Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February-2018 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2018 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

CRP, IL‑2 and TNF‑α level in patients with uremia receiving hemodialysis

  • Authors:
    • Guohui Li
    • Haijun Ma
    • Yaoyao Yin
    • Junxia Wang
  • View Affiliations / Copyright

    Affiliations: Department of Blood Purification Center, First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China
  • Pages: 3350-3355
    |
    Published online on: December 6, 2017
       https://doi.org/10.3892/mmr.2017.8197
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Uremia is a serious threat to health. Infection associated with inflammation frequently occurs in patients with uremia during hemodialysis. This study aimed to investigate the association between serum inflammatory factors and uremia in patients prior to and following hemodialysis. Patients with uremia (n=200) receiving continuous high throughput hemodialysis that had hospital‑acquired infection were enrolled between August 2013 and August 2015. Additionally, 200 cases of healthy volunteers were selected as the control. Reverse transcription‑polymerase chain reaction, ELISA and western blotting were performed to determine serum C‑reactive protein (CRP), interleukin 2 (IL‑2), and tumor necrosis factorα levels (TNF‑α) prior to hemodialysis and 8 months after hemodialysis to explore the association of CRP, IL‑2 and TNF‑α with uremia. CRP, IL‑2 and TNF‑α levels were lower at 8 months after hemodialysis than before, and the difference was statistically significant. CRP, IL‑2 and TNF‑α levels in uremia patients at 8 months after hemodialysis were similar with that in the normal control. CRP expression in patients with uremia was positively correlated with IL‑2 and TNF‑α expression. Patients with uremia with hospital‑acquired infection receiving continuous high throughput blood purification presented increased levels of inflammatory factor in the serum. In conclusion, uremia patients receiving maintenance hemodialysis with hospital‑acquired infection had increased serum inflammatory factors and high throughput hemodialysis significantly decreased CRP, IL‑2 and TNF‑α levels in the serum, suggesting that high throughput hemodialysis may be beneficial for the prevention of the infections in uremia patients.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Casimiro de Almeida J, Lou-Meda R, Olbert M, Seifert M, Weiss G, Wiegerinck ET, Swinkels DW, Solomons NW and Schümann K: The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients. PLoS One. 10:e01400622015. View Article : Google Scholar : PubMed/NCBI

2 

Naini AE, Asiabi RE, Keivandarian N and Moeinzadeh F: Effect of omega-3 supplementation on inflammatory parameters in patients on chronic ambulatory peritoneal dialysis. Adv Biomed Res. 4:1672015. View Article : Google Scholar : PubMed/NCBI

3 

Weng CH, Hu CC, Yen TH and Huang WH: Association between ambient carbon monoxide and secondary hyperparathyroidism in nondiabetic patients undergoing peritoneal dialysis. Ther Clin Risk Manag. 11:1401–1408. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Poesen R, Ramezani A, Claes K, Augustijns P, Kuypers D, Barrows IR, Muralidharan J, Evenepoel P, Meijers B and Raj DS: Associations of soluble CD14 and endotoxin with mortality, cardiovascular disease, and progression of kidney disease among patients with CKD. Clin J Am Soc Nephrol. 10:1525–1533. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Higuchi T, Abe M, Mizuno M, Yamazaki T, Suzuki H, Moriuchi M, Oikawa O, Okawa E, Ando H and Okada K: Association of restless legs syndrome with oxidative stress and inflammation in patients undergoing hemodialysis. Sleep Med. 16:941–948. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Hashemian SJ, Rismanchi M, Esfahani EN, Khoshvaghti A and Razi F: Effect of calcitriol supplementation and tail suspension on serum biomarkers of bone formation in rats. J Diabetes Metab Disord. 14:142015. View Article : Google Scholar : PubMed/NCBI

7 

Kaysen GA, Johansen KL, Chertow GM, Dalrymple LS, Kornak J, Grimes B, Dwyer T, Chassy AW and Fiehn O: Associations of Trimethylamine N-Oxide with nutritional and inflammatory biomarkers and cardiovascular outcomes in patients new to dialysis. J Ren Nutr. 25:351–356. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Xie LM, Ge YY, Huang X, Zhang YQ and Li JX: Effects of fermentable dietary fiber supplementation on oxidative and inflammatory status in hemodialysis patients. Int J Clin Exp Med. 8:1363–1369. 2015.PubMed/NCBI

