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Article

MicroRNA‑675 inhibits cell proliferation and invasion in melanoma by directly targeting metadherin

Retraction in: /10.3892/mmr.2023.12986
  • Authors:
    • Ke Liu
    • Junjun Jin
    • Kunjie Rong
    • Lukai Zhuo
    • Pingsong Li
  • View Affiliations / Copyright

    Affiliations: Department of Plastic Surgery, Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, P.R. China
  • Pages: 3372-3379
    |
    Published online on: December 12, 2017
       https://doi.org/10.3892/mmr.2017.8264
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Abstract

Melanoma is derived from melanocytes and accounts for ~80% of skin cancer-associated fatalities worldwide. The dysregulation of microRNAs (miRNAs/miRs) is involved in the development and progression of melanoma. Therefore, miRNAs may be novel diagnostic or prognostic biomarkers and promising therapeutic targets in the treatment of patients with melanoma. miR‑675 is differentially expressed in several types of human cancer and has important roles in the pathogenesis of several diseases. However, the expression levels and the biological roles of miR‑675 in melanoma remain unclear. Therefore, the present study aimed to assess the expression of miR‑675 in melanoma, explore the effects of miR‑675 on melanoma cells and investigate the underlying molecular mechanisms that may be involved in the actions of miR‑675. The present study indicated that miR‑675 expression was downregulated in melanoma tissues and cell lines. Functional assays demonstrated that the upregulation of miR‑675 impaired cell proliferation and invasion in melanoma. Bioinformatics analysis, luciferase reporter assay, reverse transcription‑quantitative polymerase chain reaction and western blot analysis demonstrated that metadherin (MTDH) was a direct target of miR‑675 in melanoma. The MTDH levels were upregulated in melanoma tissues and inversely correlated with the miR‑675 expression. Furthermore, restored MTDH expression rescued the inhibition effects in melanoma cells caused by miR‑675 overexpression. Thus, miR‑675 may be a potential therapeutic target for melanoma.
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Copy and paste a formatted citation
Spandidos Publications style
Liu K, Jin J, Rong K, Zhuo L and Li P: MicroRNA‑675 inhibits cell proliferation and invasion in melanoma by directly targeting metadherin Retraction in /10.3892/mmr.2023.12986. Mol Med Rep 17: 3372-3379, 2018.
APA
Liu, K., Jin, J., Rong, K., Zhuo, L., & Li, P. (2018). MicroRNA‑675 inhibits cell proliferation and invasion in melanoma by directly targeting metadherin Retraction in /10.3892/mmr.2023.12986. Molecular Medicine Reports, 17, 3372-3379. https://doi.org/10.3892/mmr.2017.8264
MLA
Liu, K., Jin, J., Rong, K., Zhuo, L., Li, P."MicroRNA‑675 inhibits cell proliferation and invasion in melanoma by directly targeting metadherin Retraction in /10.3892/mmr.2023.12986". Molecular Medicine Reports 17.2 (2018): 3372-3379.
Chicago
Liu, K., Jin, J., Rong, K., Zhuo, L., Li, P."MicroRNA‑675 inhibits cell proliferation and invasion in melanoma by directly targeting metadherin Retraction in /10.3892/mmr.2023.12986". Molecular Medicine Reports 17, no. 2 (2018): 3372-3379. https://doi.org/10.3892/mmr.2017.8264
Copy and paste a formatted citation
x
Spandidos Publications style
Liu K, Jin J, Rong K, Zhuo L and Li P: MicroRNA‑675 inhibits cell proliferation and invasion in melanoma by directly targeting metadherin Retraction in /10.3892/mmr.2023.12986. Mol Med Rep 17: 3372-3379, 2018.
APA
Liu, K., Jin, J., Rong, K., Zhuo, L., & Li, P. (2018). MicroRNA‑675 inhibits cell proliferation and invasion in melanoma by directly targeting metadherin Retraction in /10.3892/mmr.2023.12986. Molecular Medicine Reports, 17, 3372-3379. https://doi.org/10.3892/mmr.2017.8264
MLA
Liu, K., Jin, J., Rong, K., Zhuo, L., Li, P."MicroRNA‑675 inhibits cell proliferation and invasion in melanoma by directly targeting metadherin Retraction in /10.3892/mmr.2023.12986". Molecular Medicine Reports 17.2 (2018): 3372-3379.
Chicago
Liu, K., Jin, J., Rong, K., Zhuo, L., Li, P."MicroRNA‑675 inhibits cell proliferation and invasion in melanoma by directly targeting metadherin Retraction in /10.3892/mmr.2023.12986". Molecular Medicine Reports 17, no. 2 (2018): 3372-3379. https://doi.org/10.3892/mmr.2017.8264
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