Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February-2018 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2018 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Histone deacetylase 2 is involved in µ‑opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain

  • Authors:
    • Yong‑Hui Liao
    • Jian Wang
    • Yan‑Yan Wei
    • Ting Zhang
    • Yong Zhang
    • Zhong‑Fu Zuo
    • Xiao‑Yu Teng
    • Yun‑Qing Li
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy and K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Anatomy, Histology and Embryology, Liaoning Medical University, Jinzhou, Liaoning 121000, P.R. China
    Copyright: © Liao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2803-2810
    |
    Published online on: December 11, 2017
       https://doi.org/10.3892/mmr.2017.8245
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Chronic pain occurs in ~85-90% of chronic pancreatitis (CP) patients. However, as the pathogenesis of CP pain remains to be fully understood, the current therapies for CP pain remain inadequate. Emerging evidence has suggested that the epigenetic modulations of genes are involved in chronic pain. In the present study, intrapancreatic trinitrobenzene sulfonic acid infusions were used to establish a CP model in rats. Mechanical allodynia was measured with von Frey filaments. Immunofluorescent staining analysis was used to observe the expression changes of histone deacetylase 2 (HDAC2) and µ‑opioid receptor (MOR), and intrathecal administration of the selective HDAC2 inhibitor AR‑42 was used to assess the underlying mechanisms. The expression levels of c‑Jun N‑terminal kinase (JNK) in the thoracic spinal cord were detected by western blotting, and the mRNA expression levels of interleukin (IL)1‑β, IL‑6 and tumor necrosis factor (TNF)‑α were detected by reverse transcription‑quantitative polymerase chain reaction. The results demonstrated that HDAC2 expression was upregulated during the course of CP induction, while MOR activity in the thoracic spinal dorsal horn was significantly suppressed. Intrathecal infusion of AR‑42 significantly attenuated CP‑induced mechanical allodynia, with rescued MOR activity. Additionally, HDAC2 facilitated the release of inflammatory cytokines, including IL‑1β, IL‑6 and TNF‑α. These results suggested that the underlying mechanisms of HDAC2 regulating MOR activity under CP induction may occur via promoting the release of inflammatory cytokines, thus activating the JNK signaling pathway. The present study suggested that the epigenetic‑regulated disturbance of MOR is dependent on the endogenous analgesia system in CP, which may a provide novel therapeutic strategy for treating pain in CP.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Keefe MD, Wang H, De La OJP, Khan A, Firpo MA and Murtaugh LC: β-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice. Dis Model Mech. 5:503–514. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Braganza JM, Lee SH, McCloy RF and McMahon MJ: Chronic pancreatitis. Lancet. 377:1184–1197. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Olesen SS, Juel J, Graversen C, Kolesnikov Y, Wilder-Smith OH and Drewes AM: Pharmacological pain management in chronic pancreatitis. World J Gastroenterol. 19:7292–7301. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Drewes AM, Krarup AL, Detlefsen S, Malmstrøm ML, Dimcevski G and Funch-Jensen P: Pain in chronic pancreatitis: The role of neuropathic pain mechanisms. Gut. 57:1616–1627. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Feng W, Teng R, Zhao Y, Gao J and Chu H: Epigenetic modulation of Wnt signaling contributes to neuropathic pain in rats. Mol Med Rep. 12:4727–4733. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Gáranton SM: Targeting epigenetic mechanisms for pain relief. Curr Opin Pharmacol. 12:35–41. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Lessans S and Dorsey SG: The role for epigenetic modifications in pain and analgesia response. Nurs Res Pract 2013. 9614932013.

8 

Gilbert RE, Huang Q, Thai K, Advani SL, Lee K, Yuen DA, Connelly KA and Advani A: Histone deacetylase inhibition attenuates diabetes-associated kidney growth: Potential role for epigenetic modification of the epidermal growth factor receptor. Kidney Int. 79:1312–1321. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Capasso KE, Manners MT, Quershi RA, et al: Effect of histone deacetylase inhibitor JNJ-26481585 in pain. J Mol Neurosci. 55:570–578. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Bai G, Wei D, Zou S, Ren K and Dubner R: Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia. Mol Pain. 6:512010. View Article : Google Scholar : PubMed/NCBI