9 

Hassan K, Hassan S, Anwar S, Zaher A, Edgem R and Hassan F: Predictors of left ventricular hypertrophy and their cutoffs in peritoneal dialysis patients. Int Heart J. 56:186–191. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Mpio I, Cleaud C, Arkouche W and Laville M: Results of therapeutics strategy of protein-energy wasting in chronic hemodialysis: A prospective study during 12 months. Nephrol Ther. 11:97–103. 2015.(In French). View Article : Google Scholar : PubMed/NCBI

11 

Cao H, Ye H, Sun Z, Shen X, Song Z, Wu X, He W, Dai C and Yang J: Circulatory mitochondrial DNA is a pro-inflammatory agent in maintenance hemodialysis patients. PLoS One. 9:e1131792014. View Article : Google Scholar : PubMed/NCBI

12 

Huang WH, Yen TH, Chan MJ and Su YJ: Environmental carbon monoxide level is associated with the level of high-sensitivity C-reactive protein in peritoneal dialysis patients. Medicine (Baltimore). 93:e1812014. View Article : Google Scholar : PubMed/NCBI

13 

do Sameiro-Faria M, Kohlova M, Ribeiro S, Rocha-Pereira P, Teixeira L, Nascimento H, Reis F, Miranda V, Bronze-da-Rocha E, Quintanilha A, et al: Potential cardiovascular risk protection of bilirubin in end-stage renal disease patients under hemodialysis. Biomed Res Int. 2014:1752862014.PubMed/NCBI

14 

Hung AM, Booker C, Ellis CD, Siew ED, Graves AJ, Shintani A, Abumrad NN, Himmelfarb J and Ikizler TA: Omega-3 fatty acids inhibit the up-regulation of endothelial chemokines in maintenance hemodialysis patients. Nephrol Dial Transplant. 30:266–274. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Mikolasevic I, Lukenda V, Racki S, Milic S, Sladoje-Martinovic B and Orlic L: Nonalcoholic fatty liver disease (NAFLD)-a new factor that interplays between inflammation, malnutrition, and atherosclerosis in elderly hemodialysis patients. Clin Interv Aging. 9:1295–1303. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Janda K, Krzanowski M, Dumnicka P, Kuśnierz-Cabala B, Kraśniak A and Sulowicz W: Transforming growth factor beta 1 as a risk factor for cardiovascular diseases in end-stage renal disease patients treated with peritoneal dialysis. Clin Lab. 60:1163–1168. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Ockene IS, Matthews CE, Rifai N, Ridker PM, Reed G and Stanek E: Variability and classification accuracy of serial high-sensitivity C-reactive protein measurements in healthy adults. Clin Chem. 47:444–450. 2001.PubMed/NCBI

18 

Banerjee T, Kim SJ, Astor B, Shafi T, Coresh J and Powe NR: Vascular access type, inflammatory markers, and mortality in incident hemodialysis patients: The Choices for healthy outcomes in caring for End-Stage renal disease (CHOICE) study. Am J Kidney Dis. 64:954–961. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Tsai MT, Hu FH, Lien TJ, Chen PJ, Huang TP and Tarng DC: Interaction between geriatric nutritional risk index and decoy receptor 3 predicts mortality in chronic hemodialysis patients. Am J Nephrol. 40:191–199. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Viaene L, Meijers BK, Bammens B, Vanrenterghem Y and Evenepoel P: Serum concentrations of p-cresyl sulfate and indoxyl sulfate, but not inflammatory markers, increase in incident peritoneal dialysis patients in parallel with loss of residual renal function. Perit Dial Int. 34:71–78. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Rivara MB, Ikizler TA, Ellis CD, Mehrotra R and Himmelfarb J: Association of plasma F2-isoprostanes and isofurans concentrations with erythropoiesis-stimulating agent resistance in maintenance hemodialysis patients. BMC Nephrol. 16:792015. View Article : Google Scholar : PubMed/NCBI

22 

Mustafar RB, Mohd R, Miswan NA, Bain A, Cader R, Gafor AH, Mohammad M, Shah SA, Kamaruddin NA and Kong NC: The effects of calcitriol with calcium carbonate supplementation on inflammatory biomarkers in chronic kidney disease patients' with low vitamin D. Cent Eur J Immunol. 39:236–242. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Rivara MB, Mehrotra R, Linke L, Ruzinski J, Ikizler TA and Himmelfarb J: A pilot randomized crossover trial assessing the safety and short-term effects of pomegranate supplementation in hemodialysis patients. J Ren Nutr. 25:40–49. 2015. View Article : Google Scholar : PubMed/NCBI

