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Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation

  • Authors:
    • Agnese Gugliandolo
    • Sabrina Giacoppo
    • Marcello Ficicchia
    • Angelo Aliquò
    • Placido Bramanti
    • Emanuela Mazzon
  • View Affiliations / Copyright

    Affiliations: Department of Experimental Neurology, The IRCCS Neurolesi Center ‘Bonino‑Pulejo’, I‑98124 Messina, Italy, Agri.SA S.r.l., I‑97100 Ragusa, Italy
    Copyright: © Gugliandolo et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Pages: 6235-6244
    |
    Published online on: March 7, 2018
       https://doi.org/10.3892/mmr.2018.8695
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Abstract

Certain nutrients are able to exert health promoting effects. The consumption of Brassicaceae vegetables has increased given their reported beneficial effects on human health, due to their high content of nutraceutical compounds. The health benefits appear to be associated with the presence of glucosinolates and flavonoids. Certain nutraceutics have been revealed to have anti‑inflammatory action. In the present study, the anti‑inflammatory properties of Eruca sativa seed extract (ESE) were evaluated in NSC‑34 motor neurons exposed to the cell culture medium of lipopolysaccharide (LPS)‑stimulated RAW 264.7 macrophages. Treatment with LPS‑stimulated RAW 264.7 medium induced apoptosis and the expression of Toll‑like receptor 4 (TLR4) and cyclooxygenase 2 (COX2) in NSC‑34 motor neurons. Additionally, the stimulation of NSC‑34 motor neurons with the medium of LPS‑treated macrophages triggered the expression of NLR family pyrin domain containing 3 (NLRP3) inflammasome proteins and the production of pro‑inflammatory cytokines. Pre‑treatment with ESE counteracted the apoptosis and production of pro‑inflammatory cytokines in NSC‑34 motor neurons treated with the medium of LPS‑treated RAW 264.7. It also eliminated COX2 and TLR4/NLRP3 inflammasome expression. In addition, pre‑treatment with ESE was able to restore interleukin 10 expression in NSC‑34 cells. These results demonstrate the anti‑inflammatory and neuroprotective effects of ESE.
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View References

1 

Kalra EK: Nutraceutical-definition and introduction. AAPS Pharm Sci. 5:E252003. View Article : Google Scholar

2 

Björkman M, Klingen I, Birch AN, Bones AM, Bruce TJ, Johansen TJ, Meadow R, Mølmann J, Seljåsen R, Smart LE and Stewart D: Phytochemicals of Brassicaceae in plant protection and human health-influences of climate, environment and agronomic practice. Phytochemistry. 72:538–556. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Cartea ME, Francisco M, Soengas P and Velasco P: Phenolic compounds in Brassica vegetables. Molecules. 16:251–280. 2011. View Article : Google Scholar

4 

Prakash D and Gupta C: Glucosinolates: The phytochemicals of nutraceutical importance. J Complement Integr Med. 9:132012. View Article : Google Scholar

5 

Bhandari SR, Jo JS and Lee JG: Comparison of glucosinolate profiles in different tissues of nine brassica crops. Molecules. 20:15827–15841. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Khoobchandani M, Ganesh N, Gabbanini S, Valgimigli L and Srivastava MM: Phytochemical potential of Eruca sativa for inhibition of melanoma tumor growth. Fitoterapia. 82:647–653. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Khoobchandani M, Ojeswi BK, Ganesh N, Srivastava MM, Gabbanini S, Matera R, Iori R and Valgimigl L: Antimicrobial properties and analytical profile of traditional Eruca sativa seed oil: Comparison with various aerial and root plant extracts. Food Chem. 120:217–224. 2010. View Article : Google Scholar

8 

Fuentes E, Alarcon M, Fuentes M, Carrasco G and Palomo I: A novel role of Eruca sativa Mill. (rocket) extract: Antiplatelet (NF-κB inhibition) and antithrombotic activities. Nutrients. 6:5839–5852. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Sarwar Alam M, Kaur G, Jabbar Z, Javed K and Athar M: Eruca sativa seeds possess antioxidant activity and exert a protective effect on mercuric chloride induced renal toxicity. Food Chem Toxicol. 45:910–920. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Bell L, Oruna-Concha MJ and Wagstaff C: Identification and quantification of glucosinolate and flavonol compounds in rocket salad (Eruca sativa, Eruca vesicaria and Diplotaxis tenuifolia) by LC-MS: Highlighting the potential for improving nutritional value of rocket crops. Food Chem. 172:852–861. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Dinkova-Kostova AT and Kostov RV: Glucosinolates and isothiocyanates in health and disease. Trends Mol Med. 18:337–347. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Spencer JP, Vafeiadou K, Williams RJ and Vauzour D: Neuroinflammation: Modulation by flavonoids and mechanisms of action. Mol Aspects Med. 33:83–97. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Orhan IE, Daglia M, Nabavi SF, Loizzo MR, Sobarzo-Sánchez E and Nabavi SM: Flavonoids and dementia: An update. Curr Med Chem. 22:1004–1015. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Kempuraj D, Thangavel R, Natteru PA, Selvakumar GP, Saeed D, Zahoor H, Zaheer S, Iyer SS and Zaheer A: Neuroinflammation induces neurodegeneration. J Neurol Neurosurg Spine. 1:pii: 1003. 2016.PubMed/NCBI

