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Article Open Access

Inhibiting proliferation and migration of lung cancer using small interfering RNA targeting on Aldo-keto reductase family 1 member B10

Retraction in: /10.3892/mmr.2023.13109
  • Authors:
    • Zhen Zhou
    • Yi Zhao
    • Lingping Gu
    • Xiaoming Niu
    • Shun Lu
  • View Affiliations / Copyright

    Affiliations: Department of Lung Tumor Clinical Center, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2153-2160
    |
    Published online on: November 28, 2017
       https://doi.org/10.3892/mmr.2017.8173
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Abstract

Lung cancer is the leading cause of global cancer‑associated mortality. Genomic alterations in lung cancers have not been widely characterized, however, the molecular mechanism of tumor initiation and progression remain unknown, and no molecularly targeted have been specifically developed for its treatment and diagnosis. The present study observed the upregulation of Aldo‑keto reductase family 1 member Bio10 (AKR1B10) lung cancer tissues by analyzing two public lung cancer gene expression datasets. Further experiments in silencing AKR1B10 demonstrated that the expression of AKR1B10 was associated with cell proliferation, cell cycle, adhesion and invasion, as well as extracellular‑signal‑regulated kinase/mitogen activated protein kinase signal pathway. The overexpression of AKR1B10 in lung cancer indicates the important role of AKR1B10 in tumorigenesis. These findings suggest that AKR1B10 could be a potential diagnosis and treatment mark of lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou Z, Zhao Y, Gu L, Niu X and Lu S: Inhibiting proliferation and migration of lung cancer using small interfering RNA targeting on Aldo-keto reductase family 1 member B10 Retraction in /10.3892/mmr.2023.13109. Mol Med Rep 17: 2153-2160, 2018.
APA
Zhou, Z., Zhao, Y., Gu, L., Niu, X., & Lu, S. (2018). Inhibiting proliferation and migration of lung cancer using small interfering RNA targeting on Aldo-keto reductase family 1 member B10 Retraction in /10.3892/mmr.2023.13109. Molecular Medicine Reports, 17, 2153-2160. https://doi.org/10.3892/mmr.2017.8173
MLA
Zhou, Z., Zhao, Y., Gu, L., Niu, X., Lu, S."Inhibiting proliferation and migration of lung cancer using small interfering RNA targeting on Aldo-keto reductase family 1 member B10 Retraction in /10.3892/mmr.2023.13109". Molecular Medicine Reports 17.2 (2018): 2153-2160.
Chicago
Zhou, Z., Zhao, Y., Gu, L., Niu, X., Lu, S."Inhibiting proliferation and migration of lung cancer using small interfering RNA targeting on Aldo-keto reductase family 1 member B10 Retraction in /10.3892/mmr.2023.13109". Molecular Medicine Reports 17, no. 2 (2018): 2153-2160. https://doi.org/10.3892/mmr.2017.8173
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou Z, Zhao Y, Gu L, Niu X and Lu S: Inhibiting proliferation and migration of lung cancer using small interfering RNA targeting on Aldo-keto reductase family 1 member B10 Retraction in /10.3892/mmr.2023.13109. Mol Med Rep 17: 2153-2160, 2018.
APA
Zhou, Z., Zhao, Y., Gu, L., Niu, X., & Lu, S. (2018). Inhibiting proliferation and migration of lung cancer using small interfering RNA targeting on Aldo-keto reductase family 1 member B10 Retraction in /10.3892/mmr.2023.13109. Molecular Medicine Reports, 17, 2153-2160. https://doi.org/10.3892/mmr.2017.8173
MLA
Zhou, Z., Zhao, Y., Gu, L., Niu, X., Lu, S."Inhibiting proliferation and migration of lung cancer using small interfering RNA targeting on Aldo-keto reductase family 1 member B10 Retraction in /10.3892/mmr.2023.13109". Molecular Medicine Reports 17.2 (2018): 2153-2160.
Chicago
Zhou, Z., Zhao, Y., Gu, L., Niu, X., Lu, S."Inhibiting proliferation and migration of lung cancer using small interfering RNA targeting on Aldo-keto reductase family 1 member B10 Retraction in /10.3892/mmr.2023.13109". Molecular Medicine Reports 17, no. 2 (2018): 2153-2160. https://doi.org/10.3892/mmr.2017.8173
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