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Article

The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway

  • Authors:
    • Xueqiang Zhu
    • Hui Huang
    • Jun Zhang
    • Hao Liu
    • Rui Ao
    • Ming Xiao
    • Yuelei Wu
  • View Affiliations / Copyright

    Affiliations: Center of Oncology, Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China, Department of Oncology, The Third People's Hospital of Chengdu, Chengdu, Sichuan 610031, P.R. China, Department of Gerontology, Chengdu First People's Hospital, Chengdu, Sichuan 610041, P.R. China
  • Pages: 2750-2756
    |
    Published online on: November 22, 2017
       https://doi.org/10.3892/mmr.2017.8141
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Abstract

The present study aimed to identify potential anticancer effects of Cucurbitacin I regulators on cell growth of human non‑small cell lung cancer (NSCLC) and to explore their mechanism. The results indicated that the anticancer effects of Cucurbitacin I markedly attenuated cell proliferation, and induced apoptosis in NSCLC. Furthermore, Cucurbitacin I suppressed phosphatidylinositol‑4,5‑bisphosphate 3‑kinase (PI3K), phosphorylation (p)‑AKT and p‑p70S6K pathway in NSCLC. Then, (PI3K) inhibitor increased anticancer effects of Cucurbitacin I on NSCLC. In conclusion, the present results indicated that Cucurbitacin I inhibited cell growth of human NSCLC through PI3K/AKT/p70S6K signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu X, Huang H, Zhang J, Liu H, Ao R, Xiao M and Wu Y: The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway. Mol Med Rep 17: 2750-2756, 2018.
APA
Zhu, X., Huang, H., Zhang, J., Liu, H., Ao, R., Xiao, M., & Wu, Y. (2018). The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway. Molecular Medicine Reports, 17, 2750-2756. https://doi.org/10.3892/mmr.2017.8141
MLA
Zhu, X., Huang, H., Zhang, J., Liu, H., Ao, R., Xiao, M., Wu, Y."The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway". Molecular Medicine Reports 17.2 (2018): 2750-2756.
Chicago
Zhu, X., Huang, H., Zhang, J., Liu, H., Ao, R., Xiao, M., Wu, Y."The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway". Molecular Medicine Reports 17, no. 2 (2018): 2750-2756. https://doi.org/10.3892/mmr.2017.8141
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu X, Huang H, Zhang J, Liu H, Ao R, Xiao M and Wu Y: The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway. Mol Med Rep 17: 2750-2756, 2018.
APA
Zhu, X., Huang, H., Zhang, J., Liu, H., Ao, R., Xiao, M., & Wu, Y. (2018). The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway. Molecular Medicine Reports, 17, 2750-2756. https://doi.org/10.3892/mmr.2017.8141
MLA
Zhu, X., Huang, H., Zhang, J., Liu, H., Ao, R., Xiao, M., Wu, Y."The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway". Molecular Medicine Reports 17.2 (2018): 2750-2756.
Chicago
Zhu, X., Huang, H., Zhang, J., Liu, H., Ao, R., Xiao, M., Wu, Y."The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway". Molecular Medicine Reports 17, no. 2 (2018): 2750-2756. https://doi.org/10.3892/mmr.2017.8141
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