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Article

Association of aquaporin‑1 with tumor migration, invasion and vasculogenic mimicry in glioblastoma multiforme

  • Authors:
    • Wan‑Yong Yang
    • Ze‑Feng Tan
    • Da‑Wei Dong
    • Yan Ding
    • Heng Meng
    • Ying Zhao
    • Xiu‑Feng Xin
    • Wei Bi
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China
  • Pages: 3206-3211
    |
    Published online on: December 12, 2017
       https://doi.org/10.3892/mmr.2017.8265
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Abstract

The present study aimed to assess the expression and functional role of aquaporin-1 (AQP1) in glioblastoma multiforme (GBM) migration, invasion and vasculogenic mimicry (VM). In the primary human gliomas and human glioma‑derived cell lines tested, it was observed that the expression of AQP1 was upregulated. In addition, it was demonstrated that silencing of AQP1 expression resulted in decreased migration and invasion, in addition to vasculogenic mimicry in vitro. It was additionally observed that silencing of AQP1 expression resulted in in vivo inhibition of tumor growth, a decrease in the expression of invasion‑associated protein, and suppression of VM formation. Based on these data, it was concluded that AQP1 may serve a role in GBM migration, invasion and VM formation, and that it may serve as a novel diagnostic/prognostic biomarker and a potential therapeutic target.
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Copy and paste a formatted citation
Spandidos Publications style
Yang WY, Tan ZF, Dong DW, Ding Y, Meng H, Zhao Y, Xin XF and Bi W: Association of aquaporin‑1 with tumor migration, invasion and vasculogenic mimicry in glioblastoma multiforme. Mol Med Rep 17: 3206-3211, 2018.
APA
Yang, W., Tan, Z., Dong, D., Ding, Y., Meng, H., Zhao, Y. ... Bi, W. (2018). Association of aquaporin‑1 with tumor migration, invasion and vasculogenic mimicry in glioblastoma multiforme. Molecular Medicine Reports, 17, 3206-3211. https://doi.org/10.3892/mmr.2017.8265
MLA
Yang, W., Tan, Z., Dong, D., Ding, Y., Meng, H., Zhao, Y., Xin, X., Bi, W."Association of aquaporin‑1 with tumor migration, invasion and vasculogenic mimicry in glioblastoma multiforme". Molecular Medicine Reports 17.2 (2018): 3206-3211.
Chicago
Yang, W., Tan, Z., Dong, D., Ding, Y., Meng, H., Zhao, Y., Xin, X., Bi, W."Association of aquaporin‑1 with tumor migration, invasion and vasculogenic mimicry in glioblastoma multiforme". Molecular Medicine Reports 17, no. 2 (2018): 3206-3211. https://doi.org/10.3892/mmr.2017.8265
Copy and paste a formatted citation
x
Spandidos Publications style
Yang WY, Tan ZF, Dong DW, Ding Y, Meng H, Zhao Y, Xin XF and Bi W: Association of aquaporin‑1 with tumor migration, invasion and vasculogenic mimicry in glioblastoma multiforme. Mol Med Rep 17: 3206-3211, 2018.
APA
Yang, W., Tan, Z., Dong, D., Ding, Y., Meng, H., Zhao, Y. ... Bi, W. (2018). Association of aquaporin‑1 with tumor migration, invasion and vasculogenic mimicry in glioblastoma multiforme. Molecular Medicine Reports, 17, 3206-3211. https://doi.org/10.3892/mmr.2017.8265
MLA
Yang, W., Tan, Z., Dong, D., Ding, Y., Meng, H., Zhao, Y., Xin, X., Bi, W."Association of aquaporin‑1 with tumor migration, invasion and vasculogenic mimicry in glioblastoma multiforme". Molecular Medicine Reports 17.2 (2018): 3206-3211.
Chicago
Yang, W., Tan, Z., Dong, D., Ding, Y., Meng, H., Zhao, Y., Xin, X., Bi, W."Association of aquaporin‑1 with tumor migration, invasion and vasculogenic mimicry in glioblastoma multiforme". Molecular Medicine Reports 17, no. 2 (2018): 3206-3211. https://doi.org/10.3892/mmr.2017.8265
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