Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2018 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis

  • Authors:
    • Hyun-Ju Yu
    • Chi-Hyun Ahn
    • In-Hyoung Yang
    • Dong-Hoon Won
    • Bohwan Jin
    • Nam-Pyo Cho
    • Seong Doo Hong
    • Ji-Ae Shin
    • Sung-Dae Cho
  • View Affiliations / Copyright

    Affiliations: Department of Oral Pathology, School of Dentistry, Institute of Biodegradable Material, Institute of Oral Bioscience, Chonbuk National University, Jeonju, Jeollabuk-do 54896, Republic of Korea, Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 03080, Republic of Korea, Laboratory Animal Center, CHA University, CHA Biocomplex, Sampyeong-Dong, Seongnam, Gyeonggi 13488, Republic of Korea
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5258-5264
    |
    Published online on: January 22, 2018
       https://doi.org/10.3892/mmr.2018.8468
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Potentilla discolor has been used in traditional Chinese medicine for the treatment of hyperglycemia. However, the potential role of Potentilla discolor against cancer and its mode of action remain to be fully elucidated. The present study explored the apoptotic effect of methanol extract of Potentilla discolor (MEPD) in human mucoepidermoid carcinoma (MEC) cell lines of salivary glands. MEPD markedly suppressed the growth and induced apoptotic cell death in MC3 and YD15 cells. MEPD treatment significantly upregulated the expression of PUMA and reduced STAT3 phosphorylation. Overexpression of STAT3 partially recovered the growth of MEC cells inhibited by MEPD. In addition, dephosphorylation of STAT3 by cryptotanshinone (a potent STAT3 inhibitor) was sufficient to inhibit the growth of MEC cells and induce apoptosis via affecting PUMA protein. These results suggest that MEPD has a potential anticancer property via the STAT3/PUMA signaling axis in human MEC cells of salivary gland.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ettl T, Schwarz-Furlan S, Gosau M and Reichert TE: Salivary gland carcinomas. Oral Maxillofac Surg. 16:267–283. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Goyal G, Mehdi SA and Ganti AK: Salivary gland cancers: Biology and systemic therapy. Oncology. 29:773–780. 2015.PubMed/NCBI

3 

Zhang L, Li L, Wang Y, Liu Y and Li C: MC3 Mucoepidermoid carcinoma cell line enriched cancer stem-like cells following chemotherapy. Oncol Lett. 7:1569–1575. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Kingston DG: Modern natural products drug discovery and its relevance to biodiversity conservation. J Nat Prod. 74:496–511. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Newman DJ and Cragg GM: Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. 75:311–335. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Hung HY, Qian K, Morris-Natschke SL, Hsu CS and Lee KH: Recent discovery of plant-derived anti-diabetic natural products. Nat Prod Rep. 29:580–606. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Tarkang PA, Appiah-Opong R, Ofori MF, Ayong LS and Nyarko AK: Application of multi-target phytotherapeutic concept in malaria drug discovery: A systems biology approach in biomarker identification. Biomark Res. 4:252016. View Article : Google Scholar : PubMed/NCBI

8 

Gupta SC, Kim JH, Prasad S and Aggarwal BB: Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev. 29:405–434. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Shin JA, Kim JJ, Choi ES, Shim JH, Ryu MH, Kwon KH, Park HM, Seo JY, Lee SY, Lim DW, et al: In vitro apoptotic effects of methanol extracts of Dianthus chinensis and Acalypha australis L. targeting specificity protein 1 in human oral cancer cells. Head Neck. 35:992–998. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Shin JA, Ryu MH, Kwon KH, Choi B and Cho SD: Down-regulation of Akt by methanol extracts of Impatiens balsamina L. promotes apoptosis in human oral squamous cell carcinoma cell lines. J Oral Pathol Med. 44:420–428. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Zlotogorski A, Dayan A, Dayan D, Chaushu G, Salo T and Vered M: Nutraceuticals as new treatment approaches for oral cancer: II. Green tea extracts and resveratrol. Oral Oncol. 49:502–506. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Ramshankar V and Krishnamurthy A: Chemoprevention of oral cancer: Green tea experience. J Nat Sci Biol Med. 5:3–7. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Yang J, Chen H, Zhang L, Wang Q and Lai MX: Anti-diabetic effect of standardized extract of Potentilla discolor Bunge and identification of its active components. Drug Dev Res. 71:127–132. 2010.