15 

Chen WW, Zhang X and Huang WJ: Role of neuroinflammation in neurodegenerative diseases (Review). Mol Med Rep. 13:3391–3396. 2016. View Article : Google Scholar : PubMed/NCBI

16 

He Y, Hara H and Núñez G: Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci. 41:1012–1021. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Zhou K, Shi L, Wang Y, Chen S and Zhang J: Recent advances of the NLRP3 inflammasome in central nervous system disorders. J Immunol Res. 2016:92382902016. View Article : Google Scholar : PubMed/NCBI

18 

Virmani A, Pinto L, Binienda Z and Ali S: Food, nutrigenomics, and neurodegeneration-neuroprotection by what you eat! Mol Neurobiol. 48:353–362. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Wagner AE, Terschluesen AM and Rimbach G: Health promoting effects of brassica-derived phytochemicals: From chemopreventive and anti-inflammatory activities to epigenetic regulation. Oxid Med Cell Longev. 2013:9645392013. View Article : Google Scholar : PubMed/NCBI

20 

Kapusta-Duch J, Kopeć A, Piatkowska E, Borczak B and Leszczyńska T: The beneficial effects of Brassica vegetables on human health. Rocz Panstw Zakl Hig. 63:389–395. 2012.PubMed/NCBI

21 

Iori R, Bernardi R, Gueyrard D, Rollin P and Palmieri S: Formation of glucoraphanin by chemoselective oxidation of natural glucoerucin: A chemoenzymatic route to sulforaphane. Bioorg Med Chem Lett. 9:1047–1048. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Barillari J, Canistro D, Paolini M, Ferroni F, Pedulli GF, Iori R and Valgimigli L: Direct antioxidant activity of purified glucoerucin, the dietary secondary metabolite contained in rocket (Eruca sativa Mill.) seeds and sprouts. J Agric Food Chem. 53:2475–2482. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Pi J, Li T, Liu J, Su X, Wang R, Yang F, Bai H, Jin H and Cai J: Detection of lipopolysaccharide induced inflammatory responses in RAW264.7 macrophages using atomic force microscope. Micron. 65:1–9. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Xaus J, Comalada M, Valledor AF, Lloberas J, López-Soriano F, Argilés JM, Bogdan C and Celada A: LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-alpha. Blood. 95:3823–3831. 2000.PubMed/NCBI

25 

Ashe PC and Berry MD: Apoptotic signaling cascades. Prog Neuropsychopharmacol Biol Psychiatry. 27:199–214. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Tchernychev B, Furie B and Furie BC: Peritoneal macrophages express both P-selectin and PSGL-1. J Cell Biol. 163:1145–1155. 2003. View Article : Google Scholar : PubMed/NCBI

27 

McEver RP: Selectins: Initiators of leucocyte adhesion and signalling at the vascular wall. Cardiovasc Res. 107:331–339. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Rossol M, Heine H, Meusch U, Quandt D, Klein C, Sweet MJ and Hauschildt S: LPS-induced cytokine production in human monocytes and macrophages. Crit Rev Immunol. 31:379–446. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Choi C and Benveniste EN: Fas ligand/Fas system in the brain: Regulator of immune and apoptotic responses. Brain Res Brain Res Rev. 44:65–81. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Trotta T, Porro C, Calvello R and Panaro MA: Biological role of Toll-like receptor-4 in the brain. J Neuroimmunol. 268:1–12. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Hoozemans JJ, Veerhuis R, Janssen I, Rozemuller AJ and Eikelenboom P: Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: Implications for Alzheimer's disease. Exp Gerontol. 36:559–570. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Mark KS, Trickler WJ and Miller DW: Tumor necrosis factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells. J Pharmacol Exp Ther. 297:1051–1058. 2001.PubMed/NCBI

33 

Ulbrich F, Kaufmann K, Roesslein M, Wellner F, Auwärter V, Kempf J, Loop T, Buerkle H and Goebel U: Argon mediates anti-apoptotic signaling and neuroprotection via inhibition of Toll-like receptor 2 and 4. PLoS One. 10:e01438872015. View Article : Google Scholar : PubMed/NCBI

