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Article

Therapeutic effect of adipose‑derived stem cell transplantation on optic nerve injury in rats

  • Authors:
    • Xu Li
    • Shanyao Zhao
    • Liangjun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Yantai Infectious Diseases Hospital, Yantai, Shandong 264000, P.R. China, Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China, Department of Ophthalmology, Yantaishan Hospital, Yantai, Shandong 264000, P.R. China
  • Pages: 2529-2534
    |
    Published online on: November 20, 2017
       https://doi.org/10.3892/mmr.2017.8103
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Abstract

Adipose-derived stem cells (ADSCs) are mesenchymal stem cells in adipose tissue. ADSCs may differentiate into cells and tissues of different embryonic germ layers under specific inducing conditions. Previous studies have demonstrated that Schwann cells transformed from ADSCs can express nerve growth factors, generate nerve fibers and promote axonal regeneration in models of peripheral nerve injury. Stem cell transplantation is one of the potential techniques for the treatment of retinal ganglion cell injury. The present study developed an optic nerve crush injury rat model to investigate the therapeutic effect of fat stem cell transplantation on optic nerve injured rats. Retinal morphological changes were observed on day 3, 7, 14, 21 and 28 following optic nerve injury. It was determined that the number of retinal ganglion cells (RGCs) decreased with time following optic nerve injury; however, the number of RGCs in the stem cell transplantation group was higher compared with the buffer control group. The results of reverse transcription-quantitative polymerase chain reaction also demonstrated that the growth associated protein 43 mRNA expression level of the stem cell transplantation group was higher compared with the buffer control group. Apoptosis tests demonstrated that the stem cell transplantation group was able to resist the apoptosis of retinal cells. The present study demonstrated that in vivo transplantation of ADSCs can improve the survival rate of RGCs in rats with optic nerve injury and to resist the apoptosis of retinal cells.
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1 

Johnson TV and Martin KR: Cell transplantation approaches to retinal ganglion cell neuroprotection in glaucoma. Curr Opin Pharmacol. 13:78–82. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Meyer-Rüsenberg B, Pavlidis M, Stupp T and Thanos S: Pathological changes in human retinal ganglion cells associated with diabetic and hypertensive retinopathy. Graefes Arch Clin Exp Ophthalmol. 245:1009–1018. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Guy WM, Soparkar CN, Alford EL, Patrinely JR, Sami MS and Parke RB: Traumatic optic neuropathy and second optic nerve injuries. JAMA Ophthalmol. 132:567–571. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Berry M, Ahmed Z, Lorber B, Douglas M and Logan A: Regeneration of axons in the visual system. Restor Neurol Neurosci. 26:147–174. 2008.PubMed/NCBI

5 

Levkovitch-Verbin H, Sadan O, Vander S, Rosner M, Barhum Y, Melamed E, Offen D and Melamed S: Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection. Invest Ophthalmol Vis Sci. 51:6394–6400. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Johnson TV, Bull ND, Hunt DP, Marina N, Tomarev SI and Martin KR: Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma. Invest Ophthalmol Vis Sci. 51:2051–2059. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Mead B, Berry M, Logan A, Scott RA, Leadbeater W and Scheven BA: Stem cell treatment of degenerative eye disease. Stem Cell Res. 14:243–257. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Lim S, Cho H, Lee E, Won Y, Kim C, Ahn W, Lee E and Son Y: Osteogenic stimulation of human adipose-derived stem cells by pre-treatment with fibroblast growth factor 2. Cell Tissue Res. 364:137–147. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Gwak SJ, Bhang SH, Yang HS, Kim SS, Lee DH, Lee SH and Kim BS: In vitro cardiomyogenic differentiation of adipose-derived stromal cells using transforming growth factor-beta1. Cell Biochem Funct. 27:148–154. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Mohammadi-Sangcheshmeh A, Shafiee A, Seyedjafari E, Dinarvand P, Toghdory A, Bagherizadeh I, Schellander K, Cinar MU and Soleimani M: Isolation, characterization, and mesodermic differentiation of stem cells from adipose tissue of camel. In Vitro Cell Dev Biol Anim. 49:147–154. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Murphy MB, Moncivais K and Caplan AI: Mesenchymal stem cells: Environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 45:e542013. View Article : Google Scholar : PubMed/NCBI

