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Ginsenoside Rh2 inhibits human A172 glioma cell proliferation and induces cell cycle arrest status via modulating Akt signaling pathway

  • Authors:
    • Kai‑Fei Li
    • Chun‑Min Kang
    • Xiao‑Feng Yin
    • Hai‑Xia Li
    • Zhuo‑Yu Chen
    • Yao Li
    • Qiong Zhang
    • Yu‑Rong Qiu
  • View Affiliations / Copyright

    Affiliations: Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3062-3068
    |
    Published online on: December 5, 2017
       https://doi.org/10.3892/mmr.2017.8193
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Abstract

Ginsenoside Rh2 (G‑Rh2), the main bioactive component in American ginseng, is known to exert a wide variety of biological activities. Accumulating evidence suggests that G‑Rh2 inhibits cell proliferation and induces apoptosis of tumor cells. However, the possible mechanism through which G‑Rh2 exerts its action on malignant glioma cells have not been completely elucidated. The findings of the present study demonstrated that G‑Rh2 decreased the viability of glioma cells in a dose‑ and time‑dependent manner, and induced cell cycle arrest. G‑Rh2‑induced cell cycle arrest was accompanied by the downregulation of cyclin‑dependent kinase 4 and Cyclin E. In addition, G‑Rh2 markedly reduced the expression of total‑ RAC‑α serine/threonine‑protein kinase (Akt) and the levels of phosphorylated‑Akt. These findings provide mechanistic details of how G‑Rh2 acts on glioma cells and suggest that G‑Rh2 may function as a potential anti‑cancer drug for glioma treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Li KF, Kang CM, Yin XF, Li HX, Chen ZY, Li Y, Zhang Q and Qiu YR: Ginsenoside Rh2 inhibits human A172 glioma cell proliferation and induces cell cycle arrest status via modulating Akt signaling pathway. Mol Med Rep 17: 3062-3068, 2018.
APA
Li, K., Kang, C., Yin, X., Li, H., Chen, Z., Li, Y. ... Qiu, Y. (2018). Ginsenoside Rh2 inhibits human A172 glioma cell proliferation and induces cell cycle arrest status via modulating Akt signaling pathway. Molecular Medicine Reports, 17, 3062-3068. https://doi.org/10.3892/mmr.2017.8193
MLA
Li, K., Kang, C., Yin, X., Li, H., Chen, Z., Li, Y., Zhang, Q., Qiu, Y."Ginsenoside Rh2 inhibits human A172 glioma cell proliferation and induces cell cycle arrest status via modulating Akt signaling pathway". Molecular Medicine Reports 17.2 (2018): 3062-3068.
Chicago
Li, K., Kang, C., Yin, X., Li, H., Chen, Z., Li, Y., Zhang, Q., Qiu, Y."Ginsenoside Rh2 inhibits human A172 glioma cell proliferation and induces cell cycle arrest status via modulating Akt signaling pathway". Molecular Medicine Reports 17, no. 2 (2018): 3062-3068. https://doi.org/10.3892/mmr.2017.8193
Copy and paste a formatted citation
x
Spandidos Publications style
Li KF, Kang CM, Yin XF, Li HX, Chen ZY, Li Y, Zhang Q and Qiu YR: Ginsenoside Rh2 inhibits human A172 glioma cell proliferation and induces cell cycle arrest status via modulating Akt signaling pathway. Mol Med Rep 17: 3062-3068, 2018.
APA
Li, K., Kang, C., Yin, X., Li, H., Chen, Z., Li, Y. ... Qiu, Y. (2018). Ginsenoside Rh2 inhibits human A172 glioma cell proliferation and induces cell cycle arrest status via modulating Akt signaling pathway. Molecular Medicine Reports, 17, 3062-3068. https://doi.org/10.3892/mmr.2017.8193
MLA
Li, K., Kang, C., Yin, X., Li, H., Chen, Z., Li, Y., Zhang, Q., Qiu, Y."Ginsenoside Rh2 inhibits human A172 glioma cell proliferation and induces cell cycle arrest status via modulating Akt signaling pathway". Molecular Medicine Reports 17.2 (2018): 3062-3068.
Chicago
Li, K., Kang, C., Yin, X., Li, H., Chen, Z., Li, Y., Zhang, Q., Qiu, Y."Ginsenoside Rh2 inhibits human A172 glioma cell proliferation and induces cell cycle arrest status via modulating Akt signaling pathway". Molecular Medicine Reports 17, no. 2 (2018): 3062-3068. https://doi.org/10.3892/mmr.2017.8193
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