Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2018 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2018 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effects of HAD-B1 on the proliferation of A549 cisplatin-resistant lung cancer cells

  • Authors:
    • Hwa Jeong Kang
    • Ji‑Hye Park
    • Hwa‑Seung Yoo
    • Yu Mi Park
    • Chong‑Kwan Cho
    • In‑Cheol Kang
  • View Affiliations / Copyright

    Affiliations: Department of Biological Science, College of Life & Health Sciences and BioChip Research Center, Hoseo University, Asan‑si, Chungcheongnam‑do 336‑795, Republic of Korea, East‑West Cancer Center, Dunsan Korean Medical Hospital of Daejeon University, Daejeon 302‑869, Republic of Korea
  • Pages: 6745-6751
    |
    Published online on: March 7, 2018
       https://doi.org/10.3892/mmr.2018.8702
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study investigated the toxicity of HangAmDan-B1 (HAD-B1) on A549-Cisplatin resistant (A549CR) cells. HAD‑B1 inhibited the growth of A549CR cells in a concentration‑dependent manner; HAD‑B1 was more effective at inhibiting A549CR cell viability compared with vehicle‑treated cells. The reduction in viability may be due to S‑phase cell cycle arrest and the induction of apoptosis in HAD‑B1‑treated cells. Cell cycle protein profile analysis of HAD‑B1‑treated A549CR cells using an InnoPharmaScreen (IPS) ProteoChip‑based antibody microarray chip indicated downregulation of signal transducer and activator of transcription 3. The activities of caspase‑3, ‑8 and ‑9 were significantly increased in HAD‑B1‑treated cells when compared with the vehicle‑treated control group. Furthermore, the HAD‑B1‑treated group exhibited similarly increased caspase levels when compared with the Afatinib‑treated group. Taken together, these observations suggest that HAD‑B1 may be a promising candidate for further research into the therapeutic management of cisplatin-resistant lung cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Breathnach OS, Freidlin B, Conley B, Green MR, Johnson DH, Gandara DR, O'Connell M, Shepherd FA and Johnson BE: Twenty-two years of phase III trials for patients with advanced non-small-cell lung cancer: Sobering results. J Clin Oncol. 19:1734–1742. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Meng S, Zhou Z, Chen F, Kong X, Liu H, Jiang K, Liu W, Hu M, Zhang X, Ding C and Wu Y: Newcastle disease virus induces apoptosis in cisplatin-resistant human lung adenocarcinoma A549 cells in vitro and in vivo. Cancer Lett. 317:56–64. 2012. View Article : Google Scholar : PubMed/NCBI

5 

National Comprehensive Cancer Network (NCCN): NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®)Non-Small Cell Lung Cancer. NCCN; Fort Washington, PA: 2015

6 

Maroun JA, Anthony LB, Blais N, Burkes R, Dowden SD, Dranitsaris G, Samson B, Shah A, Thirlwell MP, Vincent MD and Wong R: Prevention and management of chemotherapy-induced diarrhea in patients with colorectal cancer: A consensus statement by the canadian working group on chemotherapy-induced diarrhea. Curr Oncol. 14:13–20. 2007. View Article : Google Scholar : PubMed/NCBI

7 

de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, Boni C, Cortes-Funes H, Cervantes A, Freyer G, et al: Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol. 18:2938–2947. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Kim JM, Park JW, Yoo HS, Lee YW and Cho CK: Case report of the pancreatic cancer patient after pancreatoduodenectomy who is taking the hangam-plus to anti-metastasis and preventing recurrence. J Korean Tradit Onco. 16:33–39. 2011.

9 

Kim KH, Park BR, Cho CK, Lee YW, Cho EJ, Yea SC, Yoo BC and Yoo HS: Proteome alteration in human colon cancer cells by the treatment of HangAmDan-B. Biochip J. 5:114–122. 2011. View Article : Google Scholar

10 

Choi YJ, Shin DY, Lee YW, Cho CK, Kim GY, Kim WJ, Yoo HS and Choi YH: Inhibition of cell motility and invasion by HangAmDan-B in NCI-H460 human non-small cell lung cancer cells. Oncol Rep. 26:1601–1608. 2011.PubMed/NCBI

11 

Zheng HM, Yoon JW, Lee YW, Cho CK, Oh DS and Yoo HS: Case series of advanced non-small cell lung cancer patients treated with Hang-Am Plus. Korean J Orient Int Med. 32:113–120. 2011.

12 

Kim KS, Jung TY, Yoo HS, Lee YW and Cho CK: Case series of advanced non-small cell lung cancer patients treated with Hang-Am-Plus. Korean J Orient Int Med. 30:893–900. 2009.

13 

Park BK, Yoo HS, Lee YW, Han SS, Cho JH, Son CG and Cho CK: Retrospective cohort analysis for lung cancer patients treated with Wheel Balance Therapy (WBT). Korean J Orient Int Med. 29:45–56. 2008.

