Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2018 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Purple sweet potato color attenuates high fat-induced neuroinflammation in mouse brain by inhibiting MAPK and NF-κB activation

  • Authors:
    • Jian Li
    • Zhao Shi
    • Yongjie Mi
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China
  • Pages: 4823-4831
    |
    Published online on: January 17, 2018
       https://doi.org/10.3892/mmr.2018.8440
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Purple sweet potato color (PSPC) is a natural anthocyanin pigment that is derived from purple sweet potato storage roots. PSPC possesses a variety of biological activities, including antioxidant, anti‑inflammatory and neuroprotective effects; however, the detailed effects of PSPC on high‑fat diet (HFD)‑induced neuroinflammation remain to be determined. The aim of the present study was to investigate whether PSPC has a protective role in HFD‑associated neuroinflammation in the mouse brain and to provide novel insight into the mechanisms of the action. C57BL 6J mice were maintained on a normal diet (10 kcal% fat), a HFD (60 kcal% fat), a HFD with PSPC (700 mg/kg/day) or PSPC alone, which was administrated over 20 weeks. Open field and step‑through tests were used to evaluate the effects of HFD and PSPC on mouse behavior and memory function. Western blotting and ELISA analyses were used to assess the expression of inflammatory cytokines and the activation of mitogen‑activated protein kinase and nuclear factor‑κB (NF‑κB). The results demonstrated that PSPC treatment was able to significantly improve the HFD‑induced impairment of mouse behavior and memory function, and suppressed the increase in body weight, fat content, hyperlipemia and the level of endotoxin. PSPC treatment also markedly decreased the expression of cyclooxygenase‑2, inducible nitric oxide synthase, tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6, and increased the level of IL‑10 in the HFD‑treated mouse brain. In addition, PSPC inhibited the HFD‑induced phosphorylation of extracellular signal‑regulated kinase (ERK), c‑Jun N‑terminal kinase (JNK) and p38, and the activation of NF‑κB. These findings indicated that PSPC treatment may alleviate HFD‑induced neuroinflammation in the mouse brain by inhibiting ERK, JNK, p38 and NF-κB activation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Meissburger B, Ukropec J, Roeder E, Beaton N, Geiger M, Teupser D, Civan B, Langhans W, Nawroth PP, Gasperikova D, et al: Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma. EMBO Mol Med. 3:637–651. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Trayhurn P and Beattie JH: Physiological role of adipose tissue: White adipose tissue as an endocrine and secretory organ. Proc Nutr Soc. 60:pp. 329–339. 2001; View Article : Google Scholar : PubMed/NCBI

3 

Proença AR, Sertié RA, Oliveira AC, Campaña AB, Caminhotto RO, Chimin P and Lima FB: New concepts in white adipose tissue physiology. Braz J Med Biol Res. 47:192–205. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Smitka K and Marešová D: Adipose tissue as an endocrine organ: An update on pro-inflammatory and anti-inflammatory microenvironment. Prague Med Rep. 116:87–111. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Wellen KE and Hotamisligil GS: Obesity-induced inflammatory changes in adipose tissue. J Clin Invest. 112:1785–1788. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Golay A and Bobbioni E: The role of dietary fat in obesity. Int J Obes Relat Metab Disord. 21 Suppl 3:S2–S11. 1997.PubMed/NCBI

7 

Ginsberg HN, Zhang YL and Hernandez-Ono A: Metabolic syndrome: Focus on dyslipidemia. Obesity (Silver Spring). 14 Suppl 1:41S–49S. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Seidell JC: Dietary fat and obesity: An epidemiologic perspective. Am J Clin Nutr. 67 3 Suppl:546S–550S. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Freeman LR, Haley-Zitlin V, Stevens C and Granholm AC: Diet-induced effects on neuronal and glial elements in the middle-aged rat hippocampus. Nutr Neurosci. 14:32–44. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Thirumangalakudi L, Prakasam A, Zhang R, Bimonte-Nelson H, Sambamurti K, Kindy MS and Bhat NR: High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J Neurochem. 106:475–485. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Kang DH, Heo RW, Yi CO, Kim H, Choi CH and Roh GS: High-fat diet-induced obesity exacerbates kainic acid-induced hippocampal cell death. BMC Neurosci. 16:722015. View Article : Google Scholar : PubMed/NCBI

12 

Nerurkar PV, Johns LM, Buesa LM, Kipyakwai G, Volper E, Sato R, Shah P, Feher D, Williams PG and Nerurkar VR: Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. J Neuroinflammation. 8:642011. View Article : Google Scholar : PubMed/NCBI

