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Article

Oxidative damage and mitochondrial injuries differ following pneumoperitoneum pressure in rabbit models of varying degrees of hydronephrosis

  • Authors:
    • Wei Li
    • Sheng Zhao
    • Fan Cheng
    • Ting Rao
    • Weimin Yu
    • Yuan Ruan
    • Run Yuan
    • Xiaobing Yao
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430000, P.R. China, Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430000, P.R. China
  • Pages: 6819-6827
    |
    Published online on: March 1, 2018
       https://doi.org/10.3892/mmr.2018.8665
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Abstract

The influence of intraabdominal pressure which is necessary to maintain the operating area during the surgery cannot be ignored especially on the kidneys. Many articles have reported the effect of intraabdominal pressure on normal kidneys. However, the influence of intraabdominal pressure on hydronephrosis kidneys is rarely studied. The aim of the present study was to clarify whether intraabdominal pressure tolerance is modified in various degrees of kidney hydronephrosis by evaluating oxidative damage and mitochondrial injuries. A total of 72 rabbits were randomly divided into three groups (groups N, M and S, which represented rabbits with no, mild and severe hydronephrosis, respectively). Rabbits in groups M (n=24) and S (n=24) underwent a surgical procedure inducing mild or severe hydronephrosis, respectively. Subsequently, rabbits in all groups were allocated to 4 subgroups (N0‑N3, M0‑M3 and S0‑S3) consisting of 6 rabbits each. Groups 0 to 3 were, respectively, subjected to intraabdominal pressures of 0, 5, 10 and 15 mmHg. Oxidative damage was assessed by analyzing levels of reactive oxygen species (ROS), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH‑Px), catalase (CAT) and lactate (LD). Mitochondrial injuries were assessed based on mitochondrial membrane potential (MMP) alterations, mitochondrial structure and cytochrome c (cytc) protein expression, as measured by JC‑1 staining, electron microscopy and western blotting, respectively. Oxidative damage and mitochondrial injuries were noticeably exacerbated in group N and M with increased levels of ROS, MDA and LD, decreased levels of SOD, GSH‑Px, CAT and MMP, mitochondrial vacuolization and higher expression of cytc when the intraabdominal pressure reached 15 mmHg. In group S, these alterations occurred at pressures of 10 and 15 mmHg. Therefore, it was concluded that in rabbits exposed to pneumoperitoneal pressure, kidneys with severe hydronephrosis were more likely to suffer from oxidative damage and mitochondrial injuries compared with kidneys with mild hydronephrosis and normal kidneys.
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1 

van der Toorn F, van den Hoek J, Wolffenbuttel KP and Scheepe JR: Laparoscopic transperitoneal pyeloplasty in children from age of 3 years: Our clinical outcomes compared with open surgery. J Pediatr Urol. 9:161–168. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Seims AD, VanHouwelingen L, Mead J, Mao S, Loh A, Sandoval JA, Davidoff AM, Wu J, Wang WC and Fernandez-Pineda I: Operative and immediate postoperative differences between traditional multiport and reduced port laparoscopic total splenectomy in pediatric patients. J Laparoendosc Adv Surg Tech A. 27:206–210. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Bartın MK, Kemik Ö, Çaparlar MA, Bostancı MT and Öner MÖ: Evaluation of the open and laparoscopic appendectomy operations with respect to their effect on serum IL-6 levels. Ulus Travma Acil Cerrahi Derg. 22:466–470. 2016.PubMed/NCBI

4 

Wever KE, Bruintjes MH, Warlé MC and Hooijmans CR: Renal perfusion and function during pneumoperitoneum: A systematic review and meta-analysis of animal studies. PLoS One. 11:e01634192016. View Article : Google Scholar : PubMed/NCBI

5 

Sodha S, Nazarian S, Adshead JM, Vasdev N and Mohan-S G: Effect of pneumoperitoneum on renal function and physiology in patients undergoing robotic renal surgery. Curr Urol. 9:1–4. 2016. View Article : Google Scholar : PubMed/NCBI