34 

De Paola M, Sestito SE, Mariani A, Memo C, Fanelli R, Freschi M, Bendotti C, Calabrese V and Peri F: Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model. Pharmacol Res. 103:180–187. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Huang Y, Liu J, Wang LZ, Zhang WY and Zhu XZ: Neuroprotective effects of cyclooxygenase-2 inhibitor celecoxib against toxicity of LPS-stimulated macrophages toward motor neurons. Acta Pharmacol Sin. 26:952–958. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Strauss KI and Marini AM: Cyclooxygenase-2 inhibition protects cultured cerebellar granule neurons from glutamate-mediated cell death. J Neurotrauma. 19:627–638. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Abdel-Rahman S, Shaban N, Haggag A, Awad D, Bassiouny A and Talaat I: Inhibition of NF-κB, Bcl-2 and COX-2 Gene expression by an extract of Eruca sativa seeds during rat mammary gland carcinogenesis. Asian Pac J Cancer Prev. 16:8411–8418. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Herz C, Tran HT, Márton MR, Maul R, Baldermann S, Schreiner M and Lamy E: Evaluation of an aqueous extract from horseradish root (Armoracia rusticana Radix) against lipopolysaccharide-induced cellular inflammation reaction. Evid Based Complement Alternat Med. 2017:19506922017. View Article : Google Scholar : PubMed/NCBI

39 

Sabat R, Grütz G, Warszawska K, Kirsch S, Witte E, Wolk K and Geginat J: Biology of interleukin-10. Cytokine Growth Factor Rev. 21:331–344. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Lobo-Silva D, Carriche GM, Castro AG, Roque S and Saraiva M: Balancing the immune response in the brain: IL-10 and its regulation. J Neuroinflammation. 13:2972016. View Article : Google Scholar : PubMed/NCBI

41 

Pereira L, Font-Nieves M, Van den Haute C, Baekelandt V, Planas AM and Pozas E: IL-10 regulates adult neurogenesis by modulating ERK and STAT3 activity. Front Cell Neurosci. 9:572015. View Article : Google Scholar : PubMed/NCBI

42 

Zhou Z, Peng X, Insolera R, Fink DJ and Mata M: Interleukin-10 provides direct trophic support to neurons. J Neurochem. 110:1617–1627. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Hua KF, Chou JC, Ka SM, Tasi YL, Chen A, Wu SH, Chiu HW, Wong WT, Wang YF, Tsai CL, et al: Cyclooxygenase-2 regulates NLRP3 inflammasome-derived IL-1β production. J Cell Physiol. 230:863–874. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Lee HW, Lee CG, Rhee DK, Um SH and Pyo S: Sinigrin inhibits production of inflammatory mediators by suppressing NF-κB/MAPK pathways or NLRP3 inflammasome activation in macrophages. Int Immunopharmacol. 45:163–173. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Tőzsér J and Benkő S: Natural compounds as regulators of NLRP3 inflammasome-mediated IL-1β production. Mediators Inflamm. 2016:54603022016. View Article : Google Scholar : PubMed/NCBI

46 

Sadeghi H, Mostafazadeh M, Sadeghi H, Naderian M, Barmak MJ, Talebianpoor MS and Mehraban F: In vivo anti-inflammatory properties of aerial parts of Nasturtium officinale. Pharm Biol. 52:169–174. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Kook SH, Choi KC, Lee YH, Cho HK and Lee JC: Raphanus sativus L. seeds prevent LPS-stimulated inflammatory response through negative regulation of the p38 MAPK-NF-κB pathway. Int Immunopharmacol. 23:726–734. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gugliandolo A, Giacoppo S, Ficicchia M, Aliquò A, Bramanti P and Mazzon E: Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation. Mol Med Rep 17: 6235-6244, 2018.
APA
Gugliandolo, A., Giacoppo, S., Ficicchia, M., Aliquò, A., Bramanti, P., & Mazzon, E. (2018). Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation. Molecular Medicine Reports, 17, 6235-6244. https://doi.org/10.3892/mmr.2018.8695
MLA
Gugliandolo, A., Giacoppo, S., Ficicchia, M., Aliquò, A., Bramanti, P., Mazzon, E."Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation". Molecular Medicine Reports 17.5 (2018): 6235-6244.
Chicago
Gugliandolo, A., Giacoppo, S., Ficicchia, M., Aliquò, A., Bramanti, P., Mazzon, E."Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation". Molecular Medicine Reports 17, no. 5 (2018): 6235-6244. https://doi.org/10.3892/mmr.2018.8695
Copy and paste a formatted citation
x
Spandidos Publications style
Gugliandolo A, Giacoppo S, Ficicchia M, Aliquò A, Bramanti P and Mazzon E: Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation. Mol Med Rep 17: 6235-6244, 2018.
APA
Gugliandolo, A., Giacoppo, S., Ficicchia, M., Aliquò, A., Bramanti, P., & Mazzon, E. (2018). Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation. Molecular Medicine Reports, 17, 6235-6244. https://doi.org/10.3892/mmr.2018.8695
MLA
Gugliandolo, A., Giacoppo, S., Ficicchia, M., Aliquò, A., Bramanti, P., Mazzon, E."Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation". Molecular Medicine Reports 17.5 (2018): 6235-6244.
Chicago
Gugliandolo, A., Giacoppo, S., Ficicchia, M., Aliquò, A., Bramanti, P., Mazzon, E."Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation". Molecular Medicine Reports 17, no. 5 (2018): 6235-6244. https://doi.org/10.3892/mmr.2018.8695
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