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Article

High sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model

  • Authors:
    • Ting Li
    • Bing Bai
    • Chenguang Tian
    • Huihui Wang
    • Deyue Jiang
    • Fangfei Ma
    • Mengting Shan
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology and Metabolic Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450014, P.R. China, Department of Endocrinology and Metabolic Diseases, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Henan Polytechnic University, Jiaozuo, Henan 454000, P.R. China
  • Pages: 6789-6795
    |
    Published online on: February 28, 2018
       https://doi.org/10.3892/mmr.2018.8651
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Abstract

The present study aimed to investigate the association between insulin resistance (IR), nitric oxide (NO) production and myocardial apoptosis in a background of coexisting hypertension in a rodent animal model. A hypertensive rat model was established by feeding Wistar and spontaneously hypertensive rats (SHR) with a high sucrose/fat (HSF) diet for 12 weeks, in conjunction with isosorbide mononitrate (ISMN). Increased IR, NO content, apoptotic gene and protein expression, and morphological alterations within rat myocardium were evaluated. Following a total of 12 weeks of feeding with HSF and ISMN resulted in increased IR and NO content within the myocardial tissue of Wistar and SHR rats. HSF and ISMN activated myocardial apoptosis by downregulating the gene transcription and protein expression levels of the anti‑apoptotic B‑cell lymphoma 2 (Bcl‑2), and increasing the pro‑apoptotic Bcl‑2 associated X protein. Apoptosis was demonstrated by DNA fragmentation in terminal deoxynucleotidyl‑transferase‑mediated dUTP nick end labelling assay. In all experiments, the combination of HSF and ISMN was associated with more pronounced effects, indicating the possible synergistic effects. In addition, the correlation analysis in the Wistar rats fed with HSF only, revealed a positive association between NO production and IR. The results of the present study indicated that HSF and ISMN simultaneously increased IR, NO production and myocardial apoptosis in the hypertensive rat model, and may therefore contribute to investigations into the long‑term clinical use of ISMN in hypertensive patients.
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View References

1 

Alberti KG, Zimmet P and Shaw J: IDF Epidemiology Task Force Consensus Group: The metabolic syndrome-a new worldwide definition. Lancet. 366:1059–1062. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Kannel WB and Cobb J: Left ventricular hypertrophy and mortality-results from the framingham study. Cardiology. 81:291–298. 1992. View Article : Google Scholar : PubMed/NCBI

3 

Chae CU, Pfeffer MA, Glynn RJ, Mitchell GF, Taylor JO and Hennekens CH: Increased pulse pressure and risk of heart failure in the elderly. JAMA. 281:634–639. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Reaven GM: Role of insulin resistance in human disease (syndrome X): An expanded definition. Annu Rev Med. 44:121–131. 1993. View Article : Google Scholar : PubMed/NCBI

5 

Meshkani R and Adeli K: Hepatic insulin resistance, metabolic syndrome and cardiovascular disease. Clin Biochem. 42:1331–1346. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Torfgård KE and Ahlner J: Mechanisms of action of nitrates. Cardiovasc Drugs Ther. 8:701–717. 1994. View Article : Google Scholar : PubMed/NCBI

7 

Boyd CS and Cadenas E: Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis. Biol Chem. 383:411–423. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Wang X, Diao Y, Liu Y, Gao N, Gao D, Wan Y, Zhong J and Jin G: Synergistic apoptosis-inducing effect of aspirin and isosorbide mononitrate on human colon cancer cells. Mol Med Rep. 12:4750–4758. 2015. View Article : Google Scholar : PubMed/NCBI

9 

National Research Council: Guide for the Care and Use of Laboratory Animals. National Academy Press; Washington, DC: pp. 1401996

10 

Frustaci A, Kajstura J, Chimenti C, Jakoniuk I, Leri A, Maseri A, Nadal-Ginard B and Anversa P: Myocardial cell death in human diabetes. Circ Res. 87:1123–1132. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Sam F, Sawyer DB, Chang DL, Eberli FR, Ngoy S, Jain M, Amin J, Apstein CS and Colucci WS: Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart. Am J Physiol Heart Circ Physiol. 279:H422–H428. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Chen HI and Hu CT: Endogenous nitric oxide on arterial hemodynamics: A comparison between normotensive and hypertensive rats. Am J Physiol. 273:H1816–H1823. 1997.PubMed/NCBI

13 

Thadani U and Lipicky RJ: Short and long-acting oral nitrates for stable angina pectoris. Cardiovasc Drugs Ther. 8:611–623. 1994. View Article : Google Scholar : PubMed/NCBI

14 

Wu CC and Yen MH: Higher level of plasma nitric oxide in spontaneously hypertensive rats. Am J Hypertens. 12:476–482. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Förstermann U and Sessa WC: Nitric oxide synthases: Regulation and function. Eur Heart J. 33(829–837): 837a–837d. 2012.