14 

Bang JY, Kim EY, Yoo HS, Lee YW, Kim YS, Cho CK, Choi Y, Jeong HJ and Kang IC: Analysis of anti-angiogenic mechanism of HangAmDan-B (HAD-B), a Korean traditional medicine, using antibody microarray chip. BioChip J. 4:350–355. 2010. View Article : Google Scholar

15 

Yoo HS, Lee HJ, Kim JS, Yoon J, Lee GH, Lee YW and Cho CK: A toxicological study of HangAmDan-B in mice. J Acupunct Meridian Stud. 4:54–60. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Kang HJ, Park SJ, Park YM, Yoo HS and Kang IC: Inhibitory effects of HangAmDan-B1 (HAD-B1) on A549 lung cancer cell proliferation and tumor growth in a xenograft model. Acad J Sci Res. 4:187–193. 2016.

17 

Bang JY, Kim EY, Kang DK, Chang SI, Han MH, Baek KH and Kang IC: Pharmacoproteomic Analysis of a Novel Cell-permeable Peptide Inhibitor of Tumor-induced Angiogenesis. Mol Cell Proteomics. 10:M110.0052642011. View Article : Google Scholar : PubMed/NCBI

18 

Fumagalli S, Totty NF, Hsuan JJ and Courtneidge SA: A target for Src in mitosis. Nature. 368:871–874. 1994. View Article : Google Scholar : PubMed/NCBI

19 

Galluzzi L, Senovilla L, Vitale I, Michels J, Martins I, Kepp O, Castedo M and Kroemer G: Molecular mechanisms of cisplatin resistance. Oncogene. 31:1869–1883. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Molassiotis A, Fernadez-Ortega P, Pub D, Ozden G, Scott JA, Panteli V, Margulies A, Browall M, Magri M, Selvekerova S, et al: Use of complementary and alternative medicine in cancer patients: A European survey. Ann Oncol. 16:655–663. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Cragg GM and Newman DJ: Plants as a source of anti-cancer agents. J Ethnopharma. 100:72–79. 2005. View Article : Google Scholar

22 

Aoki Y, Feldman GM and Tosato G: Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. 101:1535–1542. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Athikomkulchai S, Viriyaroj A, Awale S, Ruchirawat S, Svasti J and Saiki I: Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 downregulation by inhibiting STAT3 phosphorylation. Int J Oncol. 43:329–337. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Zhu Q, Hu J, Meng H, Shen Y, Zhou J and Zhu Z: S-Phase cell cycle arrest, apoptosis, and molecular mechanisms of aplasia ras homolog member i-induced human ovarian cancer SKOV3 cell lines. Int J Gynecol Cancer. 24:629–634. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kang HJ, Park JH, Yoo HS, Park YM, Cho CK and Kang IC: Effects of HAD-B1 on the proliferation of A549 cisplatin-resistant lung cancer cells. Mol Med Rep 17: 6745-6751, 2018.
APA
Kang, H.J., Park, J., Yoo, H., Park, Y.M., Cho, C., & Kang, I. (2018). Effects of HAD-B1 on the proliferation of A549 cisplatin-resistant lung cancer cells. Molecular Medicine Reports, 17, 6745-6751. https://doi.org/10.3892/mmr.2018.8702
MLA
Kang, H. J., Park, J., Yoo, H., Park, Y. M., Cho, C., Kang, I."Effects of HAD-B1 on the proliferation of A549 cisplatin-resistant lung cancer cells". Molecular Medicine Reports 17.5 (2018): 6745-6751.
Chicago
Kang, H. J., Park, J., Yoo, H., Park, Y. M., Cho, C., Kang, I."Effects of HAD-B1 on the proliferation of A549 cisplatin-resistant lung cancer cells". Molecular Medicine Reports 17, no. 5 (2018): 6745-6751. https://doi.org/10.3892/mmr.2018.8702
Copy and paste a formatted citation
x
Spandidos Publications style
Kang HJ, Park JH, Yoo HS, Park YM, Cho CK and Kang IC: Effects of HAD-B1 on the proliferation of A549 cisplatin-resistant lung cancer cells. Mol Med Rep 17: 6745-6751, 2018.
APA
Kang, H.J., Park, J., Yoo, H., Park, Y.M., Cho, C., & Kang, I. (2018). Effects of HAD-B1 on the proliferation of A549 cisplatin-resistant lung cancer cells. Molecular Medicine Reports, 17, 6745-6751. https://doi.org/10.3892/mmr.2018.8702
MLA
Kang, H. J., Park, J., Yoo, H., Park, Y. M., Cho, C., Kang, I."Effects of HAD-B1 on the proliferation of A549 cisplatin-resistant lung cancer cells". Molecular Medicine Reports 17.5 (2018): 6745-6751.
Chicago
Kang, H. J., Park, J., Yoo, H., Park, Y. M., Cho, C., Kang, I."Effects of HAD-B1 on the proliferation of A549 cisplatin-resistant lung cancer cells". Molecular Medicine Reports 17, no. 5 (2018): 6745-6751. https://doi.org/10.3892/mmr.2018.8702
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team