13 

Orr CF, Rowe DB and Halliday GM: An inflammatory review of Parkinson's disease. Prog Neurobiol. 68:325–340. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Qian L, Flood PM and Hong JS: Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. J Neural Transm (Vienna). 117:971–979. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Lee YJ, Han SB, Nam SY, Oh KW and Hong JT: Inflammation and Alzhe-imer's disease. Arch Pharm Res. 33:1539–1556. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Simmons RK, Alberti KG, Gale EA, Colagiuri S, Tuomilehto J, Qiao Q, Ramachandran A, Tajima N, Brajkovich Mirchov I, Ben-Nakhi A, et al: The metabolic syndrome: Useful concept or clinical tool? Report of a WHO Expert Consultation. Diabetologia. 53:600–605. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Palacios N, Gao X, McCullough ML, Jacobs EJ, Patel AV, Mayo T, Schwarzschild MA and Ascherio A: Obesity, diabetes, and risk of Parkinson's disease. Mov Disord. 26:2253–2259. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Iwashina T: Contribution to flower colors of flavonoids including anthocyanins: A review. Nat Prod Commun. 10:529–544. 2015.PubMed/NCBI

19 

He J and Giusti MM: Anthocyanins: Natural colorants with health-promoting properties. Annu Rev Food Sci Technol. 1:163–187. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Huang WY, Liu YM, Wang J, Wang XN and Li CY: Anti-inflammatory effect of the blueberry anthocyanins malvidin-3-glucoside and malvidin-3-galactoside in endothelial cells. Molecules. 19:12827–12841. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Pool-Zobel BL, Bub A, Schröder N and Rechkemmer G: Anthocyanins are potent antioxidants in model systems but do not reduce endogenous oxidative DNA damage in human colon cells. Eur J Nutr. 38:227–234. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Kang HG, Jeong SH and Cho JH: Antimutagenic and anticarcinogenic effect of methanol extracts of sweetpotato (Ipomea batata) leaves. Toxicol Res. 26:29–35. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Mano H, Ogasawara F, Sato K, Higo H and Minobe Y: Isolation of a regulatory gene of anthocyanin biosynthesis in tuberous roots of purple-fleshed sweet potato. Plant Physiol. 143:1252–1268. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Qiu F, Luo J, Yao S, Ma L and Kong L: Preparative isolation and purification of anthocyanins from purple sweet potato by high-speed counter-current chromatography. J Sep Sci. 32:2146–2151. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Harada K, Kano M, Takayanagi T, Yamakawa O and Ishikawa F: Absorption of acylated anthocyanins in rats and humans after ingesting an extract of Ipomoea batatas purple sweet potato tuber. Biosci Biotechnol Biochem. 68:1500–1507. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Zhang ZF, Fan SH, Zheng YL, Lu J, Wu DM, Shan Q and Hu B: Purple sweet potato color attenuates oxidative stress and inflammatory response induced by d-galactose in mouse liver. Food Chem Toxicol. 47:496–501. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Shan Q, Lu J, Zheng Y, Li J, Zhou Z, Hu B, Zhang Z, Fan S, Mao Z, Wang YJ and Ma D: Purple sweet potato color ameliorates cognition deficits and attenuates oxidative damage and inflammation in aging mouse brain induced by d-galactose. J Biomed Biotechnol. 2009:5647372009. View Article : Google Scholar : PubMed/NCBI

28 

Hwang YP, Choi JH, Yun HJ, Han EH, Kim HG, Kim JY, Park BH, Khanal T, Choi JM, Chung YC and Jeong HG: Anthocyanins from purple sweet potato attenuate dimethylnitrosamine-induced liver injury in rats by inducing Nrf2-mediated antioxidant enzymes and reducing COX-2 and iNOS expression. Food Chem Toxicol. 49:93–99. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Zhang ZF, Lu J, Zheng YL, Wu DM, Hu B, Shan Q, Cheng W, Li MQ and Sun YY: Purple sweet potato color attenuates hepatic insulin resistance via blocking oxidative stress and endoplasmic reticulum stress in high-fat-diet-treated mice. J Nutr Biochem. 24:1008–1018. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Shan Q, Zheng Y, Lu J, Zhang Z, Wu D, Fan S, Hu B, Cai X, Cai H, Liu P and Liu F: Purple sweet potato color ameliorates kidney damage via inhibiting oxidative stress mediated NLRP3 inflammasome activation in high fat diet mice. Food Chem Toxicol. 69:339–346. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Hwang YP, Choi JH, Han EH, Kim HG, Wee JH, Jung KO, Jung KH, Kwon KI, Jeong TC, Chung YC and Jeong HG: Purple sweet potato anthocyanins attenuate hepatic lipid accumulation through activating adenosine monophosphate-activated protein kinase in human HepG2 cells and obese mice. Nutr Res. 31:896–906. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Sun C, Fan S, Wang X, Lu J, Zhang Z, Wu D, Shan Q and Zheng Y: Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome. J Nutr Biochem. 26:1029–1040. 2015. View Article : Google Scholar : PubMed/NCBI

