Z."Cytochrome c is important in apoptosis of labial glands in primary Sjogren's syndrome". Molecular Medicine Reports 17.1 (2018): 1993-1997.
Chicago
Kang, Y., Sun, Y., Zhang, Y., Wang, Z."Cytochrome c is important in apoptosis of labial glands in primary Sjogren's syndrome". Molecular Medicine Reports 17, no. 1 (2018): 1993-1997. https://doi.org/10.3892/mmr.2017.8083
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