Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February-2018 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2018 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Overexpression of COUP‑TFII suppresses proliferation and metastasis of human gastric cancer cells

  • Authors:
    • Weiji Ding
    • Yunda Zhang
    • Huali Cai
    • Gang Liu
    • Yongzhi Ye
    • Guoxing Xu
    • Haibin Wang
    • Disheng Xiong
    • Chuankai Zhang
    • Zhengjie Huang
    • Qi Luo
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2393-2401
    |
    Published online on: November 27, 2017
       https://doi.org/10.3892/mmr.2017.8164
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The abnormal expression of the chicken ovalbumin upstream promoter transcription factor 2 (COUP‑TFII) is associated with numerous forms of cancer, including gastric, prostate, colon and lung cancer. However, previous studies investigating the association between COUP‑TFII expression and the occurrence, recurrence, invasion and metastasis of gastric cancer are limited in number. In the present study, it was revealed that the expression of COUP‑TFII is significantly reduced in gastric carcinoma tissues compared with normal gastric mucosa cells (GES‑1). In addition, the expression of COUP‑TFII was also reduced in gastric cancer cell lines compared with GES‑1 cells. Furthermore, it was revealed that ectopic expression of COUP‑TFII was able to suppress the proliferation, migration and invasion of gastric cells, as well as inhibit hepatic metastasis, in vivo. In addition, it was demonstrated that COUP‑TFII knockdown was able to promote the proliferation, migration and invasion of GES‑1 cells in vitro. Furthermore, database analysis suggested that COUP‑TFII expression in patients with gastric cancer is correlated with clinical stage classification and increased expression levels of COUP‑TFII improved overall survival rates in patients with gastric cancer. The results of the present study suggest that COUP‑TFII functions as a significant regulatory suppressor of gastric cancer growth and metastasis, and suggests that COUP‑TFII may serve as a novel diagnostic and prognostic biomarker for gastric cancer metastasis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Jiang Y and Ajani JA: Multidisciplinary management of gastric cancer. Curr Opin Gastroenterol. 26:640–646. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Shi W, Wang J, Zhang M, Yu C, He W and Liu P: The multivariate prognostic analysis of 1340 gastric cancer patients who received radical resection. J Nanjing Med Univ (Nat Sci Ed). 31:1310–1315. 2010.

4 

Bray F, Jemal A, Grey N, Ferlay J and Forman D: Global cancer transitions according to the human development index (2008–2030): A population-based study. Lancet Oncol. 13:790–801. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Pastorcic M, Wang H, Elbrecht A, Tsai SY, Tsai MJ and O'Malley BW: Control of transcription initiation in vitro requires binding of a transcription factor to the distal promoter of the ovalbumin gene. Mol Cell Biol. 6:2784–2791. 1986. View Article : Google Scholar : PubMed/NCBI

6 

Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ and O'Malley BW: COUP transcription factor is a member of the steroid receptor superfamily. Nature. 340:163–166. 1989. View Article : Google Scholar : PubMed/NCBI

7 

Sagami I, Tsai SY, Wang H, Tsai MJ and O'Malley BW: Identification of two factors required for transcription of the ovalbumin gene. Mol Cell Biol. 6:4259–4267. 1986. View Article : Google Scholar : PubMed/NCBI

8 

Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K and Yamamoto T: Identification of two novel members of erbA superfamily by molecular cloning: The gene products of the two are highly related to each other. Nucleic Acids Res. 16:11057–11074. 1988. View Article : Google Scholar : PubMed/NCBI

9 

Wang LH, Tsai SY, Sagami I, Tsai MJ and O'Malley BW: Purification and characterization of chicken ovalbumin upstream promoter transcription factor from HeLa cells. J Biol Chem. 262:16080–16086. 1987.PubMed/NCBI

10 

Wang LH, Ing NH, Tsai SY, O'Malley BW and Tsai MJ: The COUP-TFs compose a family of functionally related transcription factors. Gene Expr. 1:207–216. 1991.PubMed/NCBI

