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Article

Elevated expression of PD‑1 on T cells correlates with disease activity in rheumatoid arthritis

  • Authors:
    • Qing Luo
    • Jianqing Ye
    • Lulu Zeng
    • Zhongqin Luo
    • Zhen Deng
    • Xue Li
    • Yang Guo
    • Zikun Huang
    • Junming Li
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China , Department of Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China
  • Pages: 3297-3305
    |
    Published online on: December 6, 2017
       https://doi.org/10.3892/mmr.2017.8204
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Abstract

It is well known that lymphocytes are important in rheumatoid arthritis (RA). Programmed cell death-1 (PD‑1) is one of the immunosuppressive costimulatory molecules, which mediates an inhibitory effect. However, its role in RA remains to be fully elucidated. In the present study, the expression levels of PD‑1 on T cells in the peripheral blood (PB) and synovial fluid (SF) were determined using flow cytometry. In addition, the expression levels of PD‑1 on T cells in the PB and SF of patients with RA were further analyzed to determine correlation with markers of the autoimmune response, inflammation and disease activity in RA. Compared with healthy controls, the expression of PD‑1 on T cells in the PB was significantly elevated in patients with RA (P<0.0001). The expression of PD‑1 on T cells in the SF of patients with RA was significantly increased, compared with that in the autologous PB (P<0.0001). It was also found that the expression of PD‑1 on T cells in the PB of patients with RA was increased significantly in subjects with a high rheumatoid factor titer, high levels of inflammatory markers and a high disease activity score 28 (DAS28). The expression of PD‑1 on T cells in the SF of patients with RA was increased significantly in subjects with a high DAS28. These data showed that the expression of PD‑1 on T cells was elevated in patients with RA and was correlated with the disease activity.
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1 

Goekoop-Ruiterman YP and Huizinga TW: Rheumatoid arthritis: Can we achieve true drug-free remission in patients with RA? Nat Rev Rheumatol. 6:68–70. 2010. View Article : Google Scholar : PubMed/NCBI

2 

McInnes IB and Schett G: The pathogenesis of rheumatoid arthritis. N Engl J Med. 365:2205–2219. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Gravallese EM, Manning C, Tsay A, Naito A, Pan C, Amento E and Goldring SR: Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum. 43:250–258. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Shigeyama Y, Pap T, Kunzler P, Simmen BR, Gay RE and Gay S: Expression of osteoclast differentiation factor in rheumatoid arthritis. Arthritis Rheum. 43:2523–2530. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Gracie JA, Forsey RJ, Chan WL, Gilmour A, Leung BP, Greer MR, Kennedy K, Carter R, Wei XQ, Xu D, et al: A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest. 104:1393–1401. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Rech J, Hueber AJ, Finzel S, Englbrecht M, Haschka J, Manger B, Kleyer A, Reiser M, Cobra JF, Figueiredo C, et al: Prediction of disease relapses by multibiomarker disease activity and autoantibody status in patients with rheumatoid arthritis on tapering DMARD treatment. Ann Rheum Dis. 75:1637–1644. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Agrawal S, Misra R and Aggarwal A: Autoantibodies in rheumatoid arthritis: Association with severity of disease in established RA. Clin Rheumatol. 26:201–204. 2007. View Article : Google Scholar : PubMed/NCBI

8 

He J, Tsai LM, Leong YA, Hu X, Ma CS, Chevalier N, Sun X, Vandenberg K, Rockman S, Ding Y, et al: Circulating precursor CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity. 39:770–781. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Bennett JC: The role of T lymphocytes in rheumatoid arthritis and other autoimmune diseases. Arthritis Rheum. 58 Suppl 2:S53–S57. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Holmdahl R, Klareskog L, Rubin K, Björk J, Smedegård G, Jonsson R and Andersson M: Role of T lymphocytes in murine collagen induced arthritis. Agents Actions. 19:295–305. 1986. View Article : Google Scholar : PubMed/NCBI

