Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February-2018 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2018 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Lower level of IL‑35 and its reduced inhibition in Th17 cells in patients with bone marrow mononuclear cells Coombs test‑positive hemocytopenia

  • Authors:
    • Yi Li
    • Yihao Wang
    • Hui Liu
    • Kai Ding
    • Shanfeng Hao
    • Yuanyuan Shao
    • Honglei Wang
    • Jin Chen
    • Lei Huang
    • Zonghong Shao
    • Rong Fu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2973-2981
    |
    Published online on: December 11, 2017
       https://doi.org/10.3892/mmr.2017.8252
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Interleukin (IL)-35 is the latest member of IL-12 family, which plays an important role in other autoimmune diseases. Bone marrow mononuclear cells Coombs test‑positive hemocytopenia, also termed immunorelated hemocytopenia (IRH) is a type of autoimmune-associated diseases. The present study investigated the relationship of IL‑35 in patients with IRH. A total of 43 patients with IRH and 19 normal controls were enrolled in the current study. Serum levels of IL‑35 and IL‑17 in peripheral blood were evaluated by ELISA. Regulatory T cells (Tregs) level was detected by flow cytometry and IL‑35 subunits mRNA in Treg was determined using reverse transcription‑quantitative polymerase chain reaction: Epstein‑Barr virus induced 3 (EBI3) and IL‑12α chain p35. Effect of IL‑35 on T helper 17 cells (Th17) cells was determined by mix‑culture of IL‑35 with CD4+ T lymphocytes. Serum level of IL‑35 was decreased in untreated patients with IRH compared with remission patients (P<0.01) and was significantly associated with clinical indexes. Frequency of IL‑35 produced Tregs was lower and IL‑35 subunits mRNA in CD4+CD25+ Tregs were decreased in patients with IRH compared with health controls (P<0.01). Serum level of IL‑17 was increased in patients with IRH (P<0.01) and there was a negative correlation between IL‑35 and IL‑17 (r=‑0.553; P<0.01). The production of Th17 cells and IL‑17A mRNA expression were reduced (P<0.05) after mix‑culture of CD4+ T lymphocytes with IL‑35 compared with mix‑culture of CD4+ T lymphocytes without IL‑35. In conclusion, the present study revealed that IL‑35 may be a monitoring indicator of IRH occurrence and progression. IL‑35 level was lower and the inhibition on Th17 cells was reduced in the patients with IRH.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS and Vignali DA: The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 450:566–569. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB and Liew FY: IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur J Immunol. 37:3021–3029. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Kochetkova I, Golden S, Holderness K, Callis G and Pascual DW: IL-35 stimulation of CD39+ regulatory T cells confers protection against collagen II-induced arthritis via the production of IL-10. J Immunol. 184:7144–7153. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Shao Y, Fu R, Liu H, Wang Y, Ding S, Wang H, Li L and Shao Z: IgG autoantibody subclasses altered in immuno-related hemocytopenia. Cell Immunol. 294:13–20. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Fu R, Liu H, Wang Y, Liu H, He H, Chen J, Wang H, Yu H, Ding K, Huang L, et al: Distinguishing immunorelated haemocytopenia from idiopathic cytopenia of undetermined significance (ICUS): A bone marrow abnormality mediated by autoantibodies. Clin Exp Immunol. 177:412–418. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Fu R, Shao Z, He H, Liu H, Jia H, Sun J, Zhao M, He G, Shi J, Bai J, et al: Quantity and apoptosis-related protein level of B lymphocyte in patients with immunorelated pancytopenia. Zhonghua Xue Ye Xue Za Zhi. 23:236–238. 2002.(In Chinese). PubMed/NCBI

7 

Fu R, Chen J, Wang HL, Wang J, Li LJ, Liu H, Wang YH, Ren Y and Shao ZH: Quantity and function of regulatory T cells in hemocytopenic patients with positive BMMNC-Coombs test. Zhonghua Yi Xue Za Zhi. 90:2989–2993. 2010.(In Chinese). PubMed/NCBI

8 

Fu R, Wang HL, Chen J, Wang J, Li LJ, Liu H, Wang YH, Ren Y and Shao ZH: Study of the quantity and function of Th17 cells in the blood cytopenic patients with positive BMMNC-Coombs test. Zhonghua Xue Ye Xue Za Zhi. 31:684–687. 2010.(In Chinese). PubMed/NCBI

