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Article Open Access

Novel multi‑kinase inhibitor, T03 inhibits Taxol‑resistant breast cancer

  • Authors:
    • Yan Li
    • Chunxia Liu
    • Ke Tang
    • Yan Chen
    • Kang Tian
    • Zhiqiang Feng
    • Jindong Chen
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China, Department of Synthetic Medicinal Chemistry, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China, Department of Urology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2373-2383
    |
    Published online on: November 28, 2017
       https://doi.org/10.3892/mmr.2017.8179
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Abstract

Activation of kinase-associated signaling pathways is one of the leading causes of various malignant phenotypes in breast tumors. Strategies of drug discovery and development have investigated approaches to target the inhibition of protein kinase signaling. In the current study, the anti‑tumor activities of a novel multi‑kinase inhibitor, T03 were evaluated in breast cancer. T03 inhibited Taxol‑resistant breast cancer cell proliferation and induced cell cycle arrest and apoptosis in vitro and in vivo. The current results demonstrated that T03 downregulated c‑Raf, platelet‑derived growth factor receptor‑β and other kinases, thus inhibited Raf/mitogen‑activated protein kinase kinase/extracellular signal‑regulated kinase and Akt/mechanistic target of rapamycin survival pathways in MCF‑7 and MCF‑7/Taxol xenograft tumors. At a dose of 100 mg/kg, T03 inhibited tumor growth by 62.90 and 59.98% in tumor weight in MX‑1 and MX‑1/T xenograft models, respectively and by 62.60 and 60.22% in MCF‑7 and MCF‑7/T tumors, respectively. These data indicate that the novel multi‑kinase inhibitor, T03, may present as a potential compound to develop novel treatments against breast cancer and Taxol‑resistant breast tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Liu C, Tang K, Chen Y, Tian K, Feng Z and Chen J: Novel multi‑kinase inhibitor, T03 inhibits Taxol‑resistant breast cancer. Mol Med Rep 17: 2373-2383, 2018.
APA
Li, Y., Liu, C., Tang, K., Chen, Y., Tian, K., Feng, Z., & Chen, J. (2018). Novel multi‑kinase inhibitor, T03 inhibits Taxol‑resistant breast cancer. Molecular Medicine Reports, 17, 2373-2383. https://doi.org/10.3892/mmr.2017.8179
MLA
Li, Y., Liu, C., Tang, K., Chen, Y., Tian, K., Feng, Z., Chen, J."Novel multi‑kinase inhibitor, T03 inhibits Taxol‑resistant breast cancer". Molecular Medicine Reports 17.2 (2018): 2373-2383.
Chicago
Li, Y., Liu, C., Tang, K., Chen, Y., Tian, K., Feng, Z., Chen, J."Novel multi‑kinase inhibitor, T03 inhibits Taxol‑resistant breast cancer". Molecular Medicine Reports 17, no. 2 (2018): 2373-2383. https://doi.org/10.3892/mmr.2017.8179
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Liu C, Tang K, Chen Y, Tian K, Feng Z and Chen J: Novel multi‑kinase inhibitor, T03 inhibits Taxol‑resistant breast cancer. Mol Med Rep 17: 2373-2383, 2018.
APA
Li, Y., Liu, C., Tang, K., Chen, Y., Tian, K., Feng, Z., & Chen, J. (2018). Novel multi‑kinase inhibitor, T03 inhibits Taxol‑resistant breast cancer. Molecular Medicine Reports, 17, 2373-2383. https://doi.org/10.3892/mmr.2017.8179
MLA
Li, Y., Liu, C., Tang, K., Chen, Y., Tian, K., Feng, Z., Chen, J."Novel multi‑kinase inhibitor, T03 inhibits Taxol‑resistant breast cancer". Molecular Medicine Reports 17.2 (2018): 2373-2383.
Chicago
Li, Y., Liu, C., Tang, K., Chen, Y., Tian, K., Feng, Z., Chen, J."Novel multi‑kinase inhibitor, T03 inhibits Taxol‑resistant breast cancer". Molecular Medicine Reports 17, no. 2 (2018): 2373-2383. https://doi.org/10.3892/mmr.2017.8179
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