12 

Kang JW, Kang KS, Koo HC, Park JR, Choi EW and Park YH: Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells. Stem Cells Dev. 17:681–693. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP and Hedrick MH: Multilineage cells from human adipose tissue: Implications for cell-based therapies. Tissue Eng. 7:211–228. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Kingham PJ, Kalbermatten DF, Mahay D, Armstronga SJ, Wibergb M and Terenghia G: Adipose-derived stem cells differentiate into a Schwann cell phenotype and promote neurite outgrowth in vitro. Exp Neurol. 207:267–274. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Xu Y, Liu L, Li Y, Zhou C, Xiong F, Liu Z, Gu R, Hou X and Zhang C: Myelin-forming ability of Schwann cell-like cells induced from rat adipose-derived stem cells in vitro. Brain Res. 1239:49–55. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Chi GF, Kim MR, Kim DW, Jiang MH and Son Y: Schwann cells differentiated from spheroid-forming cells of rat subcutaneous fat tissue myelinate axons in the spinal cord injury. Exp Neurol. 222:304–317. 2010. View Article : Google Scholar : PubMed/NCBI

17 

di Summa PG, Kalbermatten DF, Pralong E, Raffoula W, Kinghamb PJ and Terenghi G: Long-term in vivo regeneration of peripheral nerves through bioengineered nerve grafts. Neuroscience. 181:278–291. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

De Ugarte DA, Morizono K, Elbarbary A, Alfonso Z, Zuk PA, Zhu M, Dragoo JL, Ashjian P, Thomas B, Benhaim P, et al: Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs. 174:101–109. 2003. View Article : Google Scholar : PubMed/NCBI

20 

LetoBarone AA, Khalifian S, Lee WP and Brandacher G: Immunomodulatory effects of adipose-derived stem cells: Fact or fiction? Biomed Res Int 2013. 3836852013.

21 

Arnalich-Montiel F, Pastor S, Blazquez-Martinez A, Fernandez-Delgado J, Nistal M, Alio JL and De Miguel MP: Adipose-derived stem cells are a source for cell therapy of the corneal stroma. Stem Cells. 26:570–579. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Mead B, Logan A, Berry M, Leadbeater W and Scheven BA: Intravitreally transplanted dental pulp stem cells promote neuroprotection and axon regeneration of retinal ganglion cells after optic nerve injury. Invest Ophthalmol Vis Sci 2013. 54:7544–7556. 2013.

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Zhao S and Wang L: Therapeutic effect of adipose‑derived stem cell transplantation on optic nerve injury in rats. Mol Med Rep 17: 2529-2534, 2018.
APA
Li, X., Zhao, S., & Wang, L. (2018). Therapeutic effect of adipose‑derived stem cell transplantation on optic nerve injury in rats. Molecular Medicine Reports, 17, 2529-2534. https://doi.org/10.3892/mmr.2017.8103
MLA
Li, X., Zhao, S., Wang, L."Therapeutic effect of adipose‑derived stem cell transplantation on optic nerve injury in rats". Molecular Medicine Reports 17.2 (2018): 2529-2534.
Chicago
Li, X., Zhao, S., Wang, L."Therapeutic effect of adipose‑derived stem cell transplantation on optic nerve injury in rats". Molecular Medicine Reports 17, no. 2 (2018): 2529-2534. https://doi.org/10.3892/mmr.2017.8103
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Zhao S and Wang L: Therapeutic effect of adipose‑derived stem cell transplantation on optic nerve injury in rats. Mol Med Rep 17: 2529-2534, 2018.
APA
Li, X., Zhao, S., & Wang, L. (2018). Therapeutic effect of adipose‑derived stem cell transplantation on optic nerve injury in rats. Molecular Medicine Reports, 17, 2529-2534. https://doi.org/10.3892/mmr.2017.8103
MLA
Li, X., Zhao, S., Wang, L."Therapeutic effect of adipose‑derived stem cell transplantation on optic nerve injury in rats". Molecular Medicine Reports 17.2 (2018): 2529-2534.
Chicago
Li, X., Zhao, S., Wang, L."Therapeutic effect of adipose‑derived stem cell transplantation on optic nerve injury in rats". Molecular Medicine Reports 17, no. 2 (2018): 2529-2534. https://doi.org/10.3892/mmr.2017.8103
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