|
1
|
Loeser RF, Goldring SR, Scanzello CR and
Goldring MB: Osteoarthritis: A disease of the joint as an organ.
Arthritis Rheum. 64:1697–1707. 2012. View Article : Google Scholar :
|
|
2
|
Loeser RF: Age-related changes in the
musculoskeletal system and the development of osteoarthritis. Clin
Geriat Med. 26:371–386. 2010. View Article : Google Scholar
|
|
3
|
Wang TY and Chen D: Differential roles of
TGF-β signalling in joint tissues during osteoarthritis
development. Ann Rheum Dis. 75:e722016. View Article : Google Scholar :
|
|
4
|
Davidson Blaney EN, van der Kraan PM and
van den Berg WB: TGF-beta and osteoarthritis. Osteoarthritis
Cartilage. 15:597–604. 2007. View Article : Google Scholar
|
|
5
|
Martel-Pelletier J, Wildi LM and Pelletier
JP: Future therapeutics for osteoarthritis. Bone. 51:297–311. 2012.
View Article : Google Scholar
|
|
6
|
de Caestecker M: The transforming growth
factor-β superfamily of receptors. Cytokine Growth Factor Rev.
15:1–11. 2004. View Article : Google Scholar
|
|
7
|
Lawrence DA: Latent-TGF-beta: An overview.
Mol Cell Biochem. 219:163–170. 2001. View Article : Google Scholar
|
|
8
|
Davidson Blaney EN, van Caam AP, Vitters
EL, Bennink MB, Thijssen E, van den Berg WB, Koenders MI, van Lent
PL, van de Loo FA and van der Kraan PM: TGF-β is a potent inducer
of nerve growth factor in articular cartilage via the ALK5-Smad2/3
pathway. Potential role in OA related pain? Osteoarthritis
Cartilage. 23:478–486. 2015. View Article : Google Scholar
|
|
9
|
Kamiya M, Harada A, Mizuno M, Iwata H and
Yamada Y: Association between a polymorphism of the transforming
growth factor-beta1 gene and genetic susceptibility to ossification
of the posterior longitudinal ligament in Japanese patients. Spine.
26:1264–1266. 2001. View Article : Google Scholar
|
|
10
|
Lau HH, Ho AY, Luk KD and Kung AW:
Transforming growth factor-beta1 gene polymorphisms and bone
turnover, bone mineral density and fracture risk in southern
Chinese women. Calcif Tissue Int. 74:516–521. 2004. View Article : Google Scholar
|
|
11
|
Yamada Y: Association of a Leu(10)->Pro
polymorphism of the transforming growth factor-beta1 with genetic
susceptibility to osteoporosis and spinal osteoarthritis. Mech
Geing Dev. 116:113–123. 2000. View Article : Google Scholar
|
|
12
|
Davidson Blaney EN, Remst DF, Vitters EL,
van Beuningen HM, Blom AB, Goumans MJ, van den Berg WB and van der
Kraan PM: Increase in ALK1/ALK5 ratio as a cause for elevated
MMP-13 expression in osteoarthritis in humans and mice. J Immunol.
182:7937–7945. 2009. View Article : Google Scholar
|
|
13
|
Das R, Timur UT, Edip S, Haak E, Wruck C,
Weinans H and Jahr H: TGF-β2 is involved in the preservation of the
chondrocyte phenotype under hypoxic conditions. Ann Anat. 198:1–10.
2015. View Article : Google Scholar
|
|
14
|
Saharinen J and Keski-Oja J: Specific
sequence motif of 8-Cys repeats of TGF-beta binding proteins,
LTBPs, creates a hydrophobic interaction surface for binding of
small latent TGF-beta. Mol Biol Cell. 11:2691–2704. 2000.
View Article : Google Scholar :
|
|
15
|
Rifkin DB: Latent transforming growth
factor-beta (TGF-beta) binding proteins: Orchestrators of TGF-beta
availability. J Biol Chem. 280:7409–7412. 2005. View Article : Google Scholar
|
|
16
|
Annes JP, Munger JS and Rifkin DB: Making
sense of latent TGFbeta activation. J cell Sci. 116:217–224. 2003.
View Article : Google Scholar
|
|
17
|
Ge G and Greenspan DS: BMP1 controls
TGFbeta1 activation via cleavage of latent TGFbeta-binding protein.
J Cell Biol. 175:111–120. 2006. View Article : Google Scholar :
|
|
18
|
Tatti O, Vehvilainen P, Lehti K and
Keski-Oja J: MT1-MMP releases latent TGF-beta1 from endothelial
cell extracellular matrix via proteolytic processing of LTBP-1. Exp
Cell Res. 314:2501–2514. 2008. View Article : Google Scholar
|
|
19
|
Schmierer B and Hill CS: TGFbeta-SMAD
signal transduction: Molecular specificity and functional
flexibility. Nat Rev Mol Cell Biol. 8:970–982. 2007. View Article : Google Scholar
|
|
20
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
21
|
Peng HZ, Yun Z, Wang W and Ma Ba: Dual
specificity phosphatase 1 has a protective role in osteoarthritis
fibroblast-like synoviocytes via inhibition of the MAPK signaling
pathway. Mol Med Rep. 2017. View Article : Google Scholar
|
|
22
|
Vinatier C, Merceron C and Guicheux J:
Osteoarthritis: from pathogenic mechanisms and recent clinical
developments to novel prospective therapeutic options. Drug Discov
Today. 21:1932–1937. 2016. View Article : Google Scholar
|
|
23
|
Punzi L, Oliviero F and Ramonda R:
Transforming growth factor-beta levels in synovial fluid of
osteoarthritis with or without calcium pyrophosphate dihydrate
crystals. J Rheumatol. 30:4202003.
|
|
24
|
van Beuningen HM, van der Kraan PM, Arntz
OJ and van den Berg WB: Transforming growth factor-beta 1
stimulates articular chondrocyte proteoglycan synthesis and induces
osteophyte formation in the murine knee joint. Lab Invest.