16 

Hua W, Chen Q, Gong F, Xie C, Zhou S and Gao L: Cardioprotection of H2S by downregulating iNOS and upregulating HO-1 expression in mice with CVB3-induced myocarditis. Life Sci. 93:949–954. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Li YC, Luo Q, Ge LS, Chen YH, Zhou ND, Zhang T, Guan XQ and Lin JF: Ivabradine inhibits the production of proinflammatory cytokines and inducible nitric oxide synthase in acute coxsackievirus B3-induced myocarditis. Biochem Biophys Res Commun. 431:450–455. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Brüne B: Nitric oxide: NO apoptosis or turning it ON? Cell Death Differ. 10:864–869. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Dobrin JS and Lebeche D: Diabetic cardiomyopathy: Signaling defects and therapeutic approaches. Expert Rev Cardiovasc Ther. 8:373–391. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Boudina S and Abel ED: Diabetic cardiomyopathy, causes and effects. Rev Endocr Metab Disord. 11:31–39. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Khavandi K, Khavandi A, Asghar O, Greenstein A, Withers S, Heagerty AM and Malik RA: Diabetic cardiomyopathy-a distinct disease? Best Pract Res Clin Endocrinol Metab. 23:347–360. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Singh S, Duggal J, Khosla N and Arora R: Screening guidelines for coronary heart disease in diabetes: Current recommendations. J Cardiometab Syndr. 4:107–112. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Carvalho-Filho MA, Ueno M, Carvalheira JB, Velloso LA and Saad MJ: Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta/IRS-1 and Akt and insulin resistance in muscle of mice. Am J Physiol Endocrinol Metab. 291:E476–E482. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Carvalho-Filho MA, Ueno M, Hirabara SM, Seabra AB, Carvalheira JB, de Oliveira MG, Velloso LA, Curi R and Saad MJ: S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: A novel mechanism of insulin resistance. Diabetes. 54:959–967. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Perreault M and Marette A: Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med. 7:1138–1143. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Fritz M and Rinaldi G: Blood pressure measurement with the tail-cuff method in Wistar and spontaneously hypertensive rats: Influence of adrenergic- and nitric oxide-mediated vasomotion. J Pharmacol Toxicol Methods. 58:215–221. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Lai J, Wu B, Sun J, Shang Y and Zhu J: Long-term isosorbide mononitrate treatment impairs endothelial function in patients with coronary artery disease. Coron Artery Dis. 24:566–571. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li T, Bai B, Tian C, Wang H, Jiang D, Ma F and Shan M: High sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model. Mol Med Rep 17: 6789-6795, 2018.
APA
Li, T., Bai, B., Tian, C., Wang, H., Jiang, D., Ma, F., & Shan, M. (2018). High sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model. Molecular Medicine Reports, 17, 6789-6795. https://doi.org/10.3892/mmr.2018.8651
MLA
Li, T., Bai, B., Tian, C., Wang, H., Jiang, D., Ma, F., Shan, M."High sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model". Molecular Medicine Reports 17.5 (2018): 6789-6795.
Chicago
Li, T., Bai, B., Tian, C., Wang, H., Jiang, D., Ma, F., Shan, M."High sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model". Molecular Medicine Reports 17, no. 5 (2018): 6789-6795. https://doi.org/10.3892/mmr.2018.8651
Copy and paste a formatted citation
x
Spandidos Publications style
Li T, Bai B, Tian C, Wang H, Jiang D, Ma F and Shan M: High sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model. Mol Med Rep 17: 6789-6795, 2018.
APA
Li, T., Bai, B., Tian, C., Wang, H., Jiang, D., Ma, F., & Shan, M. (2018). High sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model. Molecular Medicine Reports, 17, 6789-6795. https://doi.org/10.3892/mmr.2018.8651
MLA
Li, T., Bai, B., Tian, C., Wang, H., Jiang, D., Ma, F., Shan, M."High sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model". Molecular Medicine Reports 17.5 (2018): 6789-6795.
Chicago
Li, T., Bai, B., Tian, C., Wang, H., Jiang, D., Ma, F., Shan, M."High sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model". Molecular Medicine Reports 17, no. 5 (2018): 6789-6795. https://doi.org/10.3892/mmr.2018.8651
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