11 

Godefroy E, Zhong H, Pham P, Friedman D and Yazdanbakhsh K: TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: Potential role in sickle cell alloimmunization. Haematologica. 100:1415–1425. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Ma J, Zhu C, Ma B, Tian J, Baidoo SE, Mao C, Wu W, Chen J, Tong J, Yang M, et al: Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis. Clin Dev Immunol. 2012:8274802012. View Article : Google Scholar : PubMed/NCBI

13 

Wang J, Shan Y, Jiang Z, Feng J, Li C, Ma L and Jiang Y: High frequencies of activated B cells and T follicular helper cells are correlated with disease activity in patients with new-onset rheumatoid arthritis. Clin Exp Immunol. 174:212–220. 2013.PubMed/NCBI

14 

Raptopoulou AP, Bertsias G, Makrygiannakis D, Verginis P, Kritikos I, Tzardi M, Klareskog L, Catrina AI, Sidiropoulos P and Boumpas DT: The programmed death 1/programmed death ligand 1 inhibitory pathway is up-regulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis. Arthritis Rheum. 62:1870–1880. 2010.PubMed/NCBI

15 

Moret FM, van der Wurff-Jacobs KM, Bijlsma JW, Lafeber FP and van Roon JA: Synovial T cell hyporesponsiveness to myeloid dendritic cells is reversed by preventing PD-1/PD-L1 interactions. Arthritis Res Ther. 16:4972014. View Article : Google Scholar : PubMed/NCBI

16 

Li S, Peng D, He Y, Zhang H, Sun H, Shan S, Song Y, Zhang S, Xiao H, Song H and Zhang M: Expression of TIM-3 on CD4+ and CD8+ T cells in the peripheral blood and synovial fluid of rheumatoid arthritis. APMIS. 122:899–904. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Wang F, Hou H, Wu S, Tang Q, Liu W, Huang M, Yin B, Huang J, Mao L, Lu Y and Sun Z: TIGIT expression levels on human NK cells correlate with functional heterogeneity among healthy individuals. Eur J Immunol. 45:2886–2897. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Flores-Borja F, Jury EC, Mauri C and Ehrenstein MR: Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis. Proc Natl Acad Sci USA. 105:pp. 19396–19401. 2008; View Article : Google Scholar : PubMed/NCBI

19 

Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, et al: PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2:261–268. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A, Sasayama S, Mizoguchi A, Hiai H, Minato N and Honjo T: Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science. 291:319–322. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Dai S, Jia R, Zhang X, Fang Q and Huang L: The PD-1/PD-Ls pathway and autoimmune diseases. Cell Immunol. 290:72–79. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Wan B, Nie H, Liu A, Feng G, He D, Xu R, Zhang Q, Dong C and Zhang JZ: Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. J Immunol. 177:8844–8850. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Hatachi S, Iwai Y, Kawano S, Morinobu S, Kobayashi M, Koshiba M, Saura R, Kurosaka M, Honjo T and Kumagai S: CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid. J Rheumatol. 30:1410–1419. 2003.PubMed/NCBI

24 

Li S, Liao W, Chen M, Shan S, Song Y, Zhang S, Song H and Yuan Z: Expression of programmed death-1 (PD-1) on CD4+ and CD8+ T cells in rheumatoid arthritis. Inflammation. 37:116–121. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al: The American rheumatism assocaition 1987 revised criteria for the classification of rheumatoid arthritis. Arthr Rhuem. 31:315–324. 1988. View Article : Google Scholar

26 

Prevoo ML, van't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB and van Riel PL: Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 38:44–48. 1995. View Article : Google Scholar : PubMed/NCBI

