Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2018 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2018 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Protective effect of α-mangostin against CoCl2-induced apoptosis by suppressing oxidative stress in H9C2 rat cardiomyoblasts

  • Authors:
    • Zhao Fang
    • Wanjun Luo
    • Yanli Luo
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, International Medical Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 6697-6704
    |
    Published online on: March 6, 2018
       https://doi.org/10.3892/mmr.2018.8680
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Garcinia mangostana (a fruit) has been commonly used as a traditional drug in the treatment of various types of diseases. The aim of the present study was to evaluate the potential protective effect of α‑mangostin (α‑MG), a primary constituent extracted from the hull of the G. mangostana fruit (mangosteen), against CoCl2‑induced apoptotic damage in H9C2 rat cardiomyoblasts. α‑MG was demonstrated to significantly improve the viability of the CoCl2‑treated cells by up to 79.6%, attenuating CoCl2‑induced damage. Further studies revealed that α‑MG exerted a positive effect in terms of decreased reactive oxygen species generation, malondialdehyde concentration, cellular apoptosis, and increased superoxide dismutase activity. Furthermore, treatment with CoCl2 increased the cleavage of caspase‑9, caspase‑3 and apoptosis regulator BAX, and reduced apoptosis regulator Bcl‑2 in H9C2 cells, as measured by reverse transcription‑quantitative polymerase chain reaction and western blotting, which were significantly reversed by co‑treatment with α‑MG (0.06 and 0.3 mM). In conclusion, these results demonstrated that α‑MG protects H9C2 cells against CoCl2‑induced hypoxic injury, indicating that α‑MG is a potential therapeutic agent for cardiac hypoxic injury.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Luo D, Yao YY, Li YF, Sheng ZL, Tang Y, Fang F, Fang K, Ma GS and Teng GJ: Myocardial infarction quantification with late gadolinium-enhanced magnetic resonance imaging in rats using a 7-T scanner. Cardiovasc Pathol. 21:112–119. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N and Walsh K: Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med. 11:1096–1103. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Wu LX, Gu XF, Zhu YC and Zhu YZ: Protective effects of novel single compound, Hirsutine on hypoxic neonatal rat cardiomyocytes. Eur J Pharmacol. 650:290–297. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Zhang J, Liu A, Hou R, Zhang J, Jia X, Jiang W and Chen J: Salidroside protects cardiomyocyte against hypoxia-induced death: A HIF-1alpha-activated and VEGF-mediated pathway. Eur J Pharmacol. 607:6–14. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Zhu HM and Deng L: Evaluation of cardiomyocyte hypoxia injury models for the pharmacological study in vitro. Pharm Biol. 50:167–174. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Sharov VG, Todor AV and Sabbah HN: Left ventricular histomorphometric findings in dogs with heart failure treated with the acorn cardiac support device. Heart Fail Rev. 10:141–147. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Ibáñez B, Heusch G, Ovize M and Van de Werf F: Evolving therapies for myocardial ischemia/reperfusion injury. J Am Coll Cardiol. 65:1454–1471. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Xie Q, Li XX, Zhang P, Li JC, Cheng Y, Feng YL, Huang BS, Zhuo YF and Xu GH: Hydrogen gas protects against serum and glucose deprivation-induced myocardial injury in H9c2 cells through activation of the NF-E2-related factor 2/heme oxygenase 1 signaling pathway. Mol Med Rep. 10:1143–1149. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Li T, Zhang P, Liu J, Zhou R, Li Q, You Z and Dian K: Protective effects of hemoglobin-based oxygen carrier given to isolated heart during ischemia via attenuation of mitochondrial oxidative damage. Free Radic Biol Med. 48:1079–1089. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Dou MM, Zhang ZH, Li ZB, Zhang J and Zhao XY: Cardioprotective potential of Dendrobium officinale Kimura et Migo against myocardial ischemia in mice. Mol Med Rep. 14:4407–4414. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Yang Y, Duan W, Jin Z, Yi W, Yan J, Zhang S, Wang N, Liang Z, Li Y, Chen W, et al: JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury. J Pineal Res. 55:275–286. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Gallo S, Gatti S, Sala V, Albano R, Costelli P, Casanova E, Comoglio PM and Crepaldi T: Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy. Cell Death Dis. 5:e11852014. View Article : Google Scholar : PubMed/NCBI

13 

Pyo JO, Nah J, Kim HJ, Chang JW, Song YW, Yang DK, Jo DG, Kim HR, Chae HJ, Chae SW, et al: Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice. J Biol Chem. 283:30707–30714. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Hausenloy DJ and Yellon DM: The mitochondrial permeability transition pore: Its fundamental role in mediating cell death during ischaemia and reperfusion. J Mol Cell Cardiol. 35:339–341. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Nagy S and Shaw PE: Tropical and subtropical fruits: Composition, properties and uses. Mol Nut. 25:5821980.

