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Upregulation of miR‑598 promotes cell proliferation and cell cycle progression in human colorectal carcinoma by suppressing INPP5E expression

  • Authors:
    • Kun‑Ping Li
    • Yong‑Ping Fang
    • Jin‑Qi Liao
    • Jin‑Dong Duan
    • Li‑Guang Feng
    • Xiao‑Zai Luo
    • Zhi‑Jian Liang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Huizhou First Hospital, Huizhou, Guangdong 516000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2991-2997
    |
    Published online on: December 6, 2017
       https://doi.org/10.3892/mmr.2017.8207
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Abstract

Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Recently, microRNAs (miRs) have been considered as novel therapeutic targets for the treatment of cancer. miR‑598 is a poorly investigated miR. The underlying mechanism of miR‑598 in CRC cells remains to be elucidated. In the present study, miR‑598 was demonstrated to be significantly upregulated in CRC tissue by analyzing data from The Cancer Genome Atlas and the Gene Expression Omnibus. The results of a polymerase chain reaction demonstrated that miR‑598 expression was significantly upregulated in CRC tissues and cells. Gain of function and loss of function assays demonstrated that miR‑598 significantly promoted cell proliferation and cell cycle progression. miR‑598 was demonstrated to modulate cell functions by regulating 72 kDa inositol polyphosphate‑5‑phosphatase (INPP5E). In addition, knockdown of INPP5E counteracted the growth arrest caused by an miR‑598‑inhibitor. In conclusion, the present study demonstrated that miR‑598 contributed to cell proliferation and cell cycle progression in CRC by targeting INPP5E.
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1 

Siegel R, Desantis C and Jemal A: Colorectal cancer statistics, 2014. CA Cancer J Clin. 64:104–117. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Lieberman DA: Clinical practice. Screening for colorectal cancer. N Engl J Med. 361:1179–1187. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Haggar FA and Boushey RP: Colorectal cancer epidemiology: Incidence, mortality, survival, and risk factors. Clin Colon Rectal Surg. 22:191–197. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Wang ZS, Zhong M, Bian YH, Mu YF, Qin SL, Yu MH and Qin J: MicroRNA-187 inhibits tumor growth and invasion by directly targeting CD276 in colorectal cancer. Oncotarget. 7:44266–44276. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Minna E, Romeo P, Dugo M, De Cecco L, Todoerti K, Pilotti S, Perrone F, Seregni E, Agnelli L, Neri A, et al: miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma. Oncotarget. 7:12731–12747. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Li N, Zhao X, Wang L, Zhang S, Cui M and He J: miR-494 suppresses tumor growth of epithelial ovarian carcinoma by targeting IGF1R. Tumour Biol. 37:7767–7776. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Tian J, Hu L, Li X, Geng J, Dai M and Bai X: MicroRNA-130b promotes lung cancer progression via PPAR γ/VEGF-A/BCL-2-mediated suppression of apoptosis. J Exp Clin Cancer Res. 35:1052016. View Article : Google Scholar : PubMed/NCBI

9 

Zhao Z, Qin L and Li S: miR-411 contributes the cell proliferation of lung cancer by targeting FOXO1. Tumour Biol. 37:5551–5560. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Zhang Y, Xu G, Liu G, Ye Y, Zhang C, Fan C, Wang H, Cai H, Xiao R, Huang Z and Luo Q: miR-411-5p inhibits proliferation and metastasis of breast cancer cell via targeting GRB2. Biochem Biophys Res Commun. 476:607–613. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Xia K, Zhang Y, Cao S, Wu Y, Guo W, Yuan W and Zhang S: miR-411 regulated ITCH expression and promoted cell proliferation in human hepatocellular carcinoma cells. Biomed Pharmacother. 70:158–163. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Wang M, Wen TF, He LH, Li C, Zhu WJ and Trishul NM: A six-microRNA set as prognostic indicators for bile duct cancer. Int J Clin Exp Med. 8:17261–17270. 2015.PubMed/NCBI

13 

Zhao BS, Liu SG, Wang TY, Ji YH, Qi B, Tao YP, Li HC and Wu XN: Screening of microRNA in patients with esophageal cancer at same tumor node metastasis stage with different prognoses. Asian Pac J Cancer Prev. 14:139–143. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Zhu X, Li D, Yu F, Jia C, Xie J, Ma Y, Fan S, Cai H, Luo Q, Lv Z and Fan L: miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein. Oncotarget. 7:13139–13152. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Xue L, Xu Z, Wang K, Wang N, Zhang X and Wang S: Network analysis of microRNAs, transcription factors, target genes and host genes in human anaplastic astrocytoma. Exp Ther Med. 12:437–444. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Kang L, Yang C, Song Y, Liu W, Wang K, Li S and Zhang Y: MicroRNA-23a-3p promotes the development of osteoarthritis by directly targeting SMAD3 in chondrocytes. Biochem Biophys Res Commun. 478:467–473. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Chang PY, Chen CC, Chang YS, Tsai WS, You JF, Lin GP, Chen TW, Chen JS and Chan EC: MicroRNA-223 and microRNA-92a in stool and plasma samples act as complementary biomarkers to increase colorectal cancer detection. Oncotarget. 7:10663–10675. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Deng B, Wang B, Fang J, Zhu X, Cao Z, Lin Q, Zhou L and Sun X: MiRNA-203 suppresses cell proliferation, migration and invasion in colorectal cancer via targeting of EIF5A2. Sci Rep. 6:283012016. View Article : Google Scholar : PubMed/NCBI