14 

Zhang L, Yang J, Chen XQ, Zan K, Wen XD, Chen H, Wang Q and Lai MX: Antidiabetic and antioxidant effects of extracts from Potentilla discolor Bunge on diabetic rats induced by high fat diet and streptozotocin. J Ethnopharmacol. 132:518–524. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Song C, Huang L, Rong L, Zhou Z, Peng X, Yu S and Fang N: Anti-hyperglycemic effect of Potentilla discolor decoction on obese-diabetic (Ob-db) mice and its chemical composition. Fitoterapia. 83:1474–1483. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Wen DS, Zhu XL, Guan SM, Wu YM, Yu LL and Wu JZ: Silencing of CXCR4 inhibits the proliferation, adhesion, chemotaxis and invasion of salivary gland mucoepidermoid carcinoma Mc3 cells in vitro. Oral Oncol. 44:545–554. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Lee EJ, Kim J, Lee SA, et al: Characterization of newly established oral cancer cell lines derived from six squamous cell carcinoma and two mucoepidermoid carcinoma cells. Exp Mol Med. 37:379–390. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Shankar S, Siddiqui I and Srivastava RK: Molecular mechanisms of resveratrol (3,4,5-trihydroxy-trans-stilbene) and its interaction with TNF-related apoptosis inducing ligand (TRAIL) in androgen-insensitive prostate cancer cells. Mol Cell Biochem. 304:273–285. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Yeh CC, Hsieh HL, Lee J, Jan YH, Lai TC, Hong CY, Hsiao M and Kuo MY: Polyethylenimine-mediated PUMA gene delivery to orthotopic oral cancer: Suppression of tumor growth through apoptosis induction in situ and prolonged survival. Head Neck. 33:878–885. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Yang JG, Lu R, Ye XJ, Zhang J, Tan YQ and Zhou G: Icaritin reduces oral squamous cell carcinoma progression via the inhibition of STAT3 signaling. Int J Mol Sci. 18(pii): E1322017. View Article : Google Scholar : PubMed/NCBI

21 

Peng HY, Cheng YC, Hsu YM, Wu GH, Kuo CC, Liou JP, Chang JY, Jin SL and Shiah SG: MPT0B098, a microtubule inhibitor, suppresses JAK2/STAT3 signaling pathway through modulation of SOCS3 stability in oral squamous cell carcinoma. PLoS One. 11:e01584402016. View Article : Google Scholar : PubMed/NCBI

22 

Brown ME, Bear MD, Rosol TJ, Premanandan C, Kisseberth WC and London CA: Characterization of STAT3 expression, signaling and inhibition in feline oral squamous cell carcinoma. BMC Vet Res. 11:2062015. View Article : Google Scholar : PubMed/NCBI

23 

Niu G, Wright KL, Ma Y, Wright GM, Huang M, Irby R, Briggs J, Karras J, Cress WD, Pardoll D, et al: Role of Stat3 in regulating p53 expression and function. Mol Cell Biol. 25:7432–7440. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Hikisz P and Kiliańska ZM: PUMA, a critical mediator of cell death-one decade on from its discovery. Cell Mol Biol Lett. 17:646–669. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Chinembiri TN, du Plessis LH, Gerber M, Hamman JH and du Plessis J: Review of natural compounds for potential skin cancer treatment. Molecules. 19:11679–11721. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Mangal M, Sagar P, Singh H, Raghava GP and Agarwal SM: NPACT: Naturally occurring plant-based anti-cancer compound-activity-target database. Nucleic Acids Res. 41:D1124–D1129. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Shin JA, Kwon KH and Cho SD: AMPK-activated protein kinase activation by Impatiens balsamina L. is related to apoptosis in HSC-2 human oral cancer cells. Pharmacogn Mag. 11:136–142. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Yu HJ, Shin JA, Lee SO, Kwon KH and Cho SD: Extracellular signal-regulated kinase inhibition is required for methanol extract of Smilax china L.-induced apoptosis through death receptor 5 in human oral mucoepidermoid carcinoma cells. Mol Med Rep. 9:663–668. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Zhang J, Liu C, Huang RZ, Chen HF, Liao ZX, Sun JY, Xia XK and Wang FX: Three new C-27-carboxylated-lupane-triterpenoid derivatives from Potentilla discolor Bunge and their in vitro antitumor activities. PLoS One. 12:e01755022017. View Article : Google Scholar : PubMed/NCBI