27 

Lajas C, Abasolo L, Bellajdel B, Hernández-García C, Carmona L, Vargas E, Lázaro P and Jover JA: Costs and predictors of costs in rheumatoid arthritis: A prevalence-based study. Arthritis Rheum. 49:64–70. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Yuan FL, Li X, Lu WG, Li CW, Xu RS and Dong J: IL-33: A promising therapeutic target for rheumatoid arthritis? Expert Opin Ther Targets. 15:529–534. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Wright HL, Moots RJ and Edwards SW: The multifactorial role of neutrophils in rheumatoid arthritis. Nat Rev Rheumatol. 10:593–601. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Cohen S and Emery P: The American College of Rheumatology/European League Against Rheumatism Criteria for the classification of rheumatoid arthritis: A game changer. Ann Rheum Dis. 69:1575–1576. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Carruthers DM, Arrol HP, Bacon PA and Young SP: Dysregulated intracellular Ca2+ stores and Ca2+ signaling in synovial fluid T lymphocytes from patients with chronic inflammatory arthritis. Arthritis Rheum. 43:1257–1265. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Malemud CJ: Dysfunctional immune-mediated inflammation in rheumatoid arthritis dictates that development of anti-rheumatic disease drugs target multiple intracellular signaling pathways. Antiinflamm Antiallergy Agents Med Chem. 10:78–84. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Good-Jacobson KL, Szumilas CG, Chen L, Sharpe AH, Tomayko MM and Shlomchik MJ: PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol. 11:535–542. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Liu R, Wu Q, Su D, Che N, Chen H, Geng L, Chen J, Chen W, Li X and Sun L: A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis. Arthritis Res Ther. 14:R2552012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Luo Q, Ye J, Zeng L, Luo Z, Deng Z, Li X, Guo Y, Huang Z and Li J: Elevated expression of PD‑1 on T cells correlates with disease activity in rheumatoid arthritis. Mol Med Rep 17: 3297-3305, 2018.
APA
Luo, Q., Ye, J., Zeng, L., Luo, Z., Deng, Z., Li, X. ... Li, J. (2018). Elevated expression of PD‑1 on T cells correlates with disease activity in rheumatoid arthritis. Molecular Medicine Reports, 17, 3297-3305. https://doi.org/10.3892/mmr.2017.8204
MLA
Luo, Q., Ye, J., Zeng, L., Luo, Z., Deng, Z., Li, X., Guo, Y., Huang, Z., Li, J."Elevated expression of PD‑1 on T cells correlates with disease activity in rheumatoid arthritis". Molecular Medicine Reports 17.2 (2018): 3297-3305.
Chicago
Luo, Q., Ye, J., Zeng, L., Luo, Z., Deng, Z., Li, X., Guo, Y., Huang, Z., Li, J."Elevated expression of PD‑1 on T cells correlates with disease activity in rheumatoid arthritis". Molecular Medicine Reports 17, no. 2 (2018): 3297-3305. https://doi.org/10.3892/mmr.2017.8204
Copy and paste a formatted citation
x
Spandidos Publications style
Luo Q, Ye J, Zeng L, Luo Z, Deng Z, Li X, Guo Y, Huang Z and Li J: Elevated expression of PD‑1 on T cells correlates with disease activity in rheumatoid arthritis. Mol Med Rep 17: 3297-3305, 2018.
APA
Luo, Q., Ye, J., Zeng, L., Luo, Z., Deng, Z., Li, X. ... Li, J. (2018). Elevated expression of PD‑1 on T cells correlates with disease activity in rheumatoid arthritis. Molecular Medicine Reports, 17, 3297-3305. https://doi.org/10.3892/mmr.2017.8204
MLA
Luo, Q., Ye, J., Zeng, L., Luo, Z., Deng, Z., Li, X., Guo, Y., Huang, Z., Li, J."Elevated expression of PD‑1 on T cells correlates with disease activity in rheumatoid arthritis". Molecular Medicine Reports 17.2 (2018): 3297-3305.
Chicago
Luo, Q., Ye, J., Zeng, L., Luo, Z., Deng, Z., Li, X., Guo, Y., Huang, Z., Li, J."Elevated expression of PD‑1 on T cells correlates with disease activity in rheumatoid arthritis". Molecular Medicine Reports 17, no. 2 (2018): 3297-3305. https://doi.org/10.3892/mmr.2017.8204
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