11 

Ladias JA and Karathanasis SK: Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. Science. 251:561–565. 1991. View Article : Google Scholar : PubMed/NCBI

12 

Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala G, Lin X, Feng XH, et al: COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis. Nature. 493:236–240. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Qin J, Chen X, Xie X, Tsai MJ and Tsai SY: COUP-TFII regulates tumor growth and metastasis by modulating tumor angiogenesis. Proc Natl Acad Sci USA. 107:pp. 3687–3692. 2010; View Article : Google Scholar : PubMed/NCBI

14 

Qin J, Chen X, Yu-Lee LY, Tsai MJ and Tsai SY: Nuclear receptor COUP-TFII controls pancreatic islet tumor angiogenesis by regulating vascular endothelial growth factor/vascular endothelial growth factor receptor-2 signaling. Cancer Res. 70:8812–8821. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Polvani S, Tarocchi M, Tempesti S, Mello T, Ceni E, Buccoliero F, D'Amico M, Boddi V, Farsi M, Nesi S, et al: COUP-TFII in pancreatic adenocarcinoma: Clinical implication for patient survival and tumor progression. Int J Cancer. 134:1648–1658. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Hawkins SM, Loomans HA, Wan YW, Ghosh-Choudhury T, Coffey D, Xiao W, Liu Z, Sangi-Haghpeykar H and Anderson ML: Expression and functional pathway analysis of nuclear receptor NR2F2 in ovarian cancer. J Clin Endocrinol Metab. 98:E1152–E1162. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Bao Y, Gu D, Feng W, Sun X, Wang X, Zhang X, Shi Q, Cui G, Yu H, Tang C and Deng A: COUP-TFII regulates metastasis of colorectal adenocarcinoma cells by modulating Snail1. Br J Cancer. 111:933–943. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Edge SB and Compton CC: The American joint committee on cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Hu YM, Hu XP, Zhang L, Zhang SS and Xu JM: Uptake characteristics of levofloxacin for the eradication of Helicobacter pylori by GES-1 and MGC80-3 cells. Eur Rev Med Pharmacol Sci. 20:486–490. 2016.PubMed/NCBI

20 

Fan C, Lin Y, Mao Y, Huang Z, Liu AY, Ma H, Yu D, Maitikabili A, Xiao H, Zhang C, et al: MicroRNA-543 suppresses colorectal cancer growth and metastasis by targeting KRAS, MTA1 and HMGA2. Oncotarget. 7:21825–21839. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Zhang C, Zhang Y, Ding W, Lin Y, Huang Z and Luo Q: MiR-33a suppresses breast cancer cell proliferation and metastasis by targeting ADAM9 and ROS1. Protein Cell. 6:881–889. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Zhang Y, Xu G, Liu G, Ye Y, Zhang C, Fan C, Wang H, Cai H, Xiao R, Huang Z and Luo Q: miR-411-5p inhibits proliferation and metastasis of breast cancer cell via targeting GRB2. Biochem Biophys Res Commun. 476:607–613. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, Briggs BB, Barrette TR, Anstet MJ, Kincead-Beal C, Kulkarni P, et al: Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia. 9:166–180. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI

26 

McKenna NJ and O'Malley BW: Combinatorial control of gene expression by nuclear receptors and coregulators. Cell. 108:465–474. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Navab R, Gonzalez-Santos JM, Johnston MR, Liu J, Brodt P, Tsao MS and Hu J: Expression of chicken ovalbumin upstream promoter-transcription factor II enhances invasiveness of human lung carcinoma cells. Cancer Res. 64:5097–5105. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Safe S, Jin UH, Hedrick E, Reeder A and Lee SO: Minireview: Role of orphan nuclear receptors in cancer and potential as drug targets. Mol Endocrinol. 28:157–172. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Xu H and Xu Y: Recent advancement in metastasis of gastric cancer. Chin J Prac. 31:666–669. 2011.