71:279–290. 1994.
|
|
25
|
Frenkel SR, Saadeh PB, Mehrara BJ, Chin
GS, Steinbrech DS, Brent B, Gittes GK and Longaker MT: Transforming
growth factor beta superfamily members: Role in cartilage modeling.
Plastic Reconstr Surg. 105:980–990. 2000. View Article : Google Scholar
|
|
26
|
Yang X, Chen L, Xu X, Li C, Huang C and
Deng CX: TGF-beta/Smad3 signals repress chondrocyte hypertrophic
differentiation and are required for maintaining articular
cartilage. J Cell Biol. 153:35–46. 2001. View Article : Google Scholar :
|
|
27
|
Davidson Blaney EN, Vitters EL, van den
Berg WB and van der Kraan PM: TGF beta-induced cartilage repair is
maintained but fibrosis is blocked in the presence of Smad7.
Arthritis Res Ther. 8:R652006. View
Article : Google Scholar :
|
|
28
|
Grimaud E, Heymann D and Rédini F: Recent
advances in TGF-beta effects on chondrocyte metabolism. Potential
therapeutic roles of TGF-beta in cartilage disorders. Cytokine
Growth Factor Rev. 13:241–257. 2002. View Article : Google Scholar
|
|
29
|
Scharstuhl A, Glansbeek HL, van Beuningen
HM, Vitters EL, van der Kraan PM and van den Berg WB: Inhibition of
endogenous TGF-beta during experimental osteoarthritis prevents
osteophyte formation and impairs cartilage repair. J Immunol.
169:507–514. 2002. View Article : Google Scholar
|
|
30
|
van Beuningen HM, Glansbeek HL, van der
Kraan PM and van den Berg WB: Differential effects of local
application of BMP-2 or TGF-beta 1 on both articular cartilage
composition and osteophyte formation. Osteoarthritis Cartilage.
6:306–317. 1998. View Article : Google Scholar
|
|
31
|
Oh SP, Seki T, Goss KA, Imamura T, Yi Y,
Donahoe PK, Li L, Miyazono K, ten Dijke P, Kim S and Li E: Activin
receptor-like kinase 1 modulates transforming growth factor-beta 1
signaling in the regulation of angiogenesis. Proc Natl Acad Sci
USA. 97:2626–2631. 2000. View Article : Google Scholar :
|
|
32
|
Goumans MJ, Valdimarsdottir G, Itoh S,
Rosendahl A, Sideras P and ten Dijke P: Balancing the activation
state of the endothelium via two distinct TGF-beta type I
receptors. EMBO J. 21:1743–1753. 2002. View Article : Google Scholar :
|
|
33
|
Davidson Blaney EN, Scharstuhl A, Vitters
EL, van der Kraan PM and van den Berg WB: Reduced transforming
growth factor-beta signaling in cartilage of old mice: Role in
impaired repair capacity. Arthritis Res Ther. 7:R1338–R1347. 2005.
View Article : Google Scholar :
|
|
34
|
Davidson Blaney EN, Vitters EL, van der
Kraan PM and van den Berg WB: Expression of transforming growth
factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P
in spontaneous and instability-induced osteoarthritis: Role in
cartilage degradation, chondrogenesis and osteophyte formation. Ann
Rheum Dis. 65:1414–1421. 2006. View Article : Google Scholar :
|
|
35
|
Taipale J, Saharinen J and Keski-Oja J:
Extracellular matrix-associated transforming growth factor-beta:
Role in cancer cell growth and invasion. Adv Cancer Res. 75:87–134.
1998. View Article : Google Scholar
|
|
36
|
Annes JP, Chen Y, Munger JS and Rifkin DB:
Integrin alphaVbeta6-mediated activation of latent TGF-beta
requires the latent TGF-beta binding protein-1. J Cell Biol.
165:723–734. 2004. View Article : Google Scholar :
|
|
37
|
Koli K, Saharinen J, Hyytiäinen M,
Penttinen C and Keski-Oja J: Latency, activation and binding
proteins of TGF-beta. Microsc Res Tech. 52:354–362. 2001.
View Article : Google Scholar
|
|
38
|
Solovyan VT and Keski-Oja J: Apoptosis of
human endothelial cells is accompanied by proteolytic processing of
latent TGF-beta binding proteins and activation of TGF-beta. Cell
Death Differ. 12:815–826. 2005. View Article : Google Scholar
|
|
39
|
Leitlein J, Aulwurm S, Waltereit R,
Naumann U, Wagenknecht B, Garten W, Weller M and Platten M:
Processing of immunosuppressive pro-TGF-beta 1, 2 by human
glioblastoma cells involves cytoplasmic and secreted furin-like
proteases. J Immunol. 166:7238–7243. 2001. View Article : Google Scholar
|
|
40
|
Olofsson A, Miyazono K, Kanzaki T,
Colosetti P, Engström U and Heldin CH: Transforming growth
factor-beta 1, -beta 2 and -beta 3 secreted by a human glioblastoma
cell line. Identification of small and different forms of large
latent complexes. J Biol Chem. 267:19482–19488. 1992.
|
|
41
|
Scharstuhl A, Vitters EL, van der Kraan PM
and van den Berg WB: Reduction of osteophyte formation and synovial
thickening by adenoviral overexpression of transforming growth
factor beta/bone morphogenetic protein inhibitors during
experimental osteoarthritis. Arthritis Rheum. 48:3442–3451. 2003.
View Article : Google Scholar
|
