Open Access

Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis

  • Authors:
    • Hyun-Ju Yu
    • Chi-Hyun Ahn
    • In-Hyoung Yang
    • Dong-Hoon Won
    • Bohwan Jin
    • Nam-Pyo Cho
    • Seong Doo Hong
    • Ji-Ae Shin
    • Sung-Dae Cho
  • View Affiliations

  • Published online on: January 22, 2018     https://doi.org/10.3892/mmr.2018.8468
  • Pages: 5258-5264
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Potentilla discolor has been used in traditional Chinese medicine for the treatment of hyperglycemia. However, the potential role of Potentilla discolor against cancer and its mode of action remain to be fully elucidated. The present study explored the apoptotic effect of methanol extract of Potentilla discolor (MEPD) in human mucoepidermoid carcinoma (MEC) cell lines of salivary glands. MEPD markedly suppressed the growth and induced apoptotic cell death in MC3 and YD15 cells. MEPD treatment significantly upregulated the expression of PUMA and reduced STAT3 phosphorylation. Overexpression of STAT3 partially recovered the growth of MEC cells inhibited by MEPD. In addition, dephosphorylation of STAT3 by cryptotanshinone (a potent STAT3 inhibitor) was sufficient to inhibit the growth of MEC cells and induce apoptosis via affecting PUMA protein. These results suggest that MEPD has a potential anticancer property via the STAT3/PUMA signaling axis in human MEC cells of salivary gland.
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April-2018
Volume 17 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Yu H, Ahn C, Yang I, Won D, Jin B, Cho N, Hong SD, Shin J and Cho S: Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis. Mol Med Rep 17: 5258-5264, 2018
APA
Yu, H., Ahn, C., Yang, I., Won, D., Jin, B., Cho, N. ... Cho, S. (2018). Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis. Molecular Medicine Reports, 17, 5258-5264. https://doi.org/10.3892/mmr.2018.8468
MLA
Yu, H., Ahn, C., Yang, I., Won, D., Jin, B., Cho, N., Hong, S. D., Shin, J., Cho, S."Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis". Molecular Medicine Reports 17.4 (2018): 5258-5264.
Chicago
Yu, H., Ahn, C., Yang, I., Won, D., Jin, B., Cho, N., Hong, S. D., Shin, J., Cho, S."Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis". Molecular Medicine Reports 17, no. 4 (2018): 5258-5264. https://doi.org/10.3892/mmr.2018.8468