16 

Gupta KK, Khandelwal G, Prasad G, Chopra AK and Mishra A: A review on scientific technologies in practice to innovate plant based molecules and to improve herbal drug quality to overcome health problems. J App Nat Sci. 2:165–181. 2010. View Article : Google Scholar

17 

Gopalakrishnan G and Balaganesan B: Two novel xanthones from Garcinia mangostana. Fitoterapia. 71:607–609. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Suksamrarn S, Suwannapoch N, Ratananukul P, Aroonlerk N and Suksamrarn A: Xanthones from the green fruit hulls of Garcinia mangostana. J Nat Prod. 65:761–763. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Chomnawang MT, Surassmo S, Nukoolkarn VS and Gritsanapan W: Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes. Fitoterapia. 78:401–408. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Matsumoto K, Akao Y, Ohguchi K, Ito T, Tanaka T, Iinuma M and Nozawa Y: Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells. Bioorg Med Chem. 13:6064–6069. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Jiang DJ, Dai Z and Li YJ: Pharmacological effects of Xanthones as cardiovascular protective agents. Cardiovasc Drug Rev. 22:91–102. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Devi Sampath P and Vijayaraghavan K: Cardioprotective effect of alpha-mangostin, a xanthone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats. J Biochem Mol Toxicol. 21:336–339. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Sampath PD and Kannan V: Mitigation of mitochondrial dysfunction and regulation of eNOS expression during experimental myocardial necrosis by alpha-mangostin, a xanthonic derivative from Garcinia mangostana. Drug Chem Toxicol. 32:344–352. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Buelna-Chontal M, Correa F, Hernández-Reséndiz S, Zazueta C and Pedraza-Chaverri J: Protective effect of α-mangostin on cardiac reperfusion damage by attenuation of oxidative stress. J Med Food. 14:1370–1374. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Kumar V, Bhatt PC, Kaithwas G, Rashid M, Al-abbasi FA, Khan JAJ, Anwar F and Verma A: α-mangostin mediated pharmacological modulation of hepatic carbohydrate metabolism in diabetes induced wistar rat. Beni-Suef Uni J Basic App Sci. 5:255–276. 2016.

26 

Iinuma M, Tosa H, Tanaka T, Asai F, Kobayashi Y, Shimano R and Miyauchi K: Antibacterial activity of xanthones from guttiferaeous plants against methicillin-resistant Staphylococcus aureus. J Pharm Pharmacol. 48:861–865. 1996. View Article : Google Scholar : PubMed/NCBI

27 

Kaomongkolgit R, Jamdee K and Chaisomboon N: Antifungal activity of alpha-mangostin against Candida albicans. J Oral Sci. 51:401–406. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Williams P, Ongsakul M, Proudfoot J, Croft K and Beilin L: Mangostin inhibits the oxidative modification of human low density lipoprotein. Free Radic Res. 23:175–184. 1995. View Article : Google Scholar : PubMed/NCBI

29 

Quan X, Wang Y, Ma X, Liang Y, Tian W, Ma Q, Jiang H and Zhao Y: α-Mangostin induces apoptosis and suppresses differentiation of 3T3-L1 cells via inhibiting fatty acid synthase. PLoS One. 7:e333762012. View Article : Google Scholar : PubMed/NCBI

30 

Lee D, Choi YO, Kim KH, Chin YW, Namgung H, Yamabe N and Jung K: Protective effect of α-mangostin against iodixanol-induced apoptotic damage in LLC-PK1 cells. Bioorg Med Chem Lett. 26:3806–3809. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Goldberg MA, Dunning SP and Bunn HF: Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein. Science. 242:1412–1415. 1988. View Article : Google Scholar : PubMed/NCBI

32 

Park JK, Jeong JW, Kang MY, Baek JC, Shin JK, Lee SA, Choi WS, Lee JH and Paik WY: Inhibition of the PI3K-Akt pathway suppresses sFlt1 expression in human placental hypoxia models in vitro. Placenta. 31:621–629. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Jia SJ, Jiang DJ, Hu CP, Zhang XH, Deng HW and Li YJ: Lysophosphatidylcholine-induced elevation of asymmetric dimethylarginine level by the NADPH oxidase pathway in endothelial cells. Vascul Pharmacol. 44:143–148. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Schmid W: Ueber das Mangostin. Eur J Org Chem. 93:83–88. 1855.

36 

Ibrahim MY, Hashim NM, Mariod AA, Mohan S, Abdulla MA, Abdelwahab SI and Arbab IA: α-Mangostin from Garcinia mangostana Linn: An updated review of its pharmacological properties. Arabian J Chem. 9:317–329. 2016. View Article : Google Scholar

37 

Stout GH, Krahn MM, Yates P and Bhat HB: The structure of mangostin. Chem Commun. 4:211–212. 1968.

