Open Access

The antibacterial effect of topical ozone on the treatment of MRSA skin infection

  • Authors:
    • Mingsheng Song
    • Qinghai Zeng
    • Yaping Xiang
    • Lihua Gao
    • Jian Huang
    • Jinhua Huang
    • Kathy Wu
    • Jianyun Lu
  • View Affiliations

  • Published online on: November 24, 2017     https://doi.org/10.3892/mmr.2017.8148
  • Pages: 2449-2455
  • Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Skin can be infected by many types of microorganisms, most commonly by gram‑positive strains of Staphylococcus and Streptococcus spp. Treatment of Staphylococcus aureus (S. aureus) infections, particularly that of methicillin resistant Staphylococcus aureus (MRSA), is a challenge in clinical practice. Ozone therapy has proven to be one of the strongest antiseptics against the majority of microorganisms involved in skin infections. The purpose of the present study was to evaluate the microbicidal effects of topical ozone therapy on S. aureus and MRSA, and determine the clinical efficacy of ozone therapy on patients with MRSA skin infection. Microbicidal effects of ozonated oil and ozonated water were determined by plating and Kirby Bauer methods. Clinical efficacy and safety of topical ozone were evaluated in two cases with skin MRSA infection. The killing rates of ozonated oil for S. aureus and MRSA were greater when compared with the control oil group. Almost 100% of S. aureus were eliminated by ozonated oil following 5 min. Almost 100% MRSA were eliminated by ozonated oil following 15 min. In addition, 100% S. aureus and 100% MRSA were eliminated by ozonated water in 1 min. The inhibition zone diameters of ozonated oil for S. aureus and MRSA were 17 and 13 mm, respectively, which were significantly larger than the control group. Both cases of skin MRSA infection were completely healed with ozone therapy. In conclusion, ozone therapy is a potential treatment for S. aureus and MRSA skin infection as it has great efficacy, few side effects and low‑costs.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Song M, Zeng Q, Xiang Y, Gao L, Huang J, Huang J, Wu K and Lu J: The antibacterial effect of topical ozone on the treatment of MRSA skin infection. Mol Med Rep 17: 2449-2455, 2018
APA
Song, M., Zeng, Q., Xiang, Y., Gao, L., Huang, J., Huang, J. ... Lu, J. (2018). The antibacterial effect of topical ozone on the treatment of MRSA skin infection. Molecular Medicine Reports, 17, 2449-2455. https://doi.org/10.3892/mmr.2017.8148
MLA
Song, M., Zeng, Q., Xiang, Y., Gao, L., Huang, J., Huang, J., Wu, K., Lu, J."The antibacterial effect of topical ozone on the treatment of MRSA skin infection". Molecular Medicine Reports 17.2 (2018): 2449-2455.
Chicago
Song, M., Zeng, Q., Xiang, Y., Gao, L., Huang, J., Huang, J., Wu, K., Lu, J."The antibacterial effect of topical ozone on the treatment of MRSA skin infection". Molecular Medicine Reports 17, no. 2 (2018): 2449-2455. https://doi.org/10.3892/mmr.2017.8148