30 

Nagasaki S, Suzuki T, Miki Y, Akahira J, Shibata H, Ishida T, Ohuchi N and Sasano H: Chicken ovalbumin upstream promoter transcription factor II in human breast carcinoma: Possible regulator of lymphangiogenesis via vascular endothelial growth factor-C expression. Cancer Sci. 100:639–645. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Xu M, Qin J, Tsai SY and Tsai MJ: The role of the orphan nuclear receptor COUP-TFII in tumorigenesis. Acta Pharmacol Sin. 36:32–36. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Lin FJ, Chen X, Qin J, Hong YK, Tsai MJ and Tsai SY: Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development. J Clin Invest. 120:1694–1707. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Yang S, Chen F, Zhang C, Gu X and Chen M: Establishment of liver metastasis model in nude mice with human gastric carcinoma. Beijing Lab Anim Sci. 9:131992.

34 

Shan F, Li Z, Bu Z, Zhang L, Wu A, Wu X, Wu Qi, Zong X, Li S, Ji X, Wu J and Ji J: The analysis of gastric cancer staging AJCC 6th edition and 7th edition. Chin J Prac Surg. 31:675–680. 2011.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ding W, Zhang Y, Cai H, Liu G, Ye Y, Xu G, Wang H, Xiong D, Zhang C, Huang Z, Huang Z, et al: Overexpression of COUP‑TFII suppresses proliferation and metastasis of human gastric cancer cells. Mol Med Rep 17: 2393-2401, 2018.
APA
Ding, W., Zhang, Y., Cai, H., Liu, G., Ye, Y., Xu, G. ... Luo, Q. (2018). Overexpression of COUP‑TFII suppresses proliferation and metastasis of human gastric cancer cells. Molecular Medicine Reports, 17, 2393-2401. https://doi.org/10.3892/mmr.2017.8164
MLA
Ding, W., Zhang, Y., Cai, H., Liu, G., Ye, Y., Xu, G., Wang, H., Xiong, D., Zhang, C., Huang, Z., Luo, Q."Overexpression of COUP‑TFII suppresses proliferation and metastasis of human gastric cancer cells". Molecular Medicine Reports 17.2 (2018): 2393-2401.
Chicago
Ding, W., Zhang, Y., Cai, H., Liu, G., Ye, Y., Xu, G., Wang, H., Xiong, D., Zhang, C., Huang, Z., Luo, Q."Overexpression of COUP‑TFII suppresses proliferation and metastasis of human gastric cancer cells". Molecular Medicine Reports 17, no. 2 (2018): 2393-2401. https://doi.org/10.3892/mmr.2017.8164
Copy and paste a formatted citation
x
Spandidos Publications style
Ding W, Zhang Y, Cai H, Liu G, Ye Y, Xu G, Wang H, Xiong D, Zhang C, Huang Z, Huang Z, et al: Overexpression of COUP‑TFII suppresses proliferation and metastasis of human gastric cancer cells. Mol Med Rep 17: 2393-2401, 2018.
APA
Ding, W., Zhang, Y., Cai, H., Liu, G., Ye, Y., Xu, G. ... Luo, Q. (2018). Overexpression of COUP‑TFII suppresses proliferation and metastasis of human gastric cancer cells. Molecular Medicine Reports, 17, 2393-2401. https://doi.org/10.3892/mmr.2017.8164
MLA
Ding, W., Zhang, Y., Cai, H., Liu, G., Ye, Y., Xu, G., Wang, H., Xiong, D., Zhang, C., Huang, Z., Luo, Q."Overexpression of COUP‑TFII suppresses proliferation and metastasis of human gastric cancer cells". Molecular Medicine Reports 17.2 (2018): 2393-2401.
Chicago
Ding, W., Zhang, Y., Cai, H., Liu, G., Ye, Y., Xu, G., Wang, H., Xiong, D., Zhang, C., Huang, Z., Luo, Q."Overexpression of COUP‑TFII suppresses proliferation and metastasis of human gastric cancer cells". Molecular Medicine Reports 17, no. 2 (2018): 2393-2401. https://doi.org/10.3892/mmr.2017.8164
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team