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Article

Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROS‑dependent p38 MAPK and protects against cerebral ischemia‑reperfusion injury

  • Authors:
    • Hui Lu
    • Bincheng Wang
    • Ningning Cui
    • Yanchun Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Cangzhou Central Hospital, Cangzhou, Hebei 060000, P.R. China, Department of Neurology, Xuan Wu Hospital, Beijing 100053, P.R. China
  • Pages: 6639-6646
    |
    Published online on: March 1, 2018
       https://doi.org/10.3892/mmr.2018.8666
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Abstract

Artesunate is a semi-synthetic derivative of artemisinin that is used in the treatment of patients with malaria. Artesunate has also been reported to exert immune‑regulatory, antitumor, hepatoprotective, anti‑inflammatory and smooth muscle relaxing functions. The present study aimed to investigate the putative protective effects of artesunate against cerebral ischemia/reperfusion injury (CIRI), and to elucidate the molecular mechanisms underlying its effects. A CIRI mouse model was created via middle cerebral artery occlusion for 2 h, followed by 22 h of reperfusion. Mice were treated with 10‑40 mg/kg artesunate. The present results demonstrated that treatment with artesunate significantly reduced the cerebral infarct volume and potentiated the recovery of neurological function in CIRI mice. Oxidative stress and inflammation markers were revealed to be significantly downregulated following treatment with artesunate in CIRI mice. Furthermore, artesunate was demonstrated to activate nuclear factor erythroid 2‑related factor 2 (Nrf2), inhibit caspase‑3 activity, reduce the apoptosis regulator BAX/apoptosis regulator Bcl‑2 expression ratio and suppress the phosphorylation of the mitogen‑activated protein kinase (MAPK) p38 in CIRI mice. In conclusion, the present findings suggested that artesunate may exert protective effects against CIRI through the suppression of oxidative and inflammatory processes, via activating Nrf2 and downregulating ROS‑dependent p38 MAPK in mice.
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1 

Sorond FA, Tan CO, LaRose S, Monk AD, Fichorova R, Ryan S and Lipsitz LA: Deferoxamine, cerebrovascular hemodynamics, and vascular aging: Potential role for hypoxia-inducible transcription factor-1-regulated pathways. Stroke. 46:2576–2583. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, et al: Pioglitazone after ischemic stroke or transient ischemic attack. N Engl J Med. 374:1321–1331. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Huang X, Cheripelli BK, Lloyd SM, Kalladka D, Moreton FC, Siddiqui A, Ford I and Muir KW: Alteplase versus tenecteplase for thrombolysis after ischaemic stroke (ATTEST): A phase 2, randomised, open-label, blinded endpoint study. Lancet Neurol. 14:368–376. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Liebeskind DS, Tomsick TA, Foster LD, Yeatts SD, Carrozzella J, Demchuk AM, Jovin TG, Khatri P, von Kummer R, Sugg RM, et al: Collaterals at angiography and outcomes in the Interventional Management of Stroke (IMS) III trial. Stroke. 45:759–764. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Shan J, Sun L, Wang D and Li X: Comparison of the neuroprotective effects and recovery profiles of isoflurane, sevoflurane and desflurane as neurosurgical pre-conditioning on ischemia/reperfusion cerebral injury. Int J Clin Exp Pathol. 8:2001–2009. 2015.PubMed/NCBI

6 

Jiang F, Yang J, Zhang L, Li R, Zhuo L, Sun L and Zhao Q: Rosuvastatin reduces ischemia-reperfusion injury in patients with acute coronary syndrome treated with percutaneous coronary intervention. Clin Cardiol. 37:530–535. 2014.PubMed/NCBI

7 

Yu Q, Lu Z, Tao L, Yang L, Guo Y, Yang Y, Sun X and Ding Q: ROS-dependent neuroprotective effects of NaHS in ischemia brain injury involves the PARP/AIF pathway. Cell Physiol Biochem. 36:1539–1551. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Zhao B, Chen Y, Sun X, Zhou M, Ding J, Zhan JJ and Guo LJ: Phenolic alkaloids from Menispermum dauricum rhizome protect against brain ischemia injury via regulation of GLT-1, EAAC1 and ROS generation. Molecules. 17:2725–2737. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Wang PR, Wang JS, Zhang C, Song XF, Tian N and Kong LY: Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPK-mTOR signaling pathway. J Ethnopharmacol. 149:270–280. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Cheng CY, Lin JG, Tang NY, Kao ST and Hsieh CL: Electroacupuncture at different frequencies (5 Hz and 25 Hz) ameliorates cerebral ischemia-reperfusion injury in rats: Possible involvement of p38 MAPK-mediated anti-apoptotic signaling pathways. BMC Complement Altern Med. 15:2412015. View Article : Google Scholar : PubMed/NCBI

