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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-2018 Volume 17 Issue 5

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article Open Access

Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro

  • Authors:
    • Le Yang
    • Yong‑Song Cai
    • Ke Xu
    • Jia‑Lin Zhu
    • Yuan‑Bo Li
    • Xiao‑Qing Wu
    • Jian Sun
    • She‑Min Lu
    • Peng Xu

  • View Affiliations / Copyright

    Affiliations: Department of Joint Surgery, Xi'an Hong Hui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710054, P.R. China, Department of Genetics and Molecular Biology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6560-6568
    |
    Published online on: March 6, 2018
       https://doi.org/10.3892/mmr.2018.8679
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Abstract

The present study aimed to examine the effects of sodium selenite on the SW982 human synovial sarcoma cell line in relation to cell viability, apoptosis and autophagy. The results indicated that sodium selenite reduced cell viability and induced apoptosis by activating caspase‑3 and members of the poly (ADP‑ribose) polymerase and Bcl‑2 protein families in SW982 cells. Furthermore, autophagy was also suppressed by sodium selenite treatment in SW982 cells, and apoptosis was upregulated in cells co‑treated with sodium selenite and the autophagy inhibitor 3‑methyladenine. By contrast, apoptosis was downregulated when sodium selenite was combined with rapamycin, an inducer of autophagy. The results indicated that autophagy may protect cells from the cytotoxicity of sodium selenite. The present study results demonstrated that sodium selenite induced apoptosis and inhibited autophagy and autophagy‑protected cells from death by antagonizing sodium selenite‑induced apoptosis in SW982 cells in vitro.
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Copy and paste a formatted citation
Spandidos Publications style
Yang L, Cai YS, Xu K, Zhu JL, Li YB, Wu XQ, Sun J, Lu SM and Xu P: Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro. Mol Med Rep 17: 6560-6568, 2018.
APA
Yang, L., Cai, Y., Xu, K., Zhu, J., Li, Y., Wu, X. ... Xu, P. (2018). Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro. Molecular Medicine Reports, 17, 6560-6568. https://doi.org/10.3892/mmr.2018.8679
MLA
Yang, L., Cai, Y., Xu, K., Zhu, J., Li, Y., Wu, X., Sun, J., Lu, S., Xu, P."Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro". Molecular Medicine Reports 17.5 (2018): 6560-6568.
Chicago
Yang, L., Cai, Y., Xu, K., Zhu, J., Li, Y., Wu, X., Sun, J., Lu, S., Xu, P."Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro". Molecular Medicine Reports 17, no. 5 (2018): 6560-6568. https://doi.org/10.3892/mmr.2018.8679
Copy and paste a formatted citation
x
Spandidos Publications style
Yang L, Cai YS, Xu K, Zhu JL, Li YB, Wu XQ, Sun J, Lu SM and Xu P: Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro. Mol Med Rep 17: 6560-6568, 2018.
APA
Yang, L., Cai, Y., Xu, K., Zhu, J., Li, Y., Wu, X. ... Xu, P. (2018). Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro. Molecular Medicine Reports, 17, 6560-6568. https://doi.org/10.3892/mmr.2018.8679
MLA
Yang, L., Cai, Y., Xu, K., Zhu, J., Li, Y., Wu, X., Sun, J., Lu, S., Xu, P."Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro". Molecular Medicine Reports 17.5 (2018): 6560-6568.
Chicago
Yang, L., Cai, Y., Xu, K., Zhu, J., Li, Y., Wu, X., Sun, J., Lu, S., Xu, P."Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro". Molecular Medicine Reports 17, no. 5 (2018): 6560-6568. https://doi.org/10.3892/mmr.2018.8679
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