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Liposome encapsulated luteolin showed enhanced antitumor efficacy to colorectal carcinoma

  • Authors:
    • Guixia Wu
    • Jing Li
    • Jinqiao Yue
    • Shuying Zhang
    • Kurexi Yunusi
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China, Department of Medical Examination, Changji Vocational and Technical College, Changji, Xinjiang 830000, P.R. China, Department of Gynaecology and Obstetrics, The 474th Hospital of People's Liberation Army of China, Urumqi, Xinjiang 830011, P.R. China, Department of Biochemistry, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2456-2464
    |
    Published online on: November 29, 2017
       https://doi.org/10.3892/mmr.2017.8185
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Abstract

Luteolin is a falconoid compound that is present in various types of plants and possesses remarkable potential as a chemopreventive agent. However, the poor aqueous solubility of luteolin limits its clinical application. In the present study, an approach towards chemoprevention was explored using liposomes to deliver luteolin, and the antitumor efficacy was investigated in colorectal carcinoma. The present findings demonstrated that luteolin was efficiently encapsulated into liposomes with an encapsulation efficiency as high as 90%. The particle size of the liposomal luteolin (Lipo‑Lut) and ζ‑potential were optimized. In vitro studies demonstrated that, Lipo‑Lut had a significant inhibitory effect on the growth on the CT26 colorectal carcinoma cell line compared with free luteolin (Free‑Lut). The in vivo study indicated that Lipo‑Lut could achieve superior antitumor effects against CT26 tumor compared with luteolin alone. The present results suggested that liposome delivery of luteolin improved solubility, bioavailability and may have potential applications in chemoprevention in clinical settings.
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Copy and paste a formatted citation
Spandidos Publications style
Wu G, Li J, Yue J, Zhang S and Yunusi K: Liposome encapsulated luteolin showed enhanced antitumor efficacy to colorectal carcinoma. Mol Med Rep 17: 2456-2464, 2018.
APA
Wu, G., Li, J., Yue, J., Zhang, S., & Yunusi, K. (2018). Liposome encapsulated luteolin showed enhanced antitumor efficacy to colorectal carcinoma. Molecular Medicine Reports, 17, 2456-2464. https://doi.org/10.3892/mmr.2017.8185
MLA
Wu, G., Li, J., Yue, J., Zhang, S., Yunusi, K."Liposome encapsulated luteolin showed enhanced antitumor efficacy to colorectal carcinoma". Molecular Medicine Reports 17.2 (2018): 2456-2464.
Chicago
Wu, G., Li, J., Yue, J., Zhang, S., Yunusi, K."Liposome encapsulated luteolin showed enhanced antitumor efficacy to colorectal carcinoma". Molecular Medicine Reports 17, no. 2 (2018): 2456-2464. https://doi.org/10.3892/mmr.2017.8185
Copy and paste a formatted citation
x
Spandidos Publications style
Wu G, Li J, Yue J, Zhang S and Yunusi K: Liposome encapsulated luteolin showed enhanced antitumor efficacy to colorectal carcinoma. Mol Med Rep 17: 2456-2464, 2018.
APA
Wu, G., Li, J., Yue, J., Zhang, S., & Yunusi, K. (2018). Liposome encapsulated luteolin showed enhanced antitumor efficacy to colorectal carcinoma. Molecular Medicine Reports, 17, 2456-2464. https://doi.org/10.3892/mmr.2017.8185
MLA
Wu, G., Li, J., Yue, J., Zhang, S., Yunusi, K."Liposome encapsulated luteolin showed enhanced antitumor efficacy to colorectal carcinoma". Molecular Medicine Reports 17.2 (2018): 2456-2464.
Chicago
Wu, G., Li, J., Yue, J., Zhang, S., Yunusi, K."Liposome encapsulated luteolin showed enhanced antitumor efficacy to colorectal carcinoma". Molecular Medicine Reports 17, no. 2 (2018): 2456-2464. https://doi.org/10.3892/mmr.2017.8185
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