30 

Christodoulou MI, Kontos CK, Halabalaki M, Skaltsounis AL and Scorilas A: Nature promises new anticancer agents: Interplay with the apoptosis-related BCL2 gene family. Anticancer Agents Med Chem. 14:375–399. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Yang IH, Shin JA, Kim LH, Kwon KH and Cho SD: The caspase 3-dependent apoptotic effect of pycnogenol in human oral squamous cell carcinoma HSC-3 cells. J Clin Biochem Nutr. 58:40–47. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Yang S, Zhu Z, Zhang X, Zhang N and Yao Z: Idelalisib induces PUMA-dependent apoptosis in colon cancer cells. Oncotarget. 8:6102–6113. 2017.PubMed/NCBI

33 

Chatwichien J, Basu S, Budina-Kolomets A, Murphy ME and Winkler JD: PUMA-dependent apoptosis in NSCLC cancer cells by a dimeric β-carboline. Bioorg Med Chem Lett. 26:4884–4887. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Zhu HJ, Liu L, Fan L, Zhang LN, Fang C, Zou ZJ, Li JY and Xu W: The BH3-only protein Puma plays an essential role in p53-mediated apoptosis of chronic lymphocytic leukemia cells. Leuk Lymphoma. 54:2712–2719. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Zhang Y, Xing D and Liu L: PUMA promotes Bax translocation by both directly interacting with Bax and by competitive binding to Bcl-XL during UV-induced apoptosis. Mol Biol Cell. 20:3077–3087. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Xiong A, Yang Z, Shen Y, Zhou J and Shen Q: Transcription factor STAT3 as a novel molecular target for cancer prevention. Cancers. 6:926–957. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Al Zaid Siddiquee K and Turkson J: STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res. 18:254–267. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Mali SB: Review of STAT3 (Signal transducers and activators of transcription) in head and neck cancer. Oral Oncol. 51:565–569. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Leeman-Neill RJ, Seethala RR, Singh SV, Freilino ML, Bednash JS, Thomas SM, Panahandeh MC, Gooding WE, Joyce SC, Lingen MW, et al: Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma. Cancer Prev Res. 4:230–237. 2011. View Article : Google Scholar

40 

Yu HJ, Park C, Kim SJ, Cho NP and Cho SD: Signal transducer and activators of transcription 3 regulates cryptotanshinone-induced apoptosis in human mucoepidermoid carcinoma cells. Pharmacogn Mag. 10 Suppl 3:S622–S629. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Yu HJ, Shin JA, Jung JY, Nam JS, Hong IS, Cho NP and Cho SD: Inhibition of myeloid cell leukemia-1: Association with sorafenib-induced apoptosis in human mucoepidermoid carcinoma cells and tumor xenograft. Head Neck. 37:1326–1335. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yu H, Ahn C, Yang I, Won D, Jin B, Cho N, Hong SD, Shin J and Cho S: Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis. Mol Med Rep 17: 5258-5264, 2018.
APA
Yu, H., Ahn, C., Yang, I., Won, D., Jin, B., Cho, N. ... Cho, S. (2018). Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis. Molecular Medicine Reports, 17, 5258-5264. https://doi.org/10.3892/mmr.2018.8468
MLA
Yu, H., Ahn, C., Yang, I., Won, D., Jin, B., Cho, N., Hong, S. D., Shin, J., Cho, S."Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis". Molecular Medicine Reports 17.4 (2018): 5258-5264.
Chicago
Yu, H., Ahn, C., Yang, I., Won, D., Jin, B., Cho, N., Hong, S. D., Shin, J., Cho, S."Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis". Molecular Medicine Reports 17, no. 4 (2018): 5258-5264. https://doi.org/10.3892/mmr.2018.8468
Copy and paste a formatted citation
x
Spandidos Publications style
Yu H, Ahn C, Yang I, Won D, Jin B, Cho N, Hong SD, Shin J and Cho S: Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis. Mol Med Rep 17: 5258-5264, 2018.
APA
Yu, H., Ahn, C., Yang, I., Won, D., Jin, B., Cho, N. ... Cho, S. (2018). Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis. Molecular Medicine Reports, 17, 5258-5264. https://doi.org/10.3892/mmr.2018.8468
MLA
Yu, H., Ahn, C., Yang, I., Won, D., Jin, B., Cho, N., Hong, S. D., Shin, J., Cho, S."Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis". Molecular Medicine Reports 17.4 (2018): 5258-5264.
Chicago
Yu, H., Ahn, C., Yang, I., Won, D., Jin, B., Cho, N., Hong, S. D., Shin, J., Cho, S."Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis". Molecular Medicine Reports 17, no. 4 (2018): 5258-5264. https://doi.org/10.3892/mmr.2018.8468
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team