20 

Yang F, Xie YQ, Tang SQ, Wu XB and Zhu HY: miR-143 regulates proliferation and apoptosis of colorectal cancer cells and exhibits altered expression in colorectal cancer tissue. Int J Clin Exp Med. 8:15308–15312. 2015.PubMed/NCBI

21 

Cheng J, Deng R, Zhang P, Wu C, Wu K, Shi L, Liu X, Bai J, Deng M, Shuai X, et al: miR-219-5p plays a tumor suppressive role in colon cancer by targeting oncogene Sall4. Oncol Rep. 34:1923–1932. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Wang H, Cao F, Li X, Miao H, E J, Xing J and Fu CG: miR-320b suppresses cell proliferation by targeting c-Myc in human colorectal cancer cells. BMC Cancer. 15:7482015. View Article : Google Scholar : PubMed/NCBI

23 

Cai C, Ashktorab H, Pang X, Zhao Y, Sha W, Liu Y and Gu X: MicroRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5. PLoS One. 7:e297502012. View Article : Google Scholar : PubMed/NCBI

24 

Zhang J, Fei B, Wang Q, Song M, Yin Y, Zhang B, Ni S, Guo W, Bian Z, Quan C, et al: MicroRNA-638 inhibits cell proliferation, invasion and regulates cell cycle by targeting tetraspanin 1 in human colorectal carcinoma. Oncotarget. 5:12083–12096. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Liang WL, Cao J, Xu B, Yang P, Shen F, Sun Z, Li WL, Wang Q and Liu F: miR-892a regulated PPP2R2A expression and promoted cell proliferation of human colorectal cancer cells. Biomed Pharmacother. 72:119–124. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Ooms LM, Horan KA, Rahman P, Seaton G, Gurung R, Kethesparan DS and Mitchell CA: The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease. Biochem J. 419:29–49. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Bielas SL, Silhavy JL, Brancati F, Kisseleva MV, Al-Gazali L, Sztriha L, Bayoumi RA, Zaki MS, Abdel-Aleem A, Rosti RO, et al: Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies. Nat Genet. 41:1032–1036. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Hakim S, Bertucci MC, Conduit SE, Vuong DL and Mitchell CA: Inositol polyphosphate phosphatases in human disease. Curr Top Microbiol Immunol. 362:247–314. 2012.PubMed/NCBI

29 

Hakim S, Dyson JM, Feeney SJ, Davies EM, Sriratana A, Koenig MN, Plotnikova OV, Smyth IM, Ricardo SD, Hobbs RM and Mitchell CA: Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling. Hum Mol Genet. 25:2295–2313. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li KP, Fang YP, Liao JQ, Duan JD, Feng LG, Luo XZ and Liang ZJ: Upregulation of miR‑598 promotes cell proliferation and cell cycle progression in human colorectal carcinoma by suppressing INPP5E expression. Mol Med Rep 17: 2991-2997, 2018.
APA
Li, K., Fang, Y., Liao, J., Duan, J., Feng, L., Luo, X., & Liang, Z. (2018). Upregulation of miR‑598 promotes cell proliferation and cell cycle progression in human colorectal carcinoma by suppressing INPP5E expression. Molecular Medicine Reports, 17, 2991-2997. https://doi.org/10.3892/mmr.2017.8207
MLA
Li, K., Fang, Y., Liao, J., Duan, J., Feng, L., Luo, X., Liang, Z."Upregulation of miR‑598 promotes cell proliferation and cell cycle progression in human colorectal carcinoma by suppressing INPP5E expression". Molecular Medicine Reports 17.2 (2018): 2991-2997.
Chicago
Li, K., Fang, Y., Liao, J., Duan, J., Feng, L., Luo, X., Liang, Z."Upregulation of miR‑598 promotes cell proliferation and cell cycle progression in human colorectal carcinoma by suppressing INPP5E expression". Molecular Medicine Reports 17, no. 2 (2018): 2991-2997. https://doi.org/10.3892/mmr.2017.8207
Copy and paste a formatted citation
x
Spandidos Publications style
Li KP, Fang YP, Liao JQ, Duan JD, Feng LG, Luo XZ and Liang ZJ: Upregulation of miR‑598 promotes cell proliferation and cell cycle progression in human colorectal carcinoma by suppressing INPP5E expression. Mol Med Rep 17: 2991-2997, 2018.
APA
Li, K., Fang, Y., Liao, J., Duan, J., Feng, L., Luo, X., & Liang, Z. (2018). Upregulation of miR‑598 promotes cell proliferation and cell cycle progression in human colorectal carcinoma by suppressing INPP5E expression. Molecular Medicine Reports, 17, 2991-2997. https://doi.org/10.3892/mmr.2017.8207
MLA
Li, K., Fang, Y., Liao, J., Duan, J., Feng, L., Luo, X., Liang, Z."Upregulation of miR‑598 promotes cell proliferation and cell cycle progression in human colorectal carcinoma by suppressing INPP5E expression". Molecular Medicine Reports 17.2 (2018): 2991-2997.
Chicago
Li, K., Fang, Y., Liao, J., Duan, J., Feng, L., Luo, X., Liang, Z."Upregulation of miR‑598 promotes cell proliferation and cell cycle progression in human colorectal carcinoma by suppressing INPP5E expression". Molecular Medicine Reports 17, no. 2 (2018): 2991-2997. https://doi.org/10.3892/mmr.2017.8207
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