6 

de Geus HR, Betjes MG, Schaick Rv and Groeneveld JA: Plasma NGAL similarly predicts acute kidney injury in sepsis and nonsepsis. Biomark Med. 7:415–421. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Cekic B, Geze S, Ozkan G, Besir A, Sonmez M, Karahan SC and Mentese A: The effect of dexmedetomidine on oxidative stress during pneumoperitoneum. Biomed Res Int. 2014:7603232014. View Article : Google Scholar : PubMed/NCBI

8 

Ko KJ, Choi DK, Shin SJ, Ryoo HS, Kim TS, Song W, Jeon HG, Jeong BC and Seo SI: Predictive factors of prolonged warm ischemic time (≥30 minutes) during partial nephrectomy under pneumoperitoneum. Korean J Urol. 56:742–748. 2015. View Article : Google Scholar : PubMed/NCBI

9 

de Barros RF, Miranda ML, de Mattos AC, Gontijo JA, Silva VR, Iorio B and Bustorff-Silva JM: Kidney safety during surgical pneumoperitoneum: An experimental study in rats. Surg Endosc. 26:3195–3200. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Demyttenaere S, Feldman LS and Fried GM: Effect of pneumoperitoneum on renal perfusion and function: A systematic review. Surg Endosc. 21:152–160. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Ozmen MM, Zulfikaroglu B, Besler TH, Col C, Cinel L and Cinel I: The correlation between reactive oxygen species and histopathology of the liver, gut, and kidneys in animals with elevated intra-abdominal pressure. J Laparoendosc Adv Surg Tech A. 19:339–343. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Sammour T, Mittal A, Loveday BP, Kahokehr A, Phillips AR, Windsor JA and Hill AG: Systematic review of oxidative stress associated with pneumoperitoneum. Br J Surg. 96:836–850. 2009. View Article : Google Scholar : PubMed/NCBI

13 

de Seigneux S, Klopfenstein CE, Iselin C and Martin PY: The risk of acute kidney injury following laparoscopic surgery in a chronic kidney disease patient. NDT Plus. 4:339–341. 2011.PubMed/NCBI

14 

Dolkart O, Khoury W, Amar E and Weinbroum AA: Pneumoperitoneum in the presence of acute and chronic kidney injury: An experimental model in rats. J Urol. 192:1266–1271. 2014. View Article : Google Scholar : PubMed/NCBI

15 

National Research Council: Guide for the Care and Use of Laboratory Animals. National Acadamies Press; Washington, DC: 1996

16 

Wen JG, Chen Y, Frøkiaer J, Jørgensen TM and Djurhuus JC: Experimental partial unilateral ureter obstruction. I. Pressure flow relationship in a rat model with mild and severe acute ureter obstruction. J Urol. 160:1567–1571. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Oyanagui Y: Reevaluation of assay methods and establishment of kit for superoxide dismutase activity. Anal Biochem. 142:290–296. 1984. View Article : Google Scholar : PubMed/NCBI

18 

Perelman A, Wachtel C, Cohen M, Haupt S, Shapiro H and Tzur A: JC-1: Alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry. Cell Death Dis. 3:e4302012. View Article : Google Scholar : PubMed/NCBI

19 

Makarov DV, Kainth D, Link RE and Kavoussi LR: Physiologic changes during helium insufflation in high-risk patients during laparoscopic renal procedures. Urology. 70:35–37. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Özdemir-van Brunschot DM, van Laarhoven KC, Scheffer GJ, Pouwels S, Wever KE and Warlé MC: What is the evidence for the use of low-pressure pneumoperitoneum? A systematic review. Surg Endosc. 30:2049–2065. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Wiesenthal JD, Fazio LM, Perks AE, Blew BD, Mazer D, Hare G, Honey RJ and Pace KT: Effect of pneumoperitoneum on renal tissue oxygenation and blood flow in a rat model. Urology. 77:1508.e9–e15. 2011. View Article : Google Scholar