11 

Wang S, Liu K, Seneviratne CJ, Li X, Cheung GS, Jin L, Chu CH and Zhang C: Lipoteichoic acid from an Enterococcus faecalis clinical strain promotes TNF-α expression through the NF-κB and p38 MAPK signaling pathways in differentiated THP-1 macrophages. Biomed Rep. 3:697–702. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Nito C, Kamada H, Endo H, Niizuma K, Myer DJ and Chan PH: Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion. J Cereb Blood Flow Metab. 28:1686–1696. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Jie P, Hong Z, Tian Y, Li Y, Lin L, Zhou L, Du Y and Chen L and Chen L: Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways. Cell Death Dis. 6:e17752015. View Article : Google Scholar : PubMed/NCBI

14 

Cheng R, Li C, Li C, Wei L, Li L, Zhang Y, Yao Y, Gu X, Cai W, Yang Z, et al: The artemisinin derivative artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells. Invest Ophthalmol Vis Sci. 54:3400–3409. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Thanaketpaisarn O, Waiwut P, Sakurai H and Saiki I: Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-κB and PI3K/Akt signaling pathways. Int J Oncol. 39:279–285. 2011.PubMed/NCBI

16 

Cao TH, Jin SG, Fei DS, Kang K, Jiang L, Lian ZY, Pan SH, Zhao MR and Zhao MY: Artesunate protects against sepsis-induced lung injury via heme oxygenase-1 modulation. Inflammation. 39:651–662. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Ng DS, Liao W, Tan WS, Chan TK, Loh XY and Wong WS: Anti-malarial drug artesunate protects against cigarette smoke-induced lung injury in mice. Phytomedicine. 21:1638–1644. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Wu F, Li J, Guo N, Wang XH and Liao YQ: MiRNA-27a promotes the proliferation and invasion of human gastric cancer MGC803 cells by targeting SFRP1 via Wnt/β-catenin signaling pathway. Am J Cancer Res. 7:405–416. 2017.PubMed/NCBI

19 

Svensson LG, Blackstone EH, Apperson-Hansen C, Ruggieri PM, Ainkaran P, Naugle RI, Lima B, Roselli EE, Cooper M, Somogyi D, et al: Implications from neurologic assessment of brain protection for total arch replacement from a randomized trial. J Thorac Cardiovasc Surg. 150:1140–1147.e11. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Yuan Y, Yao YF, Hu SN, Gao J and Zhang LL: MiR-133a is functionally involved in doxorubicin-resistance in breast cancer cells MCF-7 via its regulation of the expression of uncoupling protein 2. PLoS One. 10:e01298432015. View Article : Google Scholar : PubMed/NCBI

21 

Fernandez-Twinn DS, Blackmore HL, Siggens L, Giussani DA, Cross CM, Foo R and Ozanne SE: The programming of cardiac hypertrophy in the offspring by maternal obesity is associated with hyperinsulinemia, AKT, ERK, and mTOR activation. Endocrinology. 153:5961–5971. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Jones KM, Bhattacharjee R, Krishnamurthi R, Blanton S, Theadom A, Barker-Collo S, Thrift A, Parmar P, Maujean A, Ranta A, et al: Methodology of the stroke self-management rehabilitation trial: An international, multisite pilot trial. J Stroke Cerebrovasc Dis. 24:297–303. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Saad MA, Abdelsalam RM, Kenawy SA and Attia AS: Ischemic preconditioning and postconditioning alleviates hippocampal tissue damage through abrogation of apoptosis modulated by oxidative stress and inflammation during transient global cerebral ischemia-reperfusion in rats. Chem Biol Interact. 232:21–29. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Shen MH, Zhang CB, Zhang JH and Li PF: Electroacupuncture attenuates cerebral ischemia and reperfusion injury in middle cerebral artery occlusion of rat via modulation of apoptosis, inflammation, oxidative stress, and excitotoxicity. Evid Based Complement Alternat Med. 2016:94386502016. View Article : Google Scholar : PubMed/NCBI

25 

Sosunov SA, Ameer X, Niatsetskaya ZV, Utkina-Sosunova I, Ratner VI and Ten VS: Isoflurane anesthesia initiated at the onset of reperfusion attenuates oxidative and hypoxic-ischemic brain injury. PLoS One. 10:e01204562015. View Article : Google Scholar : PubMed/NCBI