9 

Zhu X, Guan J, Xu J, Wei J, Jiang L, Yin J, Zhao L and Zhang Y: Pilot study using tacrolimus rather than cyclosporine plus antithymocyte globulin as an immunosuppressive therapy regimen option for severe aplastic anemia in adults. Blood Cells Mol Dis. 53:157–160. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Valent P, Horny HP, Bennett JM, Fonatsch C, Germing U, Greenberg P, Haferlach T, Haase D, Kolb HJ, Krieger O, et al: Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference. Leuk Res. 31:727–736. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Ando K, Kodama A, Iwabuchi T, Ohyashiki JH and Ohyashiki K: Idiopathic neutropenia with fewer than 5% dysplasia may be a distinct entity of idiopathic cytopenia of undetermined significance. Ann Hematol. 89:733–735. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Nicoletti F, Zaccone P, Di Marco R, Lunetta M, Magro G, Grasso S, Meroni P and Garotta G: Prevention of spontaneous autoimmune diabetes in diabetes-prone BB rats by prophylactic treatment with antirat interferon-gamma antibody. Endocrinology. 138:281–288. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Nicoletti F, Di Marco R, Zaccone P, Magro G, Di Mauro M, Grasso S and Meroni PL: Endogenous interleukin-12 only plays a key pathogenetic role in non-obese diabetic mouse diabetes during the very early stages of the disease. Immunology. 97:367–370. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Nicoletti F, Zaccone P, Xiang M, Magro G, Di Mauro M, Di Marco R, Garotta G and Meroni P: Essential pathogenetic role for interferon (IFN-)gamma in concanavalin A-induced T cell-dependent hepatitis: Exacerbation by exogenous IFN-gamma and prevention by IFN-gamma receptor-immunoglobulin fusion protein. Cytokine. 12:315–323. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Nicoletti F, Di Marco R, Zaccone P, Salvaggio A, Magro G, Bendtzen K and Meroni P: Murine concanavalin A-induced hepatitis is prevented by interleukin 12 (IL-12) antibody and exacerbated by exogenous IL-12 through an interferon-gamma-dependent mechanism. Hepatology. 32:728–733. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Tang H, Mignon-Godefroy K, Meroni PL, Garotta G, Charreire J and Nicoletti F: The effects of a monoclonal antibody to interferon-gamma on experimental autoimmune thyroiditis (EAT): Prevention of disease and decrease of EAT-specific T cells. Eur J Immunol. 23:275–278. 1993. View Article : Google Scholar : PubMed/NCBI

18 

Zaccone P, Hutchings P, Nicoletti F, Penna G, Adorini L and Cooke A: The involvement of IL-12 in murine experimentally induced autoimmune thyroid disease. Eur J Immunol. 29:1933–1942. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Li R, Zheng X, Popov I, Zhang X, Wang H, Suzuki M, Necochea-Campion RD, French PW, Chen D, Siu L, et al: Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis. J Transl Med. 10:192012. View Article : Google Scholar : PubMed/NCBI

20 

Karri SK and Sheela A: Potential route of Th17/Treg cell dynamics in targeting type 1 diabetes and rheumatoid arthritis: An autoimmune disorder perspective. Br J Biomed Sci. 74:8–15. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Dong Z, Du L, Xu X, Yang Y, Wang H, Qu A, Qu X and Wang C: Aberrant expression of circulating Th17, Th1 and Tc1 cells in patients with active and inactive ulcerative colitis. Int J Mol Med. 31:989–997. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Rostami A and Ciric B: Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination. J Neurol Sci. 333:76–87. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Deepak P and Loftus EV Jr: Ustekinumab in treatment of Crohn's disease: Design, development, and potential place in therapy. Drug Des Devel Ther. 10:3685–3698. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Bai F, Tian H, Niu Z, Liu M, Ren G, Yu Y, Sun T, Li S and Li D: Chimeric anti-IL-17 full-length monoclonal antibody is a novel potential candidate for the treatment of rheumatoid arthritis. Int J Mol Med. 33:711–721. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Reszke R and Szepietowski JC: Secukinumab in the treatment of psoriasis: An update. Immunotherapy. 9:229–238. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Vignali DA and Kuchroo VK: IL-12 family cytokines: Immunological playmakers. Nat Immunol. 13:722–728. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Sun L, He C, Nair L, Yeung J and Egwuagu CE: Interleukin 12 (IL-12) family cytokines: Role in immune pathogenesis and treatment of CNS autoimmune disease. Cytokine. 75:249–255. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Olson BM, Sullivan JA and Burlingham WJ: Interleukin 35: A key mediator of suppression and the propagation of infectious tolerance. Front Immunol. 4:3152013. View Article : Google Scholar : PubMed/NCBI