33 

McGrath JC, Drummond GB, McLachlan EM, Kilkenny C and Wainwright CL: Guidelines for reporting experiments involving animals: The ARRIVE guidelines. Br J Pharmacol. 160:1573–1576. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Castellano C, Introini-Collison IB and McGaugh JL: Interaction of beta-endorphin and GABAergic drugs in the regulation of memory storage. Behav Neural Biol. 60:123–128. 1993. View Article : Google Scholar : PubMed/NCBI

35 

Jain NK, Ishikawa TO, Spigelman I and Herschman HR: COX-2 expression and function in the hyperalgesic response to paw inflammation in mice. Prostaglandins Leukot Essent Fatty Acids. 79:183–190. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Wang D, Liu L, Yan J, Wu W, Zhu X and Wang Y: Cardiotrophin-1 (CT-1) improves high fat diet-induced cognitive deficits in mice. Neurochem Res. 40:843–853. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Mémet S: NF-kappaB functions in the nervous system: From development to disease. Biochem Pharmacol. 72:1180–1195. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Arthur JS and Ley SC: Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol. 13:679–692. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Krause DL and Muller N: Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimer's disease. Int J Alzheimers Dis. 2010:pii: 7328062010.

40 

Giri S, Jatana M, Rattan R, Won JS, Singh I and Singh AK: Galactosylsphingosine (psychosine)-induced expression of cytokine-mediated inducible nitric oxide synthases via AP-1 and C/EBP: Implications for Krabbe disease. FASEB J. 16:661–672. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Marcheselli VL and Bazan NG: Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist. J Biol Chem. 271:24794–24799. 1996. View Article : Google Scholar : PubMed/NCBI

42 

Koistinaho M and Koistinaho J: Role of p38 and p44/42 mitogen-activated protein kinases in microglia. Glia. 40:175–183. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Arthur JS and Ley SC: Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol. 13:679–692. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Wang YJ, Zheng YL, Lu J, Chen GQ, Wang XH, Feng J, Ruan J, Sun X, Li CX and Sun QJ: Purple sweet potato color suppresses lipopolysaccharide-induced acute inflammatory response in mouse brain. Neurochem Int. 56:424–430. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Wi SM, Moon G, Kim J, Kim ST, Shim JH, Chun E and Lee KY: TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB. J Biol Chem. 289:35205–35214. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Hayden MS and Ghosh S: Signaling to NF-kappaB. Genes Dev. 18:2195–2224. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Kim KA, Lee IA, Gu W, Hyam SR and Kim DH: β-Sitosterol attenuates high-fat diet-induced intestinal inflammation in mice by inhibiting the binding of lipopolysaccharide to toll-like receptor 4 in the NF-κB pathway. Mol Nutr Food Res. 58:963–972. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li J, Shi Z and Mi Y: Purple sweet potato color attenuates high fat-induced neuroinflammation in mouse brain by inhibiting MAPK and NF-κB activation. Mol Med Rep 17: 4823-4831, 2018.
APA
Li, J., Shi, Z., & Mi, Y. (2018). Purple sweet potato color attenuates high fat-induced neuroinflammation in mouse brain by inhibiting MAPK and NF-κB activation. Molecular Medicine Reports, 17, 4823-4831. https://doi.org/10.3892/mmr.2018.8440
MLA
Li, J., Shi, Z., Mi, Y."Purple sweet potato color attenuates high fat-induced neuroinflammation in mouse brain by inhibiting MAPK and NF-κB activation". Molecular Medicine Reports 17.3 (2018): 4823-4831.
Chicago
Li, J., Shi, Z., Mi, Y."Purple sweet potato color attenuates high fat-induced neuroinflammation in mouse brain by inhibiting MAPK and NF-κB activation". Molecular Medicine Reports 17, no. 3 (2018): 4823-4831. https://doi.org/10.3892/mmr.2018.8440
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Shi Z and Mi Y: Purple sweet potato color attenuates high fat-induced neuroinflammation in mouse brain by inhibiting MAPK and NF-κB activation. Mol Med Rep 17: 4823-4831, 2018.
APA
Li, J., Shi, Z., & Mi, Y. (2018). Purple sweet potato color attenuates high fat-induced neuroinflammation in mouse brain by inhibiting MAPK and NF-κB activation. Molecular Medicine Reports, 17, 4823-4831. https://doi.org/10.3892/mmr.2018.8440
MLA
Li, J., Shi, Z., Mi, Y."Purple sweet potato color attenuates high fat-induced neuroinflammation in mouse brain by inhibiting MAPK and NF-κB activation". Molecular Medicine Reports 17.3 (2018): 4823-4831.
Chicago
Li, J., Shi, Z., Mi, Y."Purple sweet potato color attenuates high fat-induced neuroinflammation in mouse brain by inhibiting MAPK and NF-κB activation". Molecular Medicine Reports 17, no. 3 (2018): 4823-4831. https://doi.org/10.3892/mmr.2018.8440
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team