22 

Borba M, Lopes R, Carmona M, Neto BM, Nahas SC and Pereira PR: Effects of enalaprilat on the renin-angiotensin-aldosterone system and on renal function during CO2 pneumoperitoneum. J Endourol. 19:1026–1031. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Cay A, Imamoğlu M, Unsal MA, Aydin S, Alver A, Akyol A and Sarihan H: Does anti-oxidant prophylaxis with melatonin prevent adverse outcomes related to increased oxidative stress caused by laparoscopy in experimental rat model? J Surg Res. 135:2–8. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Tosun M, Yucel M, Kucuk A and Sezen S: P53 related apoptosis in kidneys in CO2 pneumoperitoneum rat model: An immunohistochemical study. Mol Biol Rep. 41:6391–6395. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Zhong N, Zhang Y, Zhu HF and Zhou ZN: Intermittent hypoxia exposure prevents mtDNA deletion and mitochondrial structure damage produced by ischemia/reperfusion injury. Sheng Li Xue Bao. 52:375–380. 2000.PubMed/NCBI

26 

Li W, Cao Z, Xia Z, Meng Q, Yu WM, Yao X and Cheng F: Acute kidney injury induced by various pneumoperitoneum pressures in a rabbit model of mild and severe hydronephrosis. Urol Int. 94:225–233. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Cao Z, Yu W, Li W, Cheng F, Rao T, Yao X, Zhang X and Larré S: Oxidative damage and mitochondrial injuries are induced by various irrigation pressures in rabbit models of mild and severe hydronephrosis. PLoS One. 10:e01271432015. View Article : Google Scholar : PubMed/NCBI

28 

Cao Z, Yu W, Li W, Cheng F, Xia Y, Rao T, Yao X, Zhang X and Larré S: Acute kidney injuries induced by various irrigation pressures in rat models of mild and severe hydronephrosis. Urology. 82:1453.e9–16. 2013. View Article : Google Scholar

29 

Shigeta K, Kikuchi E, Hagiwara M, Hattori S, Kaneko G, Hasegawa M, Takeda T, Jinzaki M, Akita H, Miyajima A, et al: Visceral to total obesity ratio and severe hydronephrosis are independently associated with prolonged pneumoperitoneum operative time in patients undergoing laparoscopic radical nephroureterectomy for upper tract urothelial carcinoma. Springerplus. 4:2902015. View Article : Google Scholar : PubMed/NCBI

30 

Kwak GH, Kim TH and Kim HY: Down-regulation of MsrB3 induces cancer cell apoptosis through reactive oxygen species production and intrinsic mitochondrial pathway activation. Biochem Biophys Res Commun. 483:468–474. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Mehaney DA, Darwish HA, Hegazy RA, Nooh MM, Tawdy AM, Gawdat HI and El-Sawalhi MM: Analysis of oxidative stress status, catalase and catechol-O-methyltransferase polymorphisms in Egyptian vitiligo patients. PLoS One. 9:e992862014. View Article : Google Scholar : PubMed/NCBI

32 

Tortora M, Corsini S and Nistri A: Nicotinic receptors modulate the onset of reactive oxygen species production and mitochondrial dysfunction evoked by glutamate uptake block in the rat hypoglossal nucleus. Neurosci Lett. 639:43–48. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Wang Y, Gao H, Na XL, Dong SY, Dong HW, Yu J, Jia L and Wu YH: Aniline induces oxidative stress and apoptosis of primary cultured hepatocytes. Int J Environ Res Public Health. 13:E11882016. View Article : Google Scholar : PubMed/NCBI

34 

Cigremis Y, Turel H, Adiguzel K, Akgoz M, Kart A, Karaman M and Ozen H: The effects of acute acetaminophen toxicity on hepatic mRNA expression of SOD, CAT, GSH-Px, and levels of peroxynitrite, nitric oxide, reduced glutathione, and malondialdehyde in rabbit. Mol Cell Biochem. 323:31–38. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Mookerjee SA and Brand MD: Measurement and analysis of extracellular acid production to determine glycolytic rate. J Vis Exp: e53464. 2015. View Article : Google Scholar

