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Article Open Access

KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease

  • Authors:
    • Sen Wang
    • Yong Hou
    • Weiping Chen
    • Jianmin Wang
    • Weihua Xie
    • Xiaoping Zhang
    • Li Zeng
  • View Affiliations / Copyright

    Affiliations: The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, Department of Surgery, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230031, P.R. China, The College of Basic Science, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, Graduate Department, Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230012, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2195-2202
    |
    Published online on: November 20, 2017
       https://doi.org/10.3892/mmr.2017.8118
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Abstract

Long non‑coding RNAs (lncRNAs) are a novel group of non‑coding RNAs that are associated with inflammation and tumorigenesis. At present, the diagnostic efficacy of lncRNAs in inflammatory bowel disease (IBD) is unclear. The present study aimed to identify lncRNAs that may be used as potential biomarkers for IBD. The mRNA expression levels of various lncRNAs (KIF9‑AS1, LINC01272 and DIO3OS) were detected in tissue and plasma samples from patients with IBD by reverse transcription‑quantitative polymerase chain reaction. The results indicated that the mRNA expression levels of KIF9‑AS1 and LINC01272 were significantly upregulated in tissue and plasma samples from patients with IBD compared with in the healthy controls; conversely, the mRNA expression levels of DIO3OS were significantly downregulated in tissue and plasma samples from patients with IBD compared with in the healthy controls. Subsequently, the specificity and sensitivity of KIF9‑AS1, LINC01272 and DIO3OS were determined using a receiver operating characteristic (ROC) curve analysis. The results indicated that KIF9‑AS1, LINC01272 and DIO3OS had potential diagnostic value for the detection of IBD. Furthermore, there were significantly positive correlations in KIF9‑AS1, LINC01272 and DIO3OS expression between IBD tissue and plasma samples. Therefore, the present study indicated that KIF9‑AS1, LINC01272 and DIO3OS may be potential diagnostic biomarkers for IBD.
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View References

1 

Xavier RJ and Podolsky DK: Unravelling the pathogenesis of inflammatory bowel disease. Nature. 448:427–434. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Morrison G, Headon B and Gibson P: Update in inflammatory bowel disease. Aust Fam Physician. 38:956–961. 2009.PubMed/NCBI

3 

Uslu N, Usta Y, Balamtekin N, Demir H, Saltik-Temizel IN and Yüce A: Inflammatory bowel disease in infancy. Indian J Gastroenterol. 28:224–225. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Van Limbergen J, Radford-Smith G and Satsangi J: Advances in IBD genetics. Nat Rev Gastroenterol Hepatol. 11:372–385. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Sartor RB: Genetics and environmental interactions shape the intestinal microbiome to promote inflammatory bowel disease versus mucosal homeostasis. Gastroenterology. 139:1816–1819. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Abraham C and Cho JH: Inflammatory bowel disease. N Engl J Med. 361:2066–2078. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Hanauer SB, Robinson M, Pruitt R, Lazenby AJ, Persson T, Nilsson LG, Walton-Bowen K, Haskell LP and Levine JG: Budesonide enema for the treatment of active, distal ulcerative colitis and proctitis: A dose-ranging study. U.S. Budesonide enema study group. Gastroenterology. 115:525–532. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Avitabile C, Cimmino A and Romanelli A: Oligonucleotide analogues as modulators of the expression and function of noncoding RNAs (ncRNAs): Emerging therapeutics applications. J Med Chem. 57:10220–10240. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Bayoumi AS, Sayed A, Broskova Z, Teoh JP, Wilson J, Su H, Tang YL and Kim IM: Crosstalk between Long Noncoding RNAs and MicroRNAs in Health and Disease. Int J Mol Sci. 17:3562016. View Article : Google Scholar : PubMed/NCBI

10 

Wang Y, Chen L, Chen B, Li X, Kang J, Fan K, Hu Y, Xu J, Yi L, Yang J, et al: Mammalian ncRNA-disease repository: A global view of ncRNA-mediated disease network. Cell Death Dis. 4:e7652013. View Article : Google Scholar : PubMed/NCBI

11 

Xie N and Liu G: ncRNA-regulated immune response and its role in inflammatory lung diseases. Am J Physiol Lung Cell Mol Physiol. 309:L1076–L1087. 2015.PubMed/NCBI

12 

Hayes EL and Lewis-Wambi JS: Mechanisms of endocrine resistance in breast cancer: An overview of the proposed roles of noncoding RNA. Breast Cancer Res. 17:402015. View Article : Google Scholar : PubMed/NCBI

13 

Guttman M and Rinn JL: Modular regulatory principles of large non-coding RNAs. Nature. 482:339–346. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Khalil AM, Guttman M, Huarte M, Garber M, Raj A, Rivea Morales D, Thomas K, Presser A, Bernstein BE, van Oudenaarden A, et al: Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci USA. 106:pp. 11667–11672. 2009; View Article : Google Scholar : PubMed/NCBI

15 

Mirza AH, Berthelsen CH, Seemann SE, Pan X, Frederiksen KS, Vilien M, Gorodkin J and Pociot F: Transcriptomic landscape of lncRNAs in inflammatory bowel disease. Genome Med. 7:392015. View Article : Google Scholar : PubMed/NCBI