11 

Chiechio S, Copani A, Zammataro M, Battaglia G, Gereau RW IV and Nicoletti F: Transcriptional regulation of type-2 metabotropic glutamate receptors: An epigenetic path to novel treatments for chronic pain. Trends Pharmacol Sci. 31:153–160. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Gereau RW IV, Copani A and Nicoletti F: Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain. Mol Pharmacol. 75:1014–1020. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Zhang Z, Cai YQ, Zou F, Bie B and Pan ZZ: Epigenetic suppression of GAD65 expression mediates persistent pain. Nat Med. 17:1448–1455. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Harrison C: Analgesia: Unravelling epigenetic mechanisms of chronic pain. Nat Rev Drug Discov. 10:9002011.PubMed/NCBI

15 

Jamil MF, Subki MF, Lan TM, Majid MI and Adenan MI: The effect of mitragynine on cAMP formation and mRNA expression of mu-opioid receptors mediated by chronic morphine treatment in SK-N-SH neuroblastoma cell. J Ethnopharmacol. 148:135–143. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Hwang CK, Kim CS, Kim DK, Law PY, Wei LN and Loh HH: Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells. Mol Pharmacol. 78:58–68. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Wagley Y, Hwang CK, Lin HY, Kam AF, Law PY, Loh HH and Wei LN: Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells. Biochim Biophys Acta. 1833:1476–1488. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Qian NS, Liao YH, Feng QX, Tang Y, Dou KF and Tao KS: Spinal toll like receptor 3 is involved in chronic pancreatitis-induced mechanical allodynia of rat. Mol Pain. 7:152011. View Article : Google Scholar : PubMed/NCBI

19 

Ravillah D, Mohammed A, Qian L, Brewer M, Zhang Y, Biddick L, Steele VE and Rao CV: Chemopreventive effects of an HDAC2-selective inhibitor on rat colon carcinogenesis and APCmin/+ mouse intestinal tumorigenesis. J Pharmacol Exp Ther. 348:59–68. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Denk F and McMahon SB: Chronic pain: Emerging evidence for the involvement of epigenetics. Neuron. 73:435–444. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Haggarty SJ and Tsai LH: Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. Neurobiol Learn Mem. 96:41–52. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Dietz KC and Casaccia P: HDAC inhibitors and neurodegeneration: At the edge between protection and damage. Pharmacol Res. 62:11–17. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Hashioka S, Klegeris A and McGeer PL: The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-γ. J Neuroinflammation. 9:1132012. View Article : Google Scholar : PubMed/NCBI

25 

Suh HS, Choi S, Khattar P, Choi N and Lee SC: Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes. J Neuroimmune Pharmacol. 5:521–532. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Liu PY, Lu CL, Wang CC, Lee IH, Hsieh JC, Chen CC, Lee HF, Lin HC, Chang FY and Lee SD: Spinal microglia initiate and maintain hyperalgesia in a rat model of chronic pancreatitis. Gastroenterology. 142:165–173.e2. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Cheng H, Xie Z, Jones WP, Wei XT, Liu Z, Wang D, Kulp SK, Wang J, Coss CC, Chen CS, et al: Preclinical pharmacokinetics study of R- and S-enantiomers of the histone deacetylase inhibitor, AR-42 (NSC 731438), in rodents. AAPS J. 18:737–745. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Shakespear MR, Halili MA, Irvine KM, Fairlie DP and Sweet MJ: Histone deacetylases as regulators of inflammation and immunity. Trends Immunol. 32:335–343. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Xu Y, Wang D, Zhuang Z, Jin K, Zheng L, Yang Q and Guo K: Hypericin-mediated photodynamic therapy induces apoptosis in K562 human leukemia cells through JNK pathway modulation. Mol Med Rep. 12:6475–6482. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Herrmann JL, Weil BR, Abarbanell AM, Wang Y, Poynter JA, Manukyan MC and Meldrum DR: IL-6 and TGF-α costimulate mesenchymal stem cell vascular endothelial growth factor production by ERK-, JNK-, and PI3K-mediated mechanisms. Shock. 35:512–516. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Lu ZY, Chen WC, Li YH, Li L, Zhang H, Pang Y, Xiao ZF, Xiao HW and Xiao Y: TNF-α enhances vascular cell adhesion molecule-1 expression in human bone marrow mesenchymal stem cells via the NF-κB, ERK and JNK signaling pathways. Mol Med Rep. 14:643–648. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Liang R, Zhang W and Song YM: Levels of leptin and IL-6 in lungs and blood are associated with the severity of chronic obstructive pulmonary disease in patients and rat models. Mol Med Rep. 7:1470–1476. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Kim DK, Hwang CK, Wagley Y, Law PY, Wei LN and Loh HH: p38 mitogen-activated protein kinase and PI3-kinase are involved in up-regulation of mu opioid receptor transcription induced by cycloheximide. J Neurochem. 116:1077–1087. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Bian JM, Wu N, Su RB and Li J: Phosphatidylethanolamine-binding protein is not involved in µ-opioid receptor-mediated regulation of extracellular signal-regulated kinase. Mol Med Rep. 11:3368–3374. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Zhang ZY and Schluesener HJ: HDAC inhibitor MS-275 attenuates the inflammatory reaction in rat experimental autoimmune prostatitis. Prostate. 72:90–99. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Zhang B, West EJ, Van KC, Gurkoff GG, Zhou J, Zhang XM, Kozikowski AP and Lyeth BG: HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats. Brain Res. 1226:181–191. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Zhang S, Suvannasankha A, Crean CD, White VL, Chen CS and Farag SS: The novel histone deacetylase inhibitor, AR-42, inhibits gp130/Stat3 pathway and induces apoptosis and cell cycle arrest in multiple myeloma cells. Int J Cancer. 129:204–213. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Lucas DM, Alinari L, West DA, Davis ME, Edwards RB, Johnson AJ, Blum KA, Hofmeister CC, Freitas MA, Parthun MR, et al: The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo. PLoS One. 5:e109412010. View Article : Google Scholar : PubMed/NCBI