36 

Sung DK, Chang YS, Kang S, Song HY, Park WS and Lee BH: Comparative evaluation of hypoxic-ischemic brain injury by flow cytometric analysis of mitochondrial membrane potential with JC-1 in neonatal rats. J Neurosci Methods. 193:232–238. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Wang LR, Xue X, Hu XM, Wei MY, Zhang CQ, Ge GL and Liang XJ: Structure-dependent mitochondrial dysfunction and hypoxia induced with single-walled carbon nanotubes. Small. 10:2859–2869. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Kroemer G, Galluzzi L and Brenner C: Mitochondrial membrane permeabilization in cell death. Physiol Rev. 87:99–163. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Avital S, Itah R, Szomstein S, Rosenthal R, Inbar R, Sckornik Y and Weinbroum A: Correlation of CO2 pneumoperitoneal pressures between rodents and humans. Surg Endosc. 23:50–54. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Balayssac D, Pereira B, Bazin JE, Le Roy B, Pezet D and Gagnière J: Warmed and humidified carbon dioxide for abdominal laparoscopic surgery: Meta-analysis of the current literature. Surg Endosc. 31:1–12. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Sammour T, Mittal A, Delahunt B, Phillips AR and Hill AG: Warming and humidification have no effect on oxidative stress during pneumoperitoneum in rats. Minim Invasive Ther Allied Technol. 20:329–337. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Akbulut G, Polat C, Aktepe F, Yilmaz S, Kahraman A, Serteser M, Gökçe C and Gökçe O: The oxidative effect of prolonged CO2 pneumoperitoneum on renal tissue of rats. Surg Endosc. 18:1384–1388. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li W, Zhao S, Cheng F, Rao T, Yu W, Ruan Y, Yuan R and Yao X: Oxidative damage and mitochondrial injuries differ following pneumoperitoneum pressure in rabbit models of varying degrees of hydronephrosis. Mol Med Rep 17: 6819-6827, 2018.
APA
Li, W., Zhao, S., Cheng, F., Rao, T., Yu, W., Ruan, Y. ... Yao, X. (2018). Oxidative damage and mitochondrial injuries differ following pneumoperitoneum pressure in rabbit models of varying degrees of hydronephrosis. Molecular Medicine Reports, 17, 6819-6827. https://doi.org/10.3892/mmr.2018.8665
MLA
Li, W., Zhao, S., Cheng, F., Rao, T., Yu, W., Ruan, Y., Yuan, R., Yao, X."Oxidative damage and mitochondrial injuries differ following pneumoperitoneum pressure in rabbit models of varying degrees of hydronephrosis". Molecular Medicine Reports 17.5 (2018): 6819-6827.
Chicago
Li, W., Zhao, S., Cheng, F., Rao, T., Yu, W., Ruan, Y., Yuan, R., Yao, X."Oxidative damage and mitochondrial injuries differ following pneumoperitoneum pressure in rabbit models of varying degrees of hydronephrosis". Molecular Medicine Reports 17, no. 5 (2018): 6819-6827. https://doi.org/10.3892/mmr.2018.8665
Copy and paste a formatted citation
x
Spandidos Publications style
Li W, Zhao S, Cheng F, Rao T, Yu W, Ruan Y, Yuan R and Yao X: Oxidative damage and mitochondrial injuries differ following pneumoperitoneum pressure in rabbit models of varying degrees of hydronephrosis. Mol Med Rep 17: 6819-6827, 2018.
APA
Li, W., Zhao, S., Cheng, F., Rao, T., Yu, W., Ruan, Y. ... Yao, X. (2018). Oxidative damage and mitochondrial injuries differ following pneumoperitoneum pressure in rabbit models of varying degrees of hydronephrosis. Molecular Medicine Reports, 17, 6819-6827. https://doi.org/10.3892/mmr.2018.8665
MLA
Li, W., Zhao, S., Cheng, F., Rao, T., Yu, W., Ruan, Y., Yuan, R., Yao, X."Oxidative damage and mitochondrial injuries differ following pneumoperitoneum pressure in rabbit models of varying degrees of hydronephrosis". Molecular Medicine Reports 17.5 (2018): 6819-6827.
Chicago
Li, W., Zhao, S., Cheng, F., Rao, T., Yu, W., Ruan, Y., Yuan, R., Yao, X."Oxidative damage and mitochondrial injuries differ following pneumoperitoneum pressure in rabbit models of varying degrees of hydronephrosis". Molecular Medicine Reports 17, no. 5 (2018): 6819-6827. https://doi.org/10.3892/mmr.2018.8665
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