38 

Chang ST, Chung CM, Chu CM, Yang TY, Pan KL, Hsu JT and Hsiao JF: Platelet glycoprotein IIb/IIIa inhibitor tirofiban ameliorates cardiac reperfusion injury. Int Heart J. 56:335–340. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Schieber M and Chandel NS: ROS function in redox signaling and oxidative stress. Curr Biol. 24:R453–R462. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Del Rio D, Stewart AJ and Pellegrini N: A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis. 15:316–328. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Liu J, Hou J, Xia ZY, Zeng W, Wang X, Li R, Ke C, Xu J, Lei S and Xia Z: Recombinant PTD-Cu/Zn SOD attenuates hypoxia-reoxygenation injury in cardiomyocytes. Free Radic Res. 47:386–393. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Wang Y, Gong GH, Xu YN, Yu LJ and Wei CX: Sugemule-3 protects against isoprenaline-induced cardiotoxicity in vitro. Pharmacogn Mag. 13:517–522. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Moris D, Spartalis M, Tzatzaki E, Spartalis E, Karachaliou GS, Triantafyllis AS, Karaolanis GI, Tsilimigras DI and Theocharis S: The role of reactive oxygen species in myocardial redox signaling and regulation. Ann Transl Med. 5:3242017. View Article : Google Scholar : PubMed/NCBI

44 

Dai ZJ, Gao J, Ma XB, Yan K, Liu XX, Kang HF, Ji ZZ, Guan HT and Wang XJ: Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells. J Exp Clin Cancer Res. 31:282012. View Article : Google Scholar : PubMed/NCBI

45 

Grasselli F, Basini G, Bussolati S and Bianco F: Cobalt chloride, a hypoxia-mimicking agent, modulates redox status and functional parameters of cultured swine granulosa cells. Reprod Fertil Dev. 17:715–720. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Srinivasan S and Dunn JF: Stabilization of hypoxia-inducible factor-1α in buffer containing cobalt chloride for Western blot analysis. Anal Biochem. 416:120–122. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Huang BW, Miyazawa M and Tsuji Y: Distinct regulatory mechanisms of the human ferritin gene by hypoxia and hypoxia mimetic cobalt chloride at the transcriptional and post-transcriptional levels. Cell Signal. 26:2702–2709. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fang Z, Luo W and Luo Y: Protective effect of α-mangostin against CoCl2-induced apoptosis by suppressing oxidative stress in H9C2 rat cardiomyoblasts. Mol Med Rep 17: 6697-6704, 2018.
APA
Fang, Z., Luo, W., & Luo, Y. (2018). Protective effect of α-mangostin against CoCl2-induced apoptosis by suppressing oxidative stress in H9C2 rat cardiomyoblasts. Molecular Medicine Reports, 17, 6697-6704. https://doi.org/10.3892/mmr.2018.8680
MLA
Fang, Z., Luo, W., Luo, Y."Protective effect of α-mangostin against CoCl2-induced apoptosis by suppressing oxidative stress in H9C2 rat cardiomyoblasts". Molecular Medicine Reports 17.5 (2018): 6697-6704.
Chicago
Fang, Z., Luo, W., Luo, Y."Protective effect of α-mangostin against CoCl2-induced apoptosis by suppressing oxidative stress in H9C2 rat cardiomyoblasts". Molecular Medicine Reports 17, no. 5 (2018): 6697-6704. https://doi.org/10.3892/mmr.2018.8680
Copy and paste a formatted citation
x
Spandidos Publications style
Fang Z, Luo W and Luo Y: Protective effect of α-mangostin against CoCl2-induced apoptosis by suppressing oxidative stress in H9C2 rat cardiomyoblasts. Mol Med Rep 17: 6697-6704, 2018.
APA
Fang, Z., Luo, W., & Luo, Y. (2018). Protective effect of α-mangostin against CoCl2-induced apoptosis by suppressing oxidative stress in H9C2 rat cardiomyoblasts. Molecular Medicine Reports, 17, 6697-6704. https://doi.org/10.3892/mmr.2018.8680
MLA
Fang, Z., Luo, W., Luo, Y."Protective effect of α-mangostin against CoCl2-induced apoptosis by suppressing oxidative stress in H9C2 rat cardiomyoblasts". Molecular Medicine Reports 17.5 (2018): 6697-6704.
Chicago
Fang, Z., Luo, W., Luo, Y."Protective effect of α-mangostin against CoCl2-induced apoptosis by suppressing oxidative stress in H9C2 rat cardiomyoblasts". Molecular Medicine Reports 17, no. 5 (2018): 6697-6704. https://doi.org/10.3892/mmr.2018.8680
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team