29 

Hou C, Wu Q, Ouyang C and Huang T: Effects of an intravitreal injection of interleukin-35-expressing plasmid on pro-inflammatory and anti-inflammatory cytokines. Int J Mol Med. 38:713–720. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Guan SY, Leng RX, Khan MI, Qureshi H, Li XP, Ye DQ and Pan HF: Interleukin-35: A potential therapeutic agent for autoimmune diseases. Inflammation. 40:303–310. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Egwuagu CE, Yu CR, Sun L and Wang R: Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases. Cytokine Growth Factor Rev. 26:587–593. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Hori S, Nomura T and Sakaguchi S: Control of regulatory T cell development by the transcription factor Foxp3. Science. 299:1057–1061. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Wang W, Li P, Chen YF and Yang J: A potential immunopathogenic role for reduced IL-35 expression in allergic asthma. J Asthma. 52:763–771. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Zhou Y, Zhang H and Li Y: IL-35 expression in peripheral blood CD4(+) T cells from chronic hepatitis B virus-infected patients directly correlates with virus load. Cytokine. 73:169–175. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Shi M, Wei J, Dong J, Meng W, Ma J, Wang T, Wang N and Wang Y: Function of interleukin-17 and −35 in the blood of patients with hepatitis B-related liver cirrhosis. Mol Med Rep. 11:121–126. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Wang Y, Dong J, Meng W, Ma J, Wang N, Wei J and Shi M: Effects of phased joint intervention on IL-35 and IL-17 expression levels in patients with portal hypertension. Int J Mol Med. 33:1131–1139. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Collison LW, Chaturvedi V, Henderson AL, Giacomin PR, Guy C, Bankoti J, Finkelstein D, Forbes K, Workman CJ, Brown SA, et al: IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol. 11:1093–1101. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Wong CK, Leung TF, Chu IM, Dong J, Lam YY and Lam CW: Aberrant expression of regulatory cytokine IL-35 and pattern recognition receptor NOD2 in patients with allergic asthma. Inflammation. 38:348–360. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Ghaedi M, Namdari H, Rahimzadeh P, Morteza Gholi S, Azimi Mohamadabadi M and Salehi E: Different doses of transforming growth factor-b on in vitro differentiation of human naive CD4+ T cells to T helper 17. Iran J Allergy Asthma Immunol. 14:633–637. 2015.PubMed/NCBI

40 

Ghoreschi K, Laurence A, Yang XP, Tato CM, McGeachy MJ, Konkel JE, Ramos HL, Wei L, Davidson TS, Bouladoux N, et al: Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling. Nature. 467:967–971. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupé P, Barillot E and Soumelis V: A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol. 9:650–657. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Chung Y, Yamazaki T, Kim BS, Zhang Y, Reynolds JM, Martinez GJ, Chang SH, Lim H, Birkenbach M and Dong C: Epstein Barr virus-induced 3 (EBI3) together with IL-12 negatively regulates T helper 17-mediated immunity to Listeria monocytogenes infection. PLoS Pathog. 9:e10036282013. View Article : Google Scholar : PubMed/NCBI

43 

Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu CY, Gately MK and Gubler U: A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci USA. 93:pp. 14002–14007. 1996; View Article : Google Scholar : PubMed/NCBI