24 

de Vinuesa SG, Goicoechea M, Kanter J, Puerta M, Cachofeiro V, Lahera V, Gómez-Campdera F and Luño J: Insulin resistance, inflammatory biomarkers, and adipokines in patients with chronic kidney disease: effects of angiotensin II blockade. J Am Soc Nephrol. 17 12 Suppl:S206–S212. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Saddadi F, Alatab S, Pasha F, Ganji MR and Soleimanian T: The effect of treatment with N-acetylcysteine on the serum levels of C-reactive protein and interleukin-6 in patients on hemodialysis. Saudi J Kidney Dis Transpl. 25:66–72. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Bossola M, Di Stasio E, Giungi S, Rosa F and Tazza L: Fatigue is associated with serum interleukin-6 levels and symptoms of depression in patients on chronic hemodialysis. J Pain Symptom Manage. 49:578–585. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Van Buren PN, Lewis JB, Dwyer JP, Greene T, Middleton J, Sika M, Umanath K, Abraham JD, Arfeen SS, Bowline IG, et al: The phosphate binder ferric citrate and mineral metabolism and inflammatory markers in maintenance dialysis patients: Results from prespecified analyses of a randomized clinical trial. Am J Kidney Dis. 66:479–488. 2015. View Article : Google Scholar : PubMed/NCBI

28 

As'habi A, Tabibi H, Hedayati M, Mahdavi-Mazdeh M and Nozary-Heshmati B: Association of malnutrition-inflammation score, dialysis-malnutrition score and serum albumin with novel risk factors for cardiovascular diseases in hemodialysis patients. Ren Fail. 37:113–116. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Cho Y, Hawley CM and Johnson DW: Clinical causes of inflammation in peritoneal dialysis patients. Int J Nephrol. 2014:9093732014. View Article : Google Scholar : PubMed/NCBI

30 

Xing L: Effect of different dialysis methods on cellular immunity function of maintenance haemodialysis patients. West Indian Med J. 64:499–505. 2015.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li G, Ma H, Yin Y and Wang J: CRP, IL‑2 and TNF‑α level in patients with uremia receiving hemodialysis. Mol Med Rep 17: 3350-3355, 2018.
APA
Li, G., Ma, H., Yin, Y., & Wang, J. (2018). CRP, IL‑2 and TNF‑α level in patients with uremia receiving hemodialysis. Molecular Medicine Reports, 17, 3350-3355. https://doi.org/10.3892/mmr.2017.8197
MLA
Li, G., Ma, H., Yin, Y., Wang, J."CRP, IL‑2 and TNF‑α level in patients with uremia receiving hemodialysis". Molecular Medicine Reports 17.2 (2018): 3350-3355.
Chicago
Li, G., Ma, H., Yin, Y., Wang, J."CRP, IL‑2 and TNF‑α level in patients with uremia receiving hemodialysis". Molecular Medicine Reports 17, no. 2 (2018): 3350-3355. https://doi.org/10.3892/mmr.2017.8197
Copy and paste a formatted citation
x
Spandidos Publications style
Li G, Ma H, Yin Y and Wang J: CRP, IL‑2 and TNF‑α level in patients with uremia receiving hemodialysis. Mol Med Rep 17: 3350-3355, 2018.
APA
Li, G., Ma, H., Yin, Y., & Wang, J. (2018). CRP, IL‑2 and TNF‑α level in patients with uremia receiving hemodialysis. Molecular Medicine Reports, 17, 3350-3355. https://doi.org/10.3892/mmr.2017.8197
MLA
Li, G., Ma, H., Yin, Y., Wang, J."CRP, IL‑2 and TNF‑α level in patients with uremia receiving hemodialysis". Molecular Medicine Reports 17.2 (2018): 3350-3355.
Chicago
Li, G., Ma, H., Yin, Y., Wang, J."CRP, IL‑2 and TNF‑α level in patients with uremia receiving hemodialysis". Molecular Medicine Reports 17, no. 2 (2018): 3350-3355. https://doi.org/10.3892/mmr.2017.8197
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team