26 

Buch P, Patel V, Ranpariya V, Sheth N and Parmar S: Neuroprotective activityof Cymbopogon martinii against cerebral ischemia/reperfusion-induced oxidative stress in rats. J Ethnopharmacol. 142:35–40. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Palencia G, Medrano JÁ, Ortiz-Plata A, Farfán DJ, Sotelo J, Sánchez A and Trejo-Solís C: Anti-apoptotic, anti-oxidant, and anti-inflammatory effects of thalidomide on cerebral ischemia/reperfusion injury in rats. J Neurol Sci. 351:78–87. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Zhang M, Su L, Xiao Z and Liu X and Liu X: Methyl jasmonate induces apoptosis and pro-apoptotic autophagy via the ROS pathway in human non-small cell lung cancer. Am J Cancer Res. 6:187–199. 2016.PubMed/NCBI

29 

Zhou L, Chen L, Wang J and Deng Y: Astragalus polysaccharide improves cardiac function in doxorubicin-induced cardiomyopathy through ROS-p38 signaling. Int J Clin Exp Med. 8:21839–21848. 2015.PubMed/NCBI

30 

Yong Y, Matthew S, Wittwer J, Medrano JÁ, Ortiz-Plata A, Farfán DJ, Sotelo J, Sánchez A and Trejo-Solís C: Dichamanetin inhibits cancer cell growth by affecting ROS-related signaling components through mitochondrial-mediated apoptosis. Anticancer Res. 33:5349–5355. 2013.PubMed/NCBI

31 

Lin H, Gao X, Chen G, Sun J, Chu J, Jing K, Li P, Zeng R and Wei B: Indole-3-carbinol as inhibitors of glucocorticoid-induced apoptosis in osteoblastic cells through blocking ROS-mediated Nrf2 pathway. Biochem Biophys Res Commun. 460:422–427. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Lucas IK and Kolodziej H: Trans-resveratrol induces apoptosis through ROS-triggered mitochondria-dependent pathways in A549 human lung adenocarcinoma epithelial cells. Planta Med. 81:1038–1044. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Jiang M, Li J, Peng Q, Sun J, Chu J, Jing K, Li P, Zeng R and Wei B: Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation. J Neuroinflammation. 11:1672014. View Article : Google Scholar : PubMed/NCBI

34 

Qi SH, Hao LY, Yue J, Zong YY and Zhang GY: Exogenous nitric oxide negatively regulates the S-nitrosylation p38 mitogen-activated protein kinase activation during cerebral ischaemia and reperfusion. Neuropathol Appl Neurobiol. 39:284–297. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lu H, Wang B, Cui N and Zhang Y: Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROS‑dependent p38 MAPK and protects against cerebral ischemia‑reperfusion injury. Mol Med Rep 17: 6639-6646, 2018.
APA
Lu, H., Wang, B., Cui, N., & Zhang, Y. (2018). Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROS‑dependent p38 MAPK and protects against cerebral ischemia‑reperfusion injury. Molecular Medicine Reports, 17, 6639-6646. https://doi.org/10.3892/mmr.2018.8666
MLA
Lu, H., Wang, B., Cui, N., Zhang, Y."Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROS‑dependent p38 MAPK and protects against cerebral ischemia‑reperfusion injury". Molecular Medicine Reports 17.5 (2018): 6639-6646.
Chicago
Lu, H., Wang, B., Cui, N., Zhang, Y."Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROS‑dependent p38 MAPK and protects against cerebral ischemia‑reperfusion injury". Molecular Medicine Reports 17, no. 5 (2018): 6639-6646. https://doi.org/10.3892/mmr.2018.8666
Copy and paste a formatted citation
x
Spandidos Publications style
Lu H, Wang B, Cui N and Zhang Y: Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROS‑dependent p38 MAPK and protects against cerebral ischemia‑reperfusion injury. Mol Med Rep 17: 6639-6646, 2018.
APA
Lu, H., Wang, B., Cui, N., & Zhang, Y. (2018). Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROS‑dependent p38 MAPK and protects against cerebral ischemia‑reperfusion injury. Molecular Medicine Reports, 17, 6639-6646. https://doi.org/10.3892/mmr.2018.8666
MLA
Lu, H., Wang, B., Cui, N., Zhang, Y."Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROS‑dependent p38 MAPK and protects against cerebral ischemia‑reperfusion injury". Molecular Medicine Reports 17.5 (2018): 6639-6646.
Chicago
Lu, H., Wang, B., Cui, N., Zhang, Y."Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROS‑dependent p38 MAPK and protects against cerebral ischemia‑reperfusion injury". Molecular Medicine Reports 17, no. 5 (2018): 6639-6646. https://doi.org/10.3892/mmr.2018.8666
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