44 

Collison LW, Delgoffe GM, Guy CS, Vignali KM, Chaturvedi V, Fairweather D, Satoskar AR, Garcia KC, Hunter CA, Drake CG, et al: The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol. 13:290–299. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Behzadi P, Behzadi E and Ranjbar R: IL-12 family cytokines: General characteristics, pathogenic microorganisms, receptors, and signalling pathways. Acta Microbiol Immunol Hung. 63:1–25. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Liu H and Rohowsky-Kochan C: Interleukin-27-mediated suppression of human Th17 cells is associated with activation of STAT1 and suppressor of cytokine signaling protein 1. J Interferon Cytokine Res. 31:459–469. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Peters A, Fowler KD, Chalmin F, Merkler D, Kuchroo VK and Pot C: IL-27 induces Th17 differentiation in the absence of STAT1 signaling. J Immunol. 195:4144–4153. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Cai Z, Wong CK, Dong J, Chu M, Jiao D, Kam NW, Lam CW and Tam LS: Remission of systemic lupus erythematosus disease activity with regulatory cytokine interleukin (IL)-35 in Murphy Roths Large (MRL)/lpr mice. Clin Exp Immunol. 181:253–266. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Li Y, Wu S, Li Y, Jiang S, Lin T, Xia L, Shen H and Lu J: Interleukin-35 (IL-35) inhibits proliferation and promotes apoptosis of fibroblast-like synoviocytes isolated from mice with collagen-induced arthritis. Mol Biol Rep. 43:947–956. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li Y, Wang Y, Liu H, Ding K, Hao S, Shao Y, Wang H, Chen J, Huang L, Shao Z, Shao Z, et al: Lower level of IL‑35 and its reduced inhibition in Th17 cells in patients with bone marrow mononuclear cells Coombs test‑positive hemocytopenia. Mol Med Rep 17: 2973-2981, 2018.
APA
Li, Y., Wang, Y., Liu, H., Ding, K., Hao, S., Shao, Y. ... Fu, R. (2018). Lower level of IL‑35 and its reduced inhibition in Th17 cells in patients with bone marrow mononuclear cells Coombs test‑positive hemocytopenia. Molecular Medicine Reports, 17, 2973-2981. https://doi.org/10.3892/mmr.2017.8252
MLA
Li, Y., Wang, Y., Liu, H., Ding, K., Hao, S., Shao, Y., Wang, H., Chen, J., Huang, L., Shao, Z., Fu, R."Lower level of IL‑35 and its reduced inhibition in Th17 cells in patients with bone marrow mononuclear cells Coombs test‑positive hemocytopenia". Molecular Medicine Reports 17.2 (2018): 2973-2981.
Chicago
Li, Y., Wang, Y., Liu, H., Ding, K., Hao, S., Shao, Y., Wang, H., Chen, J., Huang, L., Shao, Z., Fu, R."Lower level of IL‑35 and its reduced inhibition in Th17 cells in patients with bone marrow mononuclear cells Coombs test‑positive hemocytopenia". Molecular Medicine Reports 17, no. 2 (2018): 2973-2981. https://doi.org/10.3892/mmr.2017.8252
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Wang Y, Liu H, Ding K, Hao S, Shao Y, Wang H, Chen J, Huang L, Shao Z, Shao Z, et al: Lower level of IL‑35 and its reduced inhibition in Th17 cells in patients with bone marrow mononuclear cells Coombs test‑positive hemocytopenia. Mol Med Rep 17: 2973-2981, 2018.
APA
Li, Y., Wang, Y., Liu, H., Ding, K., Hao, S., Shao, Y. ... Fu, R. (2018). Lower level of IL‑35 and its reduced inhibition in Th17 cells in patients with bone marrow mononuclear cells Coombs test‑positive hemocytopenia. Molecular Medicine Reports, 17, 2973-2981. https://doi.org/10.3892/mmr.2017.8252
MLA
Li, Y., Wang, Y., Liu, H., Ding, K., Hao, S., Shao, Y., Wang, H., Chen, J., Huang, L., Shao, Z., Fu, R."Lower level of IL‑35 and its reduced inhibition in Th17 cells in patients with bone marrow mononuclear cells Coombs test‑positive hemocytopenia". Molecular Medicine Reports 17.2 (2018): 2973-2981.
Chicago
Li, Y., Wang, Y., Liu, H., Ding, K., Hao, S., Shao, Y., Wang, H., Chen, J., Huang, L., Shao, Z., Fu, R."Lower level of IL‑35 and its reduced inhibition in Th17 cells in patients with bone marrow mononuclear cells Coombs test‑positive hemocytopenia". Molecular Medicine Reports 17, no. 2 (2018): 2973-2981. https://doi.org/10.3892/mmr.2017.8252
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team