39 

Ji RR: Neuroimmune interactions in itch: Do chronic itch, chronic pain, and chronic cough share similar mechanisms? Pulm Pharmacol Ther. 35:81–86. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liao YH, Wang J, Wei YY, Zhang T, Zhang Y, Zuo ZF, Teng XY and Li YQ: Histone deacetylase 2 is involved in µ‑opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain. Mol Med Rep 17: 2803-2810, 2018.
APA
Liao, Y., Wang, J., Wei, Y., Zhang, T., Zhang, Y., Zuo, Z. ... Li, Y. (2018). Histone deacetylase 2 is involved in µ‑opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain. Molecular Medicine Reports, 17, 2803-2810. https://doi.org/10.3892/mmr.2017.8245
MLA
Liao, Y., Wang, J., Wei, Y., Zhang, T., Zhang, Y., Zuo, Z., Teng, X., Li, Y."Histone deacetylase 2 is involved in µ‑opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain". Molecular Medicine Reports 17.2 (2018): 2803-2810.
Chicago
Liao, Y., Wang, J., Wei, Y., Zhang, T., Zhang, Y., Zuo, Z., Teng, X., Li, Y."Histone deacetylase 2 is involved in µ‑opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain". Molecular Medicine Reports 17, no. 2 (2018): 2803-2810. https://doi.org/10.3892/mmr.2017.8245
Copy and paste a formatted citation
x
Spandidos Publications style
Liao YH, Wang J, Wei YY, Zhang T, Zhang Y, Zuo ZF, Teng XY and Li YQ: Histone deacetylase 2 is involved in µ‑opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain. Mol Med Rep 17: 2803-2810, 2018.
APA
Liao, Y., Wang, J., Wei, Y., Zhang, T., Zhang, Y., Zuo, Z. ... Li, Y. (2018). Histone deacetylase 2 is involved in µ‑opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain. Molecular Medicine Reports, 17, 2803-2810. https://doi.org/10.3892/mmr.2017.8245
MLA
Liao, Y., Wang, J., Wei, Y., Zhang, T., Zhang, Y., Zuo, Z., Teng, X., Li, Y."Histone deacetylase 2 is involved in µ‑opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain". Molecular Medicine Reports 17.2 (2018): 2803-2810.
Chicago
Liao, Y., Wang, J., Wei, Y., Zhang, T., Zhang, Y., Zuo, Z., Teng, X., Li, Y."Histone deacetylase 2 is involved in µ‑opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain". Molecular Medicine Reports 17, no. 2 (2018): 2803-2810. https://doi.org/10.3892/mmr.2017.8245
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team