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Article Open Access

Twenty‑four signature genes predict the prognosis of oral squamous cell carcinoma with high accuracy and repeatability

  • Authors:
    • Jianyong Gao
    • Gang Tian
    • Xu Han
    • Qiang Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2982-2990
    |
    Published online on: December 12, 2017
       https://doi.org/10.3892/mmr.2017.8256
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Abstract

Oral squamous cell carcinoma (OSCC) is the sixth most common type cancer worldwide, with poor prognosis. The present study aimed to identify gene signatures that could classify OSCC and predict prognosis in different stages. A training data set (GSE41613) and two validation data sets (GSE42743 and GSE26549) were acquired from the online Gene Expression Omnibus database. In the training data set, patients were classified based on the tumor‑node‑metastasis staging system, and subsequently grouped into low stage (L) or high stage (H). Signature genes between L and H stages were selected by disparity index analysis, and classification was performed by the expression of these signature genes. The established classification was compared with the L and H classification, and fivefold cross validation was used to evaluate the stability. Enrichment analysis for the signature genes was implemented by the Database for Annotation, Visualization and Integration Discovery. Two validation data sets were used to determine the precise of classification. Survival analysis was conducted followed each classification using the package ‘survival’ in R software. A set of 24 signature genes was identified based on the classification model with the Fi value of 0.47, which was used to distinguish OSCC samples in two different stages. Overall survival of patients in the H stage was higher than those in the L stage. Signature genes were primarily enriched in ‘ether lipid metabolism’ pathway and biological processes such as ‘positive regulation of adaptive immune response’ and ‘apoptotic cell clearance’. The results provided a novel 24‑gene set that may be used as biomarkers to predict OSCC prognosis with high accuracy, which may be used to determine an appropriate treatment program for patients with OSCC in addition to the traditional evaluation index.
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Copy and paste a formatted citation
Spandidos Publications style
Gao J, Tian G, Han X and Zhu Q: Twenty‑four signature genes predict the prognosis of oral squamous cell carcinoma with high accuracy and repeatability. Mol Med Rep 17: 2982-2990, 2018.
APA
Gao, J., Tian, G., Han, X., & Zhu, Q. (2018). Twenty‑four signature genes predict the prognosis of oral squamous cell carcinoma with high accuracy and repeatability. Molecular Medicine Reports, 17, 2982-2990. https://doi.org/10.3892/mmr.2017.8256
MLA
Gao, J., Tian, G., Han, X., Zhu, Q."Twenty‑four signature genes predict the prognosis of oral squamous cell carcinoma with high accuracy and repeatability". Molecular Medicine Reports 17.2 (2018): 2982-2990.
Chicago
Gao, J., Tian, G., Han, X., Zhu, Q."Twenty‑four signature genes predict the prognosis of oral squamous cell carcinoma with high accuracy and repeatability". Molecular Medicine Reports 17, no. 2 (2018): 2982-2990. https://doi.org/10.3892/mmr.2017.8256
Copy and paste a formatted citation
x
Spandidos Publications style
Gao J, Tian G, Han X and Zhu Q: Twenty‑four signature genes predict the prognosis of oral squamous cell carcinoma with high accuracy and repeatability. Mol Med Rep 17: 2982-2990, 2018.
APA
Gao, J., Tian, G., Han, X., & Zhu, Q. (2018). Twenty‑four signature genes predict the prognosis of oral squamous cell carcinoma with high accuracy and repeatability. Molecular Medicine Reports, 17, 2982-2990. https://doi.org/10.3892/mmr.2017.8256
MLA
Gao, J., Tian, G., Han, X., Zhu, Q."Twenty‑four signature genes predict the prognosis of oral squamous cell carcinoma with high accuracy and repeatability". Molecular Medicine Reports 17.2 (2018): 2982-2990.
Chicago
Gao, J., Tian, G., Han, X., Zhu, Q."Twenty‑four signature genes predict the prognosis of oral squamous cell carcinoma with high accuracy and repeatability". Molecular Medicine Reports 17, no. 2 (2018): 2982-2990. https://doi.org/10.3892/mmr.2017.8256
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