Upregulation of ZBTB7A exhibits a tumor suppressive role in gastric cancer cells

  • Authors:
    • Guang Sun
    • Bo Peng
    • Quan Xie
    • Jianwen Ruan
    • Xianwen Liang
  • View Affiliations

  • Published online on: November 20, 2017     https://doi.org/10.3892/mmr.2017.8104
  • Pages: 2635-2641
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Abstract

Gastric cancer presents as a complex solid tumor and is the third leading cause of global cancer‑associated mortality. The genetic alterations in gastric cancer remain unclear and deserve further investigation. Mining The Cancer Genome Atlas gastric adenocarcinoma dataset identified a frequent loss of the zinc finger and BTB domain containing 7A (ZBTB7A) gene locus and a significant correlation between low ZBTB7A expression and poor patient survival. ZBTB7A belongs to the POZ/BTB and Kruppel transcription factor family. In the present study, overexpression of ZBTB7A in a gastric cancer cell line induced cell cycle arrest at the S phase. Upregulation of ZBTB7A also promoted apoptosis and repressed cell migration. The results of the present study indicated that ZBTB7A functions as a tumor suppressor in gastric cancer cells. Understanding the role of ZBTB7A in gastric cancer may provide important clinical insight for treatment.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Sun G, Peng B, Xie Q, Ruan J and Liang X: Upregulation of ZBTB7A exhibits a tumor suppressive role in gastric cancer cells. Mol Med Rep 17: 2635-2641, 2018
APA
Sun, G., Peng, B., Xie, Q., Ruan, J., & Liang, X. (2018). Upregulation of ZBTB7A exhibits a tumor suppressive role in gastric cancer cells. Molecular Medicine Reports, 17, 2635-2641. https://doi.org/10.3892/mmr.2017.8104
MLA
Sun, G., Peng, B., Xie, Q., Ruan, J., Liang, X."Upregulation of ZBTB7A exhibits a tumor suppressive role in gastric cancer cells". Molecular Medicine Reports 17.2 (2018): 2635-2641.
Chicago
Sun, G., Peng, B., Xie, Q., Ruan, J., Liang, X."Upregulation of ZBTB7A exhibits a tumor suppressive role in gastric cancer cells". Molecular Medicine Reports 17, no. 2 (2018): 2635-2641. https://doi.org/10.3892/mmr.2017.8104