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Molecular Medicine Reports
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Article

Investigation of the expressions of MMPs and TIMPs between isogeneic and allogeneic rat aortic transplantation

  • Authors:
    • Si‑Dong Wei
    • Ding Cao
    • Xue‑Song Xu
    • He Bai
    • Hao Wu
    • Meng‑Hao Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, People's Hospital of Zhengzhou, Southern Medical University, Zhengzhou, Henan 450003, P.R. China, Department of Hepatobiliary Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China
  • Pages: 6909-6913
    |
    Published online on: March 6, 2018
       https://doi.org/10.3892/mmr.2018.8684
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Abstract

The present study investigated the effects of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in transplantation-associated arteriosclerosis by observing their expression in transplanted aortas in rats. Allogenic and isogenic abdominal aortic transplantations were performed and grafts were removed from the recipients at the designated time points (day 7, 14, 28 and 56 post transplantation). Hematoxylin and eosin staining, immunohistochemistry, immunofluorescence and western blot analysis were used to evaluate the grafts. Significant proliferation of the intima was observed in the allogenic transplantation groups (P<0.05). The expressions of MMPs and TIMPs in the allografts were significantly increased compared with the isografts, and the suppression of MMP2 in allografts reduced injury after transplantation. The present study concluded that the imbalance of MMPs and TIMPs led to the disturbance of synthesis and the degradation of the extracellular matrix and it may represent a key cause of chronic rejection.
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Copy and paste a formatted citation
Spandidos Publications style
Wei SD, Cao D, Xu XS, Bai H, Wu H and Wang MH: Investigation of the expressions of MMPs and TIMPs between isogeneic and allogeneic rat aortic transplantation. Mol Med Rep 17: 6909-6913, 2018.
APA
Wei, S., Cao, D., Xu, X., Bai, H., Wu, H., & Wang, M. (2018). Investigation of the expressions of MMPs and TIMPs between isogeneic and allogeneic rat aortic transplantation. Molecular Medicine Reports, 17, 6909-6913. https://doi.org/10.3892/mmr.2018.8684
MLA
Wei, S., Cao, D., Xu, X., Bai, H., Wu, H., Wang, M."Investigation of the expressions of MMPs and TIMPs between isogeneic and allogeneic rat aortic transplantation". Molecular Medicine Reports 17.5 (2018): 6909-6913.
Chicago
Wei, S., Cao, D., Xu, X., Bai, H., Wu, H., Wang, M."Investigation of the expressions of MMPs and TIMPs between isogeneic and allogeneic rat aortic transplantation". Molecular Medicine Reports 17, no. 5 (2018): 6909-6913. https://doi.org/10.3892/mmr.2018.8684
Copy and paste a formatted citation
x
Spandidos Publications style
Wei SD, Cao D, Xu XS, Bai H, Wu H and Wang MH: Investigation of the expressions of MMPs and TIMPs between isogeneic and allogeneic rat aortic transplantation. Mol Med Rep 17: 6909-6913, 2018.
APA
Wei, S., Cao, D., Xu, X., Bai, H., Wu, H., & Wang, M. (2018). Investigation of the expressions of MMPs and TIMPs between isogeneic and allogeneic rat aortic transplantation. Molecular Medicine Reports, 17, 6909-6913. https://doi.org/10.3892/mmr.2018.8684
MLA
Wei, S., Cao, D., Xu, X., Bai, H., Wu, H., Wang, M."Investigation of the expressions of MMPs and TIMPs between isogeneic and allogeneic rat aortic transplantation". Molecular Medicine Reports 17.5 (2018): 6909-6913.
Chicago
Wei, S., Cao, D., Xu, X., Bai, H., Wu, H., Wang, M."Investigation of the expressions of MMPs and TIMPs between isogeneic and allogeneic rat aortic transplantation". Molecular Medicine Reports 17, no. 5 (2018): 6909-6913. https://doi.org/10.3892/mmr.2018.8684
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