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Article

Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B

  • Authors:
    • Fengxia Yan
    • Rifang Liao
    • Shaofen Lin
    • Xianguo Deng
    • Peter J. Little
    • Wenhua Zheng
  • View Affiliations / Copyright

    Affiliations: School of Pharmaceutical Sciences and State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China, School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland QLD 4102, Australia
  • Pages: 3109-3114
    |
    Published online on: December 7, 2017
       https://doi.org/10.3892/mmr.2017.8215
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Abstract

Forkhead box protein O3 (FoxO3a) is a forkhead box family transcription factor which serves an important role in a number of biological functions, including tumor growth. A previous study indicated that FoxO3a serves a role in insulin like growth factor‑induced growth, migration and invasion of uveal melanoma (UM) cells; however, whether FoxO3a is associated with the development and formation of UM remains unknown. In the present study, the role of FoxO3a in UM development and formation was investigated by modulating the expression of FoxO3a in a human UM cell line. The results of the present study demonstrated that FoxO3a overexpression in UM cells inhibited cell proliferation and promoted cellular apoptosis, leading to an accumulation of cells at the G1 cell cycle phase. Western blot analysis demonstrated that FoxO3a overexpression increased the transcription and protein expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B, and inhibited cyclin D1 transcription and expression. The opposite effects were observed when FoxO3a was knocked down in UM cells. The results of the present study indicated that FoxO3a may exhibit a negative role in UM development and formation, which is consistent with its role as a tumor suppressor.
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Copy and paste a formatted citation
Spandidos Publications style
Yan F, Liao R, Lin S, Deng X, Little PJ and Zheng W: Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B. Mol Med Rep 17: 3109-3114, 2018.
APA
Yan, F., Liao, R., Lin, S., Deng, X., Little, P.J., & Zheng, W. (2018). Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B. Molecular Medicine Reports, 17, 3109-3114. https://doi.org/10.3892/mmr.2017.8215
MLA
Yan, F., Liao, R., Lin, S., Deng, X., Little, P. J., Zheng, W."Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B". Molecular Medicine Reports 17.2 (2018): 3109-3114.
Chicago
Yan, F., Liao, R., Lin, S., Deng, X., Little, P. J., Zheng, W."Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B". Molecular Medicine Reports 17, no. 2 (2018): 3109-3114. https://doi.org/10.3892/mmr.2017.8215
Copy and paste a formatted citation
x
Spandidos Publications style
Yan F, Liao R, Lin S, Deng X, Little PJ and Zheng W: Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B. Mol Med Rep 17: 3109-3114, 2018.
APA
Yan, F., Liao, R., Lin, S., Deng, X., Little, P.J., & Zheng, W. (2018). Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B. Molecular Medicine Reports, 17, 3109-3114. https://doi.org/10.3892/mmr.2017.8215
MLA
Yan, F., Liao, R., Lin, S., Deng, X., Little, P. J., Zheng, W."Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B". Molecular Medicine Reports 17.2 (2018): 3109-3114.
Chicago
Yan, F., Liao, R., Lin, S., Deng, X., Little, P. J., Zheng, W."Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B". Molecular Medicine Reports 17, no. 2 (2018): 3109-3114. https://doi.org/10.3892/mmr.2017.8215
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