16 

Zacharopoulou E, Gazouli M, Tzouvala M, Vezakis A and Karamanolis G: The contribution of long non-coding RNAs in Inflammatory Bowel Diseases. Dig Liver Dis. 49:1067–1072. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Jakobsen C, Bartek J Jr, Wewer V, Vind I, Munkholm P, Groen R and Paerregaard A: Differences in phenotype and disease course in adult and paediatric inflammatory bowel disease-a population-based study. Aliment Pharmacol Ther. 34:1217–1224. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Peyrin-Biroulet L, Cieza A, Sandborn WJ, Coenen M, Chowers Y, Hibi T, Kostanjsek N, Stucki G and Colombel JF; International Programme to Develop New Indexes for Crohn's Disease (IPNIC) group, : Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health. Gut. 61:241–247. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Jiang L, Lai YK, Zhang J, Wang H, Lin MC, He ML and Kung HF: Targeting S100P inhibits colon cancer growth and metastasis by Lentivirus-mediated RNA interference and proteomic analysis. Mol Med. 17:709–716. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Bierhoff H, Schmitz K, Maass F, Ye J and Grummt I: Noncoding transcripts in sense and antisense orientation regulate the epigenetic state of ribosomal RNA genes. In: Cold Spring Harbor symposia on quantitative biology. Cold Spring Harb Symp Quant Biol. 2010:357–364. 2011.

22 

Qiu MT, Hu JW, Yin R and Xu L: Long noncoding RNA: An emerging paradigm of cancer research. Tumor Biol. 34:613–620. 2013. View Article : Google Scholar

23 

Eades G, Zhang YS, Li QL, Xia JX, Yao Y and Zhou Q: Long non-coding RNAs in stem cells and cancer. World J Clin Oncol. 5:134–141. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Wang KC and Chang HY: Molecular mechanisms of long noncoding RNAs. Mol Cell. 43:904–914. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Nagano T and Fraser P: No-nonsense functions for long noncoding RNAs. Cell. 145:178–181. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Mercer TR, Dinger ME and Mattick JS: Long non-coding RNAs: Insights into functions. Nat Rev Genet. 10:155–159. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, et al: Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Nat Genet. 42:1113–1117. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Liu X, Li D, Zhang W, Guo M and Zhan Q: Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay. EMBO J. 31:4415–4427. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Lakhotia SC: Long non-coding RNAs coordinate cellular responses to stress. Wiley Interdiscip Rev. 3:779–796. 2012. View Article : Google Scholar

30 

Paralkar VR and Weiss MJ: A new ‘Linc’ between noncoding RNAs and blood development. Genes Dev. 25:2555–2558. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Marques-Rocha JL, Samblas M, Milagro FI, Bressan J, Martinez JA and Marti A: Noncoding RNAs, cytokines, and inflammation-related diseases. FASEB J. 29:3595–3611. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Ilott NE, Heward JA, Roux B, Tsitsiou E, Fenwick PS, Lenzi L, Goodhead I, Hertz-Fowler C, Heger A, Hall N, et al: Corrigendum: Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes. Nat Commun. 6:68142015. View Article : Google Scholar : PubMed/NCBI

33 

IIott NE, Heward JA, Roux B, Tsitsiou E, Fenwick PS, Lenzi L, Goodhead I, Hertz-Fowler C, Heger A, Hall N, et al: Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes. Nat Commun. 5:39792014. View Article : Google Scholar : PubMed/NCBI

34 

Zhou Q, Chung AC, Huang XR, Dong Y, Yu X and Lan HY: Identification of novel long noncoding RNAs associated with TGF-β/Smad3-mediated renal inflammation and fibrosis by RNA sequencing. Am J Pathol. 184:409–417. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Qiao YQ, Huang ML, Xu AT, Zhao D, Ran ZH and Shen J: LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn's disease. J Biomed Sci. 20:872013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang S, Hou Y, Chen W, Wang J, Xie W, Zhang X and Zeng L: KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease. Mol Med Rep 17: 2195-2202, 2018.
APA
Wang, S., Hou, Y., Chen, W., Wang, J., Xie, W., Zhang, X., & Zeng, L. (2018). KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease. Molecular Medicine Reports, 17, 2195-2202. https://doi.org/10.3892/mmr.2017.8118
MLA
Wang, S., Hou, Y., Chen, W., Wang, J., Xie, W., Zhang, X., Zeng, L."KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease". Molecular Medicine Reports 17.2 (2018): 2195-2202.
Chicago
Wang, S., Hou, Y., Chen, W., Wang, J., Xie, W., Zhang, X., Zeng, L."KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease". Molecular Medicine Reports 17, no. 2 (2018): 2195-2202. https://doi.org/10.3892/mmr.2017.8118
Copy and paste a formatted citation
x
Spandidos Publications style
Wang S, Hou Y, Chen W, Wang J, Xie W, Zhang X and Zeng L: KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease. Mol Med Rep 17: 2195-2202, 2018.
APA
Wang, S., Hou, Y., Chen, W., Wang, J., Xie, W., Zhang, X., & Zeng, L. (2018). KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease. Molecular Medicine Reports, 17, 2195-2202. https://doi.org/10.3892/mmr.2017.8118
MLA
Wang, S., Hou, Y., Chen, W., Wang, J., Xie, W., Zhang, X., Zeng, L."KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease". Molecular Medicine Reports 17.2 (2018): 2195-2202.
Chicago
Wang, S., Hou, Y., Chen, W., Wang, J., Xie, W., Zhang, X., Zeng, L."KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease". Molecular Medicine Reports 17, no. 2 (2018): 2195-2202. https://doi.org/10.3892/mmr.2017.8118
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