Open Access

Role of the CRISPR system in controlling gene transcription and monitoring cell fate (Review)

  • Authors:
    • Stella Baliou
    • Maria Adamaki
    • Anthony M. Kyriakopoulos
    • Demetrios A. Spandidos
    • Michalis Panayiotidis
    • Ioannis Christodoulou
    • Vassilis Zoumpourlis
  • View Affiliations

  • Published online on: November 16, 2017     https://doi.org/10.3892/mmr.2017.8099
  • Pages: 1421-1427
  • Copyright: © Baliou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Even though the accrual of transcripts is implicated in distinct disease states, our knowledge regarding their functional role remains obscure. The CRISPR system has surged at the forefront of genome engineering tools in the field of RNA modulation. In the present review, we discuss some exciting applications of the CRISPR system, including the manipulation of RNA sequences, the visualization of chromosomal loci in living cells and the modulation of transcription. The CRISPR system has been documented to be very reliable and specific in altering gene expression, via leveraging inactive catalytically dead CRISPR-associated protein 9 (Cas9). In the present review, the CRISPR system is presented as an eminent tool for the meticulous analysis of gene regulation, loci mapping and complex pathways.
View Figures
View References

Related Articles

Journal Cover

January-2018
Volume 17 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Baliou S, Adamaki M, Kyriakopoulos AM, Spandidos DA, Panayiotidis M, Christodoulou I and Zoumpourlis V: Role of the CRISPR system in controlling gene transcription and monitoring cell fate (Review). Mol Med Rep 17: 1421-1427, 2018
APA
Baliou, S., Adamaki, M., Kyriakopoulos, A.M., Spandidos, D.A., Panayiotidis, M., Christodoulou, I., & Zoumpourlis, V. (2018). Role of the CRISPR system in controlling gene transcription and monitoring cell fate (Review). Molecular Medicine Reports, 17, 1421-1427. https://doi.org/10.3892/mmr.2017.8099
MLA
Baliou, S., Adamaki, M., Kyriakopoulos, A. M., Spandidos, D. A., Panayiotidis, M., Christodoulou, I., Zoumpourlis, V."Role of the CRISPR system in controlling gene transcription and monitoring cell fate (Review)". Molecular Medicine Reports 17.1 (2018): 1421-1427.
Chicago
Baliou, S., Adamaki, M., Kyriakopoulos, A. M., Spandidos, D. A., Panayiotidis, M., Christodoulou, I., Zoumpourlis, V."Role of the CRISPR system in controlling gene transcription and monitoring cell fate (Review)". Molecular Medicine Reports 17, no. 1 (2018): 1421-1427. https://doi.